12 results on '"De Simone, I"'
Number of results to display per page
Search Results
2. Assessing the mid-term impact of enhanced prostate cancer screening in Caucasian men with germline DNA repair pathogenic variants
- Author
-
Fasulo, V., primary, Buffi, N.M., additional, Casale, P., additional, Saita, A., additional, Hurle, R., additional, Finocchiaro, A., additional, Aljoulani, M., additional, Paciotti, M., additional, Asselta, R., additional, Soldà, G., additional, De Simone, I., additional, Colombo, P., additional, Cieri, M., additional, Maura, F., additional, Cavalli, P., additional, Lughezzani, G., additional, and Lazzeri, M., additional
- Published
- 2024
- Full Text
- View/download PDF
3. PB0214 Evaluation of Innovative Laboratory Tests to Predict a Thrombotic Phenotype in a Family with Dysfibrinogenemia and a Novel FGG Mutation
- Author
-
Monard, A., primary, Heubel-Moenen, F., additional, Castoldi, E., additional, de simone, I., additional, van der Meijden, P., additional, Wichapong, K., additional, van Doorn, W., additional, Spada, S., additional, Hellenbrand, D., additional, Stork, A., additional, ten Cate, H., additional, Beckers, E., additional, and Henskens, Y., additional
- Published
- 2023
- Full Text
- View/download PDF
4. Final results of DIADEM, a phase II study to investigate the efficacy and safety of durvalumab in advanced pretreated malignant pleural mesothelioma
- Author
-
Canova, S, Ceresoli, G, Grosso, F, Zucali, P, Gelsomino, F, Pasello, G, Mencoboni, M, Rulli, E, Galli, F, De Simone, I, Carlucci, L, De Angelis, A, Belletti, M, Bonomi, M, D'Aveni, A, Perrino, M, Bono, F, Cortinovis, D, Colonese, F, Abbate, M, Sala, L, Sala, E, Perez Gila, M, Pagni, F, Ugo, F, De Vincenzo, F, Santoro, A, Ardizzoni, A, Frega, S, D'Incalci, M, Poli, D, Torri, V, Canova S., Ceresoli G. L., Grosso F., Zucali P. A., Gelsomino F., Pasello G., Mencoboni M., Rulli E., Galli F., De Simone I., Carlucci L., De Angelis A., Belletti M., Bonomi M., D'Aveni A., Perrino M., Bono F., Cortinovis D. L., Cortinovis D., Colonese F., Abbate M. I., Sala L., Sala E., Perez Gila M., Pagni F., Ugo F., De Vincenzo F., Santoro A., Ardizzoni A., Frega S., D'Incalci M., Poli D., Torri V., Canova, S, Ceresoli, G, Grosso, F, Zucali, P, Gelsomino, F, Pasello, G, Mencoboni, M, Rulli, E, Galli, F, De Simone, I, Carlucci, L, De Angelis, A, Belletti, M, Bonomi, M, D'Aveni, A, Perrino, M, Bono, F, Cortinovis, D, Colonese, F, Abbate, M, Sala, L, Sala, E, Perez Gila, M, Pagni, F, Ugo, F, De Vincenzo, F, Santoro, A, Ardizzoni, A, Frega, S, D'Incalci, M, Poli, D, Torri, V, Canova S., Ceresoli G. L., Grosso F., Zucali P. A., Gelsomino F., Pasello G., Mencoboni M., Rulli E., Galli F., De Simone I., Carlucci L., De Angelis A., Belletti M., Bonomi M., D'Aveni A., Perrino M., Bono F., Cortinovis D. L., Cortinovis D., Colonese F., Abbate M. I., Sala L., Sala E., Perez Gila M., Pagni F., Ugo F., De Vincenzo F., Santoro A., Ardizzoni A., Frega S., D'Incalci M., Poli D., and Torri V.
- Abstract
Background: Malignant pleural mesothelioma (MPM) is a cancer with a high mortality rate and few therapeutic options. After platinum–pemetrexed combination, no further promising drug seems to be effective. Immune checkpoint inhibitors may have some activity in pretreated patients and no data are available in this population about durvalumab. Materials and methods: DIADEM was a multicenter, open-label, single-arm, phase II trial aimed at evaluating the efficacy and safety of durvalumab. Patients with locally advanced/metastatic MPM who progressed after platinum–pemetrexed chemotherapy were enrolled to receive durvalumab (1500 mg, intravenously Q4W) for 12 months or until evidence of disease progression or unacceptable toxicity. The primary endpoint was the proportion of patients alive and free from progression at 16 weeks (PFS16wks) calculated from treatment initiation. Secondary endpoints were progression-free survival, overall survival, overall response rate, and safety. Results: Sixty-nine patients with a median age of 69 years (range 44-82 years) were enrolled; 62 patients (89.9%) had epithelioid histotype. As first-line treatment, all patients received platinum derivatives–pemetrexed combination (60.9% with carboplatin and 39.1% with cisplatin). As of March 2021, the median follow-up was 9.2 months (interquartile range 5.2-11.1 months). Six patients (8.7%) completed the 12-month treatment; 60 patients discontinued, of whom 42 for progressive disease, and 4 died. Seventeen patients (28.3%; 95% confidence interval 17.5% to 41.4%) were alive or free from progression at 16 weeks. Eleven patients (18.6%) had a grade 3 or 4 treatment-related adverse event (AE), and one (1.4%) had a grade ≥3 immune-related, treatment-related AE. There was one drug-related death. Conclusion: Durvalumab alone in pretreated non-selected MPM did not reach a meaningful clinical activity, showing any new major safety issue signals.
- Published
- 2022
5. Guideline Application in Real world: multi-Institutional Based survey of Adjuvant and first-Line pancreatic Ductal adenocarcinoma treatment in Italy. Primary analysis of the GARIBALDI survey
- Author
-
Reni, M., primary, Giommoni, E., additional, Bergamo, F., additional, Milella, M., additional, Cavanna, L., additional, Di Marco, M.C., additional, Spada, M., additional, Cordio, S., additional, Aprile, G., additional, Cardellino, G.G., additional, Maiello, E., additional, Bernardini, I., additional, Ghidini, M., additional, Bozzarelli, S., additional, Macchini, M., additional, Orsi, G., additional, De Simone, I., additional, Rulli, Er., additional, Porcu, L., additional, Torri, V., additional, Pinto, C., additional, Reni, Michele, additional, Macchini, Marina, additional, Orsi, Giulia, additional, Peretti, Umberto, additional, Valente, Mariamaddalena, additional, Giommoni, Elisa, additional, Antonuzzo, Lorenzo, additional, Di Costanzo, Francesco, additional, Bergamo, Francesca, additional, Zagonel, Vittorina, additional, Lonardi, Sara, additional, Buggin, Federica, additional, Milella, Michele, additional, Palmerio, Silvia, additional, Cavanna, Luigi, additional, Di Nunzio, Camilla, additional, Di Marco, Maria Cristina, additional, Grassi, Elisa, additional, Spada, Massimiliano, additional, Messina, Marco, additional, Cordio, Stefano, additional, Avola, Francesco, additional, Aprile, Giuseppe, additional, Pagano, Salvatore, additional, Simionato, Francesca, additional, Cardellino, Giovanni Gerardo, additional, Majer, Federica, additional, Maiello, Evaristo, additional, Latiano, Tiziana Pia, additional, Chiarazzo, Cinzia, additional, Artioli, Fabrizio, additional, Razzini, Giorgia, additional, Pasqualini, Antonella, additional, Ghidini, Michele, additional, Binda, Elisa, additional, Lazzarelli, Silvia, additional, Bozzarelli, Silvia, additional, Sala, Simona, additional, Luppi, Gabriele, additional, Pettorelli, Elisa, additional, Spallanzani, Andrea, additional, Vicario, Giovanni, additional, Salmaso, Flavia, additional, Basso, Marco, additional, Silvestris, Nicola, additional, Del Curatolo, Sabina, additional, Zustovich, Fable, additional, Bongiovanni, Francesca, additional, Longobardi, Ciro, additional, Sandi, Ilenia, additional, Fontanella, Caterina, additional, Montelatici, Silvia, additional, Giordano, Monica, additional, Luchena, Giovanna, additional, Gilardoni, Micol, additional, Tamburini, Emiliano, additional, Rudnas, Britt, additional, Venturini, Barbara, additional, Merelli, Barbara, additional, Negrini, Giorgia, additional, Vici, Elio Maria, additional, Marabese, Alessandra, additional, Garetto, Cristina, additional, Curcio, Paola, additional, Cinieri, Saverio, additional, Cinefra, Margherita, additional, Ferrara, Pasqualinda, additional, Cantore, Maurizio, additional, Morselli, Patrizia, additional, Fumi, Guglielmo, additional, Isidori, Agnese, additional, Ciccarese, Giovanni, additional, Paolo Frassineti, Giovanni Luca, additional, Pagan, Flavia, additional, Vaccaro, Vanja, additional, Spoto, Chiara, additional, Ferrara, Marianna, additional, Garufi, Carlo, additional, Caporale, Marta, additional, Vasile, Enrico, additional, Salani, Francesca, additional, Barone, Elisa, additional, Berardi, Rossana, additional, Onofri, Azzurra, additional, Ballatore, Zelmira, additional, Lucarelli, Alessandra, additional, Barucca, Alessandra, additional, Pancotti, Amedeo, additional, Scipioni, Teresa, additional, Bencardino, Katia, additional, Marrapese, Giovanna, additional, Idotta, Laura, additional, Petrelli, Fausto, additional, Lonati, Veronica, additional, Ceribelli, Anna, additional, Giuli, Angelo, additional, Zannori, Cristina, additional, Bassanelli, Maria, additional, Mambrini, Andrea, additional, Ginocchi, Laura, additional, Orlandi, Massimo, additional, Celio, Luigi, additional, Niger, Monica, additional, Biamonte, Lavinia, additional, Tamberi, Stefano, additional, Piancastelli, Alessandra, additional, Papiani, Giorgio, additional, Valli, Irene, additional, Allione, Paolo, additional, Boe, Maria Giovanna, additional, Scartozzi, Mario, additional, Lai, Eleonora, additional, Pireddu, Annagrazia, additional, Ziranu, Pina, additional, Demurtas, Laura, additional, Puzzoni, Marco, additional, Mariani, Stefano, additional, Pretta, Andrea, additional, Liscia, Nicole, additional, Savastano, Clementina, additional, Malaspina, Valentina, additional, Tonini, Giuseppe, additional, Grassani, Teresa, additional, Barco, Barbara, additional, Pierosandro, Tagliaferri, additional, Ciliberto, Domenico, additional, Ierardi, Antonella, additional, Calandruccio, Natale Daniele, additional, Minotti, Vincenzo, additional, Matocci, Roberta, additional, Torri, Valter, additional, Porcu, Luca, additional, Rulli, Erica, additional, De Simone, Irene, additional, Carlucci, Luciano, additional, Rulli, Eliana, additional, Poli, Davide, additional, Tonto, Paola, additional, Scellato, Francesca, additional, and Pinto, Carmine, additional
- Published
- 2023
- Full Text
- View/download PDF
6. Final results of DIADEM, a phase II study to investigate the efficacy and safety of durvalumab in advanced pretreated malignant pleural mesothelioma
- Author
-
Canova, S., primary, Ceresoli, G.L., additional, Grosso, F., additional, Zucali, P.A., additional, Gelsomino, F., additional, Pasello, G., additional, Mencoboni, M., additional, Rulli, E., additional, Galli, F., additional, De Simone, I., additional, Carlucci, L., additional, De Angelis, A., additional, Belletti, M., additional, Bonomi, M., additional, D’Aveni, A., additional, Perrino, M., additional, Bono, F., additional, Cortinovis, D.L., additional, Cortinovis, D., additional, Canova, S., additional, Colonese, F., additional, Abbate, M.I., additional, Sala, L., additional, Sala, E., additional, Perez Gila, M., additional, Pagni, F., additional, Ugo, F., additional, De Vincenzo, F., additional, Santoro, A., additional, Ardizzoni, A., additional, Frega, S., additional, D’Incalci, M., additional, Poli, D., additional, and Torri, V., additional
- Published
- 2022
- Full Text
- View/download PDF
7. EP07.01-004 Long Survivor Epithelioid Pleural Mesotheliomas Are Characterized by Tertiary Lymphoid Structures: An Update to the MATCH Study
- Author
-
Grosso, F., primary, Mannarino, L., additional, Paracchini, L., additional, Pezzuto, F., additional, Moracci, L., additional, Olteanu, G.-E., additional, Delfanti, S., additional, Callari, M., additional, Penpa, S., additional, Maconi, A., additional, De Simone, I., additional, Bosetti, C., additional, Allavena, P., additional, Marchini, S., additional, Calabrese, F., additional, and D'Incalci, M., additional
- Published
- 2022
- Full Text
- View/download PDF
8. Post-biopsy cell-free DNA from blood in primary prostate cancer: How to get genetics data for decision making
- Author
-
Lazzeri, M., primary, Chiarelli, G., additional, Corbetta, M., additional, Asselta, R., additional, De Simone, I., additional, Soldà, G., additional, Duga, S., additional, Zuradelli, M., additional, Casale, P., additional, Saita, A., additional, Lughezzani, G., additional, Guazzoni, G., additional, Hurle, R., additional, Benetti, A., additional, Saitta, C., additional, Fasulo, V., additional, and Buffi, N., additional
- Published
- 2022
- Full Text
- View/download PDF
9. Choosing wisely first line immunotherapy in non-small cell lung cancer (NSCLC): what to add and what to leave out
- Author
-
Proto, C., primary, Ferrara, R., additional, Signorelli, D., additional, Lo Russo, G., additional, Galli, G., additional, Imbimbo, M., additional, Prelaj, A., additional, Zilembo, N., additional, Ganzinelli, M., additional, Pallavicini, L.M., additional, De Simone, I., additional, Colombo, M.P., additional, Sica, A., additional, Torri, V., additional, and Garassino, M.C., additional
- Published
- 2019
- Full Text
- View/download PDF
10. Randomized trial on adjuvant treatment with FOLFIRI followed by docetaxel and cisplatin versus 5-fluorouracil and folinic acid for radically resected gastric cancer
- Author
-
Bajetta, E., primary, Floriani, I., additional, Di Bartolomeo, M., additional, Labianca, R., additional, Falcone, A., additional, Di Costanzo, F., additional, Comella, G., additional, Amadori, D., additional, Pinto, C., additional, Carlomagno, C., additional, Nitti, D., additional, Daniele, B., additional, Mini, E., additional, Poli, D., additional, Santoro, A., additional, Mosconi, S., additional, Casaretti, R., additional, Boni, C., additional, Pinotti, G., additional, Bidoli, P., additional, Landi, L., additional, Rosati, G., additional, Ravaioli, A., additional, Cantore, M., additional, Di Fabio, F., additional, Aitini, E., additional, Marchet, A., additional, Rulli, E., additional, Cropalato Di Tullio, M., additional, Galli, F., additional, Biagioli, E., additional, De Simone, I., additional, Mangano, S., additional, Tonato, M., additional, Zucca, E., additional, Valsecchi, M.G., additional, Bajetta, E., additional, De Placido, S., additional, Catena, L., additional, Schiavo, M., additional, Proserpio, I., additional, Bordonaro, R., additional, Cordio, S., additional, Burrafato, G., additional, Bochicchio, A.M., additional, Aieta, M., additional, Fazio, N., additional, Spada, F., additional, Amoroso, V., additional, Marini, G., additional, Soto Parra, H., additional, Novello, G., additional, Massidda, B., additional, Ionta, M.T., additional, Comandè, M., additional, Venezia, R., additional, Bertolini, A., additional, Menatti, E., additional, Zanlorenzi, L., additional, Colombo, A., additional, Iop, A., additional, Bonura, S., additional, Mazza, E., additional, Viganò, M., additional, Ardizzoia, A., additional, Dell'Oro, S., additional, Lo Re, G., additional, Santeufemia, D., additional, Buonadonna, A., additional, Luisi, D., additional, Ucci, G., additional, Di Lucca, G., additional, Bonetti, A., additional, Bergamo, F., additional, Alù, M., additional, Vastola, F., additional, Marchetti, P., additional, Corsi, D.C., additional, Massa, E., additional, Di Pinto, G., additional, Duro, M., additional, Oliani, C., additional, Franchini, M., additional, Inzoli, A., additional, Gebbia, N., additional, Repetto, L., additional, Rota, S., additional, Frontini, L., additional, Quadri, A., additional, De Grossi, S., additional, Cazzaniga, M.E., additional, Villa, F., additional, Foa, P., additional, Ferrari, D., additional, Rabbi, C., additional, Barni, S., additional, Petrelli, F., additional, Giordano, M., additional, Luchena, G., additional, Pirovano, M., additional, Nasisi, A., additional, Catalano, V., additional, Giordani, P., additional, Zaniboni, A., additional, Leone, F., additional, Ferrario, S., additional, Beretta, G.D., additional, Menichetti, E.T., additional, Conte, D., additional, Mari, D., additional, Giannicola, R., additional, Pierantoni, C., additional, Luporini, A.G., additional, Tassinari, D., additional, Nicolini, M., additional, Frassineti, G.L., additional, Turci, D., additional, Zumaglini, F., additional, Tamberi, S., additional, Piancastelli, A., additional, Cruciani, G., additional, Minuti, G., additional, Orlandi, M., additional, Mambrini, A., additional, Ciarlo, A., additional, Cavaciocchi, D., additional, Del Monte, F., additional, Ricci, S., additional, Brunetti, M.I., additional, Lencioni, M., additional, Sisani, M., additional, Sozzi, P., additional, Granetto, C., additional, Chiara, S., additional, Galetto, A.S., additional, Ribecco, A.S., additional, DeCensi, A., additional, Ciuffreda, L., additional, Baldini, E.E., additional, Camisa, R., additional, Todeschini, R., additional, Rimassa, L., additional, Carnaghi, C., additional, Pressiani, T., additional, Rondini, E., additional, Gnoni, R., additional, Gasperoni, S., additional, Cavanna, L., additional, Palladino, M.A., additional, Mattioli, R., additional, Laici, G., additional, Pucci, F., additional, Alessio, M.D., additional, Bernardini, I., additional, Tomasello, G., additional, Baldino, G., additional, Rossetti, R., additional, Giaquinta, S., additional, Rijas Llimpe, F.L., additional, Brandes, A.A., additional, Marzola, M., additional, Montesarchio, V., additional, Rea, A., additional, Genua, G., additional, Silvestro, L., additional, Montano, M., additional, Sarobba, M.G., additional, Sanna, G., additional, Filippelli, G., additional, Dima, G., additional, Greco, E., additional, Roselli, M., additional, Natale, D., additional, Condemi, G., additional, Fumi, G., additional, Tafuto, S., additional, Masullo, P., additional, Tiberio, G., additional, de Manzoni, G., additional, Fiorentini, G., additional, Mazzanti, R., additional, De Stefano, A., additional, Cartenì, G., additional, and Otero, M., additional
- Published
- 2014
- Full Text
- View/download PDF
11. PA57 ACUTE RECURRENT PANCREATITIS AND GENETIC RISK FACTORS: A CASE REPORT
- Author
-
De Gregorio, F., primary, Terlizzi, V., additional, De Simone, I., additional, DeSantis, S., additional, Casale, A., additional, Amato, N., additional, Nardiello, P., additional, Castaldo, G., additional, and Raia, V., additional
- Published
- 2010
- Full Text
- View/download PDF
12. Early detection of glucose derangement in children with Cystic Fibrosis
- Author
-
Raia, V., primary, De Gregorio, F., additional, Sepe, A., additional, De Simone, I., additional, Mozzillo, E., additional, Valerio, G., additional, and Franzese, A., additional
- Published
- 2009
- Full Text
- View/download PDF
Catalog
Books, media, physical & digital resources
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.