27 results on '"Gabriella D’Ettorre"'
Search Results
2. Many Different Patterns under a Common Flag: Aortic Pathology in HIV—A Review of Case Reports in Literature
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Rita Mele, Gabriella d'Ettorre, Cristian Borrazzo, and Valeria Silvestri
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Pathology ,medicine.medical_specialty ,antiretroviral therapy ,prevalence ,adult ,aged ,antiretroviral therapy, highly active ,aortic diseases ,comorbidity ,female ,HIV infections ,health status ,humans ,immunocompromised host ,incidence ,life style ,male ,middle aged ,prognosis ,risk assessment ,risk factors ,time factors ,HIV long-term survivors ,030204 cardiovascular system & hematology ,Tertiary Syphilis ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Aortic aneurysm ,0302 clinical medicine ,Antiretroviral Therapy, Highly Active ,medicine ,highly active ,Aortitis ,Aortic dissection ,business.industry ,HIV Long-Term Survivors ,General Medicine ,medicine.disease ,Coinfection ,Etiology ,Surgery ,Syphilis ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background Availability of highly active antiretroviral therapy (HAART) for HIV has prolonged life expectancy of patients but has also increased the incidence of non-AIDS comorbid conditions. Among these, there are cardiovascular diseases, and aortic involvement has been described in patients with HIV in the form of aortitis, aneurysms, or dissections. Our study aims to describe aortic pathology occurring in patients with HIV, focusing on clinical and surgical presentation, management, and outcome, through a review of cases published in literature. Methods MEDLINE ( www.ncbi.nlm.nih.gov/pubmed ) database was reviewed for “aortitis” OR “aortic aneurysm” OR “aortic dissection” AND HIV. Research was restricted to English language. Only case reports were included. Data on patients' age, sex, traditional risk factors, timing from HIV diagnosis, pharmacological details, coinfection (syphilis, hepatitis C virus [HCV], and hepatitis B virus [HBV]), anatomical localization of lesion, presence of inflammatory involvement, rapid growing or rupture, and surgical treatment and outcomes were collected and summarized in tables. Results Forty articles (51 cases) were included in the study. The mean age of patients was 48.8 ± 8.3 years. Male sex was preponderant (43 cases, 84.3%). Among traditional risk factors, hypertension and smoking were the most frequently reported ones (14 and 13 cases, respectively), followed by vasculopathy involving other arterial districts, dyslipidemia, diabetes, and drug addiction. In 3 cases, HIV was diagnosed in the same time as aortic pathology, whereas in most cases, aortic event occurred after five years from HIV diagnosis. In 30.5% of cases for which data on pharmacologic management were available, no treatment or poor adherence was reported. Coinfection occurred in some cases (syphilis in 6, HCV in 5, and HBV in 3). As for anatomical involvement, isolated thoracic lesions were more frequent (24, 47.1%), followed by abdominal and thoracoabdominal lesions. The etiology ranged from bacterial mycotic aneurysms to tertiary syphilis, postsurgical complications, or atherosclerosis. In 3 cases, HIV vasculitis was directly suggested, and in another 2, no other potential etiology had been diagnosed through cultural tests. Open surgical treatment was carried out in 30 cases (58.8%), and in addition, 10 endovascular (19.6%) and 2 hybrid procedures were described. Inflammatory features occurred in 7 cases, and a rapid evolution of lesions in 6. In 9 cases (17.6%), rupture occurred. Mortality was reported in 8 cases (15.7%). Conclusions Aortic pathology may occur in patients with HIV. The entanglement of different patterns of pathological involvement of the aortic wall, secondary to immune dysregulation, infectious process, or atherosclerotic damage that may co-occur in one single case, results in a very challenging management of the condition. Because of the increased life expectancy of patients and immigration from regions with both high HIV and coinfection prevalence, the incidence of aortic pathology could increase in the upcoming years, suggesting the urgent need for further studies to optimize management in these very complex cases.
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- 2019
3. Preventing influenza and influenza like illness during Covid-19 pandemic: A call for action
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Massimo Ciccozzi, Gabriele d'Ettorre, Claudia Pinacchio, Gabriella d'Ettorre, and Giancarlo Ceccarelli
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2019-20 coronavirus outbreak ,Influenza-like illness ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,COVID-19 ,Obstetrics and Gynecology ,Virology ,Article ,Influenza A Virus, H1N1 Subtype ,Action (philosophy) ,Influenza, Human ,Obstetrics and Gynaecology ,Pediatrics, Perinatology and Child Health ,Pandemic ,Humans ,Medicine ,Pediatrics, Perinatology, and Child Health ,business ,Pandemics - Published
- 2022
4. Differential induction of type I and III interferon genes in the upper respiratory tract of patients with coronavirus disease 2019 (COVID-19)
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Mirko Scordio, Ombretta Turriziani, Carolina Scagnolari, Guido Antonelli, Giancarlo Ceccarelli, Gabriella d'Ettorre, Laura Mazzuti, Angelo G. Solimini, Giuseppe Oliveto, Agnese Viscido, Daniele Di Carlo, Massimo Gentile, Alessandra Pierangeli, Claudio Maria Mastroianni, Federica Frasca, Camilla Bitossi, and Francesco Pugliese
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Adult ,Male ,Cancer Research ,viruses ,Short Communication ,medicine.medical_treatment ,Oropharynx ,Biology ,Severity of Illness Index ,Interferon Lambda ,ISG ,03 medical and health sciences ,Interferon ,Virology ,Severity of illness ,medicine ,Humans ,COVID-19 ,IFN alpha/beta ,IFN lambda ,innate immunity ,SARS-CoV-2 ,skin and connective tissue diseases ,Gene ,Aged ,030304 developmental biology ,Mechanical ventilation ,0303 health sciences ,Innate immune system ,030306 microbiology ,fungi ,Middle Aged ,respiratory tract diseases ,body regions ,medicine.anatomical_structure ,Infectious Diseases ,Interferon Type I ,Immunology ,IRF7 ,Female ,Interferons ,Interferon type I ,Respiratory tract ,medicine.drug - Abstract
Highlights • SARS-CoV-2 infected patients have a differential IFN response. • IFN-stimulated genes levels are reduced in critically-ill patients. • SARS-CoV-2 viral load correlated to IFN-stimulated genes levels., The natural course of type I and III interferon (IFN) response in the respiratory tract of COVID-19 patients needs to be better defined. We showed that type I/III IFNs, IFN-regulatory factor 7 (IRF7), and IFN stimulated genes (ISGs), are highly expressed in the oropharyngeal cells of SARS-CoV-2 positive patients compared to healthy controls. Notably, the subgroup of critically-ill patients that required invasive mechanical ventilation had a general decrease in expression of IFN/ISG genes. Heterogeneous patterns of IFN-I/III response in the respiratory tract of COVID-19 patients may be associated to COVID-19 severity.
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- 2021
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5. Usefulness of bronchoalveolar lavage in suspect COVID-19 repeatedly negative swab test and interstitial lung disease
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Jacopo Vannucci, Franco Ruberto, Daniele Diso, Gioacchino Galardo, Claudio M. Mastroianni, Giammarco Raponi, Massimiliano Bassi, Giancarlo Ceccarelli, Massimo Mancone, Guido Antonelli, Federico Venuta, Francesco Pugliese, Alida Albante, Francesco Alessandri, Davide Amore, Marco Anile, Maria Gloria Antognoli, Fabio Araimo Morselli, Daniela Auricchio, Martina Bianco, Federico Bilotta, Lucia Ilaria Birtolo, Matteo Brisciani, Katia Bruno, Maurizio Bufi, Sara Cagnetti, Elena Calzecchi, Alessandro Cappannoli, Carolina Carillo, Romina Casaretti, Carlo Catalano, Paola Celli, Stella Consolo, Claudia Croce, Beatrice Crocitti, Enrica Cuscianna, Federica Gilda D’Agostino, Tiziano De Giacomo, Daniela De Lauri, Francesco De Lazzaro, Maurizio Del Monte, Gabriella D’Ettorre, Valerio Di Bella, Francesco Fedele, Massimo Gentile, Giovanni Giordano, Stefano Ianni, Carmela Imperiale, Fabio Infusino, Cinzia Loiacono, Viviana Maestrini, Eugenia Magnanimi, Federica Maldarelli, Sara Mantovani, Sabina Martelli, Paolo Messercola, Teresa Messina, Emilia Mottola, Valeria Pati, Elisa Pattelli, Filippo Pecorari, Ylenia Pecoraro, Serena Maria Perrella, Mario Piazzolla, Valeria Pietropaolo, Camilla Poggi, Monica Portieri, Fabiola Ratini, Claudia Ricci, Paolo Ricci, Mario Rumori, Gianluca Russo, Pietro Santopietro, Guglielmo Tellan, Luca Titi, Paolo Tordiglione, Antonella Tosi, Silvia Tosti, Fausto Trigilia, Ombretta Turriziani, Paola Vaccaro, Noemi Verduci, and Gabriella Vivino
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Bronchoalveolar lavage ,Microbiology (medical) ,Pathology ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Immunology ,Computed tomography ,COVID-19 testing ,pandemics ,diagnostic errors ,Microbiology ,Article ,immunoglobulin G ,Bronchoscopy ,male ,italy ,middle aged ,80 and over ,immunoglobulin M ,Medicine ,Immunology and Allergy ,In patient ,humans ,lung diseases ,Interstitial pneumonia ,Aged, 80 and over ,medicine.diagnostic_test ,business.industry ,bronchoalveolar lavage ,bronchoscopy ,coronavirus ,COVID-19 ,interstitial pneumonia ,SARS-CoV-2 ,aged ,coinfection ,female ,interstitial ,sensitivity and specificity ,specimen handling ,Interstitial lung disease ,Negativity effect ,respiratory system ,Interstitial infiltrates ,medicine.disease ,QR1-502 ,respiratory tract diseases ,Coronavirus ,Lung Diseases, Interstitial ,business - Abstract
The diagnosis of coronavirus disease 2019 (COVID-19) relies on nasopharyngeal swab, which shows a 20–30% risk of false negativity [1]. Bronchoalveolar lavage (BAL) is reported to be useful in patients with pulmonary interstitial infiltrates on high-resolution computed tomography (HRCT). We investigated the usefulness of BAL in symptomatic patients with positive HRCT and a repeatedly negative swab test (‘grey zone’).
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- 2020
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6. ACE-I AND ARBS DO NOT INFLUENCE THE CHEST CT PRESENTATION AND 1-YEAR SURVIVAL OF COVID-19 PATIENTS: ITALIAN MULTICENTER REGISTRY
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Lucia Ilaria Birtolo, Fabio Infusino, Alessandro Depaoli, Sara Cimino, Silvia Porsperi, Fabrizio D'Ascenzo, Maria Chiara Colaiacomo, Chiara Andreoli, Giovanni Battista Forleo, Marco Schiavone, Chiara Valentina Lario, Sara Monosilio, Paolo Ricci, Carlo Catalano, Giancarlo Ceccarelli, Gabriella D'Ettorre, Gioacchino Galardo, Francesco Pugliese, Gaetano Maria De Ferrari, Viviana Maestrini, Massimo Mancone, and Francesco Fedele
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Cardiology and Cardiovascular Medicine - Published
- 2022
7. Probiotics and COVID-19
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Carolina Scagnolari, Francesco Pugliese, Giancarlo Ceccarelli, Gabriella d'Ettorre, and Claudio Maria Mastroianni
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2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Pneumonia, Viral ,bacteriotherapy ,Article ,Betacoronavirus ,Pandemic ,medicine ,Humans ,Pandemics ,Coronavirus Infections ,Probiotics ,biology ,Hepatology ,SARS-CoV-2 ,business.industry ,Gastroenterology ,COVID-19 ,covid ,medicine.disease ,biology.organism_classification ,Virology ,Pneumonia ,probiotics ,business - Published
- 2020
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8. Systemic adipokines, hepatokines and interleukin-6 in HCV-monoinfected and HCV/HIV coinfected patients treated with direct antiviral agents (DAAs)
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Gabriella d'Ettorre, Miriam Lichtner, Paolo Pavone, Giulia Alfieri, Claudia Mascia, Vincenzo Vullo, Tiziana Tieghi, Claudia Pinacchio, Saeid Najafi Fard, Giuseppe Corano-Scheri, and Claudio Maria Mastroianni
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Male ,alpha-2-HS-Glycoprotein ,Human immunodeficiency virus (HIV) ,MEDLINE ,Adipokine ,HIV Infections ,medicine.disease_cause ,Antiviral Agents ,Selenoprotein P ,Diabetes mellitus ,hcv ,medicine ,Humans ,Interleukin 6 ,adipokines ,cytokines ,daas ,diabetes ,hepatokines ,hepatology ,gastroenterology ,Hepatology ,biology ,Coinfection ,Interleukin-6 ,business.industry ,Gastroenterology ,Hepatitis C ,Hepatitis C, Chronic ,Middle Aged ,medicine.disease ,Immunology ,biology.protein ,Female ,Adiponectin ,business - Published
- 2018
9. Fr577 ORAL BACTERIOTHERAPY IN THE MANAGEMENTE OF FATIGUE IN COVID-19 PATIENTS
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Gabriella d'Ettorre, Paolo Vassalini, Eugenio Nelson Cavallari, Giancarlo Ceccarelli, Luigi Celani, and Massimiliano Marazzato
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2019-20 coronavirus outbreak ,Hepatology ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Gastroenterology ,Medicine ,business ,Bacteriotherapy ,Virology - Published
- 2021
10. Fr576 ORAL BACTERIOTHERAPY IN PATIENTS WITH COVID-19: A RETROSPECTIVE COHORT STUDY
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Gabriella d'Ettorre, Massimiliano Marazzato, Luigi Celani, Letizia Santinelli, Eugenio Nelson Cavallari, Giancarlo Ceccarelli, and Claudia Pinacchio
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medicine.medical_specialty ,2019-20 coronavirus outbreak ,Hepatology ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Gastroenterology ,Retrospective cohort study ,AGA Abstracts ,Internal medicine ,medicine ,In patient ,business ,Bacteriotherapy - Published
- 2021
11. Efficacy and safety of dolutegravir-based regimens in advanced HIV-infected naïve patients: results from a multicenter cohort study
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Gabriella d'Ettorre, Filippo Lagi, Gaetana Sterrantino, Andrea De Vito, Amedeo Capetti, Andrea De Luca, Barbara Rossetti, Stefano Rusconi, Simona Di Giambenedetto, Luigi Celani, Giordano Madeddu, Arturo Ciccullo, Roberta Gagliardini, Gianmaria Baldin, Manuela Colafigli, and Andrea Giacometti
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Male ,0301 basic medicine ,HIV Infections ,Pneumocystis carinii ,Piperazines ,Cohort Studies ,chemistry.chemical_compound ,Immune Reconstitution Inflammatory Syndrome ,Antiretroviral Therapy, Highly Active ,Medicine ,Drug Interactions ,education.field_of_study ,recent hiv infection ,Middle Aged ,Viral Load ,Antiretroviral therapy ,dolutegravir ,Tolerability ,Dolutegravir ,Cohort ,Drug Therapy, Combination ,Female ,Heterocyclic Compounds, 3-Ring ,Cohort study ,Adult ,medicine.medical_specialty ,Drug-Related Side Effects and Adverse Reactions ,Anti-HIV Agents ,Pyridones ,030106 microbiology ,Population ,Settore MED/17 - MALATTIE INFETTIVE ,03 medical and health sciences ,Virology ,Internal medicine ,Oxazines ,Humans ,HIV ,Immune reconstitution inflammatory syndrome (IRIS) ,Recent HIV infection ,Adverse effect ,education ,Pharmacology ,business.industry ,antiretroviral therapy hiv ,immune reconstitution inflammatory syndrome (iris) ,Pneumonia ,CD4 Lymphocyte Count ,Discontinuation ,Regimen ,030104 developmental biology ,chemistry ,business - Abstract
The aims were to describe efficacy and tolerability of regimens containing dolutegravir (DTG) in advanced ART-naive people living with HIV (PLHIV) from the clinical practice. The frequency of Immune Reconstitution Inflammatory Syndrome (IRIS), the estimated time of discontinuation of the first ART regimen and the time to reach virological suppression in a multicenter cohort of AIDS-presenters or late-presenters with CD4
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- 2019
12. Sa1934 – The Fecal-Anti Candida Activity Can Be Modulated by Probiotic Administration
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Carolina Scagnolari, Alessandra Oliva, Eugenio Nelson Cavallari, Massimiliano De Angelis, Gabriella d'Ettorre, Luigi Celani, Vincenzo Vullo, and Giancarlo Ceccarelli
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Probiotic ,Hepatology ,business.industry ,law ,Gastroenterology ,Medicine ,Pharmacology ,business ,Administration (government) ,Feces ,law.invention - Published
- 2019
13. Sa1935 – Comparing Faecal Volatile Organic Compounds Following Administration of Two Different Probiotic Supplements
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Gabriella d'Ettorre, Chris Probert, Giancarlo Ceccarelli, Vincenzo Vullo, Massimiliano De Angelis, Alessandra Oliva, Luigi Celani, and Stephanie Michail
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Probiotic ,Hepatology ,law ,business.industry ,Gastroenterology ,Medicine ,Food science ,business ,Administration (government) ,law.invention - Published
- 2019
14. Significant coronary stenosis detected by coronary computed angiography in asymptomatic HIV infected subjects
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Lucia Palmisano, Silvia Baroncelli, Claudio Maria Mastroianni, Francesco Vullo, Marco Francone, M. Clementina Galluzzo, Carlo Catalano, Francesco Fedele, Vincenzo Vullo, Giancarlo Ceccarelli, Gabriella d'Ettorre, Stefano Strano, Massimo Mancone, and Adriano Ascarelli
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Adult ,Male ,Microbiology (medical) ,medicine.medical_specialty ,Multivariate analysis ,Population ,HIV Infections ,hiv ,heart ,ct scan ,Asymptomatic ,Coronary artery disease ,Internal medicine ,medicine ,Humans ,education ,education.field_of_study ,Framingham Risk Score ,medicine.diagnostic_test ,business.industry ,Incidence ,Incidence (epidemiology) ,Angiography ,Coronary Stenosis ,Middle Aged ,medicine.disease ,Cross-Sectional Studies ,Infectious Diseases ,Cardiology ,Female ,Metabolic syndrome ,medicine.symptom ,Tomography, X-Ray Computed ,business - Abstract
Summary Objectives increased incidence of acute coronary events, high rate of abnormal surrogate markers of atherosclerosis and increased amount of coronary calcium have been described in HIV infected population. To expand knowledge on coronary artery disease (CAD) in HIV patients, cardiac CT scan was performed in asymptomatic subjects with low cardiovascular (CV) risk. Methods A cross-sectional study using dual-source CT (MDCT) coronary angiography.was conducted in HIV-infected subjects with the following characteristics: Framingham Risk Score (FRS) ≤10, absence of metabolic syndrome, negative echocardiographic and ECG stress-test. A luminal narrowing exceeding 50% was defined as a clinically significant coronary stenosis. Calcium score was quantified using the Agatston Calcium Score method. Results Fifty-five subjects were enrolled. Significant coronary stenoses, requiring coronary angiography, were found in 16/55 (29.1%). At multivariate analysis older age was the only variable independently associated with the presence of significant luminal narrowing ( p = 0.011). Conclusions MDCT showed an unexpected, age-associated high rate of significant coronary stenosis in asymptomatic HIV positive subjects with low CV risk. These findings suggest that aggressive screening programs for coronary artery disease may be appropriate in this population; further studies are recommended to assess the appropriateness of MDCT for this purpose.
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- 2012
15. The role of IL-15 in challenging Acquired Immunodeficiency Syndrome
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Gabriella d'Ettorre, Francesca Tierno, Anna Paola Massetti, Alessandra Mallano, Giancarlo Ceccarelli, Clementina Maria Galluzzo, Roberta Amici, Claudio Maria Mastroianni, Stefano Vella, Stefano Stella, Mauro Andreotti, and Vincenzo Vullo
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CD4-Positive T-Lymphocytes ,il-15 ,il-12 ,Immunology ,HIV Core Protein p24 ,Virus Replication ,Biochemistry ,Peripheral blood mononuclear cell ,nm cells ,Interleukin 21 ,il-2 ,Acquired immunodeficiency syndrome (AIDS) ,hiv-1 infection ,nk cells ,Humans ,Immunology and Allergy ,Medicine ,Viral suppression ,Molecular Biology ,Interleukin-15 ,Acquired Immunodeficiency Syndrome ,business.industry ,Hematology ,Provirus ,medicine.disease ,Interleukin-12 ,Virology ,In vitro ,Killer Cells, Natural ,Interleukin 15 ,DNA, Viral ,HIV-1 ,Interleukin 12 ,Interleukin-2 ,business - Abstract
Objective To determine the functions of in vitro primed Natural Killer (NK) cells in Human Immunodeficiency Virus (HIV-1) infection and the role of IL-2, IL-12 and IL-15 in enhancing the NK survival and activity in terms of viral suppression and of purging of HIV provirus. Methods Peripheral Blood Mononuclear Cells (PBMCs) and CD4+ T lymphocytes cells obtained from eight healthy donors were infected in vitro with HIV-1 and p24 was measured with and without IL-2, IL-12 and IL-15. We studied the effect of NK pulsed in vitro with IL-2, IL-12 and IL-15 on HIV replication by measurement of p-24 and DNA-provirus load when added into the culture of PBMCs and CD4+ T lymphocytes cells infected in vitro. We evaluated the effect of NK cells pulsed with IL-2, IL-12 and IL-15 on HIV replication and DNA-load into the culture of CD4+ T lymphocytes cells and PBMCs by trans-well chamber. Results We found high levels of p24 in the supernatants of PBMCs and CD4+ T lymphocytes cells cultured with IL-2, IL-12, and IL-15. We observed a significant reduction of p24 in the culture both of infected PBMCs and CD4+ T lymphocytes cells in which was added NK pulsed with IL-15. We did not obtain the some results with NK pulsed with IL-2 and IL-12. We observed a power effect of NK pulsed with IL-15 on HIV-DNA. The trans-well chamber experiments showed that the effect of NK is both direct and both mediated by realizing of soluble factors. Conclusions This study highlights some important effects of IL 15 on NK in HIV patients anyway our results are preliminary and descriptive and others studies will be needed to provide rationale for immune therapies.
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- 2012
16. Multiclass HCV resistance to interferon-free direct acting antivirals regimens in real life failures advocates for tailored second-line therapies
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Ilaria Lenci, A. Di Biagio, Giuliano Rizzardini, L. Marinaro, C. D'Ambrosio, Fausto Baldanti, Ivana Maida, G.B. Gaeta, M. Puoti, T. Ruggiero, Mario Angelico, Vincenza Calvaruso, Laura Sticchi, Mario Starace, Giustino Parruti, P. Cacciatore, Nicola Caporaso, Caterina Pasquazzi, Stefania Paolucci, Anna Claudia Pellicelli, M. Andreoni, C. Masetti, Sergio Babudieri, Gabriella d'Ettorre, Francesco Santopaolo, Raffaele Cozzolongo, P. Andreone, Carlo Magni, Valeria Cento, Guido Gubertini, J. Vecchiet, Stefano Novati, Nicola Coppola, C.F. Perno, Bianca Bruzzone, F. De Leonardis, V. Pace Palitti, Marianna Aragri, A. Grieco, Pierluigi Tarquini, G. De Stefano, G. Raimondo, Teresa Pollicino, Alessia Giorgini, Giorgio Barbarini, Valeria Ghisetti, G. Verucchi, M.C. Sorbo, Savino Bruno, M. Paoloni, F. Ceccherini-Silberstein, Roberto Gulminetti, Antonio Craxì, Filomena Morisco, Manuela Merli, V.C. Di Maio, Vincenzo Sangiovanni, A. Ciancio, Simona Francioso, Simona Landonio, Aldo Bertoli, A. Mancon, Valeria Micheli, Antonio Picciotto, V. Boccaccio, M. Melis, Ennio Polilli, F.P. Antonucci, Dante Romagnoli, and Silvia Barbaliscia
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Oncology ,medicine.medical_specialty ,Hepatology ,business.industry ,Interferon free ,Gastroenterology ,DIRECT ACTING ANTIVIRALS ,03 medical and health sciences ,0302 clinical medicine ,Second line ,030220 oncology & carcinogenesis ,Internal medicine ,Medicine ,In real life ,030211 gastroenterology & hepatology ,business - Published
- 2017
17. Multiclass hepatitis C virus resistance to direct acting antivirals in real life interferon-free regimens failures advocates for tailored second-line therapies
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A. Grieco, Valeria Cento, Savino Bruno, M. Paoloni, Anna Claudia Pellicelli, Gabriella d'Ettorre, Raffaele Cozzolongo, G.D. Stefano, Carlo Magni, V. Boccaccio, M. Andreoni, Fausto Baldanti, Silvia Barbaliscia, J. Vecchiet, Valeria Micheli, Antonio Picciotto, Giustino Parruti, Guido Gubertini, M. Melis, Pierluigi Tarquini, Francesca Ceccherini-Silberstein, Bianca Bruzzone, Sergio Babudieri, Antonio Di Biagio, M. Puoti, Manuela Merli, L. Marinaro, Mario Starace, Caterina Pasquazzi, Marianna Aragri, Antonio Craxì, Teresa Pollicino, Filomena Morisco, V.C. Di Maio, Alessia Giorgini, Vincenzo Sangiovanni, Giorgio Barbarini, Valeria Ghisetti, G. Verucchi, T. Ruggiero, Ivana Maida, P. Andreone, Vincenza Calvaruso, Giovanni Raimondo, C. D'Ambrosio, Simona Francioso, F.P. Antonucci, Dante Romagnoli, C.F. Perno, Mario Angelico, Ilaria Lenci, Alessia Ciancio, Roberto Gulminetti, G.B. Gaeta, Simona Landonio, Nicola Caporaso, Francesco Santopaolo, Nicola Coppola, Laura Sticchi, Valeria Pace Palitti, Stefania Paolucci, Aldo Bertoli, and A. Mancon
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0301 basic medicine ,Hepatology ,business.industry ,Hepatitis C virus ,Interferon free ,medicine.disease_cause ,DIRECT ACTING ANTIVIRALS ,Virology ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Second line ,medicine ,In real life ,030211 gastroenterology & hepatology ,business - Published
- 2017
18. PATHOPHYSIOLOGY OF ACUTE CORONARY SYNDROME IN HIV POSITIVE PATIENTS: INSIGHT FROM VIRTUAL HISTOLOGY ANALYSIS
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Alessandra Cinque, Gennaro Sardella, Gabriella d'Ettorre, Pasqualina Bruno, Paolo Severino, Massimo Mancone, Nicolò Salvi, Simone Calcagno, Francesco Fedele, and Vincenzo Vullo
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Pathology ,medicine.medical_specialty ,Acute coronary syndrome ,business.industry ,Internal medicine ,Human immunodeficiency virus (HIV) ,medicine ,Histology ,medicine.disease_cause ,medicine.disease ,business ,Cardiology and Cardiovascular Medicine ,Pathophysiology - Published
- 2015
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19. Interleukin-15 enhances the secretion of IFN-γ and CC chemokines by natural killer cells from HIV viremic and aviremic patients
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Gabriella d'Ettorre, Carolina Andreoni, Claudio Maria Mastroianni, Stefano Vella, Martina Carnevalini, Mauro Andreotti, Vincenzo Vullo, and Lorenzo Zaffiri
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Adult ,Antigens, Differentiation, T-Lymphocyte ,Male ,medicine.medical_treatment ,Immunology ,HIV Infections ,Biology ,Interferon-gamma ,Interleukin 21 ,Immune system ,Antigens, CD ,medicine ,Humans ,Immunology and Allergy ,Lectins, C-Type ,Viremia ,Chemokine CCL4 ,Cells, Cultured ,Interleukin-15 ,Lymphokine-activated killer cell ,Innate immune system ,HIV ,Interleukin ,Immunotherapy ,Middle Aged ,Virology ,Killer Cells, Natural ,Interleukin 15 ,Chemokines, CC ,Interleukin 12 ,Female - Abstract
Several lines of evidence documented a renewed interest in the role of natural killer (NK) cells in the innate immune control of HIV infection and disease progression. To further assess the role of NK cells as target for immunotherapy in HIV infection, we evaluated the priming effect of interleukin (IL)-15 on freshly isolated human peripheral NK cells, from viremic and aviremic HIV-infected patients, measuring the production of IFN-gamma and CC chemokines. In vitro IL-15 priming induced a significant increase of IFN-gamma production in both viremic and aviremic patients. IL-15 stimulated NK cells producing CC chemokine quantities that are reported to be capable of inhibiting HIV infection and replication. This priming effect is observed both in viral suppressed patients after antiretroviral therapy, and in viremic subjects with progressive HIV infection. The combination of IL-15 plus IL-12 is the most potent costimulus for CD69 expression and production of CC chemokines by NK cells. These findings indicate that NK cells are an important target for immunotherapeutic agents and provide additional pre-clinical data supporting the great potential of IL-15 in the immune-based interventions in HIV disease.
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- 2006
20. Interleukin-15 modulates interferon-γ and β-chemokine production in patients with HIV infection: implications for immune-based therapy
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Anna P. Massetti, Claudio Maria Mastroianni, Laura Scorzolini, Martina Carnevalini, Giancarlo Ceccarelli, Gabriele Forcina, Vincenzo Vullo, Claudia D'Agostino, Gabriella d'Ettorre, and Miriam Lichtner
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Adult ,Male ,Chemokine ,Lipopolysaccharide ,Lymphocyte ,medicine.medical_treatment ,Immunology ,HIV Infections ,hiv ,interleukin-15 ,Biochemistry ,chemistry.chemical_compound ,Immune system ,Antiretroviral Therapy, Highly Active ,beta-chemokines ,haart ,interferon-gamma ,medicine ,Humans ,Immunology and Allergy ,Molecular Biology ,biology ,business.industry ,Interleukin ,Hematology ,Middle Aged ,medicine.anatomical_structure ,Cytokine ,chemistry ,Interleukin 15 ,Case-Control Studies ,Chemokines, CC ,biology.protein ,Female ,Immunotherapy ,business ,CD8 - Abstract
Interleukin (IL)-15 is a cytokine that has lymphocyte stimulatory activity similar to that of IL-2, and plays important immunoregulatory functions during HIV disease. To evaluate the role of IL-15 in HIV infection the following patients were studied: 18 antiretroviral-naive patients with advanced disease; 19 patients with continuous viral suppression and immunological response after 48-120 weeks of highly active antiretroviral therapy (HAART); and 12 patients with evidence of virological and immunological HAART treatment failure. Nineteen healthy blood donors were included as controls. The production of IL-15 by human peripheral blood monocytes stimulated with lipopolysaccharide and Mycobacterium avium complex, the priming effect of IL-15 on IFN-gamma production from purified CD4(+) and CD8(+) T cells, and the ability of IL-15 to stimulate the beta-chemokine release from purified CD4(+) and CD8(+) T cells were analyzed. In the present work IL-15 production by human peripheral blood monocytes was significantly increased in HIV-infected patients with long-term virological and immunological response to HAART. IL-15 enhanced the in vitro priming of CD4(+) and CD8(+) T cells for IFN-gamma production, also in patients receiving HAART. Finally, IL-15 had positive effects on RANTES, MIP-1alpha, and MIP-1beta release by CD4(+) and CD8(+) T cells. In conclusion IL-15 could affect the immune response of HIV-infected patients by augmenting and/or modulating IFN-gamma production and beta-chemokine release. These data about functional properties of IL-15 could provide new implications for immune-based therapies in HIV infection.
- Published
- 2004
21. Clinical relevance of accurate HCV genotype and subtype assignment by NS3/NS5A/NS5B direct sequencing in the era of new direct acting antiviral agents
- Author
-
Carlo Magni, Francesca Ceccherini-Silberstein, M. Puoti, Claudio Maria Mastroianni, A. Di Biagio, Marco Romano, Filomena Morisco, Giustino Parruti, Antonio Gasbarrini, Gloria Taliani, M. Siciliano, Simona Landonio, V.C. Di Maio, Martina Milana, Laura Gianserra, F. Deodati, Caterina Pasquazzi, M. Andreoni, J. Vecchiet, Valeria Cento, L. Lambiase, Marianna Aragri, Simona Francioso, E. D’Amico, Gabriella d'Ettorre, Giuliano Rizzardini, D. Di Paolo, Antonio Grieco, F. De Leonardis, A. Manunta, Ivana Maida, Anna Claudia Pellicelli, Mario Angelico, K. Yu La Rosa, Miriam Lichtner, P. Cacciatore, Cesare Sarrecchia, F.P. Antonucci, Aldo Bertoli, Valeria Micheli, Antonio Picciotto, Dante Romagnoli, Savino Bruno, Laura Ambra Nicolini, Ilaria Lenci, C.F. Perno, Marco Ciotti, Lorenzo Nosotti, Simona Marenco, Elisabetta Teti, M. Tontodonati, Maria Stella Mura, R. Campoli, Nicola Caporaso, S. Grieco, Sergio Babudieri, and Umberto Vespasiani-Gentilucci
- Subjects
Genetics ,chemistry.chemical_compound ,NS3 ,Hepatology ,chemistry ,Direct sequencing ,Genotype ,Gastroenterology ,Clinical significance ,Biology ,NS5A ,NS5B ,Direct acting - Published
- 2016
22. HCV and diabetes: towards a ‘Sustained’ glycaemic improvement after treatment with DAAs? – Authors' reply
- Author
-
Gabriella d'Ettorre, G. Passavanti, Miriam Lichtner, Raffaella Marocco, Vincenzo Vullo, Claudio Maria Mastroianni, Ivano Mezzaroma, Paolo Pavone, Tiziana Tieghi, and Pietro Vittozzi
- Subjects
0301 basic medicine ,Microbiology (medical) ,medicine.medical_specialty ,business.industry ,030106 microbiology ,MEDLINE ,General Medicine ,Hepatitis C ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Infectious Diseases ,Internal medicine ,Diabetes mellitus ,medicine ,030211 gastroenterology & hepatology ,business ,After treatment - Published
- 2017
23. Changes in Circulating Levels of Soluble Cell Adhesion Molecules Following Highly Active Antiretroviral Treatment of HIV-1-Infected Patients
- Author
-
Paola Santopadre, Gabriella d'Ettorre, Gabriele Forcina, Claudio Maria Mastroianni, Fabio Mengoni, Miriam Lichtner, Anna Paola Massetti, Claudia D'Agostino, and Vincenzo Vullo
- Subjects
Adult ,CD4-Positive T-Lymphocytes ,Male ,medicine.medical_specialty ,Anti-HIV Agents ,medicine.medical_treatment ,Immunology ,HIV Infections ,CD8-Positive T-Lymphocytes ,Biology ,Pharmacotherapy ,Internal medicine ,Immunopathology ,medicine ,Humans ,Immunology and Allergy ,Lymphocyte Count ,Cell adhesion ,Aged ,Chemotherapy ,Cell adhesion molecule ,Soluble cell adhesion molecules ,Adhesion ,Middle Aged ,CD4 Lymphocyte Count ,Endocrinology ,Solubility ,HIV-1 ,adhesion molecules ,anti-hiv-1 therapy ,innate immunity ,RNA, Viral ,Female ,Cell Adhesion Molecules ,Intracellular - Abstract
Increased levels of soluble cell adhesion molecules (sCAM) have been reported in HIV-1 infection and may possibly contribute to altering the adhesion mechanisms of phagocytic cells. We evaluated the effect of highly active antiretroviral therapy (HAART) on plasma levels of sL-selectin, sE-selectin, intercellular cell adhesion molecule-1 (sICAM-1), sICAM-3, and vascular cell adhesion molecule-1 (sVCAM-1). Study participants included 22 HIV-1-infected patients with a CD4+ T-cell count/μl below 500 who were started on a HAART regimen and followed up for 9 months. After the initiation of therapy, plasma sL-selectin concentrations progressively decreased to normal ranges in the majority of our patients (P < 0.001), while no changes in sE-selectin were found. In all patients sICAM-1 remained relatively constant at significantly elevated concentrations during the 9 months of therapy. A significant reduction in plasma concentrations of both sICAM-3 and sVCAM-1 was found; however, the levels of these sCAM were not normalized by HAART and remained significantly elevated throughout the study (P < 0.001). The reduced release of sL-selectin could improve the ability of phagocitic cells to migrate in response to chemotactic stimuli after starting HAART. On the other hand, the persistent elevation of sICAM-1, sICAM-3, and sVCAM-1 could reflect continuous HIV-1-mediated immune activation, despite adequate control of plasma HIV-1 replication by therapy.
- Published
- 2000
24. P0697 : Interplay between virus-specific and apoptotic epitope-specific CD8+ T cells in chronic hepatitis C virus
- Author
-
Carmela Martire, Gabriella d'Ettorre, Vincenzo Barnaba, Eugenio Nelson Cavallari, Daniele Accapezzato, Eliana M. Coccia, Martina Severa, Fabiana Rizzo, Giancarlo Labbadia, Ludovica Calvo, Alessandra Citro, and Helene Martini
- Subjects
Hepatology ,Chronic hepatitis ,Apoptosis ,Cytotoxic T cell ,Biology ,Virology ,Epitope ,Virus - Published
- 2015
25. Evaluation of HIV-DNA, soluble CD14 and inflammatory markers in HIV-1 positive patients receiving antiretroviral therapy
- Author
-
Gabriella d'Ettorre, Mauro Bucci, Giulia Tranquilli, Ombretta Turriziani, Maria Carla Re, Francesca Falasca, Guido Antonelli, Laura Mazzuti, Isabella Bon, Vincenzo Vullo, and Ivano Mezzaroma
- Subjects
Infectious Diseases ,business.industry ,Virology ,CD14 ,Immunology ,Human immunodeficiency virus (HIV) ,medicine ,medicine.disease_cause ,business ,Antiretroviral therapy - Published
- 2016
26. P126 INCREASED FREQUENCY OF CD8 T CELL RESPONSES TO T CELL APOPTOSIS-DERIVED ANTIGENS IN CHRONICALLY-HCV INFECTED INDIVIDUALS NON-RESPONDING TO PEG-IFNa/RIBAVIRIN
- Author
-
Carmela Martire, Gabriella d'Ettorre, Helene Martini, Vincenzo Barnaba, Alessandra Citro, Eugenio Nelson Cavallari, Giancarlo Labbadia, Daniele Accapezzato, and Vincenzo Vullo
- Subjects
chemistry.chemical_compound ,T-cell apoptosis ,Hepatology ,Antigen ,chemistry ,business.industry ,Ribavirin ,PEG ratio ,Cytotoxic T cell ,Medicine ,business ,Virology - Published
- 2014
27. Normocaloric low cholesterol diet modulates Th17/Treg balance in patients with chronic hepatitis C virus infection
- Author
-
Gabriella d'Ettorre, R. Maggio, Manuele Gori, Vincenzo Vullo, C. Viscomi, Clara Balsano, Barbara Barbaro, and Paola Andreozzi
- Subjects
Th17 treg ,Hepatology ,Chronic hepatitis ,Low-cholesterol diet ,business.industry ,Immunology ,Gastroenterology ,Medicine ,In patient ,business ,Virus ,Balance (ability) - Published
- 2013
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