1. Are the recommendations for post-operative antibiotics in patients with grade I or II acute calculous cholecystitis being applied in clinical practice?
- Author
-
Marc Pocard, Jean-Christophe Paquet, Jean-Jacques Tuech, Karem Slim, J. Dembinski, Orlane Guérin, Francis Navarro, François Mauvais, Jean-Luc Faucheron, Jean-Marc Regimbeau, Chirurgie digestive [CHU Amiens], CHU Amiens-Picardie, Service de Chirurgie Digestive et Hépatobiliaire [CHU Clermont-Ferrand], CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Groupe Hospitalier Nord Essonne [Longjumeau], Service de chirurgie digestive [CHU Rouen], Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU), Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de chirurgie digestive (Centre Hospitalier de Beauvais), Centre Hospitalier de Beauvais, Centre Hospitalier Universitaire [Grenoble] (CHU), and Université de Picardie Jules Verne (UPJV)
- Subjects
MESH: Cholecystectomy ,medicine.medical_specialty ,medicine.drug_class ,medicine.medical_treatment ,Cholecystitis, Acute ,Antibiotics ,030230 surgery ,MESH: Length of Stay ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,MESH: Postoperative Period ,MESH: Anti-Bacterial Agents ,MESH: Postoperative Complications ,medicine ,Clinical endpoint ,Humans ,Cholecystectomy ,In patient ,Postoperative Period ,Post operative ,10. No inequality ,Retrospective Studies ,MESH: Treatment Outcome ,MESH: Humans ,Hepatology ,business.industry ,Gastroenterology ,MESH: Cholecystitis, Acute ,MESH: Retrospective Studies ,[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology ,Perioperative ,Length of Stay ,[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences ,medicine.disease ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,Anti-Bacterial Agents ,3. Good health ,Surgery ,Clinical Practice ,Treatment Outcome ,MESH: Cholecystectomy, Laparoscopic ,Cholecystectomy, Laparoscopic ,030220 oncology & carcinogenesis ,Cholecystitis ,business - Abstract
Background There is a level-1 evidence indicating that postoperative antibiotics are unnecessary following cholecystectomy for grade I or II acute calculous cholecystitis (ACC). We wanted to evaluate the applications of this recommendation in clinical practice four years after the original publication in ABCAL-participating centers. Methods A retrospective analysis of patients operated for grade I or II ACC from January to December 2016 in ABCAL-participating centers was performed. Inclusion criteria were the same as for the ABCAL-study. The primary endpoint was the postoperative antibiotic administration rate. The secondary endpoints were postoperative outcomes. Results Of the 283 patients included, 64% received postoperative antibiotics. Only 19% received antibiotics after POD1. The perioperative outcomes were similar between those that did or did not receive antibiotics after POD1. The median [range] length of stay was significantly shorter in patients who did not receive postoperative antibiotics (4 days [1–20]) compared to the others (6 days [1–50], p > 0.001). Conclusion Despite strong recommendations included in the Tokyo 2018 guidelines, the results of the ABCAL-study are poorly applied even if the absence of postoperative antibiotics has no impact on morbidity. It is important to stress that postoperative antibiotics are not necessary after cholecystectomy for grade I or II ACC.
- Published
- 2020
- Full Text
- View/download PDF