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Your search keyword '"Elsje G. Otten"' showing total 4 results
Start Over Author "Elsje G. Otten" Publisher elsevier bv
4 results on '"Elsje G. Otten"'

1. NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency

Author

Congxin Sun, Elena Seranova, Malkiel A. Cohen, Miruna Chipara, Jennie Roberts, Dewi Astuti, Adina M. Palhegyi, Animesh Acharjee, Lucia Sedlackova, Tetsushi Kataura, Elsje G. Otten, Prashanta K. Panda, Samuel Lara-Reyna, Miriam E. Korsgen, Kevin J. Kauffman, Alejandro Huerta-Uribe, Malgorzata Zatyka, Luiz F.S.E. Silva, Jorge Torresi, Shupei Zhang, Georgina W. Hughes, Carl Ward, Erich R. Kuechler, David Cartwright, Sergey Trushin, Eugenia Trushina, Gaurav Sahay, Yosef Buganim, Gareth G. Lavery, Joerg Gsponer, Daniel G. Anderson, Eva-Maria Frickel, Tatiana R. Rosenstock, Timothy Barrett, Oliver D.K. Maddocks, Daniel A. Tennant, Haoyi Wang, Rudolf Jaenisch, Viktor I. Korolchuk, and Sovan Sarkar

Subjects
General Biochemistry, Genetics and Molecular Biology
Published
2023

2. Autophagy is Required for the Maintenance of NAD

Author

Tetsushi Kataura, Lucia Sedlackova, Elsje G. Otten, David Shapira, Filippo Scialo, Rhoda Stefanatos, Kei-ichi Ishikawa, George Kelly, Elena Seranova, Congxin Sun, Dorothea Maetzel, Niall Kenneth, Sergey Trushin, Tong Zhang, Eugenia Trushina, Charles C. Bascom, Ryan Tasseff, Robert J. Isfort, John E. Oblong, Satomi Miwa, Michael Lazarou, Rudolf Jaenisch, Masaya Imoto, Shinji Saiki, Manolis Papamichos-Chronakis, Oliver D.K. Maddocks, Alberto Sanz, Sovan Sarkar, and Viktor Korolchuk

Published
2022

3. NAD Depletion Mediates Cytotoxicity in Human Neurons With Autophagy Deficiency

Author

Congxin Sun, Elena Seranova, Malkiel A. Cohen, Miruna Chipara, Jennie Roberts, Adina M. Palhegyi, Animesh Acharjee, Lucia Sedlackova, Tetsushi Kataura, Elsje G. Otten, Prashanta K. Panda, Kevin J. Kauffman, Alejandro Huerta-Uribe, Malgorzata Zatyka, Luiz F.S.E. Silva, Jorge Torresi, Shupei Zhang, Carl Ward, Erich R. Kuechler, David Cartwright, Sergey Trushin, Eugenia Trushina, Gaurav Sahay, Yosef Buganim, Gareth G. Lavery, Joerg Gsponer, Daniel G. Anderson, Tatiana R. Rosenstock, Timothy Barrett, Oliver D.K. Maddocks, Daniel A. Tennant, Haoyi Wang, Rudolf Jaenisch, Viktor I. Korolchuk, and Sovan Sarkar

Subjects
History, Polymers and Plastics, Business and International Management, Industrial and Manufacturing Engineering
Published
2022

4. The Cargo Receptor NDP52 Initiates Selective Autophagy by Recruiting the ULK Complex to Cytosol-Invading Bacteria

Author

Benjamin J. Ravenhill, Keith B. Boyle, Ágnes Foeglein, Roger L. Williams, Elsje G. Otten, Glenn R. Masson, Cara J. Ellison, Felix Randow, and Natalia von Muhlinen

Subjects
Cytoplasm, 0303 health sciences, Kinase, Autophagy, Cell Biology, Protein Serine-Threonine Kinases, Biology, Article, Cell biology, 03 medical and health sciences, Cytosol, Galectin-8, 0302 clinical medicine, TANK-binding kinase 1, Macroautophagy, Xenophagy, Prospective Studies, Binding site, Receptor, Molecular Biology, 030217 neurology & neurosurgery, 030304 developmental biology
Abstract

Summary Xenophagy, a selective autophagy pathway that protects the cytosol against bacterial invasion, relies on cargo receptors that juxtapose bacteria and phagophore membranes. Whether phagophores are recruited from a constitutive pool or are generated de novo at prospective cargo remains unknown. Phagophore formation in situ would require recruitment of the upstream autophagy machinery to prospective cargo. Here, we show that, essential for anti-bacterial autophagy, the cargo receptor NDP52 forms a trimeric complex with FIP200 and SINTBAD/NAP1, which are subunits of the autophagy-initiating ULK and the TBK1 kinase complex, respectively. FIP200 and SINTBAD/NAP1 are each recruited independently to bacteria via NDP52, as revealed by selective point mutations in their respective binding sites, but only in their combined presence does xenophagy proceed. Such recruitment of the upstream autophagy machinery by NDP52 reveals how detection of cargo-associated “eat me” signals, induction of autophagy, and juxtaposition of cargo and phagophores are integrated in higher eukaryotes.

Published
2019

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