1. Secretin-Enhanced Magnetic Resonance Cholangiopancreatography - A Reliable Approach to Assess Exocrine Pancreatic Function?
- Author
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Markus M. Lerch, Robin Bülow, Jens-Peter Kühn, Ali A. Aghdassi, Norbert Hosten, Fabian Frost, Henry Völzke, Frank-Ulrich Weiss, Till Ittermann, Hendrik Nonnewitz, and Marie-Luise Kromrey
- Subjects
medicine.medical_specialty ,Pancreatic Disorder ,Magnetic resonance cholangiopancreatography ,medicine.diagnostic_test ,business.industry ,Concordance ,Odds ratio ,medicine.disease ,Gastroenterology ,Internal medicine ,Diabetes mellitus ,medicine ,Pancreatitis ,Exocrine pancreatic insufficiency ,business ,Pancreatic elastase - Abstract
Objectives: To investigate the relation between exocrine pancreatic function and secretin-stimulated magnetic resonance cholangiopancreatography (sMRCP) fluid volumes and its concordance to pancreatic elastase using a case-control approach. Methods: Navigator-triggered T2-weighted 3D-turbo-spin-echo sMRCP was performed on a 1·5-T-system in 977 subjects including volunteers without a history of pancreatitis (group: A n=917) and chronic pancreatic disorder patients without (group: B, n=32) and with diagnosis of exocrine pancreatic insufficiency (EPI) (group: C, n=28). After intravenous administration of 1 unit/kg secretin duodenal filling was graded (0-3) and quantified as sMRCP fluid volume. According to pancreatic elastase ELISA subjects were grouped as severe (
- Published
- 2020