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408 results on '"Higashijima, A."'

4. EP11.01-11 Clinical Significance of Soluble PD-1 and PD-L1 in Plasma of NSCLC Patients Treated with Immune Checkpoint Inhibitors

Author

Nakahara, Y., primary, Himuro, H., additional, Igarashi, Y., additional, Kouro, T., additional, Higashijima, N., additional, Matsuo, N., additional, Murakami, S., additional, Wei, F., additional, Horaguchi, S., additional, Tsuji, K., additional, Mano, Y., additional, Saito, H., additional, Azuma, K., additional, Naoki, K., additional, and Sasada, T., additional

Published
2023
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5. ARDS clinical practice guideline 2021

Author

Sadatomo Tasaka, Shinichiro Ohshimo, Muneyuki Takeuchi, Hideto Yasuda, Kazuya Ichikado, Kenji Tsushima, Moritoki Egi, Satoru Hashimoto, Nobuaki Shime, Osamu Saito, Shotaro Matsumoto, Eishu Nango, Yohei Okada, Kenichiro Hayashi, Masaaki Sakuraya, Mikio Nakajima, Satoshi Okamori, Shinya Miura, Tatsuma Fukuda, Tadashi Ishihara, Tetsuro Kamo, Tomoaki Yatabe, Yasuhiro Norisue, Yoshitaka Aoki, Yusuke Iizuka, Yutaka Kondo, Chihiro Narita, Daisuke Kawakami, Hiromu Okano, Jun Takeshita, Keisuke Anan, Satoru Robert Okazaki, Shunsuke Taito, Takuya Hayashi, Takuya Mayumi, Takero Terayama, Yoshifumi Kubota, Yoshinobu Abe, Yudai Iwasaki, Yuki Kishihara, Jun Kataoka, Tetsuro Nishimura, Hiroshi Yonekura, Koichi Ando, Takuo Yoshida, Tomoyuki Masuyama, Masamitsu Sanui, Takuro Nakashima, Aiko Masunaga, Aiko Tanaka, Akihiko Inoue, Akiko Higashi, Atsushi Tanikawa, Atsushi Ujiro, Chihiro Takayama, Daisuke Kasugai, Daisuke Ueno, Daizoh Satoh, Shinichi Kai, Kohei Ota, Yoshihiro Hagiwara, Jun Hamaguchi, Ryo Fujii, Takashi Hongo, Naohisa Masunaga, Ryohei Yamamoto, Ryo Uchimido, Tetsuro Terayama, Satoshi Hokari, Hitoshi Sakamoto, null Dongli, Emiko Nakataki, Erina Tabata, Seisuke Okazawa, Futoshi Kotajima, Go Ishimaru, Haruhiko Hoshino, Hideki Yoshida, Hidetaka Iwai, Hiroaki Nakagawa, Hiroko Sugimura, Hiromichi Narumiya, Hiroshi Nakamura, Hiroshi Sugimoto, Hiroyuki Hashimoto, Hiroyuki Ito, Hisashi Dote, Hisashi Imahase, Hitoshi Sato, Masahiro Katsurada, Ichiro Osawa, Jun Kamei, Jun Maki, Jun Sugihara, Junichi Fujimoto, Junichi Ishikawa, Junko Kosaka, Junpei Shibata, Katsuhiko Hashimoto, Yasushi Nakano, Kazuki Kikuyama, Kazushige Shimizu, Kazuya Okada, Keishi Kawano, Keisuke Ota, Ken-ichi Kano, Kengo Asano, Kenichi Hondo, Kenji Ishii, Kensuke Fujita, Kenta Ogawa, Kentaro Ito, Kentaro Tokunaga, Kenzo Ishii, Kohei Kusumoto, Kohei Takimoto, Kohei Yamada, Koichi Naito, Koichi Yamashita, Koichi Yoshinaga, Kota Yamauchi, Maki Murata, Makiko Konda, Manabu Hamamoto, Masaharu Aga, Masahiro Kashiura, Masami Ishikawa, Masayuki Ozaki, Michihiko Kono, Michihito Kyo, Minoru Hayashi, Mitsuhiro Abe, Mitsunori Sato, Mizu Sakai, Motoshi Kainuma, Naoki Tominaga, Naoya Iguchi, Natsuki Nakagawa, Nobumasa Aoki, Norihiro Nishioka, Norihisa Miyashita, Nozomu Seki, Ryo Ikebe, Ryosuke Imai, Ryota Tate, Ryuhei Sato, Sachiko Miyakawa, Satoshi Kazuma, Satoshi Nakano, Satoshi Tetsumoto, Satoshi Yoshimura, Shigenori Yoshitake, Shin-etsu Hoshi, Shingo Ohki, Shintaro Sato, Shodai Yoshihiro, Shoichi Ihara, Shota Yamamoto, Shunichi Koide, Shunsuke Kimata, Shunsuke Saito, Shunsuke Yasuo, Shusuke Sekine, Soichiro Mimuro, Soichiro Wada, Sosuke Sugimura, Tadashi Kaneko, Tadashi Nagato, Takaaki Maruhashi, Takahiro Tamura, Takanori Ohno, Takashi Ichiyama, Takashi Niwa, Takashi Ueji, Takayuki Ogura, Takeshi Kawasaki, Takeshi Tanaka, Takeshi Umegaki, Taku Furukawa, Taku Omura, Takumi Nagao, Takuya Taniguchi, Takuya Yoshida, Tatsutoshi Shimatani, Teppei Murata, Tetsuya Sato, Tohru Sawamoto, Yoshifumi Koukei, Tomohiro Takehara, Tomomi Ueda, Tomoya Katsuta, Tomoya Nishino, Toshiki Yokoyama, Ushio Higashijima, Wataru Iwanaga, Yasushi Inoue, Yoshiaki Iwashita, Yoshie Yamada, Yoshihiro Suido, Yoshihiro Tomioka, Yoshihisa Fujimoto, Yoshihito Fujita, Yoshikazu Yamaguchi, Yoshimi Nakamura, Yoshitomo Eguchi, Yoshiyasu Oshima, Yosuke Fukuda, Yuichi Yasufuku, Yuji Shono, Yuka Nakatani, Yuki Nakamori, Yukie Ito, Yuko Tanabe, Yusuke Nagamine, Yuta Nakamura, and Yutaro Kurihara

Subjects
Adult, Pulmonary and Respiratory Medicine, Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation, Prone Position, Tidal Volume, Humans, Child, Critical Care and Intensive Care Medicine, Respiration, Artificial
Abstract

Background The joint committee of the Japanese Society of Intensive Care Medicine/Japanese Respiratory Society/Japanese Society of Respiratory Care Medicine on ARDS Clinical Practice Guideline has created and released the ARDS Clinical Practice Guideline 2021. Methods The 2016 edition of the Clinical Practice Guideline covered clinical questions (CQs) that targeted only adults, but the present guideline includes 15 CQs for children in addition to 46 CQs for adults. As with the previous edition, we used a systematic review method with the Grading of Recommendations Assessment Development and Evaluation (GRADE) system as well as a degree of recommendation determination method. We also conducted systematic reviews that used meta-analyses of diagnostic accuracy and network meta-analyses as a new method. Results Recommendations for adult patients with ARDS are described: we suggest against using serum C-reactive protein and procalcitonin levels to identify bacterial pneumonia as the underlying disease (GRADE 2D); we recommend limiting tidal volume to 4–8 mL/kg for mechanical ventilation (GRADE 1D); we recommend against managements targeting an excessively low SpO2 (PaO2) (GRADE 2D); we suggest against using transpulmonary pressure as a routine basis in positive end-expiratory pressure settings (GRADE 2B); we suggest implementing extracorporeal membrane oxygenation for those with severe ARDS (GRADE 2B); we suggest against using high-dose steroids (GRADE 2C); and we recommend using low-dose steroids (GRADE 1B). The recommendations for pediatric patients with ARDS are as follows: we suggest against using non-invasive respiratory support (non-invasive positive pressure ventilation/high-flow nasal cannula oxygen therapy) (GRADE 2D), we suggest placing pediatric patients with moderate ARDS in the prone position (GRADE 2D), we suggest against routinely implementing NO inhalation therapy (GRADE 2C), and we suggest against implementing daily sedation interruption for pediatric patients with respiratory failure (GRADE 2D). Conclusions This article is a translated summary of the full version of the ARDS Clinical Practice Guideline 2021 published in Japanese (URL: https://www.jsicm.org/publication/guideline.html). The original text, which was written for Japanese healthcare professionals, may include different perspectives from healthcare professionals of other countries.

Published
2022

6. Lysine demethylase 2B regulates angiogenesis via Jumonji C dependent suppression of angiogenic transcription factors

Author

Yuji Sasaki, Yoshiki Higashijima, Jun-Ichi Suehiro, Takehito Sugasawa, Eri Oguri-Nakamura, Shigetomo Fukuhara, Nao Nagai, Yosuke Hirakawa, Youichiro Wada, Masaomi Nangaku, and Yasuharu Kanki

Subjects
Vascular Endothelial Growth Factor A, Histone demethylase, Jumonji Domain-Containing Histone Demethylases, Endothelial cell function, F-Box Proteins, Lysine, Histone modifications, Biophysics, Endothelial Cells, Cell Biology, VEGF, Biochemistry, Histones, Humans, Angiogenesis, Molecular Biology, Cell Proliferation, Transcription Factors
Abstract

Vascular endothelial growth factor (VEGF) signaling plays a central role in vascular development and maintenance of vascular homeostasis. In endothelial cells (ECs), VEGF activates the gene expression of angiogenic transcription factors (TFs), followed by induction of downstream angiogenic responsive genes. Recent findings support that histone modification dynamics contribute to the transcriptional control of genes that are important for EC functions. Lysine demethylase 2B (KDM2B) demethylates histone H3K4me3 and H3K36me2/3 and mediates the monoubiquitination of histone H2AK119. KDM2B functions as a transcriptional repressor in somatic cell reprogramming and tumor development. However, the role of KDM2B in VEGF signaling remains to be elucidated. Here, we show that KDM2B knockdown enhances VEGF-induced angiogenesis in cultured human ECs via increased migration and proliferation. In contrast, ectopic expression of KDM2B inhibits angiogenesis. The function of KDM2B may depend on its catalytic Jumonji C domain. Genome-wide analysis further reveals that KDM2B selectively controls the transcription of VEGF-induced angiogenic TFs that are associated with increased H3K4me3/H3K36me3 and decreased H2AK119ub. These findings suggest an essential role of KDM2B in VEGF signaling in ECs. As dysregulation of VEGF signaling in ECs is involved in various diseases, including cancer, KDM2B may be a potential therapeutic target in VEGF-mediated vasculopathic diseases.

Published
2022

8. Allergen-Related Coronary Vasospasm 'Kounis Syndrome' Requiring Administration of Epinephrine and a Coronary Vasodilator

Author

Haruka Inoue, Takashi Egashira, Rintaro Yano, Tsuyoshi Yonekura, Sojiro Matsumoto, Ushio Higashijima, Motohiro Sekino, Shuhei Matsumoto, Ryosuke Shintani, and Tetsuya Hara

Subjects
medicine.medical_specialty, Acute coronary syndrome, business.industry, Kounis syndrome, Vasospasm, 030204 cardiovascular system & hematology, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Anesthesiology and Pain Medicine, Epinephrine, 030202 anesthesiology, Coronary vasospasm, Internal medicine, medicine, Cardiology, Coronary vasodilator, Cardiology and Cardiovascular Medicine, Nicorandil, business, Anaphylaxis, medicine.drug
Abstract

Kounis syndrome is an anaphylactic reaction leading to acute coronary syndrome. The acute treatment of anaphylaxis is epinephrine; however, epinephrine may cause coronary vasoconstriction, reduce coronary blood flow, increase myocardial oxygen demand, and worsen myocardial ischemia. On the other hand, coronary vasodilation, a treatment for acute coronary syndrome, can aggravate hypotension in patients with anaphylaxis. Herein, the authors report a case of type II Kounis syndrome, with vasospasm in a patient with coronary disease, requiring the administration of epinephrine and a coronary vasodilator for resuscitation. The authors administered intravenous epinephrine continuously from lower dosages and performed delicate titration. The coronary vasodilator nicorandil, which has little effect on hemodynamics, also was administered. These treatments improved hemodynamics without complications. Circulatory management that considers both anaphylaxis and coronary lesions is crucial to improve prognosis in this syndrome.

Published
2021

9. Indication of imaging to identify cerebral infarction due to vertebral artery damage associated with blunt cervical spine injury

Author

Ishikawa, Shun, primary, Akimoto, Taisuke, additional, Ohtake, Makoto, additional, Kawasaki, Takafumi, additional, Shimohigoshi, Wataru, additional, Higashijima, Takefumi, additional, Nakamura, Taishi, additional, Kawasaki, Takashi, additional, Sakata, Katsumi, additional, Matsumoto, Masahiro, additional, Takeuchi, Ichiro, additional, and Yamamoto, Tetsuya, additional

Published
2022
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10. Tracheobronchial Stent Insertion Under Venovenous Extracorporeal Membrane Oxygenation in a Patient With Coronavirus Disease 2019

Author

Ichinomiya, Taiga, primary, Murata, Hiroaki, additional, Sekino, Motohiro, additional, Yokoyama, Haruka, additional, Ogami-Takamura, Keiko, additional, Higashijima, Ushio, additional, Ashizawa, Nobuyuki, additional, Izumikawa, Koichi, additional, Machino, Ryusuke, additional, Matsumoto, Keitaro, additional, Nakaji, Shun, additional, Yoshitomi, Osamu, additional, and Hara, Tetsuya, additional

Published
2022
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12. Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis

Author

Maddali, Manoj V, primary, Churpek, Matthew, additional, Pham, Tai, additional, Rezoagli, Emanuele, additional, Zhuo, Hanjing, additional, Zhao, Wendi, additional, He, June, additional, Delucchi, Kevin L, additional, Wang, Chunxue, additional, Wickersham, Nancy, additional, McNeil, J Brennan, additional, Jauregui, Alejandra, additional, Ke, Serena, additional, Vessel, Kathryn, additional, Gomez, Antonio, additional, Hendrickson, Carolyn M, additional, Kangelaris, Kirsten N, additional, Sarma, Aartik, additional, Leligdowicz, Aleksandra, additional, Liu, Kathleen D, additional, Matthay, Michael A, additional, Ware, Lorraine B, additional, Laffey, John G, additional, Bellani, Giacomo, additional, Calfee, Carolyn S, additional, Sinha, Pratik, additional, Rios, Fernando, additional, Van Haren, Frank, additional, Sottiaux, T, additional, Lora, Fredy S, additional, Azevedo, Luciano C, additional, Depuydt, P, additional, Fan, Eddy, additional, Bugedo, Guillermo, additional, Qiu, Haibo, additional, Gonzalez, Marcos, additional, Silesky, Juan, additional, Cerny, Vladimir, additional, Nielsen, Jonas, additional, Jibaja, Manuel, additional, Pham, Tài, additional, Wrigge, Hermann, additional, Matamis, Dimitrios, additional, Ranero, Jorge Luis, additional, Hashemian, S. M, additional, Amin, Pravin, additional, Clarkson, Kevin, additional, Kurahashi, Kiyoyasu, additional, Villagomez, Asisclo, additional, Zeggwagh, Amine Ali, additional, Heunks, Leo M, additional, Laake, Jon Henrik, additional, Palo, Jose Emmanuel, additional, do Vale Fernandes, Antero, additional, Sandesc, Dorel, additional, Arabi, Yaasen, additional, Bumbasierevic, Vesna, additional, Nin, Nicolas, additional, Lorente, Jose A, additional, Larsson, Anders, additional, Piquilloud, Lise, additional, Abroug, Fekri, additional, McAuley, Daniel F, additional, McNamee, Lia, additional, Hurtado, Javier, additional, Bajwa, Ed, additional, Démpaire, Gabriel, additional, Francois, Guy M, additional, Sula, Hektor, additional, Nunci, Lordian, additional, Cani, Alma, additional, Zazu, Alan, additional, Dellera, Christian, additional, Insaurralde, Carolina S, additional, Alejandro, Risso V, additional, Daldin, Julio, additional, Vinzio, Mauricio, additional, Fernandez, Ruben O, additional, Cardonnet, Luis P, additional, Bettini, Lisandro R, additional, Bisso, Mariano Carboni, additional, Osman, Emilio M, additional, Setten, Mariano G, additional, Lovazzano, Pablo, additional, Alvarez, Javier, additional, Villar, Veronica, additional, Milstein, Cesar, additional, Pozo, Norberto C, additional, Grubissich, Nicolas, additional, Plotnikow, Gustavo A, additional, Vasquez, Daniela N, additional, Ilutovich, Santiago, additional, Tiribelli, Norberto, additional, Chena, Ariel, additional, Pellegrini, Carlos A, additional, Saenz, María G, additional, Estenssoro, Elisa, additional, Brizuela, Matias, additional, Gianinetto, Hernan, additional, Gomez, Pablo E, additional, Cerrato, Valeria I, additional, Bezzi, Marco G, additional, Borello, Silvina A, additional, Loiacono, Flavia A, additional, Fernandez, Adriana M, additional, Knowles, Serena, additional, Reynolds, Claire, additional, Inskip, Deborah M, additional, Miller, Jennene J, additional, Kong, Jing, additional, Whitehead, Christina, additional, Bihari, Shailesh, additional, Seven, Aylin, additional, Krstevski, Amanda, additional, Rodgers, Helen J, additional, Millar, Rebecca T, additional, Mckenna, Toni E, additional, Bailey, Irene M, additional, Hanlon, Gabrielle C, additional, Aneman, Anders, additional, Lynch, Joan M, additional, Azad, Raman, additional, Neal, John, additional, Woods, Paul W, additional, Roberts, Brigit L, additional, Kol, Mark R, additional, Wong, Helen S, additional, Riss, Katharina C, additional, Staudinger, Thomas, additional, Wittebole, Xavier, additional, Berghe, Caroline, additional, Bulpa, Pierre A, additional, Dive, Alain M, additional, Verstraete, Rik, additional, Lebbinck, Herve, additional, Depuydt, Pieter, additional, Vermassen, Joris, additional, Meersseman, Philippe, additional, Ceunen, Helga, additional, Rosa, Jonas I, additional, Beraldo, Daniel O, additional, Piras, Claudio, additional, Ampinelli, Adenilton M R, additional, Nassar Jr, Antonio P, additional, Mataloun, Sergio, additional, Moock, Marcelo, additional, Thompson, Marlus M, additional, Gonçalves, Claudio H, additional, Antônio, Ana Carolina P, additional, Ascoli, Aline, additional, Biondi, Rodrigo S, additional, Fontenele, Danielle C, additional, Nobrega, Danielle, additional, Sales, Vanessa M, additional, Shindhe, Suresh, additional, Ismail, Dk Maizatul Aiman B Pg Hj, additional, Laffey, John, additional, Beloncle, Francois, additional, Davies, Kyle G, additional, Cirone, Rob, additional, Manoharan, Venika, additional, Ismail, Mehvish, additional, Goligher, Ewan C, additional, Jassal, Mandeep, additional, Nishikawa, Erin, additional, Javeed, Areej, additional, Curley, Gerard, additional, Rittayamai, Nuttapol, additional, Parotto, Matteo, additional, Ferguson, Niall D, additional, Mehta, Sangeeta, additional, Knoll, Jenny, additional, Pronovost, Antoine, additional, Canestrini, Sergio, additional, Bruhn, Alejandro R, additional, Garcia, Patricio H, additional, Aliaga, Felipe A, additional, Farías, Pamela A, additional, Yumha, Jacob S, additional, Ortiz, Claudia A, additional, Salas, Javier E, additional, Saez, Alejandro A, additional, Vega, Luis D, additional, Labarca, Eduardo F, additional, Martinez, Felipe T, additional, Carreño, Nicolás G, additional, Lora, Pilar, additional, Liu, Haitao, additional, Liu, Ling, additional, Tang, Rui, additional, Luo, Xiaoming, additional, An, Youzhong, additional, Zhao, Huiying, additional, Gao, Yan, additional, Zhai, Zhe, additional, Ye, Zheng L, additional, Wang, Wei, additional, Li, Wenwen, additional, Li, Qingdong, additional, Zheng, Ruiqiang, additional, Yu, Wenkui, additional, Shen, Juanhong, additional, Li, Xinyu, additional, Yu, Tao, additional, Lu, Weihua, additional, Wu, Ya Q, additional, Huang, Xiao B, additional, He, Zhenyang, additional, Lu, Yuanhua, additional, Han, Hui, additional, Zhang, Fan, additional, Sun, Renhua, additional, Wang, Hua X, additional, Qin, Shu H, additional, Zhu, Bao H, additional, Zhao, Jun, additional, Liu, Jian, additional, Li, Bin, additional, Liu, Jing L, additional, Zhou, Fa C, additional, Li, Qiong J, additional, Zhang, Xing Y, additional, Li-Xin, Zhou, additional, Xin-Hua, Qiang, additional, Jiang, Liangyan, additional, Gao, Yuan N, additional, Zhao, Xian Y, additional, Li, Yuan Y, additional, Li, Xiao L, additional, Wang, Chunting, additional, Yao, Qingchun, additional, Yu, Rongguo, additional, Chen, Kai, additional, Shao, Huanzhang, additional, Qin, Bingyu, additional, Huang, Qing Q, additional, Zhu, Wei H, additional, Hang, Ai Y, additional, Hua, Ma X, additional, Li, Yimin, additional, Xu, Yonghao, additional, Di, Yu D, additional, Ling, Long L, additional, Qin, Tie H, additional, Wang, Shou H, additional, Qin, Junping, additional, Han, Yi, additional, Zhou, Suming, additional, Vargas, Monica P, additional, Silesky Jimenez, Juan I, additional, González Rojas, Manuel A, additional, Solis-Quesada, Jaime E, additional, Ramirez-Alfaro, Christian M, additional, Máca, Jan, additional, Sklienka, Peter, additional, Gjedsted, Jakob, additional, Christiansen, Aage, additional, Villamagua, Boris G, additional, Llano, Miguel, additional, Burtin, Philippe, additional, Buzancais, Gautier, additional, Beuret, Pascal, additional, Pelletier, Nicolas, additional, Mortaza, Satar, additional, Mercat, Alain, additional, Chelly, Jonathan, additional, Jochmans, Sébastien, additional, Terzi, Nicolas, additional, Daubin, Cédric, additional, Carteaux, Guillaume, additional, de Prost, Nicolas, additional, Chiche, Jean-Daniel, additional, Daviaud, Fabrice, additional, Fartoukh, Muriel, additional, Barberet, Guillaume, additional, Biehler, Jerome, additional, Dellamonica, Jean, additional, Doyen, Denis, additional, Arnal, Jean-Michel, additional, Briquet, Anais, additional, Hraiech, Sami, additional, Papazian, Laurent, additional, Follin, Arnaud, additional, Roux, Damien, additional, Messika, Jonathan, additional, Kalaitzis, Evangelos, additional, Dangers, Laurence, additional, Combes, Alain, additional, Au, Siu-Ming, additional, Béduneau, Gaetan, additional, Carpentier, Dorothée, additional, Zogheib, Elie H, additional, Dupont, Herve, additional, Ricome, Sylvie, additional, Santoli, Francesco L, additional, Besset, Sebastien L, additional, Michel, Philippe, additional, Gelée, Bruno, additional, Danin, Pierre-Eric, additional, Goubaux, Bernard, additional, Crova, Philippe J, additional, Phan, Nga T, additional, Berkelmans, Frantz, additional, Badie, Julio C, additional, Tapponnier, Romain, additional, Gally, Josette, additional, Khebbeb, Samy, additional, Herbrecht, Jean-Etienne, additional, Schneider, Francis, additional, Declercq, Pierre-Louis M, additional, Rigaud, Jean-Philippe, additional, Duranteau, Jacques, additional, Harrois, Anatole, additional, Chabanne, Russell, additional, Marin, Julien, additional, Bigot, Charlene, additional, Thibault, Sandrine, additional, Ghazi, Mohammed, additional, Boukhazna, Messabi, additional, Ould Zein, Salem, additional, Richecoeur, Jack R, additional, Combaux, Daniele M, additional, Grelon, Fabien, additional, Le Moal, Charlene, additional, Sauvadet, Elise P, additional, Robine, Adrien, additional, Lemiale, Virginie, additional, Reuter, Danielle, additional, Dres, Martin, additional, Demoule, Alexandre, additional, Goldgran-Toledano, Dany, additional, Baboi, Loredana, additional, Guérin, Claude, additional, Lohner, Ralph, additional, Kraßler, Jens, additional, Schäfer, Susanne, additional, Zacharowski, Kai D, additional, Meybohm, Patrick, additional, Reske, Andreas W, additional, Simon, Philipp, additional, Hopf, Hans-Bernd F, additional, Schuetz, Michael, additional, Baltus, Thomas, additional, Papanikolaou, Metaxia N, additional, Papavasilopoulou, Theonymfi G, additional, Zacharas, Giannis A, additional, Ourailogloy, Vasilis, additional, Mouloudi, Eleni K, additional, Massa, Eleni V, additional, Nagy, Eva O, additional, Stamou, Electra E, additional, Kiourtzieva, Ellada V, additional, Oikonomou, Marina A, additional, Avila, Luis E, additional, Cortez, Cesar A, additional, Citalán, Johanna E, additional, Jog, Sameer A, additional, Sable, Safal D, additional, Shah, Bhagyesh, additional, Gurjar, Mohan, additional, Baronia, Arvind K, additional, Memon, Mohammedfaruk, additional, Muthuchellappan, Radhakrishnan, additional, Ramesh, Venkatapura J, additional, Shenoy, Anitha, additional, Unnikrishnan, Ramesh, additional, Dixit, Subhal B, additional, Rhayakar, Rachana V, additional, Ramakrishnan, Nagarajan, additional, Bhardwaj, Vallish K, additional, Mahto, Heera L, additional, Sagar, Sudha V, additional, Palaniswamy, Vijayanand, additional, Ganesan, Deeban, additional, Mohammadreza Hashemian, Seyed, additional, Jamaati, Hamidreza, additional, Heidari, Farshad, additional, Meaney, Edel A, additional, Nichol, Alistair, additional, Knapman, Karl M, additional, O'Croinin, Donall, additional, Dunne, Eimhin S, additional, Breen, Dorothy M, additional, Clarkson, Kevin P, additional, Jaafar, Rola F, additional, Dwyer, Rory, additional, Amir, Fahd, additional, Ajetunmobi, Olaitan O, additional, O'Muircheartaigh, Aogan C, additional, Black, Colin S, additional, Treanor, Nuala, additional, Collins, Daniel V, additional, Altaf, Wahid, additional, Zani, Gianluca, additional, Fusari, Maurizio, additional, Spadaro, Savino, additional, Volta, Carlo A, additional, Graziani, Romano, additional, Brunettini, Barbara, additional, Palmese, Salvatore, additional, Formenti, Paolo, additional, Umbrello, Michele, additional, Lombardo, Andrea, additional, Pecci, Elisabetta, additional, Botteri, Marco, additional, Savioli, Monica, additional, Protti, Alessandro, additional, Mattei, Alessia, additional, Schiavoni, Lorenzo, additional, Tinnirello, Andrea, additional, Todeschini, Manuel, additional, Giarratano, Antonino, additional, Cortegiani, Andrea, additional, Sher, Sara, additional, Rossi, Anna, additional, Antonelli, Massimo M, additional, Montini, Luca M, additional, Casalena, Paolo, additional, Scafetti, Sergio, additional, Panarello, Giovanna, additional, Occhipinti, Giovanna, additional, Patroniti, Nicolò, additional, Pozzi, Matteo, additional, Biscione, Roberto R, additional, Poli, Michela M, additional, Raimondi, Ferdinando, additional, Albiero, Daniela, additional, Crapelli, Giulia, additional, Beck, Eduardo, additional, Pota, Vincenzo, additional, Schiavone, Vincenzo, additional, Molin, Alexandre, additional, Tarantino, Fabio, additional, Monti, Giacomo, additional, Frati, Elena, additional, Mirabella, Lucia, additional, Cinnella, Gilda, additional, Fossali, Tommaso, additional, Colombo, Riccardo, additional, Terragni, Pierpaolo, additional, Pattarino, Ilaria, additional, Mojoli, Francesco, additional, Braschi, Antonio, additional, Borotto, Erika E, additional, Cracchiolo, Andrea N, additional, Palma, Daniela M, additional, Raponi, Francesco, additional, Foti, Giuseppe, additional, Vascotto, Ettore R, additional, Coppadoro, Andrea, additional, Brazzi, Luca, additional, Floris, Leda, additional, Iotti, Giorgio A, additional, Venti, Aaron, additional, Yamaguchi, Osamu, additional, Takagi, Shunsuke, additional, Maeyama, Hiroki N, additional, Watanabe, Eizo, additional, Yamaji, Yoshihiro, additional, Shimizu, Kazuyoshi, additional, Shiozaki, Kyoko, additional, Futami, Satoru, additional, Ryosuke, Sekine, additional, Saito, Koji, additional, Kameyama, Yoshinobu, additional, Ueno, Keiko, additional, Izawa, Masayo, additional, Okuda, Nao, additional, Suzuki, Hiroyuki, additional, Harasawa, Tomofumi, additional, Nasu, Michitaka, additional, Takada, Tadaaki, additional, Ito, Fumihito, additional, Nunomiya, Shin, additional, Koyama, Kansuke, additional, Abe, Toshikazu, additional, Andoh, Kohkichi, additional, Kusumoto, Kohei, additional, Hirata, Akira, additional, Takaba, Akihiro, additional, Kimura, Hiroyasu, additional, Matsumoto, Shuhei, additional, Higashijima, Ushio, additional, Honda, Hiroyuki, additional, Aoki, Nobumasa, additional, Imai, Hiroshi, additional, Ogino, Yasuaki, additional, Mizuguchi, Ichiko, additional, Ichikado, Kazuya, additional, Nitta, Kenichi, additional, Mochizuki, Katsunori, additional, Hashida, Tomoaki, additional, Tanaka, Hiroyuki, additional, Nakamura, Tomoyuki, additional, Niimi, Daisuke, additional, Ueda, Takeshi, additional, Kashiwa, Yozo, additional, Uchiyama, Akinori, additional, Sabelnikovs, Olegs, additional, Oss, Peteris, additional, Haddad, Youssef, additional, Liew, Kong Y, additional, Ñamendys-Silva, Silvio A, additional, Jarquin-Badiola, Yves D, additional, Sanchez-Hurtado, Luis A, additional, Gomez-Flores, Saira S, additional, Marin, Maria C, additional, Villagomez, Asisclo J, additional, Lemus, Jordana S, additional, Fierro, Jonathan M, additional, Cervantes, Mavy Ramirez, additional, Mejia, Francisco Javier Flores, additional, Gonzalez, Daniel R, additional, Dector, Dulce M, additional, Estrella, Claudia R, additional, Sanchez-Medina, Jorge R, 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Mcleod, Alex, additional, Casement, Jonathan, additional, Hacking, Danielle J, additional, Andersen, Finn H, additional, Dolva, Merete S, additional, Laake, Jon H, additional, Barratt-Due, Andreas, additional, Noremark, Kim Andre L, additional, Søreide, Eldar, additional, Sjøbø, Brit Å, additional, Guttormsen, Anne B, additional, Yoshido, Hector H Leon, additional, Aguilar, Ronald Zumaran, additional, Oscanoa, Fredy A Montes, additional, Alisasis, Alain U, additional, Robles, Joanne B, additional, Pasanting-Lim, Rossini Abbie B, additional, Tan, Beatriz C, additional, Andruszkiewicz, Pawel, additional, Jakubowska, Karina, additional, Cox, Cristina M, additional, Alvarez, António M, additional, Oliveira, Bruno S, additional, Montanha, Gustavo M, additional, Barros, Nelson C, additional, Pereira, Carlos S, additional, Messias, António M, additional, Monteiro, Jorge M, additional, Araujo, Ana M, additional, Catorze, Nuno T, additional, Marum, Susan M, additional, Bouw, Maria J, additional, Gomes, Rui M, additional, Brito, Vania A, additional, Castro, Silvia, additional, Estilita, Joana M, additional, Barros, Filipa M, additional, Serra, Isabel M, additional, Martinho, Aurelia M, additional, Tomescu, Dana R, additional, Marcu, Alexandra, additional, Bedreag, Ovidiu H, additional, Papurica, Marius, additional, Corneci, Dan E, additional, Negoita, Silvius Ioan, additional, Grigoriev, Evgeny, additional, Gritsan, Alexey I, additional, Gazenkampf, Andrey A, additional, Almekhlafi, Ghaleb, additional, Albarrak, Mohamad M, additional, Mustafa, Ghanem M, additional, Maghrabi, Khalid A, additional, Salahuddin, Nawal, additional, Aisa, Tharwat M, additional, Al Jabbary, Ahmed S, additional, Tabhan, Edgardo, additional, Arabi, Yaseen M, additional, Trinidad, Olivia A, additional, Al Dorzi, Hasan M, additional, Tabhan, Edgardo E, additional, Bolon, Stefan, additional, Smith, Oliver, additional, Mancebo, Jordi, additional, Aguirre-Bermeo, Hernan, additional, Lopez-Delgado, Juan C, additional, Esteve, Francisco, additional, Rialp, Gemma, additional, Forteza, Catalina, additional, De Haro, Candelaria, additional, Artigas, Antonio, additional, Albaiceta, Guillermo M, additional, De Cima-Iglesias, Sara, additional, Seoane-Quiroga, Leticia, additional, Ceniceros-Barros, Alexandra, additional, Ruiz-Aguilar, Antonio L, additional, Claraco-Vega, Luis M, additional, Soler, Juan Alfonso, additional, Lorente, Maria del Carmen, additional, Hermosa, Cecilia, additional, Gordo, Federico, additional, Prieto-González, Miryam, additional, López-Messa, Juan B, additional, Perez, Manuel P, additional, Pere, Cesar P, additional, Allue, Raquel Montoiro, additional, Roche-Campo, Ferran, additional, Ibañez-Santacruz, Marcos, additional, Temprano, Susana, additional, Pintado, Maria C, additional, De Pablo, Raul, additional, Gómez, Pilar Ricart Aroa, additional, Ruiz, Silvia Rodriguez, additional, Moles, Silvia Iglesias, additional, Jurado, Mª Teresa, additional, Arizmendi, Alfons, additional, Piacentini, Enrique A, additional, Franco, Nieves, additional, Honrubia, Teresa, additional, Perez Cheng, Meisy, additional, Perez Losada, Elena, additional, Blanco, Javier, additional, Yuste, Luis J, additional, Carbayo-Gorriz, Cecilia, additional, Cazorla-Barranquero, Francisca G, additional, Alonso, Javier G, additional, Alda, Rosa S, additional, Algaba, Ángela, additional, Navarro, Gonzalo, additional, Cereijo, Enrique, additional, Diaz-Rodriguez, Esther, additional, Marcos, Diego Pastor, additional, Montero, Laura Alvarez, additional, Para, Luis Herrera, additional, Sanchez, Roberto Jimenez, additional, Blasco Navalpotro, Miguel Angel, additional, Abad, Ricardo Diaz, additional, Montiel González, Raquel, additional, Toribio, Dácil Parrilla, additional, Castro, Alejandro G, additional, Artiga, Maria Jose D, additional, Penuelas, Oscar, additional, Roser, Tomas P, additional, Olga, Moreno F, additional, Curto, Elena Gallego, additional, Sánchez, Rocío Manzano, additional, Imma, Vallverdu P, additional, Elisabet, Garcia M, additional, Claverias, Laura, additional, Magret, Monica, additional, Pellicer, Ana M, additional, Rodriguez, Lucia L, additional, Sánchez-Ballesteros, Jesús, additional, González-Salamanca, Ángela, additional, Jimenez, Antonio G, additional, Huerta, Francisco P, additional, Diaz, Juan Carlos J Sotillo, additional, Lopez, Esther Bermejo, additional, Moya, David D Llinares, additional, Alfonso, Alec A Tallet, additional, Eugenio Luis, Palazon Sanchez, additional, Cesar, Palazon Sanchez, additional, Rafael, Sánchez I, additional, Virgilio, Corcoles G, additional, Recio, Noelia N, additional, Adamsson, Richard O, additional, Rylander, Christian C, additional, Holzgraefe, Bernhard, additional, Broman, Lars M, additional, Wessbergh, Joanna, additional, Persson, Linnea, additional, Schiöler, Fredrik, additional, Kedelv, Hans, additional, Tibblin, Anna Oscarsson, additional, Appelberg, Henrik, additional, Hedlund, Lars, additional, Helleberg, Johan, additional, Eriksson, Karin E, additional, Glietsch, Rita, additional, Larsson, Niklas, additional, Nygren, Ingela, additional, Nunes, Silvia L, additional, Morin, Anna-Karin, additional, Kander, Thomas, additional, Adolfsson, Anne, additional, Zender, Hervé O., additional, Leemann-Refondini, Corinne, additional, Elatrous, Souheil, additional, Bouchoucha, Slaheddine, additional, Chouchene, Imed, additional, Ouanes, Islem, additional, Ben Souissi, Asma, additional, Kamoun, Salma, additional, Demirkiran, Oktay, additional, Aker, Mustafa, additional, Erbabacan, Emre, additional, Ceylan, Ilkay, additional, Girgin, Nermin Kelebek, additional, Ozcelik, Menekse, additional, Ünal, Necmettin, additional, Meco, Basak Ceyda, additional, Akyol, Onat O, additional, Derman, Suleyman S, additional, Kennedy, Barry, additional, Parhar, Ken, additional, Srinivasa, Latha, additional, McAuley, Danny, additional, Steinberg, Jack, additional, Hopkins, Phil, additional, Mellis, Clare, additional, Stansil, Frank, additional, Kakar, Vivek, additional, Hadfield, Dan, additional, Brown, Christine, additional, Vercueil, Andre, additional, Bhowmick, Kaushik, additional, Humphreys, Sally K, additional, Ferguson, Andrew, additional, Mckee, Raymond, additional, Raj, Ashok S, additional, Fawkes, Danielle A, additional, Watt, Philip, additional, Twohey, Linda, additional, Thomas, Rajeev R Jha Matthew, additional, Morton, Alex, additional, Kadaba, Varsha, additional, Smith, Mark J, additional, Hormis, Anil P, additional, Kannan, Santhana G, additional, Namih, Miriam, additional, Reschreiter, Henrik, additional, Camsooksai, Julie, additional, Kumar, Alek, additional, Rugonfalvi, Szabolcs, additional, Nutt, Christopher, additional, Oneill, Orla, additional, Seasman, Colette, additional, Dempsey, Ged, additional, Scott, Christopher J, additional, Ellis, Helen E, additional, Mckechnie, Stuart, additional, Hutton, Paula J, additional, Di Tomasso, Nora N, additional, Vitale, Michela N, additional, Griffin, Ruth O, additional, Dean, Michael N, additional, Cranshaw, Julius H, additional, Willett, Emma L, additional, Ioannou, Nicholas, additional, Gillis, Sarah, additional, Csabi, Peter, additional, Macfadyen, Rosaleen, additional, Dawson, Heidi, additional, Preez, Pieter D, additional, Williams, Alexandra J, additional, Boyd, Owen, additional, De Gordoa, Laura Ortiz-Ruiz, additional, Bramall, Jon, additional, Symmonds, Sophie, additional, Chau, Simon K, additional, Wenham, Tim, additional, Szakmany, Tamas, additional, Toth-Tarsoly, Piroska, additional, Mccalman, Katie H, additional, Alexander, Peter, additional, Stephenson, Lorraine, additional, Collyer, Thomas, additional, Chapman, Rhiannon, additional, Cooper, Raphael, additional, Allan, Russell M, additional, Sim, Malcolm, additional, Wrathall, David W, additional, Irvine, Donald A, additional, Zantua, Kim S, additional, Adams, John C, additional, Burtenshaw, Andrew J, additional, Sellors, Gareth P, additional, Welters, Ingeborg D, additional, Williams, Karen E, additional, Hessell, Robert J, additional, Oldroyd, Matthew G, additional, Battle, Ceri E, additional, Pillai, Suresh, additional, Kajtor, Istvan, additional, Sivashanmugave, Mageswaran, additional, Okane, Sinead C, additional, Donnelly, Adrian, additional, Frigyik, Aniko D, additional, Careless, Jon P, additional, May, Martin M, additional, Stewart, Richard, additional, Trinder, T John, additional, Hagan, Samantha J, additional, Wise, Matt P, additional, Cole, Jade M, additional, MacFie, Caroline C, additional, Dowling, Anna T, additional, Nuñez, Edgardo, additional, Pittini, Gustavo, additional, Rodriguez, Ruben, additional, Imperio, María C, additional, Santos, Cristina, additional, França, Ana G., additional, Ebeid, Alejandro, additional, Deicas, Alberto, additional, Serra, Carolina, additional, Uppalapati, Aditya, additional, Kamel, Ghassan, additional, Banner-Goodspeed, Valerie M, additional, Beitler, Jeremy R, additional, Mukkera, Satyanarayana Reddy, additional, Kulkarni, Shreedhar, additional, Lee, Jarone, additional, Mesar, Tomaz, additional, Shinn Iii, John O, additional, Gomaa, Dina, additional, Tainter, Christopher, additional, Cowley, R Adams, additional, Yeatts, Dale J, additional, Warren, Jessica, additional, Lanspa, Michael J, additional, Miller, Russel R, additional, Grissom, Colin K, additional, Brown, Samuel M, additional, Bauer, Philippe R, additional, Gosselin, Ryan J, additional, Kitch, Barrett T, additional, Cohen, Jason E, additional, Beegle, Scott H, additional, Gueret, Renaud M, additional, Tulaimat, Aiman, additional, Choudry, Shazia, additional, Stigler, William, additional, Batra, Hitesh, additional, Huff, Nidhi G, additional, Lamb, Keith D, additional, Oetting, Trevor W, additional, Mohr, Nicholas M, additional, Judy, Claine, additional, Saito, Shigeki, additional, Kheir, Fayez M, additional, Schlichting, Adam B, additional, Delsing, Angela, additional, Elmasri, Mary, additional, Crouch, Daniel R, additional, Ismail, Dina, additional, Blakeman, Thomas C, additional, Dreyer, Kyle R, additional, Baron, Rebecca M, additional, Grijalba, Carolina Quintana, additional, Hou, Peter C, additional, Seethala, Raghu, additional, Aisiku, Imo, additional, Henderson, Galen, additional, Frendl, Gyorgy, additional, Hou, Sen-Kuang, additional, Owens, Robert L, additional, Schomer, Ashley, additional, Bumbasirevic, Vesna, additional, Jovanovic, Bojan, additional, Surbatovic, Maja, additional, and Veljovic, Milic, additional

Published
2022
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14. Association between Enterocyte Injury and Mortality in Patients on Hemodialysis Who Underwent Cardiac Surgery: An Exploratory Study

Author

Tetsuya Hara, Shuhei Matsumoto, Hiroyuki Funaoka, Taiga Ichinomiya, Ushio Higashijima, Osamu Yoshitomi, Kyoko Okada, Kiyoyuki Eishi, Shuntaro Sato, and Motohiro Sekino

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Fatty Acid-Binding Proteins, Logistic regression, Gastroenterology, law.invention, 03 medical and health sciences, Patient Admission, 0302 clinical medicine, Japan, Renal Dialysis, law, Internal medicine, medicine, Cardiopulmonary bypass, Humans, Hospital Mortality, Prospective Studies, Cardiac Surgical Procedures, Risk factor, Aged, business.industry, Odds ratio, Middle Aged, Intensive care unit, Confidence interval, Cardiac surgery, Intensive Care Units, Enterocytes, 030220 oncology & carcinogenesis, Female, 030211 gastroenterology & hepatology, Surgery, Hemodialysis, business
Abstract

Background Intestinal ischemia and enterocyte injury are significant causes of death after cardiac surgery. Hemodialysis is a well-known risk factor for intestinal ischemia. However, the relationship between enterocyte injury and mortality is unclear. This exploratory study assessed the association between intestinal fatty acid–binding protein (I-FABP), a specific marker of enterocyte injury, at intensive care unit (ICU) admission and in-hospital mortality in patients on hemodialysis who underwent cardiac surgery with cardiopulmonary bypass. Materials and methods Forty-seven consecutive patients on long-term hemodialysis who underwent elective cardiac surgery (median age, 70 y; men, 27 [57%]) were prospectively enrolled. The association between serum I-FABP levels at ICU admission and in-hospital mortality was compared with the associations between serum I-FABP levels and prognostic severity scores, vasoactive-inotropic scores, and lactate levels. Results Only I-FABP levels at ICU admission were significantly related to in-hospital mortality (odds ratio, 5.54; 95% confidence interval [CI], 1.08-28.43) in the simple logistic regression analysis. Univariate and multiple linear regression analyses indicated prolonged cardiopulmonary bypass (ρ, 0.49; 95% CI, 0.15-0.83), higher mean norepinephrine dose (ρ, 0.07; 95% CI, 0.02-0.12), lower mean dopamine dose (ρ, −0.51; 95% CI, −0.94 to −0.08), and intra-aortic balloon pump use (ρ, 3.63; 95% CI, 1.68-5.59) were significant risk factors for high I-FABP levels. Conclusions Enterocyte injury at ICU admission was associated with in-hospital mortality after cardiac surgery for patients on hemodialysis. Intraoperative hidden hypoperfusion of the intestine may impact prognoses. Enterocyte injury prevention, early diagnosis, and intervention for intestinal ischemia might be required to improve outcomes.

Published
2020

15. Lysine demethylase 2B regulates angiogenesis via Jumonji C dependent suppression of angiogenic transcription factors

Author

Sasaki, Yuji, primary, Higashijima, Yoshiki, additional, Suehiro, Jun-Ichi, additional, Sugasawa, Takehito, additional, Oguri-Nakamura, Eri, additional, Fukuhara, Shigetomo, additional, Nagai, Nao, additional, Hirakawa, Yosuke, additional, Wada, Youichiro, additional, Nangaku, Masaomi, additional, and Kanki, Yasuharu, additional

Published
2022
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17. Bivalent-histone-marked immediate-early gene regulation is vital for VEGF-responsive angiogenesis

Author

Kanki, Yasuharu, primary, Muramatsu, Masashi, additional, Miyamura, Yuri, additional, Kikuchi, Kenta, additional, Higashijima, Yoshiki, additional, Nakaki, Ryo, additional, Suehiro, Jun-ichi, additional, Sasaki, Yuji, additional, Kubota, Yoshiaki, additional, Koseki, Haruhiko, additional, Morioka, Hiroshi, additional, Kodama, Tatsuhiko, additional, Nakao, Mitsuyoshi, additional, Kurotaki, Daisuke, additional, Aburatani, Hiroyuki, additional, and Minami, Takashi, additional

Published
2022
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18. Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies

Author

Pisani, Luigi, primary, Algera, Anna Geke, additional, Neto, Ary Serpa, additional, Azevedo, Luciano, additional, Pham, Tài, additional, Paulus, Frederique, additional, de Abreu, Marcelo Gama, additional, Pelosi, Paolo, additional, Dondorp, Arjen M, additional, Bellani, Giacomo, additional, Laffey, John G, additional, Schultz, Marcus J, additional, Martinez, Amadeu, additional, Leal, Livia, additional, Jorge Pereira, Antonio, additional, de Oliveira Maia, Marcelo, additional, Neto, Josè Aires, additional, Piras, Claudio, additional, Caser, Eliana Bernadete, additional, Moreira, Cora Lavigne, additional, Braga Gusman, Pablo, additional, Dalcomune, Dyanne Moysés, additional, Ribeiro de Carvalho, Alexandre Guilherme, additional, Gondim, Louise Aline Romão, additional, Castelo Branco Reis, Lívia Mariane, additional, da Cunha Ribeiro, Daniel, additional, de Assis Simões, Leonardo, additional, Campos, Rafaela Siqueira, additional, Fernandez Versiani dos Anjos, José Carlos, additional, Bruzzi Carvalho, Frederico, additional, Alves, Rossine Ambrosio, additional, Nunes, Lilian Batista, additional, Réa-Neto, Álvaro, additional, de Oliveira, Mirella Cristine, additional, Tannous, Luana, additional, Cardoso Gomes, Brenno, additional, Rodriguez, Fernando Borges, additional, Abelha, Priscila, additional, Lugarinho, Marcelo E, additional, Japiassu, Andre, additional, de Melo, Hélder Konrad, additional, Lopes, Elton Afonso, additional, Varaschin, Pedro, additional, de Souza Dantas, Vicente Cés, additional, Freitas Knibel, Marcos, additional, Ponte, Micheli, additional, de Azambuja Rodrigues, Pedro Mendes, additional, Costa Filho, Rubens Carmo, additional, Saddy, Felipe, additional, Wanderley Castellões, Théia Forny, additional, Silva, Suzana Alves, additional, Osorio, Luiz Antonio Gomes, additional, Mannarino, Dora, additional, Espinoza, Rodolfo, additional, Righy, Cassia, additional, Soares, Marcio, additional, Salluh, Jorge, additional, Tanaka, Lilian, additional, Aragão, Daniel, additional, Tavares, Maria Eduarda, additional, Kehdi, Maura Goncalves Pereira, additional, Rezende, Valéria Maria Campos, additional, Carbonell, Roberto Carlos Cruz, additional, Teixeira, Cassiano, additional, de Oliveira, Roselaine Pinheiro, additional, Maccari, Juçara Gasparetto, additional, Castro, Priscylla Souza, additional, Berto, Paula, additional, Schwarz, Patricia, additional, Torelly, André Peretti, additional, Lisboa, Thiago, additional, Moraes, Edison, additional, Dal-Pizzol, Felipe, additional, Tomasi Damiani, Cristiane, additional, Ritter, Cristiane, additional, Ferreira, Juliana Carvalho, additional, Teixeira Costa, Ramon, additional, Caruso, Pedro, additional, Amendola, Cristina Prata, additional, de Oliveira, Amanda Maria R R, additional, Silva, Ulysses V A, additional, Sanches, Luciana Coelho, additional, Almeida, Rosana D S, additional, Azevedo, Luciano Cesar, additional, Park, Marcelo, additional, Schettino, Guilherme, additional, Assunção, Murillo Santucci, additional, Silva, Eliezer, additional, Barboza, Carlos Eduardo, additional, Junior, Antonio Paulo Nassar, additional, Marzocchi Tierno, Paulo Fernando G M, additional, Malbouisson, Luis Marcelo, additional, Oliveira, Lucas, additional, Cristovao, Davi, additional, Neto, Manoel Leitão, additional, Rego, Ênio, additional, Fernandes, Fernanda Eugênia, additional, Romano, Marcelo Luz Pereira, additional, Cavalcanti, Alexandre Biasi, additional, de Souza Barros, Dalton, additional, Suzumura, Érica Aranha, additional, Meira, Karla Loureiro, additional, de Oliveira, Gustavo Affonso, additional, Luciano, Paula Menezes, additional, Pacheco, Evelin Drociunas, additional, Mazza, Bruno Franco, additional, Machado, Flavia Ribeiro, additional, Ferreira, Elaine, additional, dos Santos, Ronaldo Batista, additional, Colombo, Alexandra Siqueira, additional, Nogueira, Antonio Carlos, additional, Fernandes, Juliana Baroni, additional, Nóbrega, Raquel Siqueira, additional, do CS Martins, Barbara, additional, Soriano, Francisco, additional, Morsch, Rafaela Deczka, additional, Nunes, Andre Luiz Baptiston, additional, de Almeida, Juliano Pinheiro, additional, Hajjar, Ludhmila, additional, Moulin, Sílvia, additional, Giannini, Fábio Poianas, additional, Baptiston Nunes, Andre Luiz, additional, Rios, Fernando, additional, Van Haren, Frank, additional, Sottiaux, T, additional, Lora, Fredy S, additional, Azevedo, Luciano C, additional, Depuydt, P, additional, Fan, Eddy, additional, Bugedo, Guillermo, additional, Qiu, Haibo, additional, Gonzalez, Marcos, additional, Silesky, Juan, additional, Cerny, Vladimir, additional, Nielsen, Jonas, additional, Jibaja, Manuel, additional, Wrigge, Hermann, additional, Matamis, Dimitrios, additional, Ranero, Jorge Luis, additional, Hashemian, S M, additional, Amin, Pravin, additional, Clarkson, Kevin, additional, Kurahashi, Kiyoyasu, additional, Villagomez, Asisclo, additional, Zeggwagh, Amine Ali, additional, Heunks, Leo M, additional, Laake, Jon Henrik, additional, Palo, Jose Emmanuel, additional, do Vale Fernandes, Antero, additional, Sandesc, Dorel, additional, Arabi, Yaasen, additional, Bumbasierevic, Vesna, additional, Lorente, Jose A, additional, Larsson, Anders, additional, Piquilloud, Lise, additional, Abroug, Fekri, additional, McAuley, Daniel F, additional, McNamee, Lia, additional, Hurtado, Javier, additional, Bajwa, Ed, additional, Démpaire, Gabriel, additional, Francois, Guy M, additional, Sula, Hektor, additional, Nunci, Lordian, additional, Cani, Alma, additional, Zazu, Alan, additional, Dellera, Christian, additional, Insaurralde, Carolina S, additional, Alejandro, Risso V, additional, Daldin, Julio, additional, Vinzio, Mauricio, additional, Fernandez, Ruben O, additional, Cardonnet, Luis P, additional, Bettini, Lisandro R, additional, Bisso, Mariano Carboni, additional, Osman, Emilio M, additional, Setten, Mariano G, additional, Lovazzano, Pablo, additional, Alvarez, Javier, additional, Villar, Veronica, additional, Milstein, Cesar, additional, Pozo, Norberto C, additional, Grubissich, Nicolas, additional, Plotnikow, Gustavo A, additional, Vasquez, Daniela N, additional, Ilutovich, Santiago, additional, Tiribelli, Norberto, additional, Chena, Ariel, additional, Pellegrini, Carlos A, additional, Saenz, María G, additional, Estenssoro, Elisa, additional, Brizuela, Matias, additional, Gianinetto, Hernan, additional, Gomez, Pablo E, additional, Cerrato, Valeria I, additional, Bezzi, Marco G, additional, Borello, Silvina A, additional, Loiacono, Flavia A, additional, Fernandez, Adriana M, additional, Knowles, Serena, additional, Reynolds, Claire, additional, Inskip, Deborah M, additional, Miller, Jennene J, additional, Kong, Jing, additional, Whitehead, Christina, additional, Bihari, Shailesh, additional, Seven, Aylin, additional, Krstevski, Amanda, additional, Rodgers, Helen J, additional, Millar, Rebecca T, additional, Mckenna, Toni E, additional, Bailey, Irene M, additional, Hanlon, Gabrielle C, additional, Aneman, Anders, additional, Lynch, Joan M, additional, Azad, Raman, additional, Neal, John, additional, Woods, Paul W, additional, Roberts, Brigit L, additional, Kol, Mark R, additional, Wong, Helen S, additional, Riss, Katharina C, additional, Staudinger, Thomas, additional, Wittebole, Xavier, additional, Berghe, Caroline, additional, Bulpa, Pierre A, additional, Dive, Alain M, additional, Verstraete, Rik, additional, Lebbinck, Herve, additional, Depuydt, Pieter, additional, Vermassen, Joris, additional, Meersseman, Philippe, additional, Ceunen, Helga, additional, Rosa, Jonas I, additional, Beraldo, Daniel O, additional, Ampinelli, Adenilton M R, additional, Nassar Jr, Antonio P, additional, Mataloun, Sergio, additional, Moock, Marcelo, additional, Thompson, Marlus M, additional, Gonçalves, Claudio H, additional, Antônio, Ana Carolina P, additional, Ascoli, Aline, additional, Biondi, Rodrigo S, additional, Fontenele, Danielle C, additional, Nobrega, Danielle, additional, Sales, Vanessa M, additional, Shindhe, Suresh, additional, Ismail, Dk Maizatul Aiman B Pg Hj, additional, Laffey, John, additional, Beloncle, Francois, additional, Davies, Kyle G, additional, Cirone, Rob, additional, Manoharan, Venika, additional, Ismail, Mehvish, additional, Goligher, Ewan C, additional, Jassal, Mandeep, additional, Nishikawa, Erin, additional, Javeed, Areej, additional, Curley, Gerard, additional, Rittayamai, Nuttapol, additional, Parotto, Matteo, additional, Ferguson, Niall D, additional, Mehta, Sangeeta, additional, Knoll, Jenny, additional, Pronovost, Antoine, additional, Canestrini, Sergio, additional, Bruhn, Alejandro R, additional, Garcia, Patricio H, additional, Aliaga, Felipe A, additional, Farías, Pamela A, additional, Yumha, Jacob S, additional, Ortiz, Claudia A, additional, Salas, Javier E, additional, Saez, Alejandro A, additional, Vega, Luis D, additional, Labarca, Eduardo F, additional, Martinez, Felipe T, additional, Carreño, Nicolás G, additional, Lora, Pilar, additional, Liu, Haitao, additional, Liu, Ling, additional, Tang, Rui, additional, Luo, Xiaoming, additional, An, Youzhong, additional, Zhao, Huiying, additional, Gao, Yan, additional, Zhai, Zhe, additional, Ye, Zheng L, additional, Wang, Wei, additional, Li, Wenwen, additional, Li, Qingdong, additional, Zheng, Ruiqiang, additional, Yu, Wenkui, additional, Shen, Juanhong, additional, Li, Xinyu, additional, Yu, Tao, additional, Lu, Weihua, additional, Wu, Ya Q, additional, Huang, Xiao B, additional, He, Zhenyang, additional, Lu, Yuanhua, additional, Han, Hui, additional, Zhang, Fan, additional, Sun, Renhua, additional, Wang, Hua X, additional, Qin, Shu H, additional, Zhu, Bao H, additional, Zhao, Jun, additional, Liu, Jian, additional, Li, Bin, additional, Liu, Jing L, additional, Zhou, Fa C, additional, Li, Qiong J, additional, Zhang, Xing Y, additional, Li-Xin, Zhou, additional, Xin-Hua, Qiang, additional, Jiang, Liangyan, additional, Gao, Yuan N, additional, Zhao, Xian Y, additional, Li, Yuan Y, additional, Li, Xiao L, additional, Wang, Chunting, additional, Yao, Qingchun, additional, Yu, Rongguo, additional, Chen, Kai, additional, Shao, Huanzhang, additional, Qin, Bingyu, additional, Huang, Qing Q, additional, Zhu, Wei H, additional, Hang, Ai Y, additional, Hua, Ma X, additional, Li, Yimin, additional, Xu, Yonghao, additional, Di, Yu D, additional, Ling, Long L, additional, Qin, Tie H, additional, Wang, Shou H, additional, Qin, Junping, additional, Han, Yi, additional, Zhou, Suming, additional, Vargas, Monica P, additional, Silesky Jimenez, Juan I, additional, González Rojas, Manuel A, additional, Solis-Quesada, Jaime E, additional, Ramirez-Alfaro, Christian M, additional, Máca, Jan, additional, Sklienka, Peter, additional, Gjedsted, Jakob, additional, Christiansen, Aage, additional, Villamagua, Boris G, additional, Llano, Miguel, additional, Burtin, Philippe, additional, Buzancais, Gautier, additional, Beuret, Pascal, additional, Pelletier, Nicolas, additional, Mortaza, Satar, additional, Mercat, Alain, additional, Chelly, Jonathan, additional, Jochmans, Sébastien, additional, Terzi, Nicolas, additional, Daubin, Cédric, additional, Carteaux, Guillaume, additional, de Prost, Nicolas, additional, Chiche, Jean-Daniel, additional, Daviaud, Fabrice, additional, Pham, Tai, additional, Fartoukh, Muriel, additional, Barberet, Guillaume, additional, Biehler, Jerome, additional, Dellamonica, Jean, additional, Doyen, Denis, additional, Arnal, Jean-Michel, additional, Briquet, Anais, additional, Hraiech, Sami, additional, Papazian, Laurent, additional, Follin, Arnaud, additional, Roux, Damien, additional, Messika, Jonathan, additional, Kalaitzis, Evangelos, additional, Dangers, Laurence, additional, Combes, Alain, additional, Au, Siu-Ming, additional, Béduneau, Gaetan, additional, Carpentier, Dorothée, additional, Zogheib, Elie H, additional, Dupont, Herve, additional, Ricome, Sylvie, additional, Santoli, Francesco L, additional, Besset, Sebastien L, additional, Michel, Philippe, additional, Gelée, Bruno, additional, Danin, Pierre-Eric, additional, Goubaux, Bernard, additional, Crova, Philippe J, additional, Phan, Nga T, additional, Berkelmans, Frantz, additional, Badie, Julio C, additional, Tapponnier, Romain, additional, Gally, Josette, additional, Khebbeb, Samy, additional, Herbrecht, Jean-Etienne, additional, Schneider, Francis, additional, Declercq, Pierre-Louis M, additional, Rigaud, Jean-Philippe, additional, Duranteau, Jacques, additional, Harrois, Anatole, additional, Chabanne, Russell, additional, Marin, Julien, additional, Bigot, Charlene, additional, Thibault, Sandrine, additional, Ghazi, Mohammed, additional, Boukhazna, Messabi, additional, Ould Zein, Salem, additional, Richecoeur, Jack R, additional, Combaux, Daniele M, additional, Grelon, Fabien, additional, Le Moal, Charlene, additional, Sauvadet, Elise P, additional, Robine, Adrien, additional, Lemiale, Virginie, additional, Reuter, Danielle, additional, Dres, Martin, additional, Demoule, Alexandre, additional, Goldgran-Toledano, Dany, additional, Baboi, Loredana, additional, Guérin, Claude, additional, Lohner, Ralph, additional, Kraßler, Jens, additional, Schäfer, Susanne, additional, Zacharowski, Kai D, additional, Meybohm, Patrick, additional, Reske, Andreas W, additional, Simon, Philipp, additional, Hopf, Hans-Bernd F, additional, Schuetz, Michael, additional, Baltus, Thomas, additional, Papanikolaou, Metaxia N, additional, Papavasilopoulou, Theonymfi G, additional, Zacharas, Giannis A, additional, Ourailogloy, Vasilis, additional, Mouloudi, Eleni K, additional, Massa, Eleni V, additional, Nagy, Eva O, additional, Stamou, Electra E, additional, Kiourtzieva, Ellada V, additional, Oikonomou, Marina A, additional, Avila, Luis E, additional, Cortez, Cesar A, additional, Citalán, Johanna E, additional, Jog, Sameer A, additional, Sable, Safal D, additional, Shah, Bhagyesh, additional, Gurjar, Mohan, additional, Baronia, Arvind K, additional, Memon, Mohammedfaruk, additional, Muthuchellappan, Radhakrishnan, additional, Ramesh, Venkatapura J, additional, Shenoy, Anitha, additional, Unnikrishnan, Ramesh, additional, Dixit, Subhal B, additional, Rhayakar, Rachana V, additional, Ramakrishnan, Nagarajan, additional, Bhardwaj, Vallish K, additional, Mahto, Heera L, additional, Sagar, Sudha V, additional, Palaniswamy, Vijayanand, additional, Ganesan, Deeban, additional, Mohammadreza Hashemian, Seyed, additional, Jamaati, Hamidreza, additional, Heidari, Farshad, additional, Meaney, Edel A, additional, Nichol, Alistair, additional, Knapman, Karl M, additional, O'Croinin, Donall, additional, Dunne, Eimhin S, additional, Breen, Dorothy M, additional, Clarkson, Kevin P, additional, Jaafar, Rola F, additional, Dwyer, Rory, additional, Amir, Fahd, additional, Ajetunmobi, Olaitan O, additional, O'Muircheartaigh, Aogan C, additional, Black, Colin S, additional, Treanor, Nuala, additional, Collins, Daniel V, additional, Altaf, Wahid, additional, Zani, Gianluca, additional, Fusari, Maurizio, additional, Spadaro, Savino, additional, Volta, Carlo A, additional, Graziani, Romano, additional, Brunettini, Barbara, additional, Palmese, Salvatore, additional, Formenti, Paolo, additional, Umbrello, Michele, additional, Lombardo, Andrea, additional, Pecci, Elisabetta, additional, Botteri, Marco, additional, Savioli, Monica, additional, Protti, Alessandro, additional, Mattei, Alessia, additional, Schiavoni, Lorenzo, additional, Tinnirello, Andrea, additional, Todeschini, Manuel, additional, Giarratano, Antonino, additional, Cortegiani, Andrea, additional, Sher, Sara, additional, Rossi, Anna, additional, Antonelli, Massimo M, additional, Montini, Luca M, additional, Casalena, Paolo, additional, Scafetti, Sergio, additional, Panarello, Giovanna, additional, Occhipinti, Giovanna, additional, Patroniti, Nicolò, additional, Pozzi, Matteo, additional, Biscione, Roberto R, additional, Poli, Michela M, additional, Raimondi, Ferdinando, additional, Albiero, Daniela, additional, Crapelli, Giulia, additional, Beck, Eduardo, additional, Pota, Vincenzo, additional, Schiavone, Vincenzo, additional, Molin, Alexandre, additional, Tarantino, Fabio, additional, Monti, Giacomo, additional, Frati, Elena, additional, Mirabella, Lucia, additional, Cinnella, Gilda, additional, Fossali, Tommaso, additional, Colombo, Riccardo, additional, Terragni, Pierpaolo, additional, Pattarino, Ilaria, additional, Mojoli, Francesco, additional, Braschi, Antonio, additional, Borotto, Erika E, additional, Cracchiolo, Andrea N, additional, Palma, Daniela M, additional, Raponi, Francesco, additional, Foti, Giuseppe, additional, Vascotto, Ettore R, additional, Coppadoro, Andrea, additional, Brazzi, Luca, additional, Floris, Leda, additional, Iotti, Giorgio A, additional, Venti, Aaron, additional, Yamaguchi, Osamu, additional, Takagi, Shunsuke, additional, Maeyama, Hiroki N, additional, Watanabe, Eizo, additional, Yamaji, Yoshihiro, additional, Shimizu, Kazuyoshi, additional, Shiozaki, Kyoko, additional, Futami, Satoru, additional, Ryosuke, Sekine, additional, Saito, Koji, additional, Kameyama, Yoshinobu, additional, Ueno, Keiko, additional, Izawa, Masayo, additional, Okuda, Nao, additional, Suzuki, Hiroyuki, additional, Harasawa, Tomofumi, additional, Nasu, Michitaka, additional, Takada, Tadaaki, additional, Ito, Fumihito, additional, Nunomiya, Shin, additional, Koyama, Kansuke, additional, Abe, Toshikazu, additional, Andoh, Kohkichi, additional, Kusumoto, Kohei, additional, Hirata, Akira, additional, Takaba, Akihiro, additional, Kimura, Hiroyasu, additional, Matsumoto, Shuhei, additional, Higashijima, Ushio, additional, Honda, Hiroyuki, additional, Aoki, Nobumasa, additional, Imai, Hiroshi, additional, Ogino, Yasuaki, additional, Mizuguchi, Ichiko, additional, Ichikado, Kazuya, additional, Nitta, Kenichi, additional, Mochizuki, Katsunori, additional, Hashida, Tomoaki, additional, Tanaka, Hiroyuki, additional, Nakamura, Tomoyuki, additional, Niimi, Daisuke, additional, Ueda, Takeshi, additional, Kashiwa, Yozo, additional, Uchiyama, Akinori, additional, Sabelnikovs, Olegs, additional, Oss, Peteris, additional, Haddad, Youssef, additional, Liew, Kong Y, additional, Ñamendys-Silva, Silvio A, additional, Jarquin-Badiola, Yves D, additional, Sanchez-Hurtado, Luis A, additional, Gomez-Flores, Saira S, additional, Marin, Maria C, additional, Villagomez, Asisclo J, additional, Lemus, Jordana S, additional, Fierro, Jonathan M, additional, Cervantes, Mavy Ramirez, additional, Mejia, Francisco Javier Flores, additional, Gonzalez, Daniel R, additional, Dector, Dulce M, additional, Estrella, Claudia R, additional, Sanchez-Medina, Jorge R, additional, Ramirez-Gutierrez, Alvaro, additional, George, Fernando G, additional, Aguirre, Janet S, additional, Buensuseso, Juan A, additional, Poblano, Manuel, additional, Dendane, Tarek, additional, Balkhi, Hicham, additional, Elkhayari, Mina, additional, Samkaoui, Nacer, additional, Ezzouine, Hanane, additional, Benslama, Abdellatif, additional, Amor, Mourad, additional, Maazouzi, Wajdi, additional, Cimic, Nedim, additional, Beck, Oliver, additional, Bruns, Monique M, additional, Schouten, Jeroen A, additional, Rinia, Myra, additional, Raaijmakers, Monique, additional, Van Wezel, Hellen M, additional, Heines, Serge J, additional, Buise, Marc P, additional, Simonis, Fabienne D, additional, Goodson, Jennifer C, additional, rowne, Troy S B, additional, Navarra, Leanlove, additional, Hunt, Anna, additional, Hutchison, Robyn A, additional, Bailey, Mathew B, additional, Newby, Lynette, additional, Mcarthur, Colin, additional, Kalkoff, Michael, additional, Mcleod, Alex, additional, Casement, Jonathan, additional, Hacking, Danielle J, additional, Andersen, Finn H, additional, Dolva, Merete S, additional, Laake, Jon H, additional, Barratt-Due, Andreas, additional, Noremark, Kim Andre L, additional, Søreide, Eldar, additional, Sjøbø, Brit Å, additional, Guttormsen, Anne B, additional, Yoshido, Hector H Leon, additional, Aguilar, Ronald Zumaran, additional, Oscanoa, Fredy A Montes, additional, Alisasis, Alain U, additional, Robles, Joanne B, additional, Pasanting-Lim, Rossini Abbie B, additional, Tan, Beatriz C, additional, Andruszkiewicz, Pawel, additional, Jakubowska, Karina, additional, Cox, Cristina M, additional, Alvarez, António M, additional, Oliveira, Bruno S, additional, Montanha, Gustavo M, additional, Barros, Nelson C, additional, Pereira, Carlos S, additional, Messias, António M, additional, Monteiro, Jorge M, additional, Araujo, Ana M, additional, Catorze, Nuno T, additional, Marum, Susan M, additional, Bouw, Maria J, additional, Gomes, Rui M, additional, Brito, Vania A, additional, Castro, Silvia, additional, Estilita, Joana M, additional, Barros, Filipa M, additional, Serra, Isabel M, additional, Martinho, Aurelia M, additional, Tomescu, Dana R, additional, Marcu, Alexandra, additional, Bedreag, Ovidiu H, additional, Papurica, Marius, additional, Corneci, Dan E, additional, Negoita, Silvius Ioan, additional, Grigoriev, Evgeny, additional, Gritsan, Alexey I, additional, Gazenkampf, Andrey A, additional, Almekhlafi, Ghaleb, additional, Albarrak, Mohamad M, additional, Mustafa, Ghanem M, additional, Maghrabi, Khalid A, additional, Salahuddin, Nawal, additional, Aisa, Tharwat M, additional, Al Jabbary, Ahmed S, additional, Tabhan, Edgardo, additional, Arabi, Yaseen M, additional, Trinidad, Olivia A, additional, Al Dorzi, Hasan M, additional, Tabhan, Edgardo E, additional, Bolon, Stefan, additional, Smith, Oliver, additional, Mancebo, Jordi, additional, Aguirre-Bermeo, Hernan, additional, Lopez-Delgado, Juan C, additional, Esteve, Francisco, additional, Rialp, Gemma, additional, Forteza, Catalina, additional, De Haro, Candelaria, additional, Artigas, Antonio, additional, Albaiceta, Guillermo M, additional, De Cima-Iglesias, Sara, additional, Seoane-Quiroga, Leticia, additional, Ceniceros-Barros, Alexandra, additional, Ruiz-Aguilar, Antonio L, additional, Claraco-Vega, Luis M, additional, Soler, Juan Alfonso, additional, Lorente, Maria del Carmen, additional, Hermosa, Cecilia, additional, Gordo, Federico, additional, Prieto-González, Miryam, additional, López-Messa, Juan B, additional, Perez, Manuel P, additional, Pere, Cesar P, additional, Allue, Raquel Montoiro, additional, Roche-Campo, Ferran, additional, Ibañez-Santacruz, Marcos, additional, Temprano, Susana, additional, Pintado, Maria C, additional, De Pablo, Raul, additional, Gómez, Pilar Ricart Aroa, additional, Ruiz, Silvia Rodriguez, additional, Moles, Silvia Iglesias, additional, Jurado, Mª Teresa, additional, Arizmendi, Alfons, additional, Piacentini, Enrique A, additional, Franco, Nieves, additional, Honrubia, Teresa, additional, Perez Cheng, Meisy, additional, Perez Losada, Elena, additional, Blanco, Javier, additional, Yuste, Luis J, additional, Carbayo-Gorriz, Cecilia, additional, Cazorla-Barranquero, Francisca G, additional, Alonso, Javier G, additional, Alda, Rosa S, additional, Algaba, Ángela, additional, Navarro, Gonzalo, additional, Cereijo, Enrique, additional, Diaz-Rodriguez, Esther, additional, Marcos, Diego Pastor, additional, Montero, Laura Alvarez, additional, Para, Luis Herrera, additional, Sanchez, Roberto Jimenez, additional, Blasco Navalpotro, Miguel Angel, additional, Abad, Ricardo Diaz, additional, Montiel González, Raquel, additional, Toribio, Dácil Parrilla, additional, Castro, Alejandro G, additional, Artiga, Maria Jose D, additional, Penuelas, Oscar, additional, Roser, Tomas P, additional, Olga, Moreno F, additional, Curto, Elena Gallego, additional, Sánchez, Rocío Manzano, additional, Imma, Vallverdu P, additional, Elisabet, Garcia M, additional, Claverias, Laura, additional, Magret, Monica, additional, Pellicer, Ana M, additional, Rodriguez, Lucia L, additional, Sánchez-Ballesteros, Jesús, additional, González-Salamanca, Ángela, additional, Jimenez, Antonio G, additional, Huerta, Francisco P, additional, Diaz, Juan Carlos J Sotillo, additional, Lopez, Esther Bermejo, additional, Moya, David D Llinares, additional, Alfonso, Alec A Tallet, additional, Eugenio Luis, Palazon Sanchez, additional, Cesar, Palazon Sanchez, additional, Rafael, Sánchez I, additional, Virgilio, Corcoles G, additional, Recio, Noelia N, additional, Adamsson, Richard O, additional, Rylander, Christian C, additional, Holzgraefe, Bernhard, additional, Broman, Lars M, additional, Wessbergh, Joanna, additional, Persson, Linnea, additional, Schiöler, Fredrik, additional, Kedelv, Hans, additional, Tibblin, Anna Oscarsson, additional, Appelberg, Henrik, additional, Hedlund, Lars, additional, Helleberg, Johan, additional, Eriksson, Karin E, additional, Glietsch, Rita, additional, Larsson, Niklas, additional, Nygren, Ingela, additional, Nunes, Silvia L, additional, Morin, Anna-Karin, additional, Kander, Thomas, additional, Adolfsson, Anne, additional, Zender, Hervé O, additional, Leemann-Refondini, Corinne, additional, Elatrous, Souheil, additional, Bouchoucha, Slaheddine, additional, Chouchene, Imed, additional, Ouanes, Islem, additional, Ben Souissi, Asma, additional, Kamoun, Salma, additional, Demirkiran, Oktay, additional, Aker, Mustafa, additional, Erbabacan, Emre, additional, Ceylan, Ilkay, additional, Girgin, Nermin Kelebek, additional, Ozcelik, Menekse, additional, Ünal, Necmettin, additional, Meco, Basak Ceyda, additional, Akyol, Onat O, additional, Derman, Suleyman S, additional, Kennedy, Barry, additional, Parhar, Ken, additional, Srinivasa, Latha, additional, McAuley, Danny, additional, Steinberg, Jack, additional, Hopkins, Phil, additional, Mellis, Clare, additional, Stansil, Frank, additional, Kakar, Vivek, additional, Hadfield, Dan, additional, Brown, Christine, additional, Vercueil, Andre, additional, Bhowmick, Kaushik, additional, Humphreys, Sally K, additional, Ferguson, Andrew, additional, Mckee, Raymond, additional, Raj, Ashok S, additional, Fawkes, Danielle A, additional, Watt, Philip, additional, Twohey, Linda, additional, Thomas, Rajeev R Jha Matthew, additional, Morton, Alex, additional, Kadaba, Varsha, additional, Smith, Mark J, additional, Hormis, Anil P, additional, Kannan, Santhana G, additional, Namih, Miriam, additional, Reschreiter, Henrik, additional, Camsooksai, Julie, additional, Kumar, Alek, additional, Rugonfalvi, Szabolcs, additional, Nutt, Christopher, additional, Oneill, Orla, additional, Seasman, Colette, additional, Dempsey, Ged, additional, Scott, Christopher J, additional, Ellis, Helen E, additional, Mckechnie, Stuart, additional, Hutton, Paula J, additional, Di Tomasso, Nora N, additional, Vitale, Michela N, additional, Griffin, Ruth O, additional, Dean, Michael N, additional, Cranshaw, Julius H, additional, Willett, Emma L, additional, Ioannou, Nicholas, additional, Gillis, Sarah, additional, Csabi, Peter, additional, Macfadyen, Rosaleen, additional, Dawson, Heidi, additional, Preez, Pieter D, additional, Williams, Alexandra J, additional, Boyd, Owen, additional, De Gordoa, Laura Ortiz-Ruiz, additional, Bramall, Jon, additional, Symmonds, Sophie, additional, Chau, Simon K, additional, Wenham, Tim, additional, Szakmany, Tamas, additional, Toth-Tarsoly, Piroska, additional, Mccalman, Katie H, additional, Alexander, Peter, additional, Stephenson, Lorraine, additional, Collyer, Thomas, additional, Chapman, Rhiannon, additional, Cooper, Raphael, additional, Allan, Russell M, additional, Sim, Malcolm, additional, Wrathall, David W, additional, Irvine, Donald A, additional, Zantua, Kim S, additional, Adams, John C, additional, Burtenshaw, Andrew J, additional, Sellors, Gareth P, additional, Welters, Ingeborg D, additional, Williams, Karen E, additional, Hessell, Robert J, additional, Oldroyd, Matthew G, additional, Battle, Ceri E, additional, Pillai, Suresh, additional, Kajtor, Istvan, additional, Sivashanmugave, Mageswaran, additional, Okane, Sinead C, additional, Donnelly, Adrian, additional, Frigyik, Aniko D, additional, Careless, Jon P, additional, May, Martin M, additional, Stewart, Richard, additional, Trinder, T John, additional, Hagan, Samantha J, additional, Wise, Matt P, additional, Cole, Jade M, additional, MacFie, Caroline C, additional, Dowling, Anna T, additional, Nin, Nicolás, additional, Nuñez, Edgardo, additional, Pittini, Gustavo, additional, Rodriguez, Ruben, additional, Imperio, María C, additional, Santos, Cristina, additional, França, Ana G, additional, Ebeid, Alejandro, additional, Deicas, Alberto, additional, Serra, Carolina, additional, Uppalapati, Aditya, additional, Kamel, Ghassan, additional, Banner-Goodspeed, Valerie M, additional, Beitler, Jeremy R, additional, Mukkera, Satyanarayana Reddy, additional, Kulkarni, Shreedhar, additional, Lee, Jarone, additional, Mesar, Tomaz, additional, Shinn Iii, John O, additional, Gomaa, Dina, additional, Tainter, Christopher, additional, Cowley, R Adams, additional, Yeatts, Dale J, additional, Warren, Jessica, additional, Lanspa, Michael J, additional, Miller, Russel R, additional, Grissom, Colin K, additional, Brown, Samuel M, additional, Bauer, Philippe R, additional, Gosselin, Ryan J, additional, Kitch, Barrett T, additional, Cohen, Jason E, additional, Beegle, Scott H, additional, Gueret, Renaud M, additional, Tulaimat, Aiman, additional, Choudry, Shazia, additional, Stigler, William, additional, Batra, Hitesh, additional, Huff, Nidhi G, additional, Lamb, Keith D, additional, Oetting, Trevor W, additional, Mohr, Nicholas M, additional, Judy, Claine, additional, Saito, Shigeki, additional, Kheir, Fayez M, additional, Schlichting, Adam B, additional, Delsing, Angela, additional, Elmasri, Mary, additional, Crouch, Daniel R, additional, Ismail, Dina, additional, Blakeman, Thomas C, additional, Dreyer, Kyle R, additional, Baron, Rebecca M, additional, Grijalba, Carolina Quintana, additional, Hou, Peter C, additional, Seethala, Raghu, additional, Aisiku, Imo, additional, Henderson, Galen, additional, Frendl, Gyorgy, additional, Hou, Sen-Kuang, additional, Owens, Robert L, additional, Schomer, Ashley, additional, Bumbasirevic, Vesna, additional, Jovanovic, Bojan, additional, Surbatovic, Maja, additional, Veljovic, Milic, additional, Rodgers, Helen, additional, Dixon, Barry, additional, Smith, Roger, additional, Kol, Mark, additional, Wong, Helen, additional, Schmid, Werner, additional, Hermans, Greet, additional, Bourgeois, Marc, additional, Anquez, Nathalie, additional, Decruyenaere, Johan, additional, DeCrop, Luc, additional, Souza dos Santos, Rafaella, additional, Beraldo, Daniel, additional, dos Santos, Moreno Calcagnotto, additional, Pellegrini, Jose Augusto Santos, additional, Oliveira, Vanessa, additional, Munhoz, Carlos, additional, Peçanha, Ana Carolina, additional, da Silva Ramos, Fernando José, additional, Maia, Israel, additional, Bahl, Marina, additional, Biondi, Rodrigo, additional, Prado, Daniel, additional, Pinto, Sérgio Felix, additional, Salgado, Jean, additional, Falcão, Luis Fernando, additional, Macruz, Tiago, additional, Ruas, Kessia, additional, Mecatti, Giovana Colozza, additional, Caser, Eliane Bernadete, additional, Gava, Isabela Ambrósio, additional, Carreño, Nicolás, additional, Morales, Mauricio, additional, Avendaño, Rossana, additional, Aguirre, Stefania, additional, Sribar, Andrej, additional, Klaric, Vlasta, additional, Skilijic, Sonja, additional, Dvorscak, Matea Bogdanovic, additional, Krkusek, Marijana, additional, Jurjevic, Matija, additional, Karanovic, Nenad, additional, Simurina, Tatjana, additional, Stourac, Petr, additional, Kratochvil, Milan, additional, Schlegel, Christian, additional, Treschan, Tanja A, additional, Schaefer, Maximilian, additional, Aytulun, Akut, additional, Kienbaum, Peter, additional, Jaafar, Rola, additional, Collins, Daniel, additional, Plant, Robert, additional, Melchionda, Giuseppe, additional, Di Lauro, Eduardo, additional, Russotto, Vincenzo, additional, Caione, Raffaele, additional, Mestria, Donatella, additional, Volta, Carlo Alberto, additional, Seghelini, Elisa, additional, Sales, Gabriele, additional, D'Antini, Davide, additional, Severgnini, Paolo, additional, Bacuzzi, Alessandro, additional, Peluso, Lorenzo, additional, Verrastro, Pasquale, additional, Raimondo, Pasquale, additional, Gecaj-Gashi, Agreta, additional, Tuinman, Pieter Roel, additional, Alberts, Erna, additional, van den Hul, Ingrid, additional, Kuiper, Michael, additional, de Wilde, Robert BP, additional, Koopmans, Matty, additional, Kose, Isil, additional, Zincircioglu, Çiler, additional, Dogan, Nazim, additional, Aydin, Demet, additional, Denker, Ahmet Sukru, additional, Buyukkocak, Unase, additional, Akgun, Nur, additional, Turan, Güldem, additional, Senturk, Evren, additional, Demirtürk, Zerrin, additional, Özcan, Perihan Ergin, additional, Ekinci, Osman, additional, Saylan, Sedat, additional, Eren, Gulay, additional, Ulger, Fatma, additional, Dilek, Ahmet, additional, Ulusoy, Hulya, additional, Goktas, Ugur, additional, Soyoral, Lokman, additional, Toman, Huseyin, additional, Orak, Yavuz, additional, Kahveci, Feda, additional, Mills, Gary H, additional, Pinder, Angela, additional, Walker, Rachel, additional, Harrison, Jonathan, additional, Snell, Jane, additional, Pearson, Rachel, additional, Sharman, Michael, additional, Kaloo, Claire, additional, Bynorth, Natalie, additional, Matthews, Kelly, additional, Hughes, Chloe, additional, Rose, Alastair, additional, Simeson, Karen, additional, Niska, Lotta, additional, Huneke, Nathan, additional, Adderly, Jane, additional, Padilla-Harris, Cheryl, additional, Oliver, Rebecca, additional, Brohi, Farooq, additional, Wilson, Natalie, additional, Talbot, Helen, additional, Wilson, Deborah, additional, Smith, Deborah, additional, Dark, Paulo, additional, Evans, Tracey, additional, Fisher, Nicola, additional, Montgomery, Jane, additional, Fitzell, Pauline, additional, Muench, Christoph, additional, Hugill, Keith, additional, Cirstea, Emanuel, additional, Bentley, Andrew, additional, Lynch, Katie, additional, White, Ian, additional, Cooper, Jonathan, additional, Brazier, Melinda, additional, Devile, Michael, additional, Parris, Michael, additional, Gill, Pardeep, additional, Patel, Tasmin, additional, Criswell, John, additional, Trodd, Dawn, additional, Griffin, Denise, additional, Martin, Jane, additional, Wreybrown, Caroline, additional, Bewley, Jeremy, additional, Sweet, Katie, additional, Grimmer, Lisa, additional, Kozlowski, Marta, additional, James, Shanaz, additional, Limb, James, additional, Cowton, Amanda, additional, Rogerson, David, additional, Downes, Charlotte, additional, Melbourne, Susan, additional, Humphries, Ryan, additional, Pulletz, Mark, additional, Moreton, Sarah, additional, Janes, Stephanie, additional, Corner, Andrew, additional, Linnett, Vanessa, additional, Ritzema, Jenny, additional, Watters, Malcolm, additional, Windebank, Steve, additional, Chenna, Shailaja, additional, Howard-Griffin, Richard, additional, Turner, Kate, additional, Suresh, Sheeba, additional, Blaylock, Heather, additional, Bell, Stephanie, additional, Blenk, Karl, additional, Everett, Lynn, additional, Hadfield, Daniel, additional, Harris, Clair, additional, Chan, Alexandre, additional, Birch, Sian, additional, Pegg, Claire, additional, Plowright, Catherine, additional, Cooper, Lucy, additional, Hatton, Tom, additional, McCullagh, Iain, additional, Wright, Stephen, additional, Scott, Carmen, additional, Boyd, Christine, additional, Holliday, Mark, additional, Poultney, Una, additional, Crowther, Hannah, additional, Thornthwaite, Sarah, additional, Hollister, Nigel, additional, Hunt, Jane, additional, Skinner, Amanda, additional, Matsa, Ramprasad, additional, Salt, Ruth, additional, Matthews, Claire, additional, Venner, Nicola, additional, Barcraft-Barnes, Helena, additional, Tbaily, Lee, additional, Pogson, David, additional, Mouland, Johanna, additional, Rose, Steve, additional, Lamb, Nicola, additional, Tarmey, Nicholas, additional, Knighton, John, additional, Giles, Julian, additional, Weller, Debbie, additional, Reed, Isabelle, additional, Hormis, Anil, additional, Pearson, Sallyane, additional, Harris, Meredith, additional, Howe, Joanne, additional, Paddle, Jonathan, additional, Burt, Karen, additional, Welters, Ingeborg, additional, Walker, Anna, additional, Youds, Laura, additional, Hendry, Sam, additional, Shaw, David, additional, Williams, Karen, additional, Hollands, Robin, additional, Carnahan, Mandy, additional, Stickley, Johanna, additional, Miller, Claire, additional, Donaldson, Denise, additional, Tonks, Louise, additional, Creagh-Brown, Ben, additional, Hull, Daniel, additional, Ortiz-Ruiz, Laura, additional, Gopal, Shammer, additional, Metherell, Stella, additional, Spencer, Hazel, additional, Frey, Christian, additional, Brown, Carly, additional, Clifford, Gayle, additional, Leaver, Susannah, additional, Ryan, Christine, additional, Mellinghoff, Johannes Mellinghoff, additional, Prudden, Sarah Prudden, additional, Green, Helen Green, additional, Roy, Alistair Roy, additional, Furneval, Julie Furneval, additional, Bell, Adam Bell, additional, Lakhani, Sandeep Lakhani, additional, Fasting, Lousie Fasting, additional, Murray, Lorna Murray, additional, Preller, Kobus, additional, McInerney, Amy, additional, Beavis, Sarah, additional, Whileman, Amanda, additional, Toms, Julie, additional, Glenn, Sue, additional, Ramali, Mohamed, additional, Ghosh, Alison, additional, Bullock, Clare, additional, Barrell, Lisa, additional, Young, Eoin, additional, Robertson, Helen, additional, Faulkner, Maria, additional, MacNaughton, Peter, additional, Tyson, Susan, additional, Pulak, Paul, additional, Sewell, Terri-Ann, additional, Smalley, Christopher, additional, Jacob, Reni, additional, Alzugaray, Pedro, additional, Vidal Melo, Marcos F, additional, Joyce, Kristen, additional, Needleman, Joseph, additional, Ahsan, Areef, additional, Faiz, Abul, additional, Alam, AKM Shamsul, additional, Khatoon, Syeda Nafisa, additional, Nath, Ranjan Kumer, additional, Rahman Chowdhury, Mohammed Abdur, additional, Banik, Debabrata, additional, Mondol, Montosh Kumar, additional, Bhuiyan, Sakibur Rahman, additional, Nazneed, Suraiya, additional, Sultana, Rozina, additional, Hamid, Tarikul, additional, Hossain, Mozaffer, additional, Reza, Syed Tariq, additional, Asaduzzaman, Muhammad, additional, Salim, Mohammad, additional, Mostafa Kamal, Abu Hena, additional, Taher, Sheikh Mohammed, additional, Taohid, Taohidul Majid, additional, Karmaker, Pranab, additional, Roy, Sabyasachi, additional, Das, Shantanu, additional, Sarkar, Sohel Ahmed, additional, Dutta, Monju Lal, additional, Roy, Poulomi, additional, Iyer, Shivakumar, additional, Krishna, Bhuvana, additional, Sampath, Sriram, additional, Pattnaik, Rajyabardhan, additional, Kasi, Chinni Krishna, additional, Shah, Jignesh, additional, Dongre, Anand, additional, Reza Hashemian, Seyed Mohammad, additional, Nooraei, Navid, additional, Raessi Estabragh, Reza, additional, Malekmohammad, Majid, additional, Khoundabi, Batoul, additional, Mobasher, Maziar, additional, Mohd Yunos, Nor'azim, additional, Kassim, Mahazir, additional, Voon, Chern Min, additional, Das, Stanis Sutharsa, additional, Azauddin, Siti Nur Suhaila, additional, Dorasamy, Dharshinie, additional, Tai, Li Ling, additional, Mat Nor, Mohd Basri, additional, Zarudin, Nurhafizah, additional, Hasan, Mohd Shahnaz, additional, Jamaluddin, Mohamad Fadhil Hadi, additional, Othman Jailani, Mohamad Irfan, additional, Kayashta, Gyan, additional, Adhikari, Aaradhana, additional, Pangeni, Raju, additional, Hashmi, Madiha, additional, Joseph, Sonia, additional, Akhtar, Aftab, additional, Qadeer, Aayesha, additional, Memon, Iqbal, additional, Ali, Syed Muneeb, additional, Idrees, Farah, additional, Kamal, Saima, additional, Hanif, Sadaf, additional, Rehman, Atta Ur, additional, Taqi, Arshad, additional, Hussain, Tanveer, additional, Farooq, Ahmed, additional, Khaskheli, Saleh, additional, Hayat, Muhammad, additional, Indraratna, Kanishka, additional, Beane, Abigail, additional, Haniffa, Rashan, additional, Samaranayake, Upeka, additional, Mathanalagan, Sathiyamoorthy, additional, Gunaratne, Asoka, additional, Mithraratne, Nimangee, additional, Thilakasiri, Kaushila, additional, Pilimatalawwe, Chamila, additional, Dilhani, Y A Hasitha, additional, Fernando, Marie, additional, Ranatunge, Kumudini, additional, Samarasinghe, Loranthi, additional, Vaas, Manori, additional, Edirisooriya, Manoj, additional, Sigera, Chathurani, additional, Arumoli, Janaki, additional, De Silva, Kesharie, additional, Kudavidanage, Bimal, additional, Pinto, Visanthi, additional, Dissanayake, Lakshman, additional, Chittawatanarat, Kaweesak, additional, Kongpolprom, Napplika, additional, Silachamroon, Udomsak, additional, Pornsuriyasak, Prapaporn, additional, Petnak, Tananchai, additional, Singhatas, Pongsasit, additional, Tangsujaritvijit, Viratch, additional, Rungruanghiranya, Suthat, additional, Piriyapatsom, Annop, additional, Juntaping, Kanokkarn, additional, Trongtrakul, Konlawij, additional, Thungtitigul, Poungrat, additional, Tajarernmuang, Pattraporn, additional, Chatmongkolchart, Sunisa, additional, Bhurayanontachai, Rungsun, additional, Akaraborworn, Osaree, additional, Navasakulpong, Asma, additional, Surasit, Karjbundid, additional, Thwaites, Louise, additional, Nadjm, Behzad, additional, Vu Quoc, Dat, additional, Nguyen Thi Thanh, Ha, additional, Nguyen Van, Kinh, additional, Duong Bich, Thuy, additional, and Lam Minh, Yen, additional

Published
2022
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23. High voltage electrical system of 8.56 GHz CW klystron for electron cyclotron heating on QUEST spherical tokamak

Author

Hiroshi Idei, Ryuichi Ashida, Yoshihiko Nagashima, Ryuya Ikezoe, Masaharu Fukuyama, Kengoh Kuroda, A. Higashijima, S. Kawasaki, Makoto Hasegawa, Katsumasa Nakamura, Takumi Onchi, Kazuaki Hanada, and Takahiro Nagata

Subjects
Tokamak, Materials science, Electrical load, Klystron, business.industry, Mechanical Engineering, High voltage, Spherical tokamak, 01 natural sciences, 010305 fluids & plasmas, law.invention, Electric power system, Electric power transmission, Nuclear Energy and Engineering, law, 0103 physical sciences, Optoelectronics, General Materials Science, 010306 general physics, business, Civil and Structural Engineering, Voltage
Abstract

A high voltage DC power supply for the cathode of the 8.56 GHz CW klystron has been set up for electron cyclotron heating (ECH) in steady state tokamak operation on QUEST spherical tokamak. The power supply is equipped with an IGBT array and a reactor for fast shutoff of the voltage in 10 μs, where the influx of electric energy at the short circuit is limited to 5 J. AC switches also have been installed in the three-phase power lines. High voltage relays are useful to save electric energy consumption. Fast three-phase AC switching by IGBT-stack is applicable to reduce the electric load of the components of the klystron power supply.

Published
2019

24. 28-GHz ECHCD system with beam focusing launcher on the QUEST spherical tokamak

Author

Atsushi Fukuyama, Shin Kubo, Takahiro Nagata, Yuichi Takase, M. Sakaguchi, Hiroshi Idei, K. Mishra, Makoto Hasegawa, Akira Ejiri, Masaharu Fukuyama, M. Ono, Yoshihiko Nagashima, Satoru Kobayashi, A. Higashijima, Toru Ii Tsujimura, Shinichiro Kojima, Katsumasa Nakamura, Osamu Watanabe, Tsuyoshi Imai, Kengoh Kuroda, Naoki Matsumoto, Tsuyoshi Kariya, S. Shimabukoro, Takumi Onchi, Kazuaki Hanada, Miu Yunoki, and Sadayoshi Murakami

Subjects
Physics, business.industry, Mechanical Engineering, Launched, Beam steering, Plasma, Polarizer, Spherical tokamak, Polarization (waves), 01 natural sciences, 010305 fluids & plasmas, law.invention, Optics, Nuclear Energy and Engineering, law, 0103 physical sciences, Incident beam, Physics::Accelerator Physics, General Materials Science, 010306 general physics, business, Civil and Structural Engineering
Abstract

New polarizer and launcher systems on a 28-GHz electron-cyclotron (EC) heating and current drive (HCD) system have been developed for non-inductive second-harmonic EC-plasma-current ramp-up in the QUEST spherical tokamak. A launcher system with two quasi-optical mirrors providing beam steering capability was designed to focus the incident beam to a small-sized waist of ∼0.05 m at the second-harmonic EC resonance layer. A relatively large focusing mirror was designed based on a Kirchhoff integral code developed to derive wave solutions. The focusing property of the launched beam was first confirmed with a 3-dimensional (3D) electromagnetic-wave simulator. Focusing characteristics were also checked at low-power test facilities, together with the steering capability. The performance of this launcher system was demonstrated to work as designed, and assembled in the QUEST device. The system was applied to the non-inductive second-harmonic EC plasma ramp-up experiments with no optimization required regarding the incident polarization. The results obtained for the non-inductive plasma ramp-up are also presented.

Published
2019

25. Novel indoline dye tetrabutylammonium carboxylates attached with a methyl group on the cyclopentane ring for dye-sensitized solar cells

Author

Hidetoshi Miura, Yasuhiro Kubota, Hiroyasu Sato, Yuya Tsuzuki, Toshiyasu Inuzuka, Shinji Higashijima, Tsukasa Yoshida, Kazuhiro Manseki, Kazumasa Funabiki, and Masaki Matsui

Subjects
Chemistry, Organic Chemistry, Energy conversion efficiency, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, Ring (chemistry), 01 natural sciences, Biochemistry, Medicinal chemistry, 0104 chemical sciences, chemistry.chemical_compound, Dye-sensitized solar cell, Drug Discovery, Indoline, 0210 nano-technology, Cyclopentane, Methyl group
Abstract

(2R,3aR,8bR)- and (2S,3aS,8bS)-2-Methyl indoline dye tetrabutylammonium carboxylates exhibited the highest conversion efficiency among four regio and stereo isomers. These indoline dyes also showed higher conversion efficiency than DN350.

Published
2018

26. MicroRNA-320a/b is a Therapeutic Target and Biomarker for Peripartum Cardiomyopathy

Author

Yoshihiro Higashijima, Yoshihiro Urade, Youichiro Wada, Ryo Nakaki, Yasuharu Kanki, Akashi Taguchi, and Takashi Shimizu

Subjects
Oncology, endocrine system, medicine.medical_specialty, Heart disease, Peripartum cardiomyopathy, Kinase, business.industry, Institutional review board, medicine.disease, Downregulation and upregulation, Internal medicine, microRNA, medicine, Biomarker (medicine), Peripartum Period, business
Abstract

Peripartum cardiomyopathy (PPCM) is a life-threatening heart disease arising in the peripartum period. 16 kDa-prolactin (16K PRL) and its subproduct microRNA (miR)-146a-5p are candidate biomarkers for PPCM. However, we showed that miR-146a-5p is not well upregulated in the sera of PPCM patients. Here, we found that miR-320a/b were the most specific miRNAs that suppressed the expression of protein kinase RNA-like endoplasmic reticulum kinase (PERK). We transfected neonatal rat cardiomyocytes with plasmids containing full-length prolactin (23K PRL) or 16K PRL in vitro. We found that 23K PRL, but not 16K PRL, upregulated PERK signaling, and hypoxia promoted this effect. During the perinatal period, cardiomyocyte-specific PERK homogenous knockout (CM-KO) mice showed PPCM phenotypes after consecutive deliveries. Downregulation of PERK or JAK/STAT signaling and upregulation of apoptosis were observed in CM-KO mouse hearts. These results demonstrated that interruption of 23K PRL-PERK interaction by miR-320a/b could be a therapeutic strategy for PPCM. Funding Statement: This study was supported by the Japan Society for the Promotion of Science KAKENHI grant number JP18K16756 and JP20K17210 (T.S.) and by the research grant from Public Trust Cardiovascular Research Fund (T.S.). Declaration of Interests: The authors declare that they have no competing interests. Ethics Approval Statement: The institutional review board of National Cerebral and Cardiovascular Center in Osaka approved this study. Eligible women were enrolled after providing written informed consent. Animal Ethics Approval Statement: All experiments were approved by the University of Tokyo Ethics Committee for Animal Experiments and strictly adhered to the guidelines for animal experiments of the University of Tokyo.

Published
2021

28. Overview of recent progress on steady state operation of all-metal plasma facing wall device QUEST

Author

Hanada, K., primary, Yoshida, N., additional, Hasegawa, M., additional, Oya, M., additional, Oya, Y., additional, Takagi, I., additional, Hatayama, A., additional, Shikama, T., additional, Idei, H., additional, Nagashima, Y., additional, Ikezoe, R., additional, Onchi, T., additional, Kuroda, K., additional, Kawasaki, S., additional, Higashijima, A., additional, Nagata, T., additional, Shimabukuro, S., additional, Nakamura, K., additional, Murakami, S., additional, Takase, Y., additional, Gao, X., additional, Liu, H., additional, and Qian, J., additional

Published
2021
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29. Enhancers are activated by p300/CBP activity-dependent PIC assembly, RNAPII recruitment, and pause release

Author

Narita, Takeo, primary, Ito, Shinsuke, additional, Higashijima, Yoshiki, additional, Chu, Wai Kit, additional, Neumann, Katrin, additional, Walter, Jonas, additional, Satpathy, Shankha, additional, Liebner, Tim, additional, Hamilton, William B., additional, Maskey, Elina, additional, Prus, Gabriela, additional, Shibata, Marika, additional, Iesmantavicius, Vytautas, additional, Brickman, Joshua M., additional, Anastassiadis, Konstantinos, additional, Koseki, Haruhiko, additional, and Choudhary, Chunaram, additional

Published
2021
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30. Bivalent-histone-marked immediate-early gene regulation is vital for VEGF-responsive angiogenesis

Author

Yasuharu Kanki, Masashi Muramatsu, Yuri Miyamura, Kenta Kikuchi, Yoshiki Higashijima, Ryo Nakaki, Jun-ichi Suehiro, Yuji Sasaki, Yoshiaki Kubota, Haruhiko Koseki, Hiroshi Morioka, Tatsuhiko Kodama, Mitsuyoshi Nakao, Daisuke Kurotaki, Hiroyuki Aburatani, and Takashi Minami

Subjects
Vascular Endothelial Growth Factor A, Chromatin Immunoprecipitation, Neovascularization, Pathologic, PTIP, QH301-705.5, VEGF, endothelial cells, General Biochemistry, Genetics and Molecular Biology, Epigenesis, Genetic, Histones, Mice, bivalent histone marks, angiogenesis, Animals, Chromatin Immunoprecipitation Sequencing, Humans, Angiogenesis Inducing Agents, Gene Silencing, Biology (General), Promoter Regions, Genetic, Genes, Immediate-Early, noncanonical polycomb
Abstract

Summary: Endothelial cells (ECs) are phenotypically heterogeneous, mainly due to their dynamic response to the tissue microenvironment. Vascular endothelial cell growth factor (VEGF), the best-known angiogenic factor, activates calcium-nuclear factor of activated T cells (NFAT) signaling following acute angiogenic gene transcription. Here, we evaluate the global mapping of VEGF-mediated dynamic transcriptional events, focusing on major histone-code profiles using chromatin immunoprecipitation sequencing (ChIP-seq). Remarkably, the gene loci of immediate-early angiogenic transcription factors (TFs) exclusively acquire bivalent H3K4me3-H3K27me3 double-positive histone marks after the VEGF stimulus. Moreover, NFAT-associated Pax transactivation domain-interacting protein (PTIP) directs bivalently marked TF genes transcription through a limited polymerase II running. The non-canonical polycomb1 variant PRC1.3 specifically binds to and allows the transactivation of PRC2-enriched bivalent angiogenic TFs until conventional PRC1-mediated gene silencing is achieved. Knockdown of these genes abrogates post-natal aberrant neovessel formation via the selective inhibition of indispensable bivalent angiogenic TF gene transcription. Collectively, the reported dynamic histone mark landscape may uncover the importance of immediate-early genes and the development of advanced anti-angiogenic strategies.

Published
2022

31. Correlation network analysis identified the key interactions of texture profiles with the sensory, physical, and organoleptic properties of cherry tomato cultivars grown under salt stress

Author

Kazufumi Zushi and Mai Higashijima

Subjects
Taste, Cherry tomato, biology, Chewiness, Locule, Organoleptic, food and beverages, Cultivar, Food science, Horticulture, Sweetness, biology.organism_classification, Texture (geology)
Abstract

Textural properties play an important role in the appreciation and acceptance of fresh tomatoes by consumers. This study aimed to clarify whether the effect of salt stress (50 and 100 mM NaCl) on texture profiles depends on the cultivars and/or tissue types of cherry tomatoes and visually identify the interactions of texture with organoleptic and consumer sensory properties using correlation network analysis. The effect of salt stress on texture profiles differed according to the cherry tomato cultivar, stress intensity, truss, and tissue (outer pericarp, locule, septa). The cohesiveness, gumminess, and chewiness of the outer pericarp and the cohesiveness of the locule were higher in salt-stressed fruit than in control fruit, but the effect was cultivar-dependent. Sensory properties such as overall taste, sweetness, and skin hardness and several organoleptic properties were 1.2–1.7-fold higher in salt-stressed fruit than in control fruit. Although no textural properties interacted with sensory properties in the control fruit network in correlation network analysis, the connectivity of textural properties such as cohesiveness with other traits in salt-stressed fruit increased with increasing salt stress intensity. In the network combining all treatments, the most connected node was cohesiveness, and cohesiveness was the key factor that enhanced the sensory and organoleptic properties of salt-stressed tomatoes, although the effects were cultivar- and tissue-specific. Thus, correlation network analysis provided visual insights into the interactions of textural properties with organoleptic and sensory properties.

Published
2022

32. Toroidal flow measurements of impurity ions in QUEST ECH plasmas using multiple viewing chords emission spectroscopy

Author

Yoneda, N., primary, Shikama, T., additional, Hanada, K., additional, Mori, S., additional, Onchi, T., additional, Kuroda, K., additional, Hasuo, M., additional, Ejiri, A., additional, Matsuzaki, K., additional, Osawa, Y., additional, Peng, Y., additional, Kawamata, Y., additional, Sakamoto, S., additional, Idei, H., additional, Ido, T., additional, Nakamura, K., additional, Nagashima, Y., additional, Ikezoe, R., additional, Hasegawa, M., additional, Higashijima, A., additional, Nagata, T., additional, and Shimabukuro, S., additional

Published
2021
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33. Investigation of radial distribution of atomic hydrogen flux to the plasma facing components in steady state discharges in QUEST tokamak

Author

Kuzmin, A., primary, Kobayashi, M., additional, Hanada, K., additional, Idei, H., additional, Onchi, T., additional, Mori, S., additional, Yoneda, N., additional, Shikama, T., additional, Hasuo, M., additional, Ido, T., additional, Nagashima, Y., additional, Ikezoe, R., additional, Hasegawa, M., additional, Kuroda, K., additional, Kono, K., additional, Matsuo, S., additional, Nagata, T., additional, Shimabukuro, S., additional, Higashijima, A., additional, Niiya, I., additional, and Zushi, H., additional

Published
2021
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38. Application of indoline dyes attached with strongly electron-withdrawing carboxylated indan-1,3-dione analogues linked with a hexylthiophene ring to dye-sensitized solar cells

Author

Nagisa Tanaka, Kazumasa Funabiki, Masaki Matsui, Yuki Haishima, Yukiko Inoue, Shinji Higashijima, Yasuhiro Kubota, Kazuhiro Manseki, and Jiye Jin

Subjects
010405 organic chemistry, Chemistry, Organic Chemistry, 010402 general chemistry, Ring (chemistry), Photochemistry, 01 natural sciences, Biochemistry, Redox, 0104 chemical sciences, chemistry.chemical_compound, Dye-sensitized solar cell, Absorption band, Drug Discovery, Indoline, Bathochromic shift, Polar effect, Moiety
Abstract

An indoline dye attached with a carboxylated indan-1,3-dione moiety linked with a hexylthiophene ring exhibited the highest conversion efficiency among six analogues and D205. This result comes from the bathochromic UV–vis absorption band, suitable energy levels, good stability for redox process, and sufficiently long excited-state lifetime.

Published
2018

39. Modification of plasma control system and hot-wall temperature control system for long-duration plasma sustainment in QUEST

Author

Yoshihiko Nagashima, Kazutoshi Tokunaga, Osamu Watanabe, Takumi Onchi, Kazuo Nakamura, Kazuaki Hanada, Kengoh Kuroda, A. Kuzmin, Shoji Kawasaki, Hiroshi Idei, Takahiro Nagata, Aki Higashijima, and Makoto Hasegawa

Subjects
010302 applied physics, Materials science, Tokamak, Temperature control, Mechanical Engineering, Nuclear engineering, Mass flow controller, Plasma, Spherical tokamak, 01 natural sciences, Signal, 010305 fluids & plasmas, law.invention, Nuclear Energy and Engineering, law, Control system, 0103 physical sciences, Water cooling, General Materials Science, Civil and Structural Engineering
Abstract

In tokamaks, the temperature of the plasma-facing wall is an important parameter for achieving particle balance and therefore steady-state operation. QUEST, which is a middle-sized spherical tokamak, has hot walls that act as plasma-facing walls. They can be actively heated with sheath heaters and actively cooled with water. To control the wall temperature, heating and cooling systems have been developed. These systems adjust the power of the sheath heaters and the motor valves of the cooling system, respectively. The two systems communicate via Ethernet through UDP and control the hot-wall temperature cooperatively. The plasma control system (PCS) in QUEST has also been modified, especially with respect to gas fueling, in order to enable long-duration plasma sustainment. A feedback controller has been installed in the PCS, together with a mass flow controller, allowing Hα emission from the plasma which is used as a reference signal, to be well controlled. Plasma density calculations using a field-programmable gate array are proposed for the feedback control system.

Published
2018

40. Political liberalization and human development: Dynamic effects of political regime change on infant mortality across three centuries (1800-2015)

Author

Susumu Annaka and Masaaki Higashijima

Subjects
Economics and Econometrics, Sociology and Political Science, Liberalization, media_common.quotation_subject, Geography, Planning and Development, Development, Human development (humanity), Infant mortality, Democracy, Politics, Regime change, Development economics, Economics, Democratization, Panel data, media_common
Abstract

It has been long debated among comparativists whether democratic states advance human development. By regressing infant mortality rates on a cumulative score of democracy, recent studies have suggested that a long tradition of democracy is of greater importance than the present degree of democracy to explain human development. This approach, however, faces several issues and also fails to pinpoint the effect of a democratic reform at a certain point in time on future human welfare. We argue that political liberalization encourages policymakers to adopt poverty-alleviating policies, but such a policy change is more likely to bear substantive fruit over the relatively long run. Using newly collected panel data on infant mortality rates from 1800 to 2015 from 172 countries, we test our theoretical expectations. Applying error correction models to this extensive time-series cross-sectional data, we find that political liberalization is more likely to increase equal access to public services immediately but that infant mortality rates are reduced in the long run. These results suggest that democratic reforms do have a positive effect on human welfare, but the effect might appear with a passage of time as well as shrinks over time. Our research implies that policymakers may need to make tireless investments in the advancement of political liberalization to continue improving human well-being in the developing world.

Published
2021

41. Application of indoline dyes having a carboxylated 1,3-indandione ring linked with thienyl or hexylthienyl ring to dye-sensitized solar cells

Author

Shinji Higashijima, Aran Hansuebsai, Masaki Matsui, Yasuhiro Kubota, Jiye Jin, Kazumasa Funabiki, Kazuhiro Manseki, Ryosuke Kimura, and Yukiko Inoue

Subjects
1,3-Indandione, Process Chemistry and Technology, General Chemical Engineering, Energy conversion efficiency, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, Ring (chemistry), Photochemistry, 01 natural sciences, 0104 chemical sciences, Dye-sensitized solar cell, chemistry.chemical_compound, chemistry, Indoline, 0210 nano-technology
Abstract

The performance of a new indoline dye having a carboxylated 1,3-idandione unit linked with a hexythienyl ring showed higher conversion efficiency than the analogous dye without the hexyl group.

Published
2017

42. Intestinal fatty acid-binding protein level as a predictor of 28-day mortality and bowel ischemia in patients with septic shock: A preliminary study

Author

Tetsuya Hara, Haruka Inoue, Shuntaro Sato, Hiroyuki Funaoka, Taiga Ichinomiya, Shuhei Matsumoto, Ushio Higashijima, Kyoko Okada, Motohiro Sekino, Rintaro Yano, and Sojiro Matsumoto

Subjects
Male, medicine.medical_specialty, Critical Care, medicine.drug_class, medicine.medical_treatment, Fatty Acid-Binding Proteins, Critical Care and Intensive Care Medicine, Gastroenterology, law.invention, 03 medical and health sciences, 0302 clinical medicine, law, Internal medicine, Natriuretic Peptide, Brain, Odds Ratio, medicine, Natriuretic peptide, Humans, Lactic Acid, Prospective Studies, 030212 general & internal medicine, Aged, Mechanical ventilation, business.industry, Septic shock, Incidence (epidemiology), Mortality rate, 030208 emergency & critical care medicine, Odds ratio, Middle Aged, Prognosis, medicine.disease, Respiration, Artificial, Shock, Septic, Intensive care unit, Peptide Fragments, Surgery, Mesenteric ischemia, Mesenteric Ischemia, Female, lipids (amino acids, peptides, and proteins), business, Biomarkers
Abstract

Purpose We sought to evaluate the levels of intestinal fatty acid-binding protein (I-FABP), a biomarker of enterocyte injury, as a predictor of 28-day mortality and bowel ischemia in septic shock patients. Material and methods In this preliminary prospective observational study, 57 adult septic shock patients under mechanical ventilation were enrolled. Serum I-FABP levels and prognostic biomarkers were recorded upon intensive care unit (ICU) admission. Results The overall 28-day mortality rate of participants was 23% (13/57). Non-survivors displayed significantly higher lactate ( p = 0.009), I-FABP ( p = 0.012), and N-terminal pro-B-type natriuretic peptide ( p = 0.039) levels compared to survivors. Only I-FABP was associated with 28-day mortality (odds ratio, 1.036; 95% confidence interval, 1.003–1.069; p = 0.031) in a multiple logistic regression analysis adjusted for the Acute Physiology and Chronic Health Evaluation II score. When divided into low and high I-FABP groups based on the optimum cut-off value of 19.0 ng/mL for predicting 28-day mortality, high-I-FABP patients had a significantly higher incidence of non-occlusive mesenteric ischemia (NOMI) (2% [1/43] vs 29% [4/14]; p = 0.011). Conclusions I-FABP level at ICU admission can serve as a predictor of 28-day mortality in septic shock patients and is associated with the incidence of NOMI.

Published
2017

50. Postoperative coagulation profiles of patients undergoing adult-to-adult living donor liver transplantation—A single-center experience

Author

Ichinomiya, Taiga, primary, Murata, Hiroaki, additional, Sekino, Motohiro, additional, Sato, Shuntaro, additional, Higashijima, Ushio, additional, Matsumoto, Shuhei, additional, Ishizaki, Hironori, additional, Yoshitomi, Osamu, additional, Maekawa, Takuji, additional, Eguchi, Susumu, additional, and Hara, Tetsuya, additional

Published
2020
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