1. Deciphering the loop of epithelial-mesenchymal transition, inflammatory cytokines and cancer immunoediting
- Author
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Gwenola Manic, Antonella Sistigu, Paola Nisticò, and Francesca Di Modugno
- Subjects
0301 basic medicine ,Epithelial-Mesenchymal Transition ,Endocrinology, Diabetes and Metabolism ,Immunology ,Tumor-associated macrophage ,Biology ,General Biochemistry, Genetics and Molecular Biology ,Mice ,03 medical and health sciences ,Cancer stem cell ,Neoplasms ,Tumor Microenvironment ,Animals ,Humans ,Immunology and Allergy ,Mesenchymal–epithelial transition ,Epithelial–mesenchymal transition ,Inflammation ,Tumor microenvironment ,Extracellular Matrix ,Cell Transformation, Neoplastic ,030104 developmental biology ,Immunoediting ,Tumor progression ,Disease Progression ,Neoplastic Stem Cells ,Cancer research ,Myeloid-derived Suppressor Cell ,Cytokines ,Signal Transduction - Abstract
Tumorigenesis and tumor progression relies on the dialectics between tumor cells, the extracellular matrix and its remodelling enzymes, neighbouring cells and soluble cues. The host immune response is crucial in eliminating or promoting tumor growth and the reciprocal coevolution of tumor and immune cells, during disease progression and in response to therapy, shapes tumor fate by activating innate and adaptive mechanisms. The phenotypic plasticity is a common feature of epithelial and immune cells and epithelial-mesenchymal transition (EMT) is a dynamic process, governed by microenvironmental stimuli, critical in tumor cell shaping, increased tumor cell heterogeneity and stemness. In this review we will outline how the dysregulation of microenvironmental signaling is crucial in determining tumor plasticity and EMT, arguing how therapy resistance hinges on these dynamics.
- Published
- 2017