1. Effects of chronic fluoride intake on the antioxidant systems of the liver and kidney in rats
- Author
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Flávia Godoy Iano, Marília Afonso Rabelo Buzalaf, Mileni da Silva Fernandes, Giovana Brino Quaggio, Valdecir Farias Ximenes, Rodrigo Cardoso de Oliveira, and Maria Cecília F. Ferreira
- Subjects
chemistry.chemical_classification ,medicine.medical_specialty ,Antioxidant ,biology ,Chemistry ,Thiobarbituric acid ,medicine.medical_treatment ,Glutathione peroxidase ,Organic Chemistry ,Glutathione ,Biochemistry ,RATOS ,Inorganic Chemistry ,Superoxide dismutase ,chemistry.chemical_compound ,Endocrinology ,Internal medicine ,medicine ,biology.protein ,TBARS ,Environmental Chemistry ,Excessive fluoride intake ,Physical and Theoretical Chemistry ,Fluoride - Abstract
Excessive fluoride intake over a long period of time can lead to fluorosis, which may cause dental and skeletal manifestations. Metabolic, functional and structural damage caused by chronic fluorosis have been reported in many tissues, but the exact mechanisms modulated by fluoride remain unclear. The aim of this study was to evaluate the effect of fluoride administered in drinking water on the antioxidant defense system of rats. Four groups of Wistar rats were used for the study (n = 10/group). The animals received drinking water containing 0 (control), 5, 15 or 50 mg/L of fluoride over 60 days. They were then euthanized, and their livers and kidneys were collected and homogenized. Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), antioxidants, thiobarbituric acid reactive substances (TBARS), lipid hydroperoxide (LH), and fluoride levels were analyzed. Data were analyzed by ANOVA and Tukey's test or by the Kruskal–Wallis and Dunn's tests (p more...
- Published
- 2014
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