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WOS: 000416202300023 PubMed: 29149968 Objectives. Sexual dysfunction occurs commonly in individuals with end-stage renal disease. Chronic renal failure as well as the treatments used for it generally has a negative impact on sexual function with a subsequent increase in the risk of depression. There is scarcity of published data on female sexual dysfunction and the degree of improvement in patients on hemodialysis (HD) and transplant (Tx) recipients. The aim of this study was to compare the sexual function and degree of depression in HD and Tx patients with control group. For this purpose, we used the validated Female Sexual Function Index (FSFI) and Beck Depression Inventory (BDI). Materials and Methods. A total of 23 renal Tx, 29 HD, and 30 control patients were enrolled in the study. HD patients were required to be undergoing HD for >= 6 months, and for renal Tx recipients, the Tx had to be performed >= 6 months before study entry. All women underwent a general and urogynecologic examination. Demographic and clinical variables were documented. FSFI and BDI scale scores were compared among groups. Results. The rates of female sexual dysfunction were 56.7%, 89.7%, arid 73.9% in the control, HD, and Tx, patients respectively. Total FSFI scores in HD group were significantly lower than those in Tx and control patients (P < .05). FSFI scores improved significantly in the Tx group. BDI scores in HD and control subjects were. 23.24 and 14.17, respectively, with a significant difference between the 2 groups (P < .005). BDI score in the Tx group was 16.65 and the difference was statistically insignificant. Conclusions. This preliminary study documented that successful Tx may positively affect sexual life in women with chronic renal failure. A diagnosis of female sexual dysfunction should be made routinely in patients with chronic renal failure.

Marcos, Ricard/0000-0001-7891-357X WOS: 000403625000001 PubMed: 28343031 Lipid peroxidation products can induce tissue damage and are implicated in diverse pathological conditions, including aging, atherosclerosis, brain disorders, cancer, lung and various liver disorders. Since in vivo studies produce relevant information, we have selected Drosophila melanogaster as a suitable in vivo model to characterise the potential risks associated to two lipid peroxidation products namely 4-oxo-2-nonenal (4-ONE) and 4-hydroxy-hexenal (4-HHE). Toxicity, intracellular reactive oxygen species production, and genotoxicity were the end-points evaluated. Haemocytes and midgut cells were the evaluated targets. Results showed that both compounds penetrate the intestine of the larvae, affecting midgut cells, and reaching haemocytes. Significant genotoxic effects, as determined by the comet assay, were observed in both selected cell targets in a concentration/time dependent manner. This study highlights the importance of D. melanogaster as a model organism in the study of the different biological effects caused by lipid peroxidation products entering via ingestion. This is the first study reporting genotoxicity data in haemocytes and midgut cells of D. melanogaster larvae for the two selected compounds. (C) 2017 Elsevier Ltd. All rights reserved.

The mixed–ligand title complex, [Co(nal)2(py)2].4H2O (Hnal=nalidixic acid, py=pyridine), was synthesized. Its structural properties were characterized by X–ray diffraction technique (XRD) and elemental analysis. The spectroscopic properties are investigated by Fourier transform infrared spectroscopy (FT–IR), UV–Vis spectroscopy and EPR spectroscopy. The Co(II) ion has slightly distorted octahedral geometry surrounded by two oxygen atoms of keto and carboxyl groups bonded as chelate from nalidixate, two nitrogen atoms from two pyridine ligands. The monomer are connected by C–H···O and C–H···C interactions to form sheet structures. The FT-IR studies of the complex were commented, focusing on the shifts in the vibrational peaks between the complex form and free nalidixic acid. The powder EPR spectra of Cu(II)-doped complex were investigated at room and at liquid nitrogen temperature. The EPR and UV–Vis spectroscopy studies showed that the unpaired electrons were found in the dx2−y2 orbitals by calculating the spin-Hamiltonian and bond parameters. 2D and 3D Hirshfeld analyses were performed in order to quantify the order and nature of intermolecular interactions in crystal network. Antibacterial activity of complex was studied against S. aureus, B. subtilis, P. aeruginosa, E. coli, C. albicans and A. flavus by using the micro dilution. The optimized complex is docked to 5J9B (S. aerous), 5BMM (E. Coli), 5HTG (C. Albicans), 1ZUV (B. Subtilis), 4F0V (P. aeruginosa) and 4YNU (A. flavus). This work was supported by Ondokuz Mayıs University Scientific Research Coordination Unit. project number: PYO.FEN.1904.15.022 .

Hizli, Omer/0000-0001-6822-2679; (Bingol) Hizli, Pelin/0000-0001-8919-3125 WOS: 000383312600004 PubMed: 26860231 Objective: To observe any changes in stria vascularis and cochlear hair cells in patients with syphilis. Materials and methods: We examined 13 human temporal bone samples from 8 patients with syphilis (our syphilis group), as well as 12 histopathologically normal samples from 9 age-matched patients without syphilis (our control group). We compared, between the two groups, the mean area of the stria vascularis (measured with conventional light microscopy connected to a personal computer) and the mean percentage of cochlear hair cell loss (obtained from cytocochleograms). Results: In our syphilis group, only 1 (7.7%) of the 13 samples had precipitate in the endolymphatic or perilymphatic spaces; 8 (61.5%) of the samples revealed the presence of endolymphatic hydrops (4 cochlear, 4 saccular). The mean area of the stria vascularis did not significantly differ, in any turn of the cochlea, between the 2 groups (P > 0.1). However, we did find significant differences between the 2 groups in the mean percentage of outer hair cells in the apical turn (P < 0.026) and in the mean percentage of inner hair cells in the basal (P = 0.001), middle (P = 0.004), and apical (P = 0.018) turns. In 7 samples in our syphilis group, we observed either complete loss of the organ of Corti or a flattened organ of Cord without any cells in addition to the absence of both outer and inner hair cells. Conclusion: In this study, syphilis led either to complete loss of the organ of Corti or to significant loss of cochlear hair cells, in addition to cochleosaccular hydrops. But the area of the stria vascularis did not change. (C) 2016 Elsevier Ireland Ltd. All rights reserved. NIH (NIDCD)United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Deafness & Other Communication Disorders (NIDCD) [U24 DC011968-01]; International Hearing Foundation; Starkey Foundation; 5M Lions International; Scientific and Technological Research Council of Turkey (TUBITAK) ScholarshipTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) This project was funded by NIH (NIDCD), grant number U24 DC011968-01; the International Hearing Foundation; the Starkey Foundation; and the 5M Lions International. Omer Hizh and Serdar Kaya received the Scientific and Technological Research Council of Turkey (TUBITAK) Scholarship.

WOS: 000375871200029 PubMed: 26806685 Objective: To study whether diminished ovarian reserve is associated with recurrent miscarriage. Design: Cross-sectional clinical study. Setting: Tertiary-care center. Patient(s): Women with history of recurrent miscarriage (RM; n = 71) and sequentially selected age-matched fertile women who were seeking contraception (control; n = 70). Intervention(s): Not applicable. Main Outcome Measures(s): Serum levels of FSH, LH, E-2, and antimullerian hormone (AMH); FSH/LH ratio; ovarian volumes; and antral follicle count (AFC). Result(s): The levels of FSH were 8.6 +/- 3.7 U/L in the RM group and 7.1 +/- 3.9 U/L in the control group; this difference was statistically significant. The levels of AMH were significantly lower in the RM group than in the control group (2.9 +/- 1.7 ng/mL vs. 3.6 +/- 1.7 ng/mL). The percentage of women with levels of FSH >= 11 U/L was significantly higher in the RM group than in the control group (18.3% vs. 4.3%). In the RM group, the percentage of women with levels of AMH

Mogan and Eymir lakes are shallow wetlands which are potentially susceptible to global warming. Previous geological studies demonstrated several complete desiccation and shrinkage events in Lake Mogan since the 1800s. Archival records show at least three desiccation events in 1910, 1934 and 1938, and many severe shrinkages later. Here, the significance of climatic and anthropogenic drivers is still a subject of curiosity. The back-analysis of the hydrological data during the regulator intervention indicates that Lake Mogan would have dried out in 1974, and would have shrunk considerably in the years 2007/2008 and 2017/2018 if human intervention was not involved. Our lake budget analysis shows that, assuming no human intervention and stream recharge, the water level of both lakes would have dropped below the threshold level in less than a week by natural downstream discharge, and the remaining volume of the lakes would evaporate in less than two years. This fact indicates the benefits of regulators for the protection of the lakes. The meteorological and lake budget data suggest that the underlying climatic threat over the studied lakes is high frequency (sub-decadal) rainfall scarcity coupled with long-term (several decades) insolation increase but not slow, steady deterioration of the climatic parameters.

In present study, the novel peripherally [3-methyl-5-oxo-4-(4-phenoxyphenyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl] substituted Zn(II), Cu(II), Co(II) phthalocyanines were synthesized and characterized spectroscopically. The light absorption/emission behavior of the synthesized phthalocyanines were determined by UV-Vis and fluorescence spectroscopy. The fluorescence quantum yields of the novel phthalocyanine Zn(II) complex in different solvents were calculated. Besides, the urease inhibition activities of the novel compounds were investigated. All synthesized phthalocyanines have a superior inhibitory activity on urease enzyme, while novel phthalocyanines Cu(II) showed the best inhibitory effect against jack bean urease with IC50 values of 0.0035 ±0.0010 µM.

The 1,3,4-thiadiazole core has been mainly used as a pharmacological scaffold in medicinal chemistry. A series of Schiff bases derived from 5-substituted-1,3,4-thiadiazole-2-amine were designed and synthesized to investigate their biological activities. Structures of compounds were clarified with FTIR, H-1 NMR and elemental analysis. Due to the importance of this core in pharmacology, all these newly synthesized compounds were tested for different biological properties at the same time. Compound 3A ((E)-N-(2,5-dimethoxybenzylidene)-5-(4-methoxyquinolin-2-yl)-1,3,4-thiadiazol-2-amine) and compound 4A ((E)-N-(2,5-dimethoxybenzylidene)-5-(3-methylbenzofuran-2-yl)-1,3,4-thiadiazol-2-amine) possessed high DNA protective ability against oxidative Fenton mixture. Compound 1A ((E)-N-(2,5-dimethoxybenzylidene)-5-(benzo[b]thiophen-2-yl)-1,3,4-thiadiazol-2-amine) and compound 2B ((E)-2-((5-(1H-indol-2-yl)-1,3,4-thiadiazol-2-ylimino)methyl)-6-methoxyphenol) showed strong antimicrobial activity against S. epidermidis. The most effective compound was detected as compound 3A which exhibited cytotoxicity on both PC-3 and MDA-MB-231 cancer cell lines. The IC50 of this compound was calculated as 370.7 mu M and 505.1 mu M for MDA-MB-231 and PC-3 cells, respectively. Molecular docking studies were also performed to examine the understanding of the mechanism behind the anti-cancer and anti-bacterial properties. For further study, compound 3A has the potential for utilization with chemotherapy drugs to establish a more efficient therapy strategy with minimum cytotoxicity against cancer cells. (C) 2020 Elsevier B.V. All rights reserved. Scientific Research Projects Council of Kastamonu University [KUBAP-01/2018-12] The authors are grateful to the Scientific Research Projects Council of Kastamonu University (KUBAP-01/2018-12). WOS:000569381800011 2-s2.0-85085842793

Location selection for citrus orchards is an important topic in terms of sustainable agriculture policies, agricultural planning, and community. This study presents a model to evaluate land suitability for cultivation of citrus in Antalya Province of Turkey. The aim of this study is to provide a Geographical Information System-Multi Criteria Evaluation based spatial decision support system, taking into account the viewpoints of local citrus growers and experts. 13 exclusion criteria, 3 main evaluation criteria (13 sub-criteria), and 52 value ranges were determined for citrus land suitability analysis. Analytic Hierarchy Process was utilised to calculate the weights of evaluation criteria. Inverse Distance Weighting interpolation approach was used to estimate the values of meteorological parameters. Thematic maps were presented for each of the criteria and final suitability map was prepared using Weighted Overlay method in Geographic Information System environment. The final suitability thematic map showed that the suitable zones (1281.19 km2) for citrus cultivation were located in the coastal regions of Antalya province. The average temperature in the winter season was determined to be the most important sub-criteria for citrus cultivation, followed by elevation, the average temperature in the flowering period, land use capability, daily average sunshine time, annual average precipitation, proximity to irrigation ponds and dam lakes and others. Most of the cultivated citrus orchards often coincided with the appropriate sites presented as a result of the study, and most of these sites were generally classified as high and moderate suitable zones. This study will be an important and useful regional guideline in terms of agricultural land use planning, citrus orchards management and community.

This study investigated the radiation shielding capacity of undoped polymer composite and lead (II) chloride (PbCl2)-containing polymer composite samples. The PbCl(2 )and polyester resin were used as filler and base materials, respectively. The PbCl2 was added to the polyester resin from 5 wt% to 20 wt%, and so an undoped polymer composite and four polymer composite samples each with different PbCl(2 )polymer resin ratios were investigated for their radiation attenuation capacity. Experimental data of the samples were taken using an HPGe detector, and Am-241, Ba-133, Co-57, Na-22, Cs-137, (152) Eu, Mn-54 and Co-60 radioactive point sources were used with energies in the range of 59.5-1408.0 keV. The experimental data were compared with both those simulated with FLUKA code and those theoretically calculated in WinXCOM. Mass attenuation coefficients used in estimating the shielding capacity of the samples were in good agreement with those found using FLUKA and WinXCOM. Radiation protection efficiency was improved by 244% especially at 59.5 keV energy by using PbCl2 (20%) polymer composite compared to undoped polymer composite. The sample with the maximum weight percentage of PbCl2, PbCl2 (20%), had the highest attenuation coefficients and lowest absorption thicknesses, and had the best radiation shielding property compared to the other polymer composite samples.

New Schiff base derivatives with thiophene, 1- (4-(((5-phenylthiophene-2-yl) methylene) amino) phenyl) ethan-1-one (I) and 1-(4)-((benzo [b] thiophene-2-ylmethylene) amino) phenyl) ethan-1-one (II), were synthesized and characterized by FTIR and NMR (1 H- and 13C NMR) spectroscopic methods. The structural parameters and spectral data of Schiff base derivatives were obtained by DFT/B3LYP/6- 311þþG(d,p) method and theoretical spectral data were compared with the experimental ones. Both compounds were tested for their antibacterial and antifungal properties against to the selected 15 bacteria and 4 fungi isolates, which could be threat to the public health, by microdilution broth assay with alamar blue. In vitro antimicrobial activity was determined by using the Minimum Inhibitory Concentration (MIC) values. Results show that, both compounds have high antibacterial activities against Enterococcus faecalis, Streptococcus agalactiae, Shigella flexneri isolates and the MIC values obtained for compounds I and II are 1250/2500, 1250/2500, 1250/ 312 mg/ml, respectively. These data may be supported by in vivo studies to contribute to alternative drug development studies. This study was supported by Gazi University, Scientific Research Projects Coordination Department (Gazi/BAP) (Project No: 65/2019-04). The numerical calculations reported in this paper were fully performed at TUBITAK ULAKBIM, High Performance and Grid Computing Center (TRUBA resources).

Sixteen new quinoline derivatives (3e18) have been synthesized through cyclocondensation, nucleophilic substitution and alkylation reactions. All the obtained compounds have been characterized using 1 H-, 13C and 19F NMR spectroscopic measurements. The molecular and crystal structures of four of these compounds (10, 11, 15 and 18) have also been further examined by single crystal X-ray crystallography. The predicted spectral data were also obtained and compared to the experimental results using density functional theory (DFT). in order to understand the non-bonding intermolecular interactions in solid phase crystal packing. The closest contacts between active atoms of the four studied molecules were identified through both 2D and 3D Hirshfeld surface analyses. The different structures of the four compounds are optimized and their both energies highest occupied molecular orbitals (HOMO) and lowest unoccupied molecular orbitals (LUMO), as well as their clouds are evaluated. The obtained experimental results are correlated to the calculated ones and showed great compatibility. Finally, molecular docking studies are performed to investigate the binding patterns of the title compounds with the Protein Data Bank (PDB: 1M17) inhibitor targets and showed good insights on the possible interactions using the Auto-Dock Vina program. Author would like to thank Prof. Jerry P. Jasinski acknowledges the NSF-MRI program (Grant No. CHE-1039027) for funds to purchase the X-ray diffractometer. T. H. is grateful to Hacettepe University Scientific Research Project Unit (Grant No. 013 D04 602 004).

The aim of the study was to synthesize a new series of benzimidazole derivatives and to investigate the underlying molecular mechanisms of the potential cell cycle inhibition and apoptotic effects against a panel of selected human cancer cell lines along with HEK-293 human embryonic kidney cells. MTT assay was used to evaluate cytotoxic effects. Muse™ Cell Analyzer was used to assess cell cycle progression. Annexin-V/PI staining assay was used for detecting apoptosis. All the synthesized compounds showed a significant cytotoxic effect against cancer cells with the IC50 values between 9.2 and 166.1 μg/mL. Among the tested derivatives, compound 5 showed significant cytotoxic activity against MCF-7, DU-145 and H69AR cancer cells with the IC50 values of 17.8 ± 0.24, 10.2 ± 1.4 and 49.9 ± 0.22 μg/mL respectively. The compounds 5 was also tested on HEK-293 human embryonic kidney cells and found to be safer with lesser cytotoxicity. The results revealed that compound 5 significantly increased cell population in the G2/M-phase which is modulated by a p53 independent mechanism. Compound 5 caused an increase in the percentage of late apoptotic cells in all tested cancer cells in a concentration-dependent manner. Among all synthesized derivatives, compound 5 the bromo-derivative, showed the highest cytotoxic potential, induced G2/M cell cycle arrest and apoptotic cell death in genotypically different human cancer cells. These results suggest that compound 5 might be a promising agent for cancer therapy and further structural modifications of benzimidazole derivatives may create promising anticancer agents. © 2020 Elsevier B.V.

PubMed ID: 26129972, Background: A. baumannii is an important nosocomial pathogen associated with high mortality, morbidity and medical cost. Aim: The aim of this study was to investigate risk factors for MDR A. baumannii bacteremia and also evaluate cost of hospitalization of these patients. Methods: Study was conducted in Ankara Atatürk Training and Research Hospital. Patients who were hospitalized in ICU and diagnosed for nosocomial blood stream infection (BSI) between January 2007 and December 2010 were checked retrospectively. Patients with nosocomial BSI caused by multidrug resistant A. baumannii were compared with the patients who had BSI caused by other Gram-negative microorganisms in terms of risk factors, mortality and medical costs. Findings: In multivariate analysis previous use of carbapenem, quinolone and metronidazole, and SAPS II score were found as independent risk factors. In case group; immunosupression, SAPS II score, and hospital stay until infection were independently associated with mortality in multivariate analysis. Conclusion: Our results suggest that the occurrence of MDR A.baumannii bacteremia was related with the usage of the wide spectrum antibiotics, and mortality rates were increased in patients that high SAPS II scores, long term hospitalization. Infection control procedures and limited antibiotic usage are very important for prevent nosocomial infections. © 2015 The Authors.

WOS: 000354157700016 PubMed: 25772252 Background: Serum fibroblast growth factor 23 (FGF-23) and fetuin-A are established predictors of morbidity and mortality due to cardiovascular disease. The objective of the present study is to evaluate the relationship between coronary artery disease (CAD) and serum concentrations of FGF-23 and fetuin-A. Methods: A total of 383 subjects who underwent coronary computed tomography angiography (CCTA) were included in the study. CCTA detected CAD in 208 patients; the rest of the patients had no detectable CAD. Results: Serum FGF-23 and fetuin-A levels were significantly increased in CAD patients compared to non-CAD patients (26.6 +/- 21.1 pg/mL vs. 17.9 +/- 16.1 pg/mL, p = 0.001 and 826 +/- 350 mg/L vs. 595 +/- 300 mg/L, p < 0.001, respectively). Serum FGF-23, fetuin-A, low-density lipoprotein (LDL)-cholesterol, and uric acid values were elevated in non-diabetic patients with CAD when compared to those without CAD. FGF-23, and fetuin-A were not significantly different in diabetic patients with CAD when compared to those without CAD. Using multivariate logistic regression analysis, we found that age, hypertension, LDL-Cholesterol, highdensity lipoprotein (HDL)-Cholesterol, hs-CRP, uric acid, FGF-23 and fetuin-A levels were independently associated with the presence of CAD. Conclusion: FGF-23 and fetuin-A were positively correlated with coronary atherosclerosis Similar trends were seen among diabetic patients, but this did not reach statistical significance. FGF-23 and fetuin-A could be used as novel risk markers of cardiovascular disease. (C) 2015 Elsevier Inc. All rights reserved. Mugla Saki Kocman UniversityMugla Sitki Kocman University Mugla Saki Kocman University.

WOS: 000329959100011 PubMed: 24268721 Objectives: Snoring during sleep is a major clinical symptom of adenoid and tonsil hypertrophy in paediatric patients. The aim of this study was to determine the effects of adenoid and tonsil size on snoring sound frequency and intensity in children. Methods: Twenty-seven patients with adenotonsillar hypertrophy were included the study. Adenoid size was graded from 1+ to 4+ by rigid endoscopy. Patients were staged (I-III) according to body mass index (BMI) and tonsil and adenoid size. Snoring was recorded and analysed. The analysis focused on the highest power frequency (Fmax) and snoring sound intensity levels (SSILs). Results: SSIL and Fmax values for Stage III were significantly higher than those for Stages I and II. BMI for Stage III was higher than for Stages land II, and that for Stage II was higher than for Stage I. The BMI, SSIL, and Fmax values increased at each stage and tonsil/adenoid grade. Conclusions: SSIL seems to be related to Adenoid and Tonsils size and BMI. As stage increased, both Fmax and SSILs increased proportionally. Also, Fmax values shifted to higher frequencies. Physicians and parents should be aware of snoring, and be informed that a higher frequency and intensity may be related to obesity and/or adenotonsillar hypertrophy. Snoring analysis may be a useful tool for detecting cases of Adenoid and Tonsils hypertrophy and/or upper airway obstruction during sleep. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

Highlights • Subacromial impingement syndrome is one of the most common disorders of shoulder. • Osteochondromas arising under the acromion rarely cause impingement syndrome. • The diagnosis of subacromial osteochondroma should be considered in any patient with shoulder impingement syndrome and good functional results can be expected following total excision., Introduction Subacromial impingement syndrome is one of the most common disorders of shoulder. Scapula is a very rare site for osteochondromas, and osteochondromas arising under the acromion cause impingement syndrome. Presentation of case We presented 34-year old female patient with subacromial impingement syndrome secondary to osteochondroma. She had received conservative treatment several times in other clinics. The osteochondroma causing impingement was not diagnosed. Physical examination of the right shoulder revealed 90° flexion, 70° abduction, 20° external rotation and internal rotation to sacrum. X-ray, CT and MRI of the shoulder was obtained. Osteochondroma of the acromion (35 × 33 × 25 mm) causing impingement was detected. The osteochondroma of acromion compressed, displaced and ruptured the supraspinatus tendon. Also an osseous prominence of glenoid was detected during shoulder arthroscopy, and it was removed arthroscopically. The giant osteochondroma of acromion could not remove arthroscopically due to the size of the lesion, and it was removed totally through a mini open approach. Histopathological examination confirmed the diagnosis of osteochondroma. Discussion Scapular, clavicular and humeral osteochondromas cause impingement syndrome. Osteochondroma should be treated with total excision. Recurrences can be seen due to insufficient removal of osteochondromas. We think that, total excision is important to prevent recurrence. Subacromial osteochondroma is a very rare cause of impingement syndrome, and if it isn’t diagnosed early it limits shoulder movements, causes severe shoulder impingement and rotator cuff tear. Conclusion The diagnosis of subacromial osteochondroma should be considered in any patient with shoulder impingement syndrome and good functional results can be expected following total excision.

WOS: 000327687300008 PubMed: 23937963 Purpose: Antiepileptic drugs may affect the endocrine system. We investigated the effects of valproic acid and topiramate on the levels of insulin, c-peptide and adipocytokines in pre-pubertal patients with idiopathic partial and generalized epilepsy. Methods: Forty-one children with epilepsy were included. The patients were divided into two groups (valproic acid; n = 21, topiramate; n = 20). The weight, height, body mass index and homeostasis model assessment of insulin resistance (HOMA-IR) were recorded and insulin, c-peptide, leptin, neuropeptide Y, adiponectin, visfatin and resistin levels were determined at 0, 6 and 12 months of therapy. Results: In the valproate group, weight and height increased significantly. Seven of 21 patients were overweight at the end of one year. Leptin was higher in the overweight subgroup. Although insulin and HOMA-IR increased (p < 0.05), none of the patients showed hyperinsulinism or IR. Resistin had decreased at the 6th and 12th months (p < 0.05). In the topiramate group, some statistically nonsignificant changes were demonstrated. Conclusion: The mechanisms behind valproate and topiramate-related weight control are still unclear, especially in children. Valproate and topiramate affect the weight, BMI, and insulin, leptin and adipocytokine levels in prepubertal children. We suggest that further studies including more patients with a long follow-up period are necessary to draw a firm conclusion regarding an association between the treatment with these drugs and the levels of leptin, insulin and adipocytokines. (C) 2013 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved. Karadeniz Technical University Research Foundation [2006-114031] This study was supported by the Karadeniz Technical University Research Foundation (Project number: 2006-114031).

1st World Conference on Learning, Teaching and Administration (WCLTA) -- OCT 29-31, 2010 -- Amer Univ, Cairo, EGYPT WOS: 000298553200232 There is a belief about not to able to achieve learning science and it is generally thought to be hard to learn science. As a result of this belief, the target level of success can not be achieved in science studying science lesson by experiment makes the students' success and interest more powerful and it makes them love this lesson. The need of using the simulation program in the laboratories, which are inadequate for experiment due to the physical impossibility and many different problems, has been inevitable. The basic target of this work is to find out the benefits of the simulation methods supported by computer. In order to make this target possible, the "Work-Power-Energy" topic, which takes place in the science and technology book of primary schools, is choose for making this topic appear properly in students mind, a simulation has been constructed. At the end of the experiment it has been made clear that the way of teaching supported by simulation in science teaching is more effective than the classic way of teaching. It has been proved to be an effective way of raising the success of the students. (C) 2010 Published by Elsevier Ltd.

Gok, Halil Zeki/0000-0001-7641-2683 WOS: 000260942400048 PubMed: 18395340 Two new macrocyclic ligands (3) and (4), containing nitrogen-sulfur donor atoms, were designed and synthesized in a multi-step reaction sequence. The macrocycles (3) and (4)were used in solvent extraction of metal picrates such as Ag(+), Hg(2+), Cd(2+), Zn(2+), Cu(2+), Ni(2+), Mn(2+), Co(2+), and Pb(2+) from aqueous phase to the organic phase. The metal picrate extractions were investigated at 25 +/- 0.1 degrees C by using UV-visible spectrometry. The extractability and selectivity of the mentioned metal picrates were evaluated according to the organic solvents. The values of the extraction constants (log K(ex)) and the complex compositions were determined for the extracted complexes. (C) 2008 Elsevier B.V. All rights reserved. Karadeniz Technical UniversityKaradeniz Teknik University This study was supported by the Research Fund of Karadeniz Technical University (Trabzon/Turkey).

Soylak, Mustafa/0000-0002-1017-0244 WOS: 000250640600009 PubMed: 17482351 A simple and accurate method was developed for separation and enrichment of trace levels of gold in environmental samples. The method is based on the adsorption of Au(III)-diethyldithiocarbamate complex on Amberlite XAD-2000 resin prior to the analysis of gold by flame atomic absorption spectrometry after elution with 1 mol L-1 HNO3 in acetone. Some parameters including nitric acid concentration, eluent type, matrix ions, sample volume, sample flow rate and adsorption capacity were investigated on the recovery of gold(III). The recovery values for gold(III) and detection limit of gold were greater than 95% and 16.6 mu g L-1, respectively. The preconcentration factor was 200. The relative standard deviation of the method was < 6%. The adsorption capacity of the resin was 12.3 mg g(-1). The validation of the presented procedure was checked by the analysis of CRM-SA-C Sandy Soil certified reference material. The presented procedure was applied to the determination of gold in some environmental samples. (c) 2007 Elsevier B.V. All rights reserved.

Soylak, Mustafa/0000-0002-1017-0244 WOS: 000248159700045 PubMed: 17223260 A new method using a column packed with Amberlite XAD-2010 resin as a solid-phase extractant has been developed for the multi-element preconcentration of Nln(R), Co(II), Ni(II), Cu(II), Cd(II), and Pb(II) ions based on their complex formation with the sodium diethyldithiocarbamate (Na-DDTC) prior to flame atomic absorption spectrometric (FAAS) determinations. Metal complexes sorbed on the resin were eluted by 1 mol L-1 HNO3 in acetone. Effects of the analytical conditions over the preconcentration yields of the metal ions, such as pH, quantity of Na-DDTC, eluent type, sample volume and flow rate, foreign ions etc. have been investigated. The limits of detection (LOD) of the analytes were found in the range 0.08-0.26 mu g L-1 . The method was validated by analyzing three certified reference materials. The method has been applied for the determination of trace elements in some environmental samples. (C) 2007 Elsevier B.V. All rights reserved.

Soylak, Mustafa/0000-0002-1017-0244 WOS: 000246465800015 PubMed: 17030420 A speciation procedure for Cr(III) and Cr(VI) based on column solid phase extraction on Amberlite XAD-2010 and flame atomic absorption spectrometry combination. Cr(VI) was quantitatively recovered on Amberlite XAD-2010 resin at pH range of 2.0-3.0 as its diethyldithiocarbamate complex, while the recoveries of Cr(III) was below 5%. The influences of the various parameters including amounts of the reagents, eluent type and its volume, sample volume, etc., on the quantitative recoveries were examined. The interference of matrix and coexistent elements for method were studied. The detection limit (corresponding to three times the standard deviation of the blank) and the enrichment factor for Cr(VI) were found to be 1.28 mu g/L and 25, respectively. To verify the accuracy of the method, drinking water certified reference material (CRM-TMDW-500) was analyzed and the results obtained were in good agreement with the certified value. The proposed method has been successfully applied to the speciation of Cr(III) and Cr(VI) in water samples and preconcentration of total chromium in environmental samples. (C) 2006 Elsevier B.V. All rights reserved.

Aktas, Munir/0000-0002-3188-8757 WOS: 000188537100001 PubMed: 15036571 A total of 2388 cattle and 442 shelters, from two provinces (Elazig and Malatya) endemic for tropical theileriosis in the east of Turkey, were studied for Hyalomma tick populations from July 1993 to July 1995 in Elazig and from May 1998 to January 1999 in Malatya. Four thousand five hundred and eighty one of 7455 Hyalomma ticks were collected from cattle, the other ticks (2874) were collected from shelters. All of the ticks collected from shelters were Hyalomma anatolicum anatolicum. Two thousand eight hundred and ninety five (63.1%) of 4581 Hyalomma ticks collected from cattle were H.a. anatolicum. 23.8% (1047/4581), 11.7% (536/4581) and 0.6% (3/4581). of Hyalomma ticks were Hyalomma anatolicum excavatum, Hyalomma detritum and Hyalomma marginatum marginatum, respectively. A total of 5909 Hyalomma adult ticks collected from cattle (3362/5909) and shelters (2447/5909) were dissected and salivary glands were stained with Methyl-green/Pyronin method. Thousand one hundred and fifty (46.9%) of 2447 H.a. anatolicum collected from shelters and 412 (19.1%) of 2147 H.a. anatolicum collected from cattle were positive for Theileria infection. Twenty (2.4%) of 820 H.a. excavatum and 23 (4.6%) of 495. H. detritum collected from cattle were positive. The mean number of infected acini per infected male and female ticks collected from cattle were 11.3 and 22.4 in H.a. anatolicum, 4 and 6.8 in H.a. excavatum, 17.9 and 18.3 in H. detritum, respectively. In H.a. anatolicum collected from shelters, the above rates were 11.8 and 17.6 in male and female ticks, respectively. The prevalence and intensity of Theileria infection was greater in female ticks than in males. (C) 2003 Elsevier B.V. All rights reserved.