1. Sensing change: The emerging role of calcium sensors in neuronal disease
- Author
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Jihoon Jo, Kwangwook Cho, Ellen L. Hogg, Gillian Seaton, and Daniel J. Whitcomb
- Subjects
Neuronal Calcium-Sensor Proteins ,Excitotoxicity ,AMPA receptor ,medicine.disease_cause ,CREB ,Alzheimer Disease ,medicine ,Humans ,Calcium Signaling ,EF Hand Motifs ,TRPC ,Neurons ,Neuronal Plasticity ,biology ,Neurodegeneration ,Neurodegenerative Diseases ,Long-term potentiation ,Cell Biology ,medicine.disease ,Metabotropic glutamate receptor ,Synaptic plasticity ,biology.protein ,Calcium ,Calcium Channels ,Neuroscience ,Developmental Biology - Abstract
Calcium (Ca(2+)) is a fundamental intracellular signalling molecule in neurons. Therefore, significant interest has been expressed in understanding how the dysregulation of Ca(2+) signals might impact on neuronal function and the progression of different disease states. Many previous studies have examined the role of Ca(2+) in neuronal excitotoxicity and some have started to understand how Ca(2+) dysregulation might be a cause or consequence of neurodegeneration. This review will therefore focus on the significance of Ca(2+) sensors, proteins that transduce Ca(2+) signals, in neuronal function and dysfunction. Finally, we will assess their potential role in neurodegenerative processes, such as Alzheimer's disease (AD), arguing that they could serve as potential therapeutic targets.
- Published
- 2011
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