1. Immunogenicity of seasonal inactivated influenza and inactivated polio vaccines among children in Senegal: Results from a cluster-randomized trial
- Author
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Meagan E. Deming, Justin R. Ortiz, Mbayame Ndiaye Niang, Aldiouma Diallo, Ousmane M. Diop, Doudou Diop, Déborah Goudiaby, Kathryn E. Lafond, John C. Victor, Kristen D.C. Lewis, Ndongo Dia, Marc-Alain Widdowson, and Kathleen M. Neuzil
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medicine.medical_specialty ,Influenza vaccine ,030231 tropical medicine ,Antibodies, Viral ,Article ,03 medical and health sciences ,Influenza A Virus, H1N1 Subtype ,0302 clinical medicine ,Internal medicine ,Influenza, Human ,medicine ,Humans ,030212 general & internal medicine ,Seroconversion ,Child ,Hemagglutination assay ,General Veterinary ,General Immunology and Microbiology ,business.industry ,Influenza A Virus, H3N2 Subtype ,Immunogenicity ,Public Health, Environmental and Occupational Health ,Antibody titer ,Infant ,virus diseases ,Hemagglutination Inhibition Tests ,medicine.disease ,Senegal ,Poliomyelitis ,Vaccination ,Titer ,Infectious Diseases ,Vaccines, Inactivated ,Influenza Vaccines ,Child, Preschool ,Molecular Medicine ,Seasons ,business - Abstract
Data on influenza vaccine immunogenicity in children are limited from tropical developing countries. We recently reported significant, moderate effectiveness of a trivalent inactivated influenza vaccine (IIV) in a controlled, cluster-randomized trial in children in rural Senegal during 2009, a year of H3N2 vaccine mismatch (NCT00893906). We report immunogenicity of IIV3 and inactivated polio vaccine (IPV) from that trial. We evaluated hemagglutination inhibition (HAI) and polio antibody titers in response to vaccination of three age groups (6 through 35 months, 3 through 5 years, and 6 through 8 years). As all children were IIV naive, each received two vaccine doses, although titers were assessed after only the first dose for subjects aged 6 through 8 years. Seroconversion rates (4-fold titer rise or increase from
- Published
- 2020
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