Search

Your search keyword '"Freeman, Samuel S."' showing total 12 results
Start Over Author "Freeman, Samuel S." Publisher elsevier bv
12 results on '"Freeman, Samuel S."'

2. Personalised progression prediction in patients with monoclonal gammopathy of undetermined significance or smouldering multiple myeloma (PANGEA): a retrospective, multicohort study

Author

Cowan, Annie, primary, Ferrari, Federico, additional, Freeman, Samuel S, additional, Redd, Robert, additional, El-Khoury, Habib, additional, Perry, Jacqueline, additional, Patel, Vidhi, additional, Kaur, Priya, additional, Barr, Hadley, additional, Lee, David J, additional, Lightbody, Elizabeth, additional, Downey, Katelyn, additional, Argyelan, David, additional, Theodorakakou, Foteini, additional, Fotiou, Despina, additional, Liacos, Christine Ivy, additional, Kanellias, Nikolaos, additional, Chavda, Selina J, additional, Ainley, Louise, additional, Sandecká, Viera, additional, Pospíšilová, Lenka, additional, Minarik, Jiri, additional, Jungova, Alexandra, additional, Radocha, Jakub, additional, Spicka, Ivan, additional, Nadeem, Omar, additional, Yong, Kwee, additional, Hájek, Roman, additional, Kastritis, Efstathios, additional, Marinac, Catherine R, additional, Dimopoulos, Meletios A, additional, Get, Gad, additional, Trippa, Lorenzo, additional, and Ghobrial, Irene M, additional

Published
2023
Full Text
View/download PDF

3. Longitudinal characterization of circulating neutrophils uncovers phenotypes associated with severity in hospitalized COVID-19 patients

Author

LaSalle, Thomas J., primary, Gonye, Anna L.K., additional, Freeman, Samuel S., additional, Kaplonek, Paulina, additional, Gushterova, Irena, additional, Kays, Kyle R., additional, Manakongtreecheep, Kasidet, additional, Tantivit, Jessica, additional, Rojas-Lopez, Maricarmen, additional, Russo, Brian C., additional, Sharma, Nihaarika, additional, Thomas, Molly F., additional, Lavin-Parsons, Kendall M., additional, Lilly, Brendan M., additional, Mckaig, Brenna N., additional, Charland, Nicole C., additional, Khanna, Hargun K., additional, Lodenstein, Carl L., additional, Margolin, Justin D., additional, Blaum, Emily M., additional, Lirofonis, Paola B., additional, Revach, Or-Yam, additional, Mehta, Arnav, additional, Sonny, Abraham, additional, Bhattacharyya, Roby P., additional, Parry, Blair Alden, additional, Goldberg, Marcia B., additional, Alter, Galit, additional, Filbin, Michael R., additional, Villani, Alexandra-Chloé, additional, Hacohen, Nir, additional, and Sade-Feldman, Moshe, additional

Published
2022
Full Text
View/download PDF

4. Structural Alterations Driving Castration-Resistant Prostate Cancer Revealed by Linked-Read Genome Sequencing

Author

Koch Institute for Integrative Cancer Research at MIT, Viswanathan, Srinivas R., Ha, Gavin, Hoff, Andreas M., Wala, Jeremiah A., Carrot-Zhang, Jian, Whelan, Christopher W., Haradhvala, Nicholas J., Freeman, Samuel S., Reed, Sarah C., Rhoades, Justin, Polak, Paz, Cipicchio, Michelle, Wankowicz, Stephanie A., Wong, Alicia, Kamath, Tushar, Zhang, Zhenwei, Gydush, Gregory J., Rotem, Denisse, Love, J. Christopher, Getz, Gad, Gabriel, Stacey, Zhang, Cheng-Zhong, Dehm, Scott M., Nelson, Peter S., Van Allen, Eliezer M., Choudhury, Atish D., Adalsteinsson, Viktor A., Beroukhim, Rameen, Taplin, Mary-Ellen, Meyerson, Matthew, Koch Institute for Integrative Cancer Research at MIT, Viswanathan, Srinivas R., Ha, Gavin, Hoff, Andreas M., Wala, Jeremiah A., Carrot-Zhang, Jian, Whelan, Christopher W., Haradhvala, Nicholas J., Freeman, Samuel S., Reed, Sarah C., Rhoades, Justin, Polak, Paz, Cipicchio, Michelle, Wankowicz, Stephanie A., Wong, Alicia, Kamath, Tushar, Zhang, Zhenwei, Gydush, Gregory J., Rotem, Denisse, Love, J. Christopher, Getz, Gad, Gabriel, Stacey, Zhang, Cheng-Zhong, Dehm, Scott M., Nelson, Peter S., Van Allen, Eliezer M., Choudhury, Atish D., Adalsteinsson, Viktor A., Beroukhim, Rameen, Taplin, Mary-Ellen, and Meyerson, Matthew

Abstract

© 2018 Elsevier Inc. Nearly all prostate cancer deaths are from metastatic castration-resistant prostate cancer (mCRPC), but there have been few whole-genome sequencing (WGS) studies of this disease state. We performed linked-read WGS on 23 mCRPC biopsy specimens and analyzed cell-free DNA sequencing data from 86 patients with mCRPC. In addition to frequent rearrangements affecting known prostate cancer genes, we observed complex rearrangements of the AR locus in most cases. Unexpectedly, these rearrangements include highly recurrent tandem duplications involving an upstream enhancer of AR in 70%–87% of cases compared with <2% of primary prostate cancers. A subset of cases displayed AR or MYC enhancer duplication in the context of a genome-wide tandem duplicator phenotype associated with CDK12 inactivation. Our findings highlight the complex genomic structure of mCRPC, nominate alterations that may inform prostate cancer treatment, and suggest that additional recurrent events in the non-coding mCRPC genome remain to be discovered. Linked-read genome sequencing data from patients highlight that amplification of an enhancer upstream of the androgen receptor locus is a key feature of metastatic castration-resistant prostate cancer.

Published
2022

5. Combined tumor and immune signals from genomes or transcriptomes predict outcomes of checkpoint inhibition in melanoma

Author

Freeman, Samuel S., primary, Sade-Feldman, Moshe, additional, Kim, Jaegil, additional, Stewart, Chip, additional, Gonye, Anna L.K., additional, Ravi, Arvind, additional, Arniella, Monica B., additional, Gushterova, Irena, additional, LaSalle, Thomas J., additional, Blaum, Emily M., additional, Yizhak, Keren, additional, Frederick, Dennie T., additional, Sharova, Tatyana, additional, Leshchiner, Ignaty, additional, Elagina, Liudmila, additional, Spiro, Oliver G., additional, Livitz, Dimitri, additional, Rosebrock, Daniel, additional, Aguet, François, additional, Carrot-Zhang, Jian, additional, Ha, Gavin, additional, Lin, Ziao, additional, Chen, Jonathan H., additional, Barzily-Rokni, Michal, additional, Hammond, Marc R., additional, Vitzthum von Eckstaedt, Hans C., additional, Blackmon, Shauna M., additional, Jiao, Yunxin J., additional, Gabriel, Stacey, additional, Lawrence, Donald P., additional, Duncan, Lyn M., additional, Stemmer-Rachamimov, Anat O., additional, Wargo, Jennifer A., additional, Flaherty, Keith T., additional, Sullivan, Ryan J., additional, Boland, Genevieve M., additional, Meyerson, Matthew, additional, Getz, Gad, additional, and Hacohen, Nir, additional

Published
2022
Full Text
View/download PDF

7. Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

Author

Sade-Feldman, Moshe, primary, Yizhak, Keren, additional, Bjorgaard, Stacey L., additional, Ray, John P., additional, de Boer, Carl G., additional, Jenkins, Russell W., additional, Lieb, David J., additional, Chen, Jonathan H., additional, Frederick, Dennie T., additional, Barzily-Rokni, Michal, additional, Freeman, Samuel S., additional, Reuben, Alexandre, additional, Hoover, Paul J., additional, Villani, Alexandra-Chloé, additional, Ivanova, Elena, additional, Portell, Andrew, additional, Lizotte, Patrick H., additional, Aref, Amir R., additional, Eliane, Jean-Pierre, additional, Hammond, Marc R., additional, Vitzthum, Hans, additional, Blackmon, Shauna M., additional, Li, Bo, additional, Gopalakrishnan, Vancheswaran, additional, Reddy, Sangeetha M., additional, Cooper, Zachary A., additional, Paweletz, Cloud P., additional, Barbie, David A., additional, Stemmer-Rachamimov, Anat, additional, Flaherty, Keith T., additional, Wargo, Jennifer A., additional, Boland, Genevieve M., additional, Sullivan, Ryan J., additional, Getz, Gad, additional, and Hacohen, Nir, additional

Published
2019
Full Text
View/download PDF

8. Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

Author

Sade-Feldman, Moshe, primary, Yizhak, Keren, additional, Bjorgaard, Stacey L., additional, Ray, John P., additional, de Boer, Carl G., additional, Jenkins, Russell W., additional, Lieb, David J., additional, Chen, Jonathan H., additional, Frederick, Dennie T., additional, Barzily-Rokni, Michal, additional, Freeman, Samuel S., additional, Reuben, Alexandre, additional, Hoover, Paul J., additional, Villani, Alexandra-Chloé, additional, Ivanova, Elena, additional, Portell, Andrew, additional, Lizotte, Patrick H., additional, Aref, Amir R., additional, Eliane, Jean-Pierre, additional, Hammond, Marc R., additional, Vitzthum, Hans, additional, Blackmon, Shauna M., additional, Li, Bo, additional, Gopalakrishnan, Vancheswaran, additional, Reddy, Sangeetha M., additional, Cooper, Zachary A., additional, Paweletz, Cloud P., additional, Barbie, David A., additional, Stemmer-Rachamimov, Anat, additional, Flaherty, Keith T., additional, Wargo, Jennifer A., additional, Boland, Genevieve M., additional, Sullivan, Ryan J., additional, Getz, Gad, additional, and Hacohen, Nir, additional

Published
2018
Full Text
View/download PDF

9. Structural Alterations Driving Castration-Resistant Prostate Cancer Revealed by Linked-Read Genome Sequencing

Author

Viswanathan, Srinivas R., primary, Ha, Gavin, additional, Hoff, Andreas M., additional, Wala, Jeremiah A., additional, Carrot-Zhang, Jian, additional, Whelan, Christopher W., additional, Haradhvala, Nicholas J., additional, Freeman, Samuel S., additional, Reed, Sarah C., additional, Rhoades, Justin, additional, Polak, Paz, additional, Cipicchio, Michelle, additional, Wankowicz, Stephanie A., additional, Wong, Alicia, additional, Kamath, Tushar, additional, Zhang, Zhenwei, additional, Gydush, Gregory J., additional, Rotem, Denisse, additional, Love, J. Christopher, additional, Getz, Gad, additional, Gabriel, Stacey, additional, Zhang, Cheng-Zhong, additional, Dehm, Scott M., additional, Nelson, Peter S., additional, Van Allen, Eliezer M., additional, Choudhury, Atish D., additional, Adalsteinsson, Viktor A., additional, Beroukhim, Rameen, additional, Taplin, Mary-Ellen, additional, and Meyerson, Matthew, additional

Published
2018
Full Text
View/download PDF

10. The Mutational Landscape of Circulating Tumor Cells in Multiple Myeloma

Author

Mishima, Yuji, primary, Paiva, Bruno, additional, Shi, Jiantao, additional, Park, Jihye, additional, Manier, Salomon, additional, Takagi, Satoshi, additional, Massoud, Mira, additional, Perilla-Glen, Adriana, additional, Aljawai, Yosra, additional, Huynh, Daisy, additional, Roccaro, Aldo M., additional, Sacco, Antonio, additional, Capelletti, Marzia, additional, Detappe, Alexandre, additional, Alignani, Diego, additional, Anderson, Kenneth C., additional, Munshi, Nikhil C., additional, Prosper, Felipe, additional, Lohr, Jens G., additional, Ha, Gavin, additional, Freeman, Samuel S., additional, Van Allen, Eliezer M., additional, Adalsteinsson, Viktor A., additional, Michor, Franziska, additional, San Miguel, Jesus F., additional, and Ghobrial, Irene M., additional

Published
2017
Full Text
View/download PDF

11. Transcriptomic Characterization of SF3B1 Mutation Reveals Its Pleiotropic Effects in Chronic Lymphocytic Leukemia

Author

Wang, Lili, primary, Brooks, Angela N., additional, Fan, Jean, additional, Wan, Youzhong, additional, Gambe, Rutendo, additional, Li, Shuqiang, additional, Hergert, Sarah, additional, Yin, Shanye, additional, Freeman, Samuel S., additional, Levin, Joshua Z., additional, Fan, Lin, additional, Seiler, Michael, additional, Buonamici, Silvia, additional, Smith, Peter G., additional, Chau, Kevin F., additional, Cibulskis, Carrie L., additional, Zhang, Wandi, additional, Rassenti, Laura Z., additional, Ghia, Emanuela M., additional, Kipps, Thomas J., additional, Fernandes, Stacey, additional, Bloch, Donald B., additional, Kotliar, Dylan, additional, Landau, Dan A., additional, Shukla, Sachet A., additional, Aster, Jon C., additional, Reed, Robin, additional, DeLuca, David S., additional, Brown, Jennifer R., additional, Neuberg, Donna, additional, Getz, Gad, additional, Livak, Kenneth J., additional, Meyerson, Matthew M., additional, Kharchenko, Peter V., additional, and Wu, Catherine J., additional

Published
2016
Full Text
View/download PDF

12. Metagenomic Characterization of Microbial Communities In Situ Within the Deeper Layers of the Ileum in Crohn’s Disease

Author

Pedamallu, Chandra Sekhar, primary, Bhatt, Ami S., additional, Bullman, Susan, additional, Fowler, Sharyle, additional, Freeman, Samuel S., additional, Durand, Jacqueline, additional, Jung, Joonil, additional, Duke, Fujiko, additional, Manzo, Veronica, additional, Cai, Diana, additional, Ananthakrishnan, Ashwin, additional, Ojesina, Akinyemi I., additional, Ramachandran, Aruna, additional, Gevers, Dirk, additional, Xavier, Ramnik J., additional, Bhan, Atul K., additional, Meyerson, Matthew, additional, and Yajnik, Vijay, additional

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results