1. Differential effect of short-term REM sleep deprivation on NGF and BDNF protein levels in the rat brain
- Author
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Yusuke Morita, Kyoji Morita, Kei Yamamoto, Daisuke Saitoh, and Hiroyoshi Sei
- Subjects
Male ,Rapid eye movement sleep ,Sleep, REM ,Hippocampus ,Memory ,Neurotrophic factors ,Cerebellum ,Physical Stimulation ,Nerve Growth Factor ,medicine ,Animals ,Rats, Wistar ,Molecular Biology ,Brain Chemistry ,Brain-derived neurotrophic factor ,Brain-Derived Neurotrophic Factor ,General Neuroscience ,Brain ,Rats ,Sleep deprivation ,Nerve growth factor ,nervous system ,Synaptic plasticity ,Sleep Deprivation ,Memory consolidation ,Neurology (clinical) ,medicine.symptom ,Arousal ,Psychology ,Neuroscience ,Brain Stem ,Developmental Biology - Abstract
It is well known that REM sleep is associated with memory consolidation, especially, procedural skill learning. Neurotrophic factors are known to be involved in synaptic plasticity. We therefore investigated the effects of selective REM sleep deprivation (RSD) on NGF and BDNF proteins in the hippocampus, cerebellum and brainstem in the rat. NGF and BDNF were detected by an ELISA. Our findings show that 6 h RSD affected the NGF and BDNF protein levels in different manner. In the cerebellum and brainstem, BDNF was significantly decreased, while NGF was not changed. Conversely, in the hippocampus, NGF was significantly decreased while BDNF was not changed. This study indicates that REM sleep may be associated with the secretion of neurotrophic factors and thus contribute to the memory functions.
- Published
- 2000
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