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This individual patient data meta-analysis aimed to evaluate the effects of exercise on quality of life (QoL) and physical function (PF) in patients with cancer, and to identify moderator effects of demographic (age, sex, marital status, education), clinical (body mass index, cancer type, presence of metastasis), intervention-related (intervention timing, delivery mode and duration, and type of control group), and exercise-related (exercise frequency, intensity, type, time) characteristics. Relevant published and unpublished studies were identified in September 2012 via PubMed, EMBASE, PsycINFO, and CINAHL, reference checking and personal communications. Principle investigators of all 69 eligible trials were requested to share IPD from their study. IPD from 34 randomised controlled trials (n = 4519 patients) that evaluated the effects of exercise compared to a usual care, wait-list or attention control group on QoL and PF in adult patients with cancer were retrieved and pooled. Linear mixed-effect models were used to evaluate the effects of the exercise on post-intervention outcome values (z-score) adjusting for baseline values. Moderator effects were studies by testing interactions. Exercise significantly improved QoL (β = 0.15, 95%CI = 0.10;0.20) and PF (β = 0.18, 95%CI = 0.13;0.23). The effects were not moderated by demographic, clinical or exercise characteristics. Effects on QoL (βdifference_in_effect = 0.13, 95%CI = 0.03;0.22) and PF (βdifference_in_effect = 0.10, 95%CI = 0.01;0.20) were significantly larger for supervised than unsupervised interventions. In conclusion, exercise, and particularly supervised exercise, effectively improves QoL and PF in patients with cancer with different demographic and clinical characteristics during and following treatment. Although effect sizes are small, there is consistent empirical evidence to support implementation of exercise as part of cancer care. Alpe d’HuZes foundation/Dutch Cancer Society (VU 2011-5045) 8.122 JCR (2017) Q1, 21/222 Oncology 3.420 SJR (2017) Q1, 62/2878 Medicine (miscellaneous), 19/378 Oncology, 6/344 Radiology, Nuclear Medicine and Imaging No data IDR 2017 UEM

Purpose: A structured, tailored exercise therapy strategy was found to significantly improve physical functioning, reduce pain and was safe for patients with knee osteoarthritis (OA) and severe comorbidity. The intervention was performed in a specialized, secondary care center. Before the intervention can be implemented in primary care, appropriate education as well as insight into barriers and facilitators is needed. This study aimed to 1) evaluate the feasibility and effect of an interactive course on the exercise therapy strategy for patients with OA and comorbidity for physiotherapists (PTs) working in primary care; and 2) map barriers for a larger scale implementation of the protocol in primary care.Methods: A pre-posttest study was performed among PTs who were member of a network for rheumatic diseases and PTs from regional subdivisions of the Royal Dutch Society for Physical Therapy (KNGF) in the Netherlands (North-Holland and Mid-Holland) all working in primary care. PTs were offered a postgraduate blended educational course consisting of an e-learning lecture (7 hours study load) and two interactive workshops (each 3 hours study load). Measures of its feasibility and effectiveness included a questionnaire on knowledge (50 multiple choice questions, score ranging from 1 to 50) before (T0) and two weeks after the course (T1)) and a patient vignette to measure clinical reasoning (nine open questions, score ranging from 0 to 5) before the course (T0) and six months after the course (T2). Course satisfaction was administered on a 0-10 point scale (higher score means more satisfaction), directly after the course. Barriers for using the protocol were measured at T2 by means of a 27 item questionnaire, comprising five different dimensions: (i) Design, Content and Feasibility; (ii) Change in working method; (iii) Knowledge and Skills; (iv) Applicability; and (v) Social environment (each item was scored on a 5-point Likert scale, ranging from 0 totally agree to 4 totally disagree).Results: In total, 34 physiotherapists were included. Statistically significant (P < 0.05) improvement was found in knowledge about knee OA and comorbidity between baseline and two- weeks post education, with an average increase of 4.4 points above the baseline score. Also, a statistically significant improvement (P < 0.05) was found for clinical reasoning on adapting knee OA exercise therapy to the comorbid disease between baseline and six- months post education. Overall, the PTs were satisfied with the educational course (7.9 points (SD 0.9) (n ¼ 33)). The majority of PTs found the protocol to be supportive regarding clinical reasoning and clinical decision making. In a period of six months, 15 out of 34 PTs had treated at least one patient with knee OAand comorbidity according to the protocol. Perceived barriers for implementation included the small number of patients with OA and severe comorbidity being referred or referring themselves, treatment time needed to provide care according the protocol, and the limited number of treatments reimbursement by the insurance companies.Conclusions: An interactive educational course on exercise therapy for knee OA patients with comorbidity proved to be effective in improving knowledge and clinical reasoning skills of primary care PTs. Main barriers for larger scale implementation include limited referrals of patients with knee OA and severe comorbidity to PTs and limited number of treatments reimbursement by the insurance companies. Specialists and patients should be encouraged to consider exercise therapy as a treatment option for patients with knee OA and comorbidity.

Objective. To present the effects of a relatively modest environmental intervention on biological cardiovascular risk indicators. Method. A controlled trial, including two worksites. Measurements (i.e., body composition, blood pressure and serum cholesterol) took place at baseline and at 3- and 12-month follow-up. The 12-month environmental intervention (The Hague, The Netherlands, 2004) consisted of: a ‘Food’-part: to stimulate healthier food choices by means of product information in the canteen, and a ‘Steps’-part: focused on stimulating stair use by means of motivational prompts in staircases and on elevator doors. Results. Significant differences in change between groups ( n = 540) in favor of the intervention group were found on: [1] total cholesterol for women (− 0.35 mmol/l); [2] HDL for men at 3 months (0.05 mmol/l) and 12 months (0.10 mmol/l); and [3] the total–HDL ratio for the total intervention group at 3 and 12 months (− 0.45 mmol/l). Both groups showed a decrease in all body composition values at both follow-ups. A significant difference in change in systolic BP was found in favor of the control group (∼ 4 mm Hg), due to an increase in the intervention group at both follow-ups. Conclusions. Based on the contrasting results, this modest environmental intervention was ineffective in reducing cardiovascular risk in a population of office workers.

This paper describes five recent Dutch studies of the effectiveness of physical activity interventions carried out in diverse settings: general practice (GP), aged care facilities, and workplaces. The stage-based physical activity counselling carried out in the GP setting demonstrated a beneficial effect on the determinants of physical activity, but did not show any additional effect on physical activity behaviour, compared with standard physical activity advice. In contrast, the stage-based intervention through the workplace was effective in increasing physical activity, due mostly to an increase in vigorous-intensity activities. In the aged care setting, functional-skills training alone or in combination with resistance training showed functional improvement only in participants with high participation rates. Functional-skills training appeared to be more feasible than resistance training in this population of frail elderly. The two studies which aimed to promote earlier return-to-work among workers with sick leave due to non-specific low back pain also showed promising results. As a result, it was recommended that occupational physicians (OP) should refer workers with low back pain in the subacute phase of their sick leave to a low intensity intervention consisting of short meetings and exercises aimed at changing behaviour, and that the OPs contact other health care providers (GPs and physiotherapists) about the treatment strategy. Together, the results of these five Dutch studies suggest that it is feasible to successfully promote physical activity to groups of people in diverse places, with benefits in terms of both prevention and management of chronic disease and injury.

EMGO Institute for Health and Care Research and the Department of Public and Occupational Health, VU University Medical Center, Amsterdam, The etherlands EMGO Institute for Health and Care Research and the Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The etherlands Department of Movement and Sport Sciences, Ghent University, Ghent, Belgium The Federal Institute of Sport, Magglingen, Switzerland Department of Nutrition and Dietetics, Harokopio University of Athens, Athens, Greece Department of Paediatrics, University of Pecs, Pecs, Hungary