1. Neurodevelopmental Outcomes after Premedication with Atropine/Propofol vs Atropine/Atracurium/Sufentanil for Neonatal Intubation: 2-Year Follow-Up of a Randomized Clinical Trial
- Author
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Decobert Fabrice, Bloom Marie-Claude, Savey Baptiste, Renault Anais, Olivier Claris, Alix Antoine, Moussa Yasser, Lacour Sandrine, Dassieu Gilles, Blanc Sébastien, Razafimanantsoa Lucie, Planchenault Déborah, Guillemin Marie-Gabrielle, Eyvrard Frédéric, Laetitia Marchand-Martin, Pladys Patrick, Cra Toure Judith, Ramay Isabelle, Auriol Françoise, Cudel Muriel, Guillois Bernard, Romeo Bernard, Clamadieu Catherine, Leport Mathilde, Caeymaex Laurence, Roullet Nicolas, Panici Maud, Cottin Xavier, Cohen Robert, Marcoux Marie-Odile, Vedrenne-Cloquet Meryl, Manon Tauzin, Mus Marianne, Dorriere Valérie, Decock-Giraudaud Aliette, Agnès Dechartres, Gaillot Théophile, Bouamari Hocine, Chauvel Jennifer, Danan Claude, Noseda Céline, Lelong Sandrine, Millot Estelle, Bechet Stéphane, Cénéric Alexandre, Cantagrel Sylvain, Ramadan GhostineGhida, Delahaye Séverine, Bacher Marjorie, Lamour Anne-Marie, Pelluau Sonia, Beissel Anne, Bouissou Antoine, Delaunay Mickaël, Jurado Camille, Cra, Younes Bouthaina, Popov Isabelle, Bruschet Lydie, Pinto Da Costa Nathalina, Prudon Malika, Crosse Julien, Merlot Elodie, eToulouse: Alberge Corinne, Jourdan Diane, Bourgoin Laura, Cornaton Elise, Chantreuil Julie, Chazal Christèle, Dassy Audrey, Henri Hélène, Lallemant Carine, Camille Jung, Sophie Breinig, Barcat Lucile, Peluchon Anne, Leke André, Plaisant Franck, Breant Valentine, Berthomieu Lionel, Beuchee Alain, Prieur Claire, Tirel Olivier, Amadieu Romain, Boddaert Sophie, Saliba Elie, Deniau Anne-Laure, Boucherat Michel, Azcona Barbara, Corinne Levy, Adamon Latif, Labarthe François, Rots Delphine, Meteier Véronique, Fontaine Cécile, Lebas Fanny, Bellemin Karine, Boiron Emilie, Arberet Camille, Moreau François, Ratsimbazafy Lanto, Gauthier-Moulinier Hélène, Pierre Tourneux, Brussieux Maxime, Bouafif Firas, Gaba Mabel, Carpentier Eléonore, Dahan Sonia, Layouni Inès, Xavier Durrmeyer, Sauret Anne, Perez Thierry, Degorre Coralie, Kongolo Guy, Thomas de La Pintiere Armelle, Le Gouez Morgane, Norbert Karine, Ozanne Bruno, Alexandre Mélanie, Tellai Leila, Issa Amelle, Gineste Martine, Bellot Anne, Suc Anne-Laure, An Chu Huu Kim, Kieffer Isabelle, Goudjil Sabrina, Caron-Lesenechal Evelyne, Ghyselen Laurent, Trentesaux Anne-Sophie, and Cécile Lebeaux
- Subjects
Atropine ,Male ,Time Factors ,Sufentanil ,medicine.medical_treatment ,Nervous System ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Double-Blind Method ,Randomized controlled trial ,law ,030225 pediatrics ,Intubation, Intratracheal ,Humans ,Medicine ,Intubation ,030212 general & internal medicine ,Propofol ,business.industry ,Tracheal intubation ,Significant difference ,Infant, Newborn ,Anesthetics, Combined ,Treatment Outcome ,Child, Preschool ,Anesthesia ,Pediatrics, Perinatology and Child Health ,Atracurium ,Female ,Premedication ,business ,Adjuvants, Anesthesia ,Follow-Up Studies ,medicine.drug - Abstract
This study followed 173 newborn infants in the PREmedication Trial for Tracheal Intubation of the NEOnate multicenter, double-blind, randomized controlled trial of atropine-propofol vs atropine-atracurium-sufentanil for premedication before nonemergency intubation. At 2 years of corrected age, there was no significant difference between the groups in death or risk of neurodevelopmental delay assessed with the Ages and Stages Questionnaire. Trial registration Clinicaltrials.gov : NCT01490580 .
- Published
- 2021