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Your search keyword '"Danny Kupka"' showing total 2 results
Start Over Author "Danny Kupka" Publisher elsevier bv
2 results on '"Danny Kupka"'

1. Timing of Active Left Ventricular Unloading in Patients on Venoarterial Extracorporeal Membrane Oxygenation Therapy

Author

Benedikt Schrage, Jonas Sundermeyer, Stefan Blankenberg, Pascal Colson, Dennis Eckner, Matthias Eden, Ingo Eitel, Derk Frank, Norbert Frey, Tobias Graf, Paulus Kirchhof, Danny Kupka, Ulf Landmesser, Axel Linke, Nicolas Majunke, Norman Mangner, Octavian Maniuc, Johannes Mierke, Sven Möbius-Winkler, David A. Morrow, Marc Mourad, Peter Nordbeck, Martin Orban, Federico Pappalardo, Sandeep M. Patel, Matthias Pauschinger, Vittorio Pazzanese, Darko Radakovic, P. Christian Schulze, Clemens Scherer, Robert H.G. Schwinger, Carsten Skurk, Holger Thiele, Anubodh Varshney, Lukas Wechsler, and Dirk Westermann

Subjects
Cardiology and Cardiovascular Medicine
Published
2023

2. Clec12a Is an Inhibitory Receptor for Uric Acid Crystals that Regulates Inflammation in Response to Cell Death

Author

Olaf Groß, Andreas Gewies, Hans-Joachim Anders, Ronald Naumann, Maciej Lech, Jürgen Ruland, Ulrike Höckendorf, Konstantin Neumann, Danny Kupka, Simone Lemeer, Bernhard Kuster, Svenia Meyermann, Dirk H. Busch, Mercedes Castineiras-Vilarino, and Nicole Hannesschläger

Subjects
Programmed cell death, Neutrophils, Immunology, Inflammation, Biology, medicine.disease_cause, Models, Biological, Neutrophil Activation, Cell Line, Autoimmunity, Mice, 03 medical and health sciences, 0302 clinical medicine, Immunity, Sense (molecular biology), medicine, Animals, Immunology and Allergy, Lectins, C-Type, Receptor, 030304 developmental biology, Mice, Knockout, 0303 health sciences, Innate immune system, Cell Death, Uric Acid, 3. Good health, Thymocyte, Infectious Diseases, Receptors, Mitogen, medicine.symptom, 030215 immunology
Abstract

SummaryRecognition of cell death by the innate immune system triggers inflammatory responses. However, how these reactions are regulated is not well understood. Here, we identify the inhibitory C-type lectin receptor Clec12a as a specific receptor for dead cells. Both human and mouse Clec12a could physically sense uric acid crystals (monosodium urate, MSU), which are key danger signals for cell-death-induced immunity. Clec12a inhibited inflammatory responses to MSU in vitro, and Clec12a-deficient mice exhibited hyperinflammatory responses after being challenged with MSU or necrotic cells and after radiation-induced thymocyte killing in vivo. Thus, we identified a negative regulatory MSU receptor that controls noninfectious inflammation in response to cell death that has implications for autoimmunity and inflammatory disease.

Published
2014

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