Search

Your search keyword '"Jack A. Bikker"' showing total 2 results
Start Over Author "Jack A. Bikker" Publisher elsevier bv
2 results on '"Jack A. Bikker"'

1. Synthesis of a non-peptide analogue of omega-conotoxin MVIIA

Author

Stefan Menzler, David Christopher Horwell, and Jack A Bikker

Subjects
chemistry.chemical_classification, biology, Voltage-dependent calcium channel, Peptidomimetic, Stereochemistry, Organic Chemistry, Conus magus, Ether, Cone shell, biology.organism_classification, Biochemistry, Combinatorial chemistry, Non peptide, Amino acid, chemistry.chemical_compound, Omega-conotoxin MVIIA, chemistry, Drug Discovery
Abstract

An efficient synthesis of an alkylphenyl ether based peptidomimetic is described. The compound mimics three key amino acids of omega-conotoxin MVIIA from the cone shell Conus magus and may provide an entry to the design of low molecular weight antagonists of N-type neuronal calcium channels.

Published
1998
Full Text
View/download PDF

2. Theoretical studies applicable to the design of novel anticonvulsants

Author

Donald F. Weaver and Jack Andrew Bikker

Subjects
Fit/gap analysis, Chemistry, Dihydropyridine, MNDO, DHPS, Condensed Matter Physics, Biochemistry, Root mean square, Turn (biochemistry), Investigation methods, Computational chemistry, medicine, Physical and Theoretical Chemistry, medicine.drug
Abstract

The optimization of the anticonvulsant activity of dihydropyridine calcium channel blockers (DHPs) requires suitable structure-activity studies, which in turn require reliable methods of conformational analysis. The utility of AM1, MNDO, and PM3 as methods of conformational analysis for the DHPs was critically assessed. Eighteen DHPs were fully optimized using AM1, MNDO, and PM3, and the results were compared with crystal geometries. AM1 was best suited to the modelling of DHP geometries, based on root mean square fit analysis and the treatment of specific functional groups. The performance of the three techniques was related to the corrective term of the core repulsion function of the semiempirical hamiltonians.

Published
1993
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results