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In patients with chronic cough, nearly 40% of the population does not experience definitive improvement of their cough despite correctly applying the anatomic diagnosis. In many of these patients with refractory cough, laryngeal symptoms are frequent. The region of the larynx/pharynx is configured as a bridge between the esophagus and the upper and lower respiratory tract. The association of reflux in patients with chronic cough and symptoms such as globus pharyngis, itchiness or the need to clear one's throat have recently been given attention due to the possibility of joint therapeutic intervention of the gastroesophageal reflux and larynx, both with new medications as well as with laryngeal rehabilitation therapies, with observed benefits in the disappearance of chronic cough in cases that had been previously labeled as refractory.

Fifty patients with a diagnosis of globus pharyngis and 33 control patients attending the same ENT clinic were interviewed using the (Royal Holloway &) Bedford College Life Events and Difficulties Schedule (LEDS). Information was elicited concerning life events and difficulties over the 12 months before globus onset, and this was compared with the experiences of the control patients for the year before symptom onset or, where appropriate, before the interview. Globus patients had significantly more severe events than the control patients throughout the year. Moreover, globus patients had significantly fewer close confiding relationships with their partners than did controls. There is evidence, therefore, for both psychological diathesis and social stress factors in the etiology of globus pharyngis.

One hundred and five consecutive patients attending an ENT out-patients' clinic with a diagnosis of globus pharyngis completed a 10-item questionnaire concerning common throat symptoms. Principal components analysis of the questionnaire revealed a general throat pathology factor, and three orthogonal rotated factors which were related to dysphagia, globus sensation, and pain/swelling in the throat. Of 10 throat symptoms, the globus patients most commonly complained of: "Feeling of something stuck in the throat," "Discomfort/irritation in the throat," and "Want to swallow all the time." These were the symptoms which had highest loadings on the 'globus' factor. The clear factor structure and the satisfactory internal consistency of the Glasgow-Edinburgh Throat Scale (GETS) suggest that it offers a clinically useful instrument for assessing and monitoring the severity of some common throat ailments. The degree of distress caused by throat symptoms was predicted independently by the intensity of the globus sensation and by anxiety level.