1. Roles of EBF and Pax-5 in B lineage commitment and development
- Author
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Holly Maier and James Hagman
- Subjects
Lymphocyte ,Immunology ,Biology ,Protein Structure, Secondary ,Chromatin remodeling ,Transcription (biology) ,medicine ,Animals ,Humans ,Immunology and Allergy ,Cell Lineage ,Nuclear protein ,Gene Rearrangement, B-Lymphocyte ,Gene ,B cell ,Genetics ,B-Lymphocytes ,Lineage commitment ,Early B-Cell Factor ,Lymphopoiesis ,PAX5 Transcription Factor ,Gene Expression Regulation, Developmental ,DNA-Binding Proteins ,medicine.anatomical_structure ,Trans-Activators ,Transcription Factors - Abstract
B lymphocyte development is regulated by the nuclear proteins Early B cell factor (EBF) and Pax-5. EBF and Pax-5 work separately and in concert to activate genes required for B cell differentiation. Recent studies have defined mechanisms by which these two factors control transcription, including chromatin remodeling activities and recruitment of partner proteins. This review addresses the structures, functions, and roles of these proteins in early B cell commitment and development, as well as in later stages of B cell differentiation.
- Published
- 2002
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