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Start Over Author "Hye-Ji Moon" Publisher elsevier bv
2 results on '"Hye-Ji Moon"'

2. Generation of Parkinson’s disease patient-derived human induced pluripotent stem cells line (PNUSCRi001-A) carrying a N227S mutation in GBA gene

Author

Nayeon Lee, Hye-Ji Moon, So-Hyun Park, Ji-Young Moon, Ka-Kyung Park, Jae-Ho Kim, and Jae-Hyeok Lee

Subjects
Male, Induced Pluripotent Stem Cells, Mutation, Leukocytes, Mononuclear, Humans, Parkinson Disease, Cell Biology, General Medicine, Developmental Biology
Abstract

The hiPSC line was generated from peripheral blood mononuclear cells (PBMCs) collected by a male patient with young onset Parkinson's disease, carrying on heterozygous c.680 A G (N227S) mutation in the GBA gene. The PBMCs was reprogrammed into an induced pluripotent stem cell (iPSC) line (PNUSCRi001-A hiPSCs) using non-integrative sendai virus. The hiPSC line, PNUSCRi001-A displayed a normal karyotype and the Expression of pluripotency markers that is capable of producing derivatives of three germ layers (Ectoderm, Endoderm and Mesoderm).

Published
2022
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