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1. A systematic evaluation of seven different scores representing the EAT–Lancet reference diet and mortality, stroke, and greenhouse gas emissions in three cohorts

Author

Stubbendorff, Anna, primary, Stern, Dalia, additional, Ericson, Ulrika, additional, Sonestedt, Emily, additional, Hallström, Elinor, additional, Borné, Yan, additional, Lajous, Martin, additional, Forouhi, Nita G, additional, Olsen, Anja, additional, Dahm, Christina C, additional, and Ibsen, Daniel B, additional

Published
2024
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2. P14-036-23 One Score To Rule Them All? – Comparison of EAT-Lancet Diet Scores and Their Associations With Disease Risk and Greenhouse Gas Emissions in Three Cohorts

Author

Ibsen, Daniel, primary, Stubbendorff, Anna, additional, Stern, Dalia, additional, Ericson, Ulrika, additional, Sonestedt, Emily, additional, Hallström, Elinor, additional, Borné, Yan, additional, Lajous, Martin, additional, Forouhi, Nita, additional, Olsen, Anja, additional, and Dahm, Christina, additional

Published
2023
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3. Association of Dietary Diversity with Incident Type 2 Diabetes by Sex and Obesity Status in Eight European Countries: The Epic-Interact Case-Cohort Study

Author

Mozaffari, Hadis, primary, Imamura, Fumiaki, additional, Murphy, Rachel, additional, Jessri, Mahsa, additional, Sharp, Stephen, additional, Forouhi, Nita, additional, Wareham, Nicholas J., additional, Ibsen, Daniel Borch, additional, Dahm, Christina C., additional, María Huerta, José, additional, Molina-Montes, Esther, additional, Nickel, Daniela, additional, Rolandsson, Olov, additional, Sacerdote, Carlotta, additional, Schulze, Matthias, additional, Gonzalez-Martin, Jon Ander, additional, Guevara, Marcela, additional, Nilsson, Peter M., additional, Panico, Salvatore, additional, Winkvist, Anna, additional, and Conklin, Annalijn, additional

Published
2023
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4. One Score to Rule Them All? – A Systematic Evaluation of Seven Different Scores Representing the EAT-Lancet Reference Diet and Mortality, Stroke, and Greenhouse Gas Emissions in Three Cohorts

Author

Stubbendorff, Anna, primary, Stern, Dalia, additional, Ericson, Ulrika, additional, Sonestedt, Emily, additional, Hallström, Elinor, additional, Borné, Yan, additional, Lajous, Martin, additional, Forouhi, Nita, additional, Olsen, Anja, additional, Dahm, Christina C., additional, and Ibsen, Daniel Borch, additional

Published
2023
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6. Development and validation of a metabolite score for red meat intake: an observational cohort study and randomized controlled dietary intervention

Author

Li, Chunxiao, primary, Imamura, Fumiaki, additional, Wedekind, Roland, additional, Stewart, Isobel D, additional, Pietzner, Maik, additional, Wheeler, Eleanor, additional, Forouhi, Nita G, additional, Langenberg, Claudia, additional, Scalbert, Augustin, additional, and Wareham, Nicholas J, additional

Published
2022
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7. Resting Heart Rate Is a Biomarker of Cardiorespiratory Fitness: The Fenland Study

Author

Gonzales, Tomas, primary, Jeon, Justin, additional, Lindsay, Timothy, additional, Westgate, Kate, additional, Perez-Pozuelo, Ignacio, additional, Hollidge, Stefanie, additional, Wijndaele, Katrien, additional, Rennie, Kirsten, additional, Forouhi, Nita, additional, Griffin, Simon, additional, Wareham, Nicholas J., additional, and Brage, Soren, additional

Published
2022
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8. Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses

Author

Sofianopoulou, Eleni, primary, Kaptoge, Stephen K, additional, Afzal, Shoaib, additional, Jiang, Tao, additional, Gill, Dipender, additional, Gundersen, Thomas E, additional, Bolton, Thomas R, additional, Allara, Elias, additional, Arnold, Matthew G, additional, Mason, Amy M, additional, Chung, Ryan, additional, Pennells, Lisa A M, additional, Shi, Fanchao, additional, Sun, Luanluan, additional, Willeit, Peter, additional, Forouhi, Nita G, additional, Langenberg, Claudia, additional, Sharp, Stephen J, additional, Panico, Salvatore, additional, Engström, Gunnar, additional, Melander, Olle, additional, Tong, Tammy Y N, additional, Perez-Cornago, Aurora, additional, Norberg, Margareta, additional, Johansson, Ingegerd, additional, Katzke, Verena, additional, Srour, Bernard, additional, José Sánchez, María, additional, Redondo-Sánchez, Daniel, additional, Olsen, Anja, additional, Dahm, Christina C, additional, Overvad, Kim, additional, Brustad, Magritt, additional, Skeie, Guri, additional, Moreno-Iribas, Conchi, additional, Onland-Moret, N Charlotte, additional, van der Schouw, Yvonne T, additional, Tsilidis, Konstantinos K, additional, Heath, Alicia K, additional, Agnoli, Claudia, additional, Krogh, Vittorio, additional, de Boer, Ian H, additional, Kobylecki, Camilla Jannie, additional, Çolak, Yunus, additional, Zittermann, Armin, additional, Sundström, Johan, additional, Welsh, Paul, additional, Weiderpass, Elisabete, additional, Aglago, Elom K, additional, Ferrari, Pietro, additional, Clarke, Robert, additional, Boutron, Marie-Christine, additional, Severi, Gianluca, additional, MacDonald, Conor, additional, Providencia, Rui, additional, Masala, Giovanna, additional, Zamora Ros, Raul, additional, Boer, Jolanda, additional, Verschuren, WM Monique, additional, Cawthon, Peggy, additional, Schierbeck, Louise L, additional, Cooper, Cyrus, additional, Schulze, Matthias B, additional, Bergmann, Manuela M, additional, Hannemann, Anke, additional, Kiechl, Stefan, additional, Brenner, Hermann, additional, van Schoor, Natasja M, additional, Albertorio, Juan R, additional, Sacerdote, Carlotta, additional, Linneberg, Allan, additional, Kårhus, Line L, additional, Huerta, José María, additional, Imaz, Liher, additional, Joergensen, Christel, additional, Ben-Shlomo, Yoav, additional, Lundqvist, Annamari, additional, Gallacher, John, additional, Sattar, Naveed, additional, Wood, Angela M, additional, Wareham, Nicholas J, additional, Nordestgaard, Børge G, additional, Di Angelantonio, Emanuele, additional, Danesh, John, additional, Butterworth, Adam S, additional, and Burgess, Stephen, additional

Published
2021
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9. Associations of Total Legume, Pulse, and Soy Consumption with Incident Type 2 Diabetes: Federated Meta-Analysis of 27 Studies from Diverse World Regions

Author

Pearce, Matthew, Fanidi, Anouar, Bishop, Tom RP, Sharp, Stephen J, Imamura, Fumiaki, Dietrich, Stefan, Akbaraly, Tasnime, Bes-Rastrollo, Maira, Beulens, Joline WJ, Byberg, Liisa, Canhada, Scheine, Molina, Maria Del Carmen B, Chen, Zhengming, Cortes-Valencia, Adrian, Du, Huaidong, Duncan, Bruce B, Härkänen, Tommi, Hashemian, Maryam, Kim, Jihye, Kim, Mi Kyung, Kim, Yeonjung, Knekt, Paul, Kromhout, Daan, Lassale, Camille, Ridaura, Ruy Lopez, Magliano, Dianna J, Malekzadeh, Reza, Marques-Vidal, Pedro, Martínez-González, Miguel Ángel, O'Donoghue, Gráinne, O'Gorman, Donal, Shaw, Jonathan E, Soedamah-Muthu, Sabita S, Stern, Dalia, Wolk, Alicja, Woo, Hye Won, EPIC-InterAct Consortium, Wareham, Nicholas J, Forouhi, Nita G, Imamura, Fumiaki [0000-0002-6841-8396], Bes-Rastrollo, Maira [0000-0002-9139-4206], Du, Huaidong [0000-0002-9814-0049], Wareham, Nicholas J [0000-0003-1422-2993], and Apollo - University of Cambridge Repository

Subjects
diabetes, legumes, Incidence, pea, Fabaceae, Global Health, lentil, Diet, Cohort Studies, soy, Diabetes Mellitus, Type 2, Risk Factors, chickpea, Soybean Proteins, Humans, bean, peanut, pulse
Abstract

BACKGROUND: The consumption of legumes is promoted as part of a healthy diet in many countries but associations of total and types of legume consumption with type 2 diabetes (T2D) are not well established. Analyses across diverse populations are lacking despite the availability of unpublished legume consumption data in prospective cohort studies. OBJECTIVE: To examine the prospective associations of total and types of legume intake with the risk of incident T2D. METHODS: Meta-analyses of associations between total legume, pulse, and soy consumption and T2D were conducted using a federated approach without physical data-pooling. Prospective cohorts were included if legume exposure and T2D outcome data were available and the cohort investigators agreed to participate. We estimated incidence rate ratios (IRRs) and CIs of associations using individual participant data including ≤42,473 incident cases among 807,785 adults without diabetes in 27 cohorts across the Americas, Eastern Mediterranean, Europe, and Western Pacific. Random-effects meta-analysis was used to combine effect estimates and estimate heterogeneity. RESULTS: Median total legume intake ranged from 0-140 g/d across cohorts. We observed a weak positive association between total legume consumption and T2D (IRR = 1.02, 95% CI: 1.01 to 1.04) per 20 g/d higher intake, with moderately high heterogeneity (I2 = 74%). Analysis by region showed no evidence of associations in the Americas, Eastern Mediterranean, and Western Pacific. The positive association in Europe (IRR = 1.05, 95% CI: 1.01 to 1.10, I2 = 82%) was mainly driven by studies from Germany, UK, and Sweden. No evidence of associations was observed for the consumption of pulses or soy. CONCLUSIONS: These findings suggest no evidence of an association of legume intakes with T2D in several world regions. The positive association observed in some European studies warrants further investigation relating to overall dietary contexts in which legumes are consumed, including accompanying foods which may be positively associated with T2D.

Published
2021
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10. Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses

Author

Sofianopoulou, Eleni, Kaptoge, Stephen K, Afzal, Shoaib, Jiang, Tao, Gill, Dipender, Gundersen, Thomas E, Bolton, Thomas R, Allara, Elias, Arnold, Matthew G, Mason, Amy M, Chung, Ryan, Pennells, Lisa A M, Shi, Fanchao, Sun, Luanluan, Willeit, Peter, Forouhi, Nita G, Langenberg, Claudia, Sharp, Stephen J, Panico, Salvatore, Engström, Gunnar, Melander, Olle, Tong, Tammy Y N, Perez-Cornago, Aurora, Norberg, Margareta, Johansson, Ingegerd, Katzke, Verena, Srour, Bernard, José Sánchez, María, Redondo-Sánchez, Daniel, Olsen, Anja, Dahm, Christina C, Overvad, Kim, Brustad, Magritt, Skeie, Guri, Moreno-Iribas, Conchi, Onland-Moret, N Charlotte, van der Schouw, Yvonne T, Tsilidis, Konstantinos K, Heath, Alicia K, Agnoli, Claudia, Krogh, Vittorio, de Boer, Ian H, Kobylecki, Camilla Jannie, Çolak, Yunus, Zittermann, Armin, Sundström, Johan, Welsh, Paul, Weiderpass, Elisabete, Aglago, Elom K, Ferrari, Pietro, Sofianopoulou, Eleni, Kaptoge, Stephen K, Afzal, Shoaib, Jiang, Tao, Gill, Dipender, Gundersen, Thomas E, Bolton, Thomas R, Allara, Elias, Arnold, Matthew G, Mason, Amy M, Chung, Ryan, Pennells, Lisa A M, Shi, Fanchao, Sun, Luanluan, Willeit, Peter, Forouhi, Nita G, Langenberg, Claudia, Sharp, Stephen J, Panico, Salvatore, Engström, Gunnar, Melander, Olle, Tong, Tammy Y N, Perez-Cornago, Aurora, Norberg, Margareta, Johansson, Ingegerd, Katzke, Verena, Srour, Bernard, José Sánchez, María, Redondo-Sánchez, Daniel, Olsen, Anja, Dahm, Christina C, Overvad, Kim, Brustad, Magritt, Skeie, Guri, Moreno-Iribas, Conchi, Onland-Moret, N Charlotte, van der Schouw, Yvonne T, Tsilidis, Konstantinos K, Heath, Alicia K, Agnoli, Claudia, Krogh, Vittorio, de Boer, Ian H, Kobylecki, Camilla Jannie, Çolak, Yunus, Zittermann, Armin, Sundström, Johan, Welsh, Paul, Weiderpass, Elisabete, Aglago, Elom K, and Ferrari, Pietro

Published
2021
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11. Associations of circulating very-long-chain saturated fatty acids and incident type 2 diabetes: a pooled analysis of prospective cohort studies

Author

Fretts, Amanda M, Imamura, Fumiaki, Marklund, Matti, Micha, Renata, Wu, Jason HY, Murphy, Rachel A, Chien, Kuo-Liong, McKnight, Barbara, Tintle, Nathan, Forouhi, Nita G, Qureshi, Waqas T, Virtanen, Jyrki K, Wong, Kerry, Wood, Alexis C, Lankinen, Maria, Rajaobelina, Kalina, Harris, Tamara B, Djoussé, Luc, Harris, Bill, Wareham, Nick J, Steffen, Lyn M, Laakso, Markku, Veenstra, Jenna, Samieri, Cécilia, Brouwer, Ingeborg A, Yu, Chaoyu Ian, Koulman, Albert, Steffen, Brian T, Helmer, Catherine, Sotoodehnia, Nona, Siscovick, David, Gudnason, Vilmundur, InterAct Consortium, Wagenknecht, Lynne, Voutilainen, Sari, Tsai, Michael Y, Uusitupa, Matti, Kalsbeek, Anya, Berr, Claudine, Mozaffarian, Dariush, Lemaitre, Rozenn N, Imamura, Fumiaki [0000-0002-6841-8396], Forouhi, Nita [0000-0002-5041-248X], Wareham, Nicholas [0000-0003-1422-2993], Koulman, Albert [0000-0001-9998-051X], and Apollo - University of Cambridge Repository

Subjects
Adult, Aged, 80 and over, Male, Fatty Acids and Outcomes Research Consortium, diabetes, Fatty Acids, Middle Aged, very-long-chain saturated fatty acids, meta-analysis, Diabetes Mellitus, Type 2, Eicosanoic Acids, Cohorts for Heart and Aging Research in Genomic Epidemiology, Humans, saturated fatty acids, Female, Prospective Studies, Aged
Abstract

BACKGROUND: Saturated fatty acids (SFAs) of different chain lengths have unique metabolic and biological effects, and a small number of recent studies suggest that higher circulating concentrations of the very-long-chain SFAs (VLSFAs) arachidic acid (20:0), behenic acid (22:0), and lignoceric acid (24:0) are associated with a lower risk of diabetes. Confirmation of these findings in a large and diverse population is needed. OBJECTIVE: We investigated the associations of circulating VLSFAs 20:0, 22:0, and 24:0 with incident type 2 diabetes in prospective studies. METHODS: Twelve studies that are part of the Fatty Acids and Outcomes Research Consortium participated in the analysis. Using Cox or logistic regression within studies and an inverse-variance-weighted meta-analysis across studies, we examined the associations of VLSFAs 20:0, 22:0, and 24:0 with incident diabetes among 51,431 participants. RESULTS: There were 14,276 cases of incident diabetes across participating studies. Higher circulating concentrations of 20:0, 22:0, and 24:0 were each associated with a lower risk of incident diabetes. Pooling across cohorts, the RR (95% CI) for incident diabetes comparing the 90th percentile to the 10th percentile was 0.78 (0.70, 0.87) for 20:0, 0.84 (0.77, 0.91) for 22:0, and 0.75 (0.69, 0.83) for 24:0 after adjustment for demographic, lifestyle, adiposity, and other health factors. Results were fully attenuated in exploratory models that adjusted for circulating 16:0 and triglycerides. CONCLUSIONS: Results from this pooled analysis indicate that higher concentrations of circulating VLSFAs 20:0, 22:0, and 24:0 are each associated with a lower risk of diabetes.

Published
2019

12. Global diet and health: old questions, fresh evidence, and new horizons

Author

Forouhi, Nita G, Unwin, Nigel, Forouhi, Nita [0000-0002-5041-248X], and Apollo - University of Cambridge Repository

Subjects
Humans, Diet, Global Burden of Disease
Abstract

Few, if any, would contest that diet and nutrition have a critical and substantial impact on human health. But, the devil is in the details. Common questions include: is there such as thing as an optimal diet? What is suboptimal? Which dietary components matter most? And given the necessity to take action on climate change and planetary health, what should the world eat?1 The Global Burden of Disease (GBD) Study contributes towards answering these questions through estimating the burden of mortality and disability attributable to specific dietary risks, within a comparative risk assessment framework which currently considers 84 behavioural, environmental, occupational and metabolic risks across 195 countries and territories.2 The latest in the series is the current report by the GBD Diet Collaborators,3 using data from GBD20172. Fifteen dietary risks are evaluated for their impacts on mortality and disability from cancers, cardiovascular diseases and diabetes.

Published
2019
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14. Associations of Total Legume, Pulse, and Soy Consumption with Incident Type 2 Diabetes: Federated Meta-Analysis of 27 Studies from Diverse World Regions

Author

Pearce, Matthew, primary, Fanidi, Anouar, additional, Bishop, Tom R P, additional, Sharp, Stephen J, additional, Imamura, Fumiaki, additional, Dietrich, Stefan, additional, Akbaraly, Tasnime, additional, Bes-Rastrollo, Maira, additional, Beulens, Joline W J, additional, Byberg, Liisa, additional, Canhada, Scheine, additional, Molina, Maria del Carmen B, additional, Chen, Zhengming, additional, Cortes-Valencia, Adrian, additional, Du, Huaidong, additional, Duncan, Bruce B, additional, Härkänen, Tommi, additional, Hashemian, Maryam, additional, Kim, Jihye, additional, Kim, Mi Kyung, additional, Kim, Yeonjung, additional, Knekt, Paul, additional, Kromhout, Daan, additional, Lassale, Camille, additional, Ridaura, Ruy Lopez, additional, Magliano, Dianna J, additional, Malekzadeh, Reza, additional, Marques-Vidal, Pedro, additional, Martínez-González, Miguel Ángel, additional, O’Donoghue, Gráinne, additional, O’Gorman, Donal, additional, Shaw, Jonathan E, additional, Soedamah-Muthu, Sabita S, additional, Stern, Dalia, additional, Wolk, Alicja, additional, Woo, Hye Won, additional, Wareham, Nicholas J, additional, and Forouhi, Nita G, additional

Published
2021
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15. The Lancet Commission on diabetes: using data to transform diabetes care and patient lives

Author

Chan, Juliana C N, primary, Lim, Lee-Ling, additional, Wareham, Nicholas J, additional, Shaw, Jonathan E, additional, Orchard, Trevor J, additional, Zhang, Ping, additional, Lau, Eric S H, additional, Eliasson, Björn, additional, Kong, Alice P S, additional, Ezzati, Majid, additional, Aguilar-Salinas, Carlos A, additional, McGill, Margaret, additional, Levitt, Naomi S, additional, Ning, Guang, additional, So, Wing-Yee, additional, Adams, Jean, additional, Bracco, Paula, additional, Forouhi, Nita G, additional, Gregory, Gabriel A, additional, Guo, Jingchuan, additional, Hua, Xinyang, additional, Klatman, Emma L, additional, Magliano, Dianna J, additional, Ng, Boon-Peng, additional, Ogilvie, David, additional, Panter, Jenna, additional, Pavkov, Meda, additional, Shao, Hui, additional, Unwin, Nigel, additional, White, Martin, additional, Wou, Constance, additional, Ma, Ronald C W, additional, Schmidt, Maria I, additional, Ramachandran, Ambady, additional, Seino, Yutaka, additional, Bennett, Peter H, additional, Oldenburg, Brian, additional, Gagliardino, Juan José, additional, Luk, Andrea O Y, additional, Clarke, Philip M, additional, Ogle, Graham D, additional, Davies, Melanie J, additional, Holman, Rury R, additional, and Gregg, Edward W, additional

Published
2020
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16. Glycemic index, glycemic load, and risk of coronary heart disease: a pan-European cohort study

Author

Sieri, Sabina, primary, Agnoli, Claudia, additional, Grioni, Sara, additional, Weiderpass, Elisabete, additional, Mattiello, Amalia, additional, Sluijs, Ivonne, additional, Sanchez, Maria Jose, additional, Jakobsen, Marianne Uhre, additional, Sweeting, Michael, additional, van der Schouw, Yvonne T, additional, Nilsson, Lena Maria, additional, Wennberg, Patrik, additional, Katzke, Verena A, additional, Kühn, Tilman, additional, Overvad, Kim, additional, Tong, Tammy YN, additional, Conchi, Moreno-Iribas, additional, Quirós, José Ramón, additional, García-Torrecillas, Juan Manuel, additional, Mokoroa, Olatz, additional, Gómez, Jesús-Humberto, additional, Tjønneland, Anne, additional, Sonestedt, Emiliy, additional, Trichopoulou, Antonia, additional, Karakatsani, Anna, additional, Valanou, Elissavet, additional, Boer, Jolanda MA, additional, Verschuren, WM Monique, additional, Boutron-Ruault, Marie-Christine, additional, Fagherazzi, Guy, additional, Madika, Anne-Laure, additional, Bergmann, Manuela M, additional, Schulze, Matthias B, additional, Ferrari, Pietro, additional, Freisling, Heinz, additional, Lennon, Hannah, additional, Sacerdote, Carlotta, additional, Masala, Giovanna, additional, Tumino, Rosario, additional, Riboli, Elio, additional, Wareham, Nicholas J, additional, Danesh, John, additional, Forouhi, Nita G, additional, Butterworth, Adam S, additional, and Krogh, Vittorio, additional

Published
2020
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21. HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials

Author

Swerdlow, Daniel I., Preiss, David, Kuchenbaecker, Karoline B., Holmes, Michael V., Engmann, Jorgen E. L., Shah, Tina, Sofat, Reecha, Stender, Stefan, Johnson, Paul C. D., Scott, Robert A., Leusink, Maarten, Verweij, Niek, Sharp, Stephen J., Guo, Yiran, Giambartolomei, Claudia, Chung, Christina, Peasey, Anne, Amuzu, Antoinette, Li, KaWah, Palmen, Jutta, Howard, Philip, Cooper, Jackie A., Drenos, Fotios, Lowe, Gordon, Gallacher, John, Stewart, Marlene C. W., Tzoulaki, Ioanna, Buxbaum, Sarah G., van der A, Daphne L., Forouhi, Nita G., Onland-Moret, N. Charlotte, van der Schouw, Yvonne T., Hubacek, Jaroslav A., Kubinova, Ruzena, Baceviciene, Migle, Tamosiunas, Abdonas, Pajak, Andrzej, Topor-Madry, Roman, Stepaniak, Urszula, Malyutina, Sofia, Baldassarre, Damiano, Sennblad, Bengt, Tremoli, Elena, de Faire, Ulf, Veglia, Fabrizio, Ford, Ian, Wouter Jukema, J., Westendorp, Rudi G. J., de Borst, Gert Jan, de Jong, Pim A., Algra, Ale, Spiering, Wilko, H Maitland-van der Zee, Anke H., Klungel, Olaf H., de Boer, Anthonius, Doevendans, Pieter A., Eaton, Charles B., Robinson, Jennifer G., Duggan, David, DIAGRAM Consortium, MAGIC Consortium, InterAct Consortium, Kjekshus, John, Downs, John R., Gotto, Antonio M., Keech, Anthony C., Marchioli, Roberto, Tognoni, Gianni, Sever, Peter S., Poulter, Neil R., Waters, David D., Pedersen, Terje R., Amarenco, Pierre, Nakamura, Haruo, McMurray, John J. V., Lewsey, James D., Chasman, Daniel I., Ridker, Paul M., Maggioni, Aldo P., Tavazzi, Luigi, Ray, Kausik K., Kondapally Seshasai, Sreenivasa Rao, Manson, JoAnn E., Price, Jackie F., Whincup, Peter H., Morris, Richard W., Lawlor, Debbie A., Smith, George Davey, Ben-Shlomo, Yoav, Schreiner, Pamela J., Fornage, Myriam, Siscovick, David S., Cushman, Mary, Kumari, Meena, Wareham, Nick J., Verschuren, W. M. Monique, Redline, Susan, Patel, Sanjay R., Whittaker, John C., Hamsten, Anders, Delaney, Joseph A., Dale, Caroline, Gaunt, Tom R., Wong, Andrew, Kuh, Diana, Hardy, Rebecca, Kathiresan, Sekar, Castillo, Berta A., van der Harst, Pim, Brunner, Eric J., Tybjaerg-Hansen, Anne, Marmot, Michael G., Krauss, Ronald M., Tsai, Michael, Coresh, Josef, Hoogeveen, Ronald C., Psaty, Bruce M., Lange, Leslie A., Hakonarson, Hakon, Dudbridge, Frank, Humphries, Steve E., Talmud, Philippa J., Kivimäki, Mika, Timpson, Nicholas J., Langenberg, Claudia, Asselbergs, Folkert W., Voevoda, Mikhail, Bobak, Martin, Pikhart, Hynek, Wilson, James G., Reiner, Alex P., Keating, Brendan J., Hingorani, Aroon D., Sattar, Naveed, Li, Yun R., Imperial College Healthcare NHS Trust- BRC Funding, National Institute for Health Research, Cardiovascular Centre (CVC), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Sharp, Stephen [0000-0003-2375-1440], Forouhi, Nita [0000-0002-5041-248X], Wareham, Nicholas [0000-0003-1422-2993], Langenberg, Claudia [0000-0002-5017-7344], and Apollo - University of Cambridge Repository

Subjects
Male, STATIN THERAPY, Type 2 diabetes, 030204 cardiovascular system & hematology, Gastroenterology, DISEASE, Body Mass Index, chemistry.chemical_compound, 0302 clinical medicine, Risk Factors, Medicine, HIGH-DOSE ATORVASTATIN, Randomized Controlled Trials as Topic, RISK, 0303 health sciences, MAGIC Consortium, Articles, 11 Medical And Health Sciences, General Medicine, Middle Aged, 3. Good health, MENDELIAN RANDOMIZATION, Female, Life Sciences & Biomedicine, medicine.medical_specialty, Statin, medicine.drug_class, DIAGRAM Consortium, Placebo, Polymorphism, Single Nucleotide, 03 medical and health sciences, Medicine, General & Internal, General & Internal Medicine, Internal medicine, Diabetes mellitus, Humans, Genetic Testing, METAANALYSIS, Aged, 030304 developmental biology, Science & Technology, business.industry, Cholesterol, Body Weight, Cholesterol, HDL, Type 2 Diabetes Mellitus, Cholesterol, LDL, Odds ratio, InterAct Consortium, medicine.disease, R1, PREVENTION, BODY-MASS INDEX, Endocrinology, Diabetes Mellitus, Type 2, chemistry, Hydroxymethylglutaryl CoA Reductases, Hydroxymethylglutaryl-CoA Reductase Inhibitors, LDL CHOLESTEROL, business, ASSOCIATION ANALYSES, Body mass index
Abstract

Background: Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the intended drug target.Methods: We used single nucleotide polymorphisms in the HMGCR gene, rs17238484 (for the main analysis) and rs12916 (for a subsidiary analysis) as proxies for HMGCR inhibition by statins. We examined associations of these variants with plasma lipid, glucose, and insulin concentrations; bodyweight; waist circumference; and prevalent and incident type 2 diabetes. Study-specific effect estimates per copy of each LDL-lowering allele were pooled by meta-analysis. These findings were compared with a meta-analysis of new-onset type 2 diabetes and bodyweight change data from randomised trials of statin drugs. The effects of statins in each randomised trial were assessed using meta-analysis.Findings: Data were available for up to 223 463 individuals from 43 genetic studies. Each additional rs17238484-G allele was associated with a mean 0·06 mmol/L (95% CI 0·05–0·07) lower LDL cholesterol and higher body weight (0·30 kg, 0·18–0·43), waist circumference (0·32 cm, 0·16–0·47), plasma insulin concentration (1·62%, 0·53–2·72), and plasma glucose concentration (0·23%, 0·02–0·44). The rs12916 SNP had similar effects on LDL cholesterol, bodyweight, and waist circumference. The rs17238484-G allele seemed to be associated with higher risk of type 2 diabetes (odds ratio [OR] per allele 1·02, 95% CI 1·00–1·05); the rs12916-T allele association was consistent (1·06, 1·03–1·09). In 129 170 individuals in randomised trials, statins lowered LDL cholesterol by 0·92 mmol/L (95% CI 0·18–1·67) at 1-year of follow-up, increased bodyweight by 0·24 kg (95% CI 0·10–0·38 in all trials; 0·33 kg, 95% CI 0·24–0·42 in placebo or standard care controlled trials and −0·15 kg, 95% CI −0·39 to 0·08 in intensive-dose vs moderate-dose trials) at a mean of 4·2 years (range 1·9–6·7) of follow-up, and increased the odds of new-onset type 2 diabetes (OR 1·12, 95% CI 1·06–1·18 in all trials; 1·11, 95% CI 1·03–1·20 in placebo or standard care controlled trials and 1·12, 95% CI 1·04–1·22 in intensive-dose vs moderate dose trials).Interpretation: The increased risk of type 2 diabetes noted with statins is at least partially explained by HMGCR inhibition.Funding: The funding sources are cited at the end of the paper.

Published
2015
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22. Estimated Substitution of Tea or Coffee for Sugar-Sweetened Beverages Was Associated with Lower Type 2 Diabetes Incidence in Case–Cohort Analysis across 8 European Countries in the EPIC-InterAct Study

Author

Imamura, Fumiaki, primary, Schulze, Matthias B, additional, Sharp, Stephen J, additional, Guevara, Marcela, additional, Romaguera, Dora, additional, Bendinelli, Benedetta, additional, Salamanca-Fernández, Elena, additional, Ardanaz, Eva, additional, Arriola, Larraitz, additional, Aune, Dagfinn, additional, Boeing, Heiner, additional, Dow, Courtney, additional, Fagherazzi, Guy, additional, Franks, Paul W, additional, Freisling, Heinz, additional, Jakszyn, Paula, additional, Kaaks, Rudolf, additional, Khaw, Kay-Tee, additional, Kühn, Tilman, additional, Mancini, Francesca R, additional, Masala, Giovanna, additional, Chirlaque, Maria-Dolores, additional, Nilsson, Peter M, additional, Overvad, Kim, additional, Pala, Valeria M, additional, Panico, Salvatore, additional, Perez-Cornago, Aurora, additional, Quirós, Jose R, additional, Ricceri, Fulvio, additional, Rodríguez-Barranco, Miguel, additional, Rolandsson, Olov, additional, Sluijs, Ivonne, additional, Stepien, Magdalena, additional, Spijkerman, Annemieke M W, additional, Tjønneland, Anne, additional, Tong, Tammy Y N, additional, Tumino, Rosario, additional, Vissers, Linda E T, additional, Ward, Heather A, additional, Langenberg, Claudia, additional, Riboli, Elio, additional, Forouhi, Nita G, additional, and Wareham, Nick J, additional

Published
2019
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24. Changes in plasma phospholipid fatty acid profiles over 13 years and correlates of change: European Prospective Investigation into Cancer and Nutrition-Norfolk Study

Author

Zheng, Ju-Sheng, primary, Imamura, Fumiaki, additional, Sharp, Stephen J, additional, Koulman, Albert, additional, Griffin, Julian L, additional, Mulligan, Angela A, additional, Luben, Robert, additional, Khaw, Kay-Tee, additional, Wareham, Nicholas J, additional, and Forouhi, Nita G, additional

Published
2019
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25. Generalizability of a Diabetes-Associated Country-Specific Exploratory Dietary Pattern Is Feasible Across European Populations

Author

Jannasch, Franziska, primary, Kröger, Janine, additional, Agnoli, Claudia, additional, Barricarte, Aurelio, additional, Boeing, Heiner, additional, Cayssials, Valerie, additional, Colorado-Yohar, Sandra, additional, Dahm, Christina C, additional, Dow, Courtney, additional, Fagherazzi, Guy, additional, Franks, Paul W, additional, Freisling, Heinz, additional, Gunter, Marc J, additional, Nicola, D, additional, Key, Timothy J, additional, Khaw, Kay-Tee, additional, Kühn, Tilman, additional, Kyro, Cecilie, additional, Mancini, Francesca Romana, additional, Mokoroa, Olatz, additional, Nilsson, Peter, additional, Overvad, Kim, additional, Palli, Domenico, additional, Panico, Salvatore, additional, García, Jose Ramón Quirós, additional, Rolandsson, Olov, additional, Sacerdote, Carlotta, additional, Sánchez, Mariá-José, additional, Sahrai, Mohammad Sediq, additional, Schübel, Ruth, additional, Sluijs, Ivonne, additional, Spijkerman, Annemieke M W, additional, Tjonneland, Anne, additional, Tong, Tammy Y N, additional, Tumino, Rosario, additional, Riboli, Elio, additional, Langenberg, Claudia, additional, Sharp, Stephen J, additional, Forouhi, Nita G, additional, Schulze, Matthias B, additional, and Wareham, Nicholas J, additional

Published
2019
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26. Trans Fatty Acid Biomarkers and Incident Type 2 Diabetes: Pooled Analysis from 10 Prospective Cohort Studies in the Fatty Acids and Outcome Research Consortium (FORCE) (OR33-02-19)

Author

Lai, Heidi, primary, Imamura, Fumiaki, additional, Korat, Andres Ardisson, additional, Murphy, Rachel, additional, Tintle, Nathan, additional, Bassett, Julie, additional, Chen, Jiaying, additional, Kröger, Janine, additional, Forouhi, Nita, additional, Schulze, Matthias, additional, Harris, William, additional, Ramachandran, Vasan, additional, Hu, Frank, additional, Giles, Graham, additional, Djousse, Luc, additional, Brouwer, Ingeborg, additional, Wu, Jason, additional, Marklund, Matti, additional, Micha, Renata, additional, Lemaitre, Rozenn, additional, McKnight, Barbara, additional, Siscovick, David, additional, Shadyab, Aladdin, additional, Manson, JoAnn, additional, Howard, Barbara, additional, Robinson, Jennifer, additional, Wallace, Robert, additional, and Mozaffarian, Dariush, additional

Published
2019
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28. Associations of circulating very-long-chain saturated fatty acids and incident type 2 diabetes: a pooled analysis of prospective cohort studies

Author

Fretts, Amanda M, primary, Imamura, Fumiaki, additional, Marklund, Matti, additional, Micha, Renata, additional, Wu, Jason H Y, additional, Murphy, Rachel A, additional, Chien, Kuo-Liong, additional, McKnight, Barbara, additional, Tintle, Nathan, additional, Forouhi, Nita G, additional, Qureshi, Waqas T, additional, Virtanen, Jyrki K, additional, Wong, Kerry, additional, Wood, Alexis C, additional, Lankinen, Maria, additional, Rajaobelina, Kalina, additional, Harris, Tamara B, additional, Djoussé, Luc, additional, Harris, Bill, additional, Wareham, Nick J, additional, Steffen, Lyn M, additional, Laakso, Markku, additional, Veenstra, Jenna, additional, Samieri, Cécilia, additional, Brouwer, Ingeborg A, additional, Yu, Chaoyu Ian, additional, Koulman, Albert, additional, Steffen, Brian T, additional, Helmer, Catherine, additional, Sotoodehnia, Nona, additional, Siscovick, David, additional, Gudnason, Vilmundur, additional, Wagenknecht, Lynne, additional, Voutilainen, Sari, additional, Tsai, Michael Y, additional, Uusitupa, Matti, additional, Kalsbeek, Anya, additional, Berr, Claudine, additional, Mozaffarian, Dariush, additional, and Lemaitre, Rozenn N, additional

Published
2019
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30. Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits

Author

Kraja, Aldi T., primary, Liu, Chunyu, additional, Fetterman, Jessica L., additional, Graff, Mariaelisa, additional, Have, Christian Theil, additional, Gu, Charles, additional, Yanek, Lisa R., additional, Feitosa, Mary F., additional, Arking, Dan E., additional, Chasman, Daniel I., additional, Young, Kristin, additional, Ligthart, Symen, additional, Hill, W. David, additional, Weiss, Stefan, additional, Luan, Jian’an, additional, Giulianini, Franco, additional, Li-Gao, Ruifang, additional, Hartwig, Fernando P., additional, Lin, Shiow J., additional, Wang, Lihua, additional, Richardson, Tom G., additional, Yao, Jie, additional, Fernandez, Eliana P., additional, Ghanbari, Mohsen, additional, Wojczynski, Mary K., additional, Lee, Wen-Jane, additional, Argos, Maria, additional, Armasu, Sebastian M., additional, Barve, Ruteja A., additional, Ryan, Kathleen A., additional, An, Ping, additional, Baranski, Thomas J., additional, Bielinski, Suzette J., additional, Bowden, Donald W., additional, Broeckel, Ulrich, additional, Christensen, Kaare, additional, Chu, Audrey Y., additional, Corley, Janie, additional, Cox, Simon R., additional, Uitterlinden, Andre G., additional, Rivadeneira, Fernando, additional, Cropp, Cheryl D., additional, Daw, E. Warwick, additional, van Heemst, Diana, additional, de las Fuentes, Lisa, additional, Gao, He, additional, Tzoulaki, Ioanna, additional, Ahluwalia, Tarunveer S., additional, de Mutsert, Renée, additional, Emery, Leslie S., additional, Erzurumluoglu, A. Mesut, additional, Perry, James A., additional, Fu, Mao, additional, Forouhi, Nita G., additional, Gu, Zhenglong, additional, Hai, Yang, additional, Harris, Sarah E., additional, Hemani, Gibran, additional, Hunt, Steven C., additional, Irvin, Marguerite R., additional, Jonsson, Anna E., additional, Justice, Anne E., additional, Kerrison, Nicola D., additional, Larson, Nicholas B., additional, Lin, Keng-Hung, additional, Love-Gregory, Latisha D., additional, Mathias, Rasika A., additional, Lee, Joseph H., additional, Nauck, Matthias, additional, Noordam, Raymond, additional, Ong, Ken K., additional, Pankow, James, additional, Patki, Amit, additional, Pattie, Alison, additional, Petersmann, Astrid, additional, Qi, Qibin, additional, Ribel-Madsen, Rasmus, additional, Rohde, Rebecca, additional, Sandow, Kevin, additional, Schnurr, Theresia M., additional, Sofer, Tamar, additional, Starr, John M., additional, Taylor, Adele M., additional, Teumer, Alexander, additional, Timpson, Nicholas J., additional, de Haan, Hugoline G., additional, Wang, Yujie, additional, Weeke, Peter E., additional, Williams, Christine, additional, Wu, Hongsheng, additional, Yang, Wei, additional, Zeng, Donglin, additional, Witte, Daniel R., additional, Weir, Bruce S., additional, Wareham, Nicholas J., additional, Vestergaard, Henrik, additional, Turner, Stephen T., additional, Torp-Pedersen, Christian, additional, Stergiakouli, Evie, additional, Sheu, Wayne Huey-Herng, additional, Rosendaal, Frits R., additional, Ikram, M. Arfan, additional, Franco, Oscar H., additional, Ridker, Paul M., additional, Perls, Thomas T., additional, Pedersen, Oluf, additional, Nohr, Ellen A., additional, Newman, Anne B., additional, Linneberg, Allan, additional, Langenberg, Claudia, additional, Kilpeläinen, Tuomas O., additional, Kardia, Sharon L.R., additional, Jørgensen, Marit E., additional, Jørgensen, Torben, additional, Sørensen, Thorkild I.A., additional, Homuth, Georg, additional, Hansen, Torben, additional, Goodarzi, Mark O., additional, Deary, Ian J., additional, Christensen, Cramer, additional, Chen, Yii-Der Ida, additional, Chakravarti, Aravinda, additional, Brandslund, Ivan, additional, Bonnelykke, Klaus, additional, Taylor, Kent D., additional, Wilson, James G., additional, Rodriguez, Santiago, additional, Davies, Gail, additional, Horta, Bernardo L., additional, Thyagarajan, Bharat, additional, Rao, D.C., additional, Grarup, Niels, additional, Davila-Roman, Victor G., additional, Hudson, Gavin, additional, Guo, Xiuqing, additional, Arnett, Donna K., additional, Hayward, Caroline, additional, Vaidya, Dhananjay, additional, Mook-Kanamori, Dennis O., additional, Tiwari, Hemant K., additional, Levy, Daniel, additional, Loos, Ruth J.F., additional, Dehghan, Abbas, additional, Elliott, Paul, additional, Malik, Afshan N., additional, Scott, Robert A., additional, Becker, Diane M., additional, de Andrade, Mariza, additional, Province, Michael A., additional, Meigs, James B., additional, Rotter, Jerome I., additional, and North, Kari E., additional

Published
2019
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31. Association between circulating 25-hydroxyvitamin D and incident type 2 diabetes: a mendelian randomisation study

Author

Ye, Zheng, Sharp, Stephen J, Burgess, Stephen, Scott, Robert A, Imamura, Fumiaki, InterAct Consortium, Langenberg, Claudia, Wareham, Nicholas J, Forouhi, Nita G, Sharp, Stephen [0000-0003-2375-1440], Burgess, Stephen [0000-0001-5365-8760], Imamura, Fumiaki [0000-0002-6841-8396], Langenberg, Claudia [0000-0002-5017-7344], Wareham, Nicholas [0000-0003-1422-2993], Forouhi, Nita [0000-0002-5041-248X], and Apollo - University of Cambridge Repository

Subjects
Male, Diabetes Mellitus, Type 2, Risk Factors, Incidence, Humans, Female, Mendelian Randomization Analysis, Middle Aged, Vitamin D, Polymorphism, Single Nucleotide
Abstract

BACKGROUND: Low circulating concentrations of 25-hydroxyvitamin D (25[OH]D), a marker of vitamin D status, are associated with an increased risk of type 2 diabetes, but whether this association is causal remains unclear. We aimed to estimate the unconfounded, causal association between 25(OH)D concentration and risk of type 2 diabetes using a mendelian randomisation approach. METHODS: Using several data sources from populations of European descent, including type 2 diabetes cases and non-cases, we did a mendelian randomisation analysis using single nucleotide polymorphisms (SNPs) within or near four genes related to 25(OH)D synthesis and metabolism: DHCR7 (related to vitamin D synthesis), CYP2R1 (hepatic 25-hydroxylation), DBP (also known as GC; transport), and CYP24A1 (catabolism). We assessed each SNP for an association with circulating 25(OH)D concentration (5449 non-cases; two studies), risk of type 2 diabetes (28 144 cases, 76 344 non-cases; five studies), and glycaemic traits (concentrations of fasting glucose, 2-h glucose, fasting insulin, and HbA1c; 46 368 non-cases; study consortium). We combined these associations in a likelihood-based mendelian randomisation analysis to estimate the causal association of 25(OH)D concentration with type 2 diabetes and the glycaemic traits, and compared them with that from a meta-analysis of data from observational studies (8492 cases, 89 698 non-cases; 22 studies) that assessed the association between 25(OH)D concentration and type 2 diabetes. FINDINGS: All four SNPs were associated with 25(OH)D concentrations (p0·25). INTERPRETATION: The association between 25(OH)D concentration and type 2 diabetes is unlikely to be causal. Efforts to increase 25(OH)D concentrations might not reduce the risk of type 2 diabetes as would be expected on the basis of observational evidence. These findings warrant further investigations to identify causal factors that might increase 25(OH)D concentration and also reduce the risk of type 2 diabetes. FUNDING: UK Medical Research Council Epidemiology Unit and European Union Sixth Framework Programme.

Published
2015

34. Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies

Author

Wood, Angela M, primary, Kaptoge, Stephen, additional, Butterworth, Adam S, additional, Willeit, Peter, additional, Warnakula, Samantha, additional, Bolton, Thomas, additional, Paige, Ellie, additional, Paul, Dirk S, additional, Sweeting, Michael, additional, Burgess, Stephen, additional, Bell, Steven, additional, Astle, William, additional, Stevens, David, additional, Koulman, Albert, additional, Selmer, Randi M, additional, Verschuren, W M Monique, additional, Sato, Shinichi, additional, Njølstad, Inger, additional, Woodward, Mark, additional, Salomaa, Veikko, additional, Nordestgaard, Børge G, additional, Yeap, Bu B, additional, Fletcher, Astrid, additional, Melander, Olle, additional, Kuller, Lewis H, additional, Balkau, Beverley, additional, Marmot, Michael, additional, Koenig, Wolfgang, additional, Casiglia, Edoardo, additional, Cooper, Cyrus, additional, Arndt, Volker, additional, Franco, Oscar H, additional, Wennberg, Patrik, additional, Gallacher, John, additional, de la Cámara, Agustín Gómez, additional, Völzke, Henry, additional, Dahm, Christina C, additional, Dale, Caroline E, additional, Bergmann, Manuela M, additional, Crespo, Carlos J, additional, van der Schouw, Yvonne T, additional, Kaaks, Rudolf, additional, Simons, Leon A, additional, Lagiou, Pagona, additional, Schoufour, Josje D, additional, Boer, Jolanda M A, additional, Key, Timothy J, additional, Rodriguez, Beatriz, additional, Moreno-Iribas, Conchi, additional, Davidson, Karina W, additional, Taylor, James O, additional, Sacerdote, Carlotta, additional, Wallace, Robert B, additional, Quiros, J Ramon, additional, Tumino, Rosario, additional, Blazer, Dan G, additional, Linneberg, Allan, additional, Daimon, Makoto, additional, Panico, Salvatore, additional, Howard, Barbara, additional, Skeie, Guri, additional, Strandberg, Timo, additional, Weiderpass, Elisabete, additional, Nietert, Paul J, additional, Psaty, Bruce M, additional, Kromhout, Daan, additional, Salamanca-Fernandez, Elena, additional, Kiechl, Stefan, additional, Krumholz, Harlan M, additional, Grioni, Sara, additional, Palli, Domenico, additional, Huerta, José M, additional, Price, Jackie, additional, Sundström, Johan, additional, Arriola, Larraitz, additional, Arima, Hisatomi, additional, Travis, Ruth C, additional, Panagiotakos, Demosthenes B, additional, Karakatsani, Anna, additional, Trichopoulou, Antonia, additional, Kühn, Tilman, additional, Grobbee, Diederick E, additional, Barrett-Connor, Elizabeth, additional, van Schoor, Natasja, additional, Boeing, Heiner, additional, Overvad, Kim, additional, Kauhanen, Jussi, additional, Wareham, Nick, additional, Langenberg, Claudia, additional, Forouhi, Nita, additional, Wennberg, Maria, additional, Després, Jean-Pierre, additional, Cushman, Mary, additional, Cooper, Jackie A, additional, Rodriguez, Carlos J, additional, Sakurai, Masaru, additional, Shaw, Jonathan E, additional, Knuiman, Matthew, additional, Voortman, Trudy, additional, Meisinger, Christa, additional, Tjønneland, Anne, additional, Brenner, Hermann, additional, Palmieri, Luigi, additional, Dallongeville, Jean, additional, Brunner, Eric J, additional, Assmann, Gerd, additional, Trevisan, Maurizio, additional, Gillum, Richard F, additional, Ford, Ian, additional, Sattar, Naveed, additional, Lazo, Mariana, additional, Thompson, Simon G, additional, Ferrari, Pietro, additional, Leon, David A, additional, Smith, George Davey, additional, Peto, Richard, additional, Jackson, Rod, additional, Banks, Emily, additional, Di Angelantonio, Emanuele, additional, Danesh, John, additional, Wood, Angela M, additional, Butterworth, Adam, additional, Verschuren, Monique, additional, Veikko, Salomaa, additional, Flecther, Astrid, additional, Gómez de la Cámara, Agustín, additional, Bergmann, Manuela, additional, Crespo, Carlos, additional, Boer, Jolanda M.A, additional, Quiros, J. Ramon, additional, Rimm, Eric B, additional, Blazer III, Dan G, additional, Dallongeville, Jean-Pierre, additional, Gillumn, Richard F, additional, Ford, Ian Ford, additional, Thompson, Simon, additional, and Davey Smith, George, additional

Published
2018
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35. A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

Author

Sung, Yun J., primary, Winkler, Thomas W., additional, de las Fuentes, Lisa, additional, Bentley, Amy R., additional, Brown, Michael R., additional, Kraja, Aldi T., additional, Schwander, Karen, additional, Ntalla, Ioanna, additional, Guo, Xiuqing, additional, Franceschini, Nora, additional, Lu, Yingchang, additional, Cheng, Ching-Yu, additional, Sim, Xueling, additional, Vojinovic, Dina, additional, Marten, Jonathan, additional, Musani, Solomon K., additional, Li, Changwei, additional, Feitosa, Mary F., additional, Kilpeläinen, Tuomas O., additional, Richard, Melissa A., additional, Noordam, Raymond, additional, Aslibekyan, Stella, additional, Aschard, Hugues, additional, Bartz, Traci M., additional, Dorajoo, Rajkumar, additional, Liu, Yongmei, additional, Manning, Alisa K., additional, Rankinen, Tuomo, additional, Smith, Albert Vernon, additional, Tajuddin, Salman M., additional, Tayo, Bamidele O., additional, Warren, Helen R., additional, Zhao, Wei, additional, Zhou, Yanhua, additional, Matoba, Nana, additional, Sofer, Tamar, additional, Alver, Maris, additional, Amini, Marzyeh, additional, Boissel, Mathilde, additional, Chai, Jin Fang, additional, Chen, Xu, additional, Divers, Jasmin, additional, Gandin, Ilaria, additional, Gao, Chuan, additional, Giulianini, Franco, additional, Goel, Anuj, additional, Harris, Sarah E., additional, Hartwig, Fernando Pires, additional, Horimoto, Andrea R.V.R., additional, Hsu, Fang-Chi, additional, Jackson, Anne U., additional, Kähönen, Mika, additional, Kasturiratne, Anuradhani, additional, Kühnel, Brigitte, additional, Leander, Karin, additional, Lee, Wen-Jane, additional, Lin, Keng-Hung, additional, ’an Luan, Jian, additional, McKenzie, Colin A., additional, Meian, He, additional, Nelson, Christopher P., additional, Rauramaa, Rainer, additional, Schupf, Nicole, additional, Scott, Robert A., additional, Sheu, Wayne H.H., additional, Stančáková, Alena, additional, Takeuchi, Fumihiko, additional, van der Most, Peter J., additional, Varga, Tibor V., additional, Wang, Heming, additional, Wang, Yajuan, additional, Ware, Erin B., additional, Weiss, Stefan, additional, Wen, Wanqing, additional, Yanek, Lisa R., additional, Zhang, Weihua, additional, Zhao, Jing Hua, additional, Afaq, Saima, additional, Alfred, Tamuno, additional, Amin, Najaf, additional, Arking, Dan, additional, Aung, Tin, additional, Barr, R. Graham, additional, Bielak, Lawrence F., additional, Boerwinkle, Eric, additional, Bottinger, Erwin P., additional, Braund, Peter S., additional, Brody, Jennifer A., additional, Broeckel, Ulrich, additional, Cabrera, Claudia P., additional, Cade, Brian, additional, Caizheng, Yu, additional, Campbell, Archie, additional, Canouil, Mickaël, additional, Chakravarti, Aravinda, additional, Chauhan, Ganesh, additional, Christensen, Kaare, additional, Cocca, Massimiliano, additional, Collins, Francis S., additional, Connell, John M., additional, de Mutsert, Renée, additional, de Silva, H. Janaka, additional, Debette, Stephanie, additional, Dörr, Marcus, additional, Duan, Qing, additional, Eaton, Charles B., additional, Ehret, Georg, additional, Evangelou, Evangelos, additional, Faul, Jessica D., additional, Fisher, Virginia A., additional, Forouhi, Nita G., additional, Franco, Oscar H., additional, Friedlander, Yechiel, additional, Gao, He, additional, Gigante, Bruna, additional, Graff, Misa, additional, Gu, C. Charles, additional, Gu, Dongfeng, additional, Gupta, Preeti, additional, Hagenaars, Saskia P., additional, Harris, Tamara B., additional, He, Jiang, additional, Heikkinen, Sami, additional, Heng, Chew-Kiat, additional, Hirata, Makoto, additional, Hofman, Albert, additional, Howard, Barbara V., additional, Hunt, Steven, additional, Irvin, Marguerite R., additional, Jia, Yucheng, additional, Joehanes, Roby, additional, Justice, Anne E., additional, Katsuya, Tomohiro, additional, Kaufman, Joel, additional, Kerrison, Nicola D., additional, Khor, Chiea Chuen, additional, Koh, Woon-Puay, additional, Koistinen, Heikki A., additional, Komulainen, Pirjo, additional, Kooperberg, Charles, additional, Krieger, Jose E., additional, Kubo, Michiaki, additional, Kuusisto, Johanna, additional, Langefeld, Carl D., additional, Langenberg, Claudia, additional, Launer, Lenore J., additional, Lehne, Benjamin, additional, Lewis, Cora E., additional, Li, Yize, additional, Lim, Sing Hui, additional, Lin, Shiow, additional, Liu, Ching-Ti, additional, Liu, Jianjun, additional, Liu, Jingmin, additional, Liu, Kiang, additional, Liu, Yeheng, additional, Loh, Marie, additional, Lohman, Kurt K., additional, Long, Jirong, additional, Louie, Tin, additional, Mägi, Reedik, additional, Mahajan, Anubha, additional, Meitinger, Thomas, additional, Metspalu, Andres, additional, Milani, Lili, additional, Momozawa, Yukihide, additional, Morris, Andrew P., additional, Mosley, Thomas H., additional, Munson, Peter, additional, Murray, Alison D., additional, Nalls, Mike A., additional, Nasri, Ubaydah, additional, Norris, Jill M., additional, North, Kari, additional, Ogunniyi, Adesola, additional, Padmanabhan, Sandosh, additional, Palmas, Walter R., additional, Palmer, Nicholette D., additional, Pankow, James S., additional, Pedersen, Nancy L., additional, Peters, Annette, additional, Peyser, Patricia A., additional, Polasek, Ozren, additional, Raitakari, Olli T., additional, Renström, Frida, additional, Rice, Treva K., additional, Ridker, Paul M., additional, Robino, Antonietta, additional, Robinson, Jennifer G., additional, Rose, Lynda M., additional, Rudan, Igor, additional, Sabanayagam, Charumathi, additional, Salako, Babatunde L., additional, Sandow, Kevin, additional, Schmidt, Carsten O., additional, Schreiner, Pamela J., additional, Scott, William R., additional, Seshadri, Sudha, additional, Sever, Peter, additional, Sitlani, Colleen M., additional, Smith, Jennifer A., additional, Snieder, Harold, additional, Starr, John M., additional, Strauch, Konstantin, additional, Tang, Hua, additional, Taylor, Kent D., additional, Teo, Yik Ying, additional, Tham, Yih Chung, additional, Uitterlinden, André G., additional, Waldenberger, Melanie, additional, Wang, Lihua, additional, Wang, Ya X., additional, Wei, Wen Bin, additional, Williams, Christine, additional, Wilson, Gregory, additional, Wojczynski, Mary K., additional, Yao, Jie, additional, Yuan, Jian-Min, additional, Zonderman, Alan B., additional, Becker, Diane M., additional, Boehnke, Michael, additional, Bowden, Donald W., additional, Chambers, John C., additional, Chen, Yii-Der Ida, additional, de Faire, Ulf, additional, Deary, Ian J., additional, Esko, Tõnu, additional, Farrall, Martin, additional, Forrester, Terrence, additional, Franks, Paul W., additional, Freedman, Barry I., additional, Froguel, Philippe, additional, Gasparini, Paolo, additional, Gieger, Christian, additional, Horta, Bernardo Lessa, additional, Hung, Yi-Jen, additional, Jonas, Jost B., additional, Kato, Norihiro, additional, Kooner, Jaspal S., additional, Laakso, Markku, additional, Lehtimäki, Terho, additional, Liang, Kae-Woei, additional, Magnusson, Patrik K.E., additional, Newman, Anne B., additional, Oldehinkel, Albertine J., additional, Pereira, Alexandre C., additional, Redline, Susan, additional, Rettig, Rainer, additional, Samani, Nilesh J., additional, Scott, James, additional, Shu, Xiao-Ou, additional, van der Harst, Pim, additional, Wagenknecht, Lynne E., additional, Wareham, Nicholas J., additional, Watkins, Hugh, additional, Weir, David R., additional, Wickremasinghe, Ananda R., additional, Wu, Tangchun, additional, Zheng, Wei, additional, Kamatani, Yoichiro, additional, Laurie, Cathy C., additional, Bouchard, Claude, additional, Cooper, Richard S., additional, Evans, Michele K., additional, Gudnason, Vilmundur, additional, Kardia, Sharon L.R., additional, Kritchevsky, Stephen B., additional, Levy, Daniel, additional, O’Connell, Jeff R., additional, Psaty, Bruce M., additional, van Dam, Rob M., additional, Sims, Mario, additional, Arnett, Donna K., additional, Mook-Kanamori, Dennis O., additional, Kelly, Tanika N., additional, Fox, Ervin R., additional, Hayward, Caroline, additional, Fornage, Myriam, additional, Rotimi, Charles N., additional, Province, Michael A., additional, van Duijn, Cornelia M., additional, Tai, E. Shyong, additional, Wong, Tien Yin, additional, Loos, Ruth J.F., additional, Reiner, Alex P., additional, Rotter, Jerome I., additional, Zhu, Xiaofeng, additional, Bierut, Laura J., additional, Gauderman, W. James, additional, Caulfield, Mark J., additional, Elliott, Paul, additional, Rice, Kenneth, additional, Munroe, Patricia B., additional, Morrison, Alanna C., additional, Cupples, L. Adrienne, additional, Rao, Dabeeru C., additional, and Chasman, Daniel I., additional

Published
2018
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36. Does neighborhood fast-food outlet exposure amplify inequalities in diet and obesity? A cross-sectional study

Author

Burgoine, Thomas, Forouhi, Nita G, Griffin, Simon J, Brage, Søren, Wareham, Nicholas J, Monsivais, Pablo, Burgoine, Thomas [0000-0001-6936-3801], Monsivais, Pablo [0000-0002-7088-6674], and Apollo - University of Cambridge Repository

Subjects
Adult, Male, obesity, deprivation amplification, Health Promotion, Environment, Body Mass Index, Cohort Studies, fast-food, Residence Characteristics, Surveys and Questionnaires, Humans, Aged, geographic information systems, Feeding Behavior, Middle Aged, Diet Records, United Kingdom, Diet, Cross-Sectional Studies, Logistic Models, Socioeconomic Factors, educational attainment, Educational Status, Fast Foods, Female
Abstract

BACKGROUND: Greater exposures to fast-food outlets and lower levels of education are independently associated with less healthy diets and obesity. Little is known about the interplay between these environmental and individual factors. OBJECTIVE: The purpose of this study was to test whether observed differences in fast-food consumption and obesity by fast-food outlet exposure are moderated by educational attainment. DESIGN: In a population-based cohort of 5958 adults aged 29-62 y in Cambridgeshire, United Kingdom, we used educational attainment-stratified regression models to estimate the food-frequency questionnaire-derived consumption of energy-dense "fast foods" (g/d) typically sold in fast-food restaurants and measured body mass index (BMI; in kg/m(2)) across geographic information system-derived home and work fast-food exposure quartiles. We used logistic regression to estimate the odds of obesity (BMI ≥30) and calculated relative excess risk due to interaction (RERI) on an additive scale. Participant data were collected during 2005-2013 and analyzed in 2015. RESULTS: Greater fast-food consumption, BMI, and odds of obesity were associated with greater fast-food outlet exposure and a lower educational level. Fast-food consumption and BMI were significantly different across education groups at all levels of fast-food outlet exposure (P < 0.05). High fast-food outlet exposure amplified differences in fast-food consumption across levels of education. The relation between fast-food outlet exposure and obesity was only significant among those who were least educated (OR: 2.05; 95% CI: 1.08, 3.87; RERI = 0.88), which suggested a positive additive interaction between education and fast-food outlet exposure. CONCLUSION: These findings suggest that efforts to improve diets and health through neighborhood-level fast-food outlet regulation might be effective across socioeconomic groups and may serve to reduce observed socioeconomic inequalities in diet and obesity.

Published
2016

37. Omega-6 fatty acid biomarkers and incident type 2 diabetes: pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies

Author

Wu, Jason H Y, primary, Marklund, Matti, additional, Imamura, Fumiaki, additional, Tintle, Nathan, additional, Ardisson Korat, Andres V, additional, de Goede, Janette, additional, Zhou, Xia, additional, Yang, Wei-Sin, additional, de Oliveira Otto, Marcia C, additional, Kröger, Janine, additional, Qureshi, Waqas, additional, Virtanen, Jyrki K, additional, Bassett, Julie K, additional, Frazier-Wood, Alexis C, additional, Lankinen, Maria, additional, Murphy, Rachel A, additional, Rajaobelina, Kalina, additional, Del Gobbo, Liana C, additional, Forouhi, Nita G, additional, Luben, Robert, additional, Khaw, Kay-Tee, additional, Wareham, Nick, additional, Kalsbeek, Anya, additional, Veenstra, Jenna, additional, Luo, Juhua, additional, Hu, Frank B, additional, Lin, Hung-Ju, additional, Siscovick, David S, additional, Boeing, Heiner, additional, Chen, Tzu-An, additional, Steffen, Brian, additional, Steffen, Lyn M, additional, Hodge, Allison, additional, Eriksdottir, Gudny, additional, Smith, Albert V, additional, Gudnason, Vilmunder, additional, Harris, Tamara B, additional, Brouwer, Ingeborg A, additional, Berr, Claudine, additional, Helmer, Catherine, additional, Samieri, Cecilia, additional, Laakso, Markku, additional, Tsai, Michael Y, additional, Giles, Graham G, additional, Nurmi, Tarja, additional, Wagenknecht, Lynne, additional, Schulze, Matthias B, additional, Lemaitre, Rozenn N, additional, Chien, Kuo-Liong, additional, Soedamah-Muthu, Sabita S, additional, Geleijnse, Johanna M, additional, Sun, Qi, additional, Harris, William S, additional, Lind, Lars, additional, Ärnlöv, Johan, additional, Riserus, Ulf, additional, Micha, Renata, additional, and Mozaffarian, Dariush, additional

Published
2017
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40. Interaction between genes and macronutrient intake on the risk of developing type 2 diabetes: systematic review and findings from European Prospective Investigation into Cancer (EPIC)-InterAct

Author

Li, Sherly X, primary, Imamura, Fumiaki, additional, Ye, Zheng, additional, Schulze, Matthias B, additional, Zheng, Jusheng, additional, Ardanaz, Eva, additional, Arriola, Larraitz, additional, Boeing, Heiner, additional, Dow, Courtney, additional, Fagherazzi, Guy, additional, Franks, Paul W, additional, Agudo, Antonio, additional, Grioni, Sara, additional, Kaaks, Rudolf, additional, Katzke, Verena A, additional, Key, Timothy J, additional, Khaw, Kay Tee, additional, Mancini, Francesca R, additional, Navarro, Carmen, additional, Nilsson, Peter M, additional, Onland-Moret, N Charlotte, additional, Overvad, Kim, additional, Palli, Domenico, additional, Panico, Salvatore, additional, Quirós, J Ramón, additional, Rolandsson, Olov, additional, Sacerdote, Carlotta, additional, Sánchez, María-José, additional, Slimani, Nadia, additional, Sluijs, Ivonne, additional, Spijkerman, Annemieke MW, additional, Tjonneland, Anne, additional, Tumino, Rosario, additional, Sharp, Stephen J, additional, Riboli, Elio, additional, Langenberg, Claudia, additional, Scott, Robert A, additional, Forouhi, Nita G, additional, and Wareham, Nicholas J, additional

Published
2017
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41. Mediation and modification of genetic susceptibility to obesity by eating behaviors

Author

de Lauzon-Guillain, Blandine, primary, Clifton, Emma AD, additional, Day, Felix R, additional, Clément, Karine, additional, Brage, Soren, additional, Forouhi, Nita G, additional, Griffin, Simon J, additional, Koudou, Yves Akoli, additional, Pelloux, Véronique, additional, Wareham, Nicholas J, additional, Charles, Marie-Aline, additional, Heude, Barbara, additional, and Ong, Ken K, additional

Published
2017
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45. Reply to KJ Petzke

Author

Forouhi, Nita G, primary, Kuhnle, Gunter GC, additional, Patel, Pinal S, additional, and O’Connell, Tamsin C, additional

Published
2015
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46. Variation in the SLC23A1 gene does not influence cardiometabolic outcomes to the extent expected given its association with l-ascorbic acid

Author

Wade, Kaitlin H, primary, Forouhi, Nita G, additional, Cook, Derek G, additional, Johnson, Paul, additional, McConnachie, Alex, additional, Morris, Richard W, additional, Rodriguez, Santiago, additional, Ye, Zheng, additional, Ebrahim, Shah, additional, Padmanabhan, Sandosh, additional, Watt, Graham, additional, Bruckdorfer, K Richard, additional, Wareham, Nick J, additional, Whincup, Peter H, additional, Chanock, Stephen, additional, Sattar, Naveed, additional, Lawlor, Debbie A, additional, Davey Smith, George, additional, and Timpson, Nicholas J, additional

Published
2015
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