6 results on '"Congrong Liu"'
Search Results
2. Study of the revisited, revised, and expanded Silva pattern system for Chinese endocervical adenocarcinoma patients
- Author
-
Xingzheng Zheng, Wei Wang, Yan Liu, Congrong Liu, Guangyao Song, Yuxiang Wang, and Jie Lin
- Subjects
Adult ,0301 basic medicine ,Oncology ,medicine.medical_specialty ,Perineural invasion ,Uterine Cervical Neoplasms ,Lymph node metastasis ,Adenocarcinoma ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,Asian People ,Internal medicine ,Statistical significance ,medicine ,Humans ,Stage (cooking) ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Middle Aged ,Endocervical Adenocarcinoma ,030104 developmental biology ,030220 oncology & carcinogenesis ,Cohort ,Female ,business - Abstract
As a new pattern-based classification, the Silva pattern system has been recently developed to evaluate invasive lymph node metastasis and the prognosis of endocervical adenocarcinoma (EAC). Therefore, our study was conducted to explore the reproducibility and prognostic significance of this system in a multi-institutional Chinese cohort, with the goal of revising and expanding its application. The clinicopathological data of 191 EAC patients from 3 medical centers were examined in a retrospective manner. The Silva pattern system demonstrated great prognostic value, significance in guiding treatment selection, and acceptable reproducibility in 191 patients that included additional histologic variants and 124 usual-type EAC patients. Collectively, compared with usual-type EAC, the whole cohort demonstrated similar statistical significance for relevant clinicopathological parameters, such as International Federation of Gynecology and Obstetrics stage (R = 0.612 versus R = 0.600), tumor thickness (P .0001 versus P .0001), lymphovascular invasion (P .0001 versus P .0001), lymph node metastasis (P = .033 versus P = .018), perineural invasion (P = .003 versus P = .001), and recurrence-free survival (P = .047 versus P = .020). Moreover, perineural invasion was significantly correlated (P = .001) with the Silva pattern system and appeared in most Silva C tumors. In conclusion, the Silva pattern system is consistent with the biological behavior of EAC and has acceptable reproducibility. Compared with International Federation of Gynecology and Obstetrics stage, it can predict patient prognosis before surgery. We suggest revising the Silva C criteria by adding perineural invasion as a factor and propose expanding the Silva pattern system to include more histologic variants. It seems that the Silva pattern system can be applied in routine clinical practice to guide EAC therapeutic strategies in the near future.
- Published
- 2019
3. Tunable photoluminescence of water-soluble AgInZnS–graphene oxide (GO) nanocomposites and their application in-vivo bioimaging
- Author
-
Congrong Liu, Xiaofeng Zeng, Ming Wang, Xiaosheng Tang, Wei Hu, and Zhigang Zang
- Subjects
Materials science ,Photoluminescence ,Biocompatibility ,Oxide ,Nanotechnology ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,law.invention ,chemistry.chemical_compound ,law ,Materials Chemistry ,MTT assay ,Electrical and Electronic Engineering ,Instrumentation ,Nanocomposite ,Graphene ,Metals and Alloys ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,chemistry ,Quantum dot ,0210 nano-technology ,Preclinical imaging - Abstract
Water-soluble quantum dots (QDs) with biocompatibility and photostability show a potential application in biomedical optical imaging. Herein, we reported biocompatible, photostable and eco-friendly AgInZnS–graphene oxide (AIZS–GO) nanocomposites with tunable emissions by transferring hydrophobic AIZS QDs on water-soluble GO via a mini-emulsion method. The as-prepared hydrophilic AIZS–GO nanocomposites still exhibited bright and stable photoluminescence (PL) even after phase-transfer by using GO, moreover, their PL emission could be well tuned widely in the range of 530 nm–680 nm by controlling the composition of Zn. In addition, AIZS–GO nanocomposites could be used for imaging of SK-BR-3 breast cancer cells via intratumoral administration. MTT assay result proved that these nanocomposites demonstrated comparable low cytotoxicity due to the absence of highly toxic cadmium. The in vivo imaging experiments of mice indicated that the prepared red emitted AIZS–GO nanocomposites could be used for the cancer cell and organ of mice labeling, which shows potential applications in bioimaging and related fields such as phototherapy and imaging.
- Published
- 2017
4. Intravoxel incoherent motion diffusion weighted MRI of cervical cancer — Correlated with tumor differentiation and perfusion
- Author
-
Wei He, Weidan Lu, Yang Shen, Huici Zhu, Zhenyu Zhou, Nan Li, Jing Jia, Jianyu Liu, Dandan Zheng, Ziheng Zhang, Lizhi Xie, Yan Zhou, and Congrong Liu
- Subjects
medicine.medical_specialty ,Uterine cervical cancer ,Biomedical Engineering ,Biophysics ,Contrast Media ,Uterine Cervical Neoplasms ,Cervix Uteri ,030218 nuclear medicine & medical imaging ,Diagnosis, Differential ,Motion ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Effective diffusion coefficient ,Radiology, Nuclear Medicine and imaging ,Grading (tumors) ,Intravoxel incoherent motion ,Cervical cancer ,Tumor differentiation ,business.industry ,Middle Aged ,Image Enhancement ,medicine.disease ,Magnetic Resonance Imaging ,Perfusion ,Diffusion Magnetic Resonance Imaging ,030220 oncology & carcinogenesis ,Female ,Radiology ,Neoplasm Grading ,business ,Nuclear medicine ,Diffusion MRI - Abstract
To investigate the value of parameters derived from IVIM model in grading of uterine cervical cancer and the relationship between perfusion parameters derived from IVIM and that from DCE-MRI.Parameters of DWI (ADC, D, f, D*) and semi-quantitative parameters of DCE-MRI (Slop, Maxslop, CER, Washout, AUC90) were assessed in 24 female with cervical cancers. Except for ROIs encompassed all of the area of tumors in axial plane (A_all), ROIs on tumor edge (A_peri) and tumor center (A_central) were drawn. All of the parameters were compared among three pathology grades. Perfusion parameters derived from IVIM were correlated with that from DCE-MRI.For G1, G2 and G3 tumors, on tumor edge ADC=(1.03±0.11), (1.05±0.10), (0.90±0.05)×10(-3)mm(2)/s, D=(0.80±0.11), (0.78±0.07), (0.69±0.06)×10(-3)mm(2)/s, and f=(0.19±0.03), (0.22±0.02), (0.24±0.03). The differences among groups were significant (P0.05). On tumor center, ADC=(0.90±0.10), (0.85±0.03), (0.80±0.07)×10(-3)mm(2)/s with significant differences (P=0.027). The other parameter, D and f of tumor center, as well as D* of all tumor areas, were of no statistic significance. Most of the DCE-MRI parameters negatively correlated with tumor volume. Although the correlation between f and slop was statistic significant, R=0.277 meant a negligible correlation. f had week correlation with Maxslop, CER and AUC90 (R=0.361, 0.400 and 0.405; P0.001). D* showed no statistic significant correlation with all of the DCE parameters.IVIM model could possibly be used to evaluate tumor differentiation and perfusion, providing an alternative for DCE-MRI.
- Published
- 2016
5. Design and analysis of an intensified column with side reactor configuration for ethylene glycol production from ethylene oxide
- Author
-
Jihai Tang, Gongde Wu, Congrong Liu, Xu Qiao, Yunbo Xue, and Lianghui Ding
- Subjects
Materials science ,General Chemical Engineering ,Energy Engineering and Power Technology ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Column (database) ,Industrial and Manufacturing Engineering ,Isothermal process ,law.invention ,chemistry.chemical_compound ,law ,Electrical conductor ,Distillation ,Ethylene oxide ,Process Chemistry and Technology ,technology, industry, and agriculture ,General Chemistry ,Atmospheric temperature range ,equipment and supplies ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,chemistry ,Chemical engineering ,Sequential analysis ,0210 nano-technology ,Ethylene glycol - Abstract
The side reactor concept (SRC), comprising a non-reactive column coupled with side reactors, is proposed for the synthesis of ethylene glycol (EG) by ethylene oxide (EO) hydration. Parallel isothermal continuous stirred tank reactors are employed and the combinations of the reactors and the column are cautiously examined. A preliminary analysis of the operating conditions for the reaction and separation and the detailed SRC configurations (such as the side stream rate, side stream location) are performed to generate the suggested values or ranges for their further optimization. The decisive variables are subsequently optimized by a sequential design procedure. The significant effects of the key decision variables on the trade-off between the reaction cost and the separation cost are well investigated. The reactor–separation unit, configured with a total liquid withdrawn and recycled back to the column stage below, demonstrates better system performance. Furthermore, the reaction at elevated temperature (150 °C) conductive for reaction and the separation occurring at the distillation temperature range of 106∼204 °C (124 kPa) gives out improved economic performance. Flexibility in the operating conditions in SRC makes it a competitive alternative to the RD process for EG production.
- Published
- 2020
6. Defective expression of Protein 4.1N is correlated to tumor progression, aggressive behaviors and chemotherapy resistance in epithelial ovarian cancer
- Author
-
Ajin Hu, Zifen Gao, Congrong Liu, Qian Yao, Chenguang Xi, Caixia Ren, Yue Wang, Xiuli An, and Jie Lin
- Subjects
Pathology ,medicine.medical_specialty ,endocrine system diseases ,Carcinoma, Ovarian Epithelial ,Biology ,medicine.disease_cause ,Malignant transformation ,Cell Line, Tumor ,medicine ,Humans ,Epithelial ovarian cancer ,Neoplasms, Glandular and Epithelial ,Cell adhesion ,Neoplasm Staging ,Ovarian Neoplasms ,Neuropeptides ,Membrane Proteins ,Obstetrics and Gynecology ,Middle Aged ,Immunohistochemistry ,Blot ,Cytoskeletal Proteins ,Oncology ,Drug Resistance, Neoplasm ,Tumor progression ,Cell culture ,Disease Progression ,Female ,Neoplasm Grading ,Carcinogenesis - Abstract
Protein 4.1N (4.1N) is a member of the Protein 4.1 family that is involved in cellular processes such as cell adhesion, migration and signaling. In this study, we evaluated the expression of 4.1N protein and its potential roles in epithelial ovarian cancer (EOC) tumorigenesis and progression.4.1N protein expression was investigated in a total of 280 samples including 74 normal tissues, 35 benign, 30 borderline and 141 malignant epithelial ovarian tumors by immunohistochemistry. Correlation between 4.1N expression levels and clinicopathologic features was statistically analyzed. The expression of 4.1N in EOC cell lines was examined by western blotting.Immunohistochemistry analysis revealed that, although there was no loss of 4.1N expression in normal tissues and benign tumors, absence of Protein 4.1N was significantly more common in EOCs (44.0%) than in borderline tumors (3.3%) (p0.001). Furthermore, loss or decreased expression of 4.1N protein expression was correlated with malignant potential of the tumors (14.3% in benign tumors, 56.7% in borderline tumors and 92.9% in malignancy) (p0.001). In EOC samples, loss of 4.1N protein was significantly associated with advanced-stage (p=0.004), ascites (p=0.009), omental metastasis (p=0.018), suboptimal debulking (p=0.024), poorly histological differentiation (p=0.009), high-grade serous carcinoma (p=0.001), short progression-free-survival (p=0.018) and poor chemosensitivity to first-line chemotherapy (p=0.029). Moreover, western blotting analysis revealed that expression of 4.1N protein was lost in 4/8 (50%) EOC cell lines.4.1N protein expression level was significantly decreased during malignant transformation of epithelial ovarian tumors and that loss of 4.1N expression was closely correlated to poorly differentiated and biologically aggressive EOCs.
- Published
- 2013
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.