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Your search keyword '"Guzzardo, V."' showing total 15 results
Start Over Author "Guzzardo, V." Publisher elsevier bv
15 results on '"Guzzardo, V."'

4. Intratumor morphologic and transcriptomic heterogeneity in V600EBRAF-mutated metastatic colorectal adenocarcinomas

Author

Angerilli, V., primary, Fontana, E., additional, Lonardi, S., additional, Sbaraglia, M., additional, Borelli, B., additional, Munari, G., additional, Salmaso, R., additional, Guzzardo, V., additional, Spolverato, G., additional, Pucciarelli, S., additional, Pilati, P., additional, Hahne, J.C., additional, Bergamo, F., additional, Zagonel, V., additional, Dei Tos, A.P., additional, Sadanandam, A., additional, Loupakis, F., additional, Valeri, N., additional, and Fassan, M., additional

Published
2021
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11. Prognostic value of the immune-related transcriptome in biliary tract cancers

Author

Ghidini, M., primary, Cascione, L., additional, Lampis, A., additional, Pandolfo, R., additional, Carotenuto, P., additional, Trevisani, F., additional, Hahne, J.C., additional, Zito, D., additional, Guzzardo, V., additional, Zerbi, A., additional, Torzilli, G., additional, Roncalli, M., additional, Rimassa, L., additional, Santoro, A., additional, Fassan, M., additional, Valeri, N., additional, and Braconi, C., additional

Published
2016
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15. A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis

Author

Anna Parenti, Sara Bobisse, Byron Hann, Silvio Bicciato, Allan Balmain, Maria Rondina, Christine E. Wong, Stefano Piccolo, Aldo Solari, Vincenza Guzzardo, Marco Montagner, Antonio Rosato, Maddalena Adorno, Sirio Dupont, Michelangelo Cordenonsi, Adorno, M, Cordenonsi, M, Montagner, M, Dupont, S, Wong, C, Hann, B, Solari, A, Bobisse, S, Rondina, M, Guzzardo, V, Parenti, A, Rosato, A, Bicciato, S, Balmain, A, and Piccolo, S

Subjects
Breast Neoplasms, Smad Proteins, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, law.invention, Metastasis, 03 medical and health sciences, Mice, 0302 clinical medicine, law, Transforming Growth Factor beta, Cell Line, Tumor, medicine, Animals, Humans, Neoplasm Metastasis, Ternary complex, Transcription factor, 030304 developmental biology, 0303 health sciences, Mutation, biology, Biochemistry, Genetics and Molecular Biology(all), Tumor Suppressor Proteins, Cell migration, Transforming growth factor beta, medicine.disease, Specific Pathogen-Free Organisms, TGFβ. p53, metastasis, breast cancer, microarray, gene expression, bioinformatics, Metastasis Suppressor Gene, 030220 oncology & carcinogenesis, Immunology, Cancer research, biology.protein, Trans-Activators, ras Proteins, Suppressor, Tumor Suppressor Protein p53, signaling, Neoplasm Transplantation, Transcription Factors
Abstract

TGFbeta ligands act as tumor suppressors in early stage tumors but are paradoxically diverted into potent prometastatic factors in advanced cancers. The molecular nature of this switch remains enigmatic. Here, we show that TGFbeta-dependent cell migration, invasion and metastasis are empowered by mutant-p53 and opposed by p63. Mechanistically, TGFbeta acts in concert with oncogenic Ras and mutant-p53 to induce the assembly of a mutant-p53/p63 protein complex in which Smads serve as essential platforms. Within this ternary complex, p63 functions are antagonized. Downstream of p63, we identified two candidate metastasis suppressor genes associated with metastasis risk in a large cohort of breast cancer patients. Thus, two common oncogenic lesions, mutant-p53 and Ras, selected in early neoplasms to promote growth and survival, also prefigure a cellular set-up with particular metastasis proclivity by TGFbeta-dependent inhibition of p63 function.

Published
2009
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