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25 results on '"Costabile G"'

4. Effects of an isoenergetic multifactorial diet on pancreatic fat and insulin secretion in patients with type 2 diabetes: A randomized controlled trial

Author

Della Pepa, G., primary, Costabile, G., additional, Salamone, D., additional, Brancato, V., additional, Monti, S., additional, Salvatore, M., additional, Cipriano, P., additional, Vitale, M., additional, Riccardi, G., additional, Rivellese, A.A., additional, Annuzzi, G., additional, and Bozzetto, L., additional

Published
2022
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6. Plasma TMAO increase after healthy diets: results from two randomized controlled trials with dietary fish, polyphenols, and whole grain cereals

Author

Costabile, G., primary, Vetrani, C., additional, Bozzetto, L., additional, Giacco, R., additional, Bresciani, L., additional, Del Rio, D., additional, Vitale, M., additional, Della Pepa, G., additional, Brighenti, F., additional, Riccardi, G., additional, Rivellese, A.A., additional, and Annuzzi, G., additional

Published
2021
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7. Grape pomace polyphenols improve insulin response to a standard meal in healthy individuals: A pilot study

Author

Costabile, G., primary, Vitale, M., additional, Luongo, D., additional, Naviglio, D., additional, Vetrani, C., additional, Ciciola, P., additional, Tura, A., additional, Castello, F., additional, Mena, P., additional, Del Rio, D., additional, Capaldo, B., additional, Rivellese, A.A., additional, Riccardi, G., additional, and Giacco, R., additional

Published
2019
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10. Development of inhalable hyaluronan/mannitol composite dry powders for flucytosine repositioning in local therapy of lung infections

Author

Costabile, G., primary, d'Angelo, I., additional, d'Emmanuele di Villa Bianca, R., additional, Mitidieri, E., additional, Pompili, B., additional, Del Porto, P., additional, Leoni, L., additional, Visca, P., additional, Miro, A., additional, Quaglia, F., additional, Imperi, F., additional, Sorrentino, R., additional, and Ungaro, F., additional

Published
2016
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12. Diets naturally-rich in polyphenols improve glucose metabolism in people at high cardiovascular risk: A controlled randomized trial

Author

Bozzetto, L., primary, Annuzzi, G., additional, Pacini, G., additional, Vetrani, C., additional, Costabile, G., additional, Mangione, A., additional, Della Pepa, G., additional, Cocozza, S., additional, Griffo, E., additional, Anniballi, G., additional, Tura, A., additional, Giacco, A., additional, Riccardi, G., additional, and Rivellese, A.A., additional

Published
2014
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13. A whole-grain cereal-based diet lowers postprandial plasma insulin and triglyceride levels in individuals with metabolic syndrome

Author

Giacco, R., primary, Costabile, G., additional, Della Pepa, G., additional, Anniballi, G., additional, Griffo, E., additional, Mangione, A., additional, Cipriano, P., additional, Viscovo, D., additional, Clemente, G., additional, Landberg, R., additional, Pacini, G., additional, Rivellese, A.A., additional, and Riccardi, G., additional

Published
2014
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24. A wheat aleurone-rich diet improves oxidative stress but does not influence glucose metabolism in overweight/obese individuals: Results from a randomized controlled trial

Author

Giuseppina Costabile, Marilena Vitale, Giuseppe Della Pepa, Paola Cipriano, Claudia Vetrani, Roberta Testa, Pedro Mena, Letizia Bresciani, Michele Tassotti, Luca Calani, Daniele Del Rio, Furio Brighenti, Raffaele Napoli, Angela A. Rivellese, Gabriele Riccardi, Rosalba Giacco, Costabile, G., Vitale, M., Della Pepa, G., Cipriano, P., Vetrani, C., Testa, R., Mena, P., Bresciani, L., Tassotti, M., Calani, L., Del Rio, D., Brighenti, F., Napoli, R., Rivellese, A. A., Riccardi, G., and Giacco, R.

Subjects
Blood Glucose, Dietary Fiber, Inflammation, Glucose metabolism, Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism, Whole-grain cereals, Plant Protein, Medicine (miscellaneous), Oxidative Stre, Middle Aged, Overweight, Diet, Betaine, Oxidative stress, Wheat-aleurone, Humans, Whole-grain cereal, Obesity, Cardiology and Cardiovascular Medicine, Human, Aged, Plant Proteins
Abstract

Background and aims: Aleurone is the innermost layer of wheat bran, rich in fiber, minerals, vitamins, phenolic compounds, and betaine. The metabolic effects of aleurone rich foods are still unknown. Our aim was to investigate the effects of consuming a Wheat Aleurone rich diet vs. a Refined Wheat diet for 8 weeks on fasting and postprandial glycemic and lipid metabolism, inflammation, and oxidative stress in overweight/obese individuals. Methods and results: According to a randomized cross-over study design, 23 overweight/obese individuals, age 56 +/- 9 years (M +/- SD), were assigned to two isoenergetic diet - Wheat Aleurone and Refined Wheat diets - for 8 weeks. The diets were similar for macronutrient composition but different for the aleurone content (40-50 g/day in the Wheat Aleurone diet). After each diet, fasting and postprandial plasma metabolic profile, ferulic acid metabolites and 8-isoprostane concentrations in 24-h urine samples were evaluated. Compared with the Refined Wheat Diet, the Wheat Aleurone Diet increased fasting plasma concentrations of betaine by 15% (p = 0.042) and decreased the excretion of 8-isoprostane by 33% (p = 0.035). Conversely, it did not affect the fasting and postprandial glucose, insulin and triglyceride responses, homocysteine, and C-Reactive Protein concentrations, nor excretion of phenolic metabolites. Conclusion: An 8-week Wheat Aleurone Diet improves the oxidative stress and increases plasma betaine levels in overweight/obese individuals with an increased cardiometabolic risk. However, further studies with longer duration and larger sample size are needed to evaluate the benefits of aleurone-rich foods on glucose and lipid metabolism in individuals with more severe metabolic abnormalities. (c) 2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

Published
2022
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25. Intra-tracheal administration increases gallium availability in lung: implications for antibacterial chemotherapy

Author

Domenico Vanacore, Gabriella Costabile, Raffaella Sorrentino, Emanuela Frangipani, Roberta d'Emmanuele di Villa Bianca, Romina Provenzano, Daniela Visaggio, Carlotta Turnaturi, Emma Mitidieri, Francesca Ungaro, Paolo Visca, Mitidieri, E., Visaggio, D., Frangipani, E., Turnaturi, C., Vanacore, D., Provenzano, R., Costabile, G., Sorrentino, R., Ungaro, F., Visca, P., and d'Emmanuele di Villa Bianca, R.

Subjects
Male, 0301 basic medicine, medicine.drug_class, Antibiotic, Gallium, Intra-tracheal route, Lung, Pneumonia, Rat, Toxicity, medicine.medical_treatment, Antibiotics, Biological Availability, Gallium, Administration, Intravenou, Pharmacology, Nephrotoxicity, 03 medical and health sciences, 0302 clinical medicine, In vivo, Anti-Bacterial Agent, Administration, Inhalation, medicine, Animals, Tissue Distribution, Rats, Wistar, Aerosol, Lung, Aerosols, Chemotherapy, Toxicity, Inhalation, Animal, business.industry, Antibiotic, Intra-tracheal route, Pneumonia, Rat, Acute toxicity, Anti-Bacterial Agents, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Administration, Intravenous, business
Abstract

The emergence of pan-resistant strains in nosocomial settings underscores the urgent need of novel therapies targeting vital bacterial functions. Bacterial iron metabolism is a fascinating target for new antimicrobials. Iron mimetic metal Ga(III) has been repurposed as an antimicrobial drug, in pre-clinical studies and recent clinical studies have raised the possibility of using Ga(III) for the treatment of P. aeruginosa pulmonary infection. Ga(III) has been approved by FDA for the treatment of cancer, autoimmune and bone resorption disorders. However, some critical issues affect the therapeutic schedule of Ga(III), principally the intra-venous (i.v.) administration, and the nephrotoxicity caused by prolonged administration. Ga(III) aerosolization could represent a viable alternative for treatment of lung infections, since delivery of antimicrobial agents to the airways maximizes drug concentration at the site of infection, improves the therapeutic efficacy, and alleviates systemic toxic effects. We demonstrate the advantage of inhaled vs i.v. administered Ga(III), in terms of bio-distribution and lung acute toxicity, by using a rat model. In vivo results support the use of Ga(III) for inhalation since intra-tracheal Ga(III) delivery improved its persistence in the lung, while the i.v. administration caused rapid clearance and did not allow to attain a significant Ga(III) concentration in this organ. Moreover, local and systemic acute toxicity following intra-tracheal administration was not observed, since no significant signs of inflammation were found. At this stage of evidence, the direct administration of Ga(III) to the lung appears feasible and safe, boosting the development of Ga(III)-based drugs for inhalation therapy.

Published
2021
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