From 2012 to comply with the ED 2010/31/EU and its recasts, all new buildings will perform as Nearly Zero Energy Buildings (NearlyZEBs). Buildings are going to be transformed through a careful design into energy generation systems, and the conventional, centralized system of energy generation is going to be replaced by a “web” of energy generation systems. Photovoltaics (PV) seems to be one of the most suitable energy generation technologies for enabling this change, thanks to its “fair” cost, technical features, and multifunctional use in the building's envelope, as well as in the urban environment. PV will be an indispensable technology for Net Zero Energy Buildings (NetZEBs), with the consequence of being a kind of “ubiquitous” technology, also suitable for added uses than the traditional ones. For example: in addition to the multifunctional use in the building's envelope, it might offer advanced services for improving the efficiency and participation in the city processes. A multidisciplinary investigation on possible ways for PV and NetZEBs to change the future urban scenario is proposed, focusing on design, energy management and technological issues to support a Smart City (SC) vision.