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One new limonoid, named 19-hydroxy methyl isoobacunoate diosphenol (1); one new degraded limonoid, named 9α-methoxyl dictamdiol (9); two new quinolone alkaloids, 1-methyl-3-[(7E,9E,12Z)-7,9,12-pentadecadienyl]-4(1H)-quinolone (11) and 1-methyl-3-[(7E,9E,11E)-7,9,11-pentadecadienyl]-4(1H)-quinolone (12), along with eight known compounds, evodol (2), 7β-acetoxy-5-epilimonin (3), rutaevine (4), 6β-acetoxy-5-epilimonin (5), limonin (6), obacunone (7), clauemargine L (8), hiiranlactone E (10) were isolated from the fruits of Evodia rutaecarpa (Juss.) Benth.. Structures of the four new compounds were elucidated on the basis of extensive spectroscopic techniques, including 1D and 2D NMR techniques. Compounds 3, 5, 9, 11 and 12 showed obviously cytotoxic activity against six human tumor lines, while compounds 11, 12 displayed anti-platelet aggregation induced by ADP at 50 μM and 100 μM.

Three new bisditerpenoid alkaloids, navicularines A-C (1-3), and three known ones (4-6), were isolated from the ground parts of Aconitum naviculare. Their structures were elucidated by spectroscopic methods. All the new compounds were tested against five cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480). It was found that navicularine B exhibited certain cytotoxic activities in vitro, with IC50 values of 13.50, 18.52, 17.22, 11.18, and 16.36μM, respectively.

Phytochemical investigation of Zygophyllum fabago L. afforded seven compounds, including a new valencane type sesquiterpenoid ( 1 ), a new phenylpropanoid derivative ( 2 ) and two new quinovic acid derivatives ( 3 and 4 ), and 3- O -[β- d -glucopyranosyl]-quinovic acid ( 5 ). Their structures were elucidated by the extensive use of 1D ( 1 H NMR and 13 C NMR) and 2D (COSY, HSQC, HMBC and ROESY) NMR experiments, as well as IR and HREIMS spectral data. These new compounds were evaluated for their cytotoxic activity against five cancer cell lines (HL-60, SMMC-721, A-549, MCF-7, and SW-480). All new compounds exhibited no cytotoxic activities (>40 μm).