1. ITPKB and ZNF184 are associated with Parkinson's disease risk in East Asians
- Author
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Kumar M. Prakash, Jia Nee Foo, Wing Lok Au, Louis C.S. Tan, Elaine Guo Yan Chew, Jianjun Liu, Eng-King Tan, and Lee Kong Chian School of Medicine (LKCMedicine)
- Subjects
Risk ,0301 basic medicine ,Aging ,Parkinson's disease ,Population ,Single-nucleotide polymorphism ,Disease ,Biology ,Polymorphism, Single Nucleotide ,White People ,Parkinson’s Disease ,03 medical and health sciences ,0302 clinical medicine ,Asian People ,Genetics ,medicine ,Humans ,Biological sciences::Genetics [Science] ,education ,Genetic association ,education.field_of_study ,General Neuroscience ,Parkinson Disease ,European population ,LIM Domain Proteins ,medicine.disease ,Cytoskeletal Proteins ,Phosphotransferases (Alcohol Group Acceptor) ,Genetics, Population ,030104 developmental biology ,Genetic Loci ,Neurology (clinical) ,Geriatrics and Gerontology ,030217 neurology & neurosurgery ,Genome-Wide Association Study ,Developmental Biology - Abstract
A recent meta-analysis of Parkinson's disease (PD) genome-wide association studies has identified 17 novel risk loci in the European population. We aim to assess if these reported novel risk loci are similarly implicated in PD risk within the East Asian population by analyzing the reported risk single nucleotide polymorphism or proxy single nucleotide polymorphism in 14,006 East Asian samples (779 patients and 13,227 controls). We found that 9 of the 17 reported novel PD risk loci showed very similar effects in Europeans and East Asians (I2 = 0 to 10.7%), of which 2 loci ITPKB and ZNF184 were significantly associated with PD in our samples. Two of the reported risk loci, ANK2/CAMK2D and CTSB, were non-polymorphic in East Asians and therefore not implicated in PD risk in the East Asian population. Given the small effect sizes of these risk loci, further validation is needed in additional Asian samples. NRF (Natl Research Foundation, S’pore) ASTAR (Agency for Sci., Tech. and Research, S’pore) NMRC (Natl Medical Research Council, S’pore) Accepted version
- Published
- 2020