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1. The impact of clinical genome sequencing in a global population with suspected rare genetic disease

Author

Thorpe, Erin, primary, Williams, Taylor, additional, Shaw, Chad, additional, Chekalin, Evgenii, additional, Ortega, Julia, additional, Robinson, Keisha, additional, Button, Jason, additional, Jones, Marilyn C., additional, Campo, Miguel del, additional, Basel, Donald, additional, McCarrier, Julie, additional, Keppen, Laura Davis, additional, Royer, Erin, additional, Foster-Bonds, Romina, additional, Duenas-Roque, Milagros M., additional, Urraca, Nora, additional, Bosfield, Kerri, additional, Brown, Chester W., additional, Lydigsen, Holly, additional, Mroczkowski, Henry J., additional, Ward, Jewell, additional, Sirchia, Fabio, additional, Giorgio, Elisa, additional, Vaux, Keith, additional, Salguero, Hildegard Peña, additional, Lumaka, Aimé, additional, Mubungu, Gerrye, additional, Makay, Prince, additional, Ngole, Mamy, additional, Lukusa, Prosper Tshilobo, additional, Vanderver, Adeline, additional, Muirhead, Kayla, additional, Sherbini, Omar, additional, Lah, Melissa D., additional, Anderson, Katelynn, additional, Bazalar-Montoya, Jeny, additional, Rodriguez, Richard S., additional, Cornejo-Olivas, Mario, additional, Milla-Neyra, Karina, additional, Shinawi, Marwan, additional, Magoulas, Pilar, additional, Henry, Duncan, additional, Gibson, Kate, additional, Wiafe, Samuel, additional, Jayakar, Parul, additional, Salyakina, Daria, additional, Masser-Frye, Diane, additional, Serize, Arturo, additional, Perez, Jorge E., additional, Taylor, Alan, additional, Shenbagam, Shruti, additional, Abou Tayoun, Ahmad, additional, Malhotra, Alka, additional, Bennett, Maren, additional, Rajan, Vani, additional, Avecilla, James, additional, Warren, Andrew, additional, Arseneault, Max, additional, Kalista, Tasha, additional, Crawford, Ali, additional, Ajay, Subramanian S., additional, Perry, Denise L., additional, Belmont, John, additional, and Taft, Ryan J., additional

Published
2024
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3. Scalable generation of sensory neurons from human pluripotent stem cells

Author

Tao Deng, Vukasin M. Jovanovic, Carlos A. Tristan, Claire Weber, Pei-Hsuan Chu, Jason Inman, Seungmi Ryu, Yogita Jethmalani, Juliana Ferreira de Sousa, Pinar Ormanoglu, Prisca Twumasi, Chaitali Sen, Jaehoon Shim, Selwyn Jayakar, Han-Xiong Bear Zhang, Sooyeon Jo, Weifeng Yu, Ty C. Voss, Anton Simeonov, Bruce P. Bean, Clifford J. Woolf, and Ilyas Singeç

Subjects
Genetics, Cell Biology, Biochemistry, Developmental Biology
Published
2023
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6. Clinical, biochemical and molecular characterization of 12 patients with pyruvate carboxylase deficiency treated with triheptanoin

Author

Lasio, M. Laura Duque, primary, Leshinski, Angela C., additional, Ducich, Nicole H., additional, Flore, Leigh Anne, additional, Lehman, April, additional, Shur, Natasha, additional, Jayakar, Parul B., additional, Hainline, Bryan E., additional, Basinger, Alice A., additional, Wilson, William G., additional, Diaz, George A., additional, Erbe, Richard W., additional, Koeberl, Dwight D., additional, Vockley, Jerry, additional, and Bedoyan, Jirair K., additional

Published
2023
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7. Scalable generation of sensory neurons from human pluripotent stem cells

Author

Deng, Tao, primary, Jovanovic, Vukasin M., additional, Tristan, Carlos A., additional, Weber, Claire, additional, Chu, Pei-Hsuan, additional, Inman, Jason, additional, Ryu, Seungmi, additional, Jethmalani, Yogita, additional, Ferreira de Sousa, Juliana, additional, Ormanoglu, Pinar, additional, Twumasi, Prisca, additional, Sen, Chaitali, additional, Shim, Jaehoon, additional, Jayakar, Selwyn, additional, Bear Zhang, Han-Xiong, additional, Jo, Sooyeon, additional, Yu, Weifeng, additional, Voss, Ty C., additional, Simeonov, Anton, additional, Bean, Bruce P., additional, Woolf, Clifford J., additional, and Singeç, Ilyas, additional

Published
2023
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10. P572: Detecting short tandem repeat expansions: Three-year experience with clinical whole genome sequencing (cWGS) for a rare and undiagnosed population

Author

Thomas, Brittany, primary, Kesari, Akanchha, additional, Lumaka, Aime, additional, Cornejo-Olivas, Mario, additional, Ward, David, additional, Jayakar, Parul, additional, Basel, Donald, additional, Jones, Marilyn, additional, Thorpe, Erin, additional, Perry, Denise, additional, and Taft, Ryan, additional

Published
2023
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11. SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming

Author

Wu, Chien-Ting, primary, Lidsky, Peter V., additional, Xiao, Yinghong, additional, Cheng, Ran, additional, Lee, Ivan T., additional, Nakayama, Tsuguhisa, additional, Jiang, Sizun, additional, He, Wei, additional, Demeter, Janos, additional, Knight, Miguel G., additional, Turn, Rachel E., additional, Rojas-Hernandez, Laura S., additional, Ye, Chengjin, additional, Chiem, Kevin, additional, Shon, Judy, additional, Martinez-Sobrido, Luis, additional, Bertozzi, Carolyn R., additional, Nolan, Garry P., additional, Nayak, Jayakar V., additional, Milla, Carlos, additional, Andino, Raul, additional, and Jackson, Peter K., additional

Published
2023
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12. EE144 Real-World Economic Evaluation of Prospective Rapid Whole-Genome Sequencing Compared to a Matched Retrospective Cohort of Critically Ill Pediatric Patients in the United States

Author

Diaby, K, primary, Babcock, A, additional, Huang, Y, additional, Moussa, RK, additional, Gupta, A, additional, Espinal, P, additional, Janvier, M, additional, Soler, D, additional, Jayakar, P, additional, Diaz-Barbosa, M, additional, Totapally, B, additional, Sasaki, J, additional, Jayakar, A, additional, and Salyakina, D, additional

Published
2022
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13. A Survey of Neuromonitoring Practices in North American Pediatric Intensive Care Units

Author

Saptharishi Lalgudi Ganesan, Jennifer Erklauer, Conall Francoeur, Mark S. Wainwright, Michael S. Wolf, Craig A. Press, Brian Appavu, Anuj Jayakar, Peter Ferrazzano, Binod Balakrishnan, Kerri L. LaRovere, Matthew P. Kirschen, Marlina Lovett, and Matthew Luchette

Subjects
medicine.medical_specialty, Critical Care, Intracranial Pressure, Ultrasonography, Doppler, Transcranial, Survey result, Intensive Care Units, Pediatric, Article, Developmental Neuroscience, Intensive care, medicine, Humans, Practice Patterns, Physicians', Modalities, Descriptive statistics, business.industry, Neurointensive care, Electroencephalography, medicine.disease, Neurophysiological Monitoring, Neurology, Health Care Surveys, North America, Pediatrics, Perinatology and Child Health, Neurology (clinical), Neurosurgery, Pediatric critical care, Medical emergency, business
Abstract

BACKGROUND: Neuromonitoring is the use of continuous measures of brain physiology to detect clinically important events in real-time. Neuromonitoring devices can be invasive or non-invasive and are typically used on patients with acute brain injury or at high risk for brain injury. The goal of this study was to characterize neuromonitoring infrastructure and practices in North American pediatric intensive care units (PICUs). METHODS: An electronic, web-based survey was distributed to 70 North American institutions participating in the Pediatric Neurocritical Care Research Group. Questions related to the clinical use of neuromonitoring devices, integrative multimodality neuromonitoring capabilities, and neuromonitoring infrastructure were included. Survey results were presented using descriptive statistics. RESULTS: The survey was completed by faculty at 74% (52 of 70) of institutions. All 52 institutions measure intracranial pressure and have electroencephalography capability, whereas 87% (45 of 52) use near-infrared spectroscopy and 40% (21/52) use transcranial Doppler. Individual patient monitoring decisions were driven by institutional protocols and collaboration between critical care, neurology, and neurosurgery attendings. Reported device utilization varied by brain injury etiology. Only 15% (eight of 52) of institutions utilized a multimodality neuromonitoring platform to integrate and synchronize data from multiple devices. A database of neuromonitoring patients was maintained at 35% (18 of 52) of institutions. Funding for neuromonitoring programs was variable with contributions from hospitals (19%, 10 of 52), private donations (12%, six of 52), and research funds (12%, six of 52), although 73% (40 of 52) have no dedicated funds. CONCLUSIONS: Neuromonitoring indications, devices, and infrastructure vary by institution in North American pediatric critical care units. Noninvasive modalities were utilized more liberally, although not uniformly, than invasive monitoring. Further studies are needed to standardize the acquisition, interpretation, and reporting of clinical neuromonitoring data, and to determine whether neuromonitoring systems impact neurological outcomes.

Published
2022
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15. Discovery of a neuromuscular syndrome caused by biallelic variants in ASCC3

Author

Nair, Divya, primary, Li, Dong, additional, Erdogan, Hannah, additional, Yoon, Andrew, additional, Harr, Margaret H., additional, Bergant, Gaber, additional, Peterlin, Borut, additional, Pušenjak, Maruša Škrjanec, additional, Jayakar, Parul, additional, Pfundt, Rolph, additional, Jansen, Sandra, additional, McWalter, Kirsty, additional, Sidhu, Alpa, additional, Saliganan, Sheila, additional, Agolini, Emanuele, additional, Jacob, Arthur, additional, Pasquier, Jennifer, additional, Arash, Rafii, additional, Kahrizi, Kimia, additional, Najmabadi, Hossein, additional, Ropers, Hans-Hilger, additional, and Bhoj, Elizabeth J., additional

Published
2022
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16. UBA2 variants underlie a recognizable syndrome with variable aplasia cutis congenita and ectrodactyly

Author

Rory J. Olson, Jane Juusola, Mark Flage, Carlos E. Prada, Srikar Kuppa, Gustavo Adolfo Contreras-García, Camilo A. Peñaloza-Mantilla, Maria J. Guillen Sacoto, Gail E. Graham, Lindsay Rhodes, James Liu, Pavel N. Pichurin, Michael Marble, Regina M. Zambrano, Wendy K. Chung, Parul Jayakar, Matthew J. Schultz, Mary Ella M Pierpont, Karina A. Campo-Neira, Matthew Osmond, Ingrid M. Wentzensen, Sairah Yousaf, Robert B. Hufnagel, Rhonda E. Schnur, Nara Sobreira, Maria I. Scarano, and Karina Navarro

Subjects
0301 basic medicine, Microcephaly, Ectrodactyly, Limb Deformities, Congenital, Ubiquitin-Activating Enzymes, 030105 genetics & heredity, Microphthalmia, Article, Aplasia cutis congenita, 03 medical and health sciences, Ectodermal Dysplasia, medicine, Animals, Humans, Missense mutation, Abnormalities, Multiple, Zebrafish, Genetics (clinical), Exome sequencing, Loss function, Genetics, biology, medicine.disease, biology.organism_classification, 030104 developmental biology, medicine.symptom
Abstract

Purpose: The human chromosome 19q13.11 deletion syndrome is associated with a variable phenotype that includes aplasia cutis congenita (ACC) and ectrodactyly as specific features. UBA2 (ubiquitin-like modifier-activating enzyme 2) lies adjacent to the minimal deletion overlap region. We aim to define the UBA2-related phenotypic spectrum in humans and zebrafish due to sequence variants and to establish the mechanism of disease. Methods: Exome Sequencing was used to detect UBA2 sequence variants in 16 subjects in 7 unrelated families. uba2 loss-of-function was modeled in zebrafish. Effects of human missense variants were assessed in zebrafish rescue experiments. Results: 7 human UBA2 loss-of-function and missense sequence variants were detected. UBA2-phenotypes included ACC, ectrodactyly, neurodevelopmental abnormalities, ectodermal, skeletal, craniofacial, cardiac, renal, and genital anomalies. uba2 was expressed in zebrafish eye, brain, and pectoral fins; uba2-null fish showed deficient growth, microcephaly, microphthalmia, mandibular hypoplasia, and abnormal fins. uba2-mRNAs with human missense variants failed to rescue nullizygous zebrafish phenotypes. Conclusion: UBA2 variants cause a recognizable syndrome with a wide phenotypic spectrum. Our data suggest that loss of UBA2 function underlies the human UBA2 monogenic disorder and highlights the importance of SUMOylation in the development of affected tissues.

Published
2021
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18. Clinical, biochemical and molecular characterization of 12 patients with pyruvate carboxylase deficiency treated with triheptanoin

Author

M. Laura Duque Lasio, Angela C. Leshinski, Nicole H. Ducich, Leigh Anne Flore, April Lehman, Natasha Shur, Parul B. Jayakar, Bryan E. Hainline, Alice A. Basinger, William G. Wilson, George A. Diaz, Richard W. Erbe, Dwight D. Koeberl, Jerry Vockley, and Jirair K. Bedoyan

Subjects
Endocrinology, Endocrinology, Diabetes and Metabolism, Genetics, Molecular Biology, Biochemistry
Published
2023
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19. Experimental investigation of friction stir welding on aluminium AA6063

Author

V. Venkata Kamesh, J. Jayakar, V. Hariharan, M. Parthasarathy, M. Nambiraj, and P.V. Elumalai

Subjects
010302 applied physics, Materials science, Tension (physics), Weldability, Alloy, chemistry.chemical_element, 02 engineering and technology, Process variable, engineering.material, 021001 nanoscience & nanotechnology, 01 natural sciences, Fatigue limit, Corrosion, chemistry, Aluminium, 0103 physical sciences, engineering, Friction stir welding, Composite material, 0210 nano-technology
Abstract

Friction Stir Welding, at which relative motion between the specimen and tool generates heat, as a result of which the edges are connected. Because of its excellent properties including very strong resistance to corrosion, weldability, and high fatigue strength, aluminum alloy is used in aerospace applications. Experiments were carried out on Aluminum alloy AA6063 and AA6201 in a Vertical CNC Machine. The performance parameters were calculated and the results indicate a definite relationship with the strength in tension as well as process parameters. For a selection of desired process parameters, friction stir welding process variable database is, therefore, to be created. ANOVA test found the most important process parameter which affects the strength in tension.

Published
2021
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22. Inflammatory molecular endotypes of nasal polyps derived from White and Japanese populations

Author

Nakayama, Tsuguhisa, primary, Lee, Ivan T., additional, Le, Wei, additional, Tsunemi, Yasuhiro, additional, Borchard, Nicole A., additional, Zarabanda, David, additional, Dholakia, Sachi S., additional, Gall, Philip A., additional, Yang, Angela, additional, Kim, Dayoung, additional, Akutsu, Makoto, additional, Kashiwagi, Takashi, additional, Patel, Zara M., additional, Hwang, Peter H., additional, Frank, Daniel N., additional, Haruna, Shin-ichi, additional, Ramakrishnan, Vijay R., additional, Nolan, Garry P., additional, Jiang, Sizun, additional, and Nayak, Jayakar V., additional

Published
2022
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23. Graph Neural Networks in EEG Spike Detection

Author

Ahmed Hossam Mohammed, Mercedes Cabrerizo, Alberto Pinzon, Ilker Yaylali, Prasanna Jayakar, and Malek Adjouadi

Subjects
History, Polymers and Plastics, Business and International Management, Industrial and Manufacturing Engineering
Published
2022
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25. SARS-CoV-2 Replication in Airway Epithelia Requires Motile Cilia and Microvillar Reprogramming

Author

Chien-Ting Wu, Peter V. Lidsky, Yinghong Xiao, Ran Cheng, Ivan T. Lee, Tsuguhisa Nakayama, Sizun Jiang, Wei He, Janos Demeter, Miguel G. Knight, Rachel E. Turn, Laura S. Rojas-Hernandez, Garry Nolan, Carlos Milla, Jayakar V. Nayak, Raul Andino, and Peter K. Jackson

Subjects
History, Polymers and Plastics, Business and International Management, Industrial and Manufacturing Engineering
Published
2022
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26. SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming

Author

Chien-Ting Wu, Peter V. Lidsky, Yinghong Xiao, Ran Cheng, Ivan T. Lee, Tsuguhisa Nakayama, Sizun Jiang, Wei He, Janos Demeter, Miguel G. Knight, Rachel E. Turn, Laura S. Rojas-Hernandez, Chengjin Ye, Kevin Chiem, Judy Shon, Luis Martinez-Sobrido, Carolyn R. Bertozzi, Garry P. Nolan, Jayakar V. Nayak, Carlos Milla, Raul Andino, and Peter K. Jackson

Subjects
General Biochemistry, Genetics and Molecular Biology
Abstract

How SARS-CoV-2 penetrates the airway barrier of mucus and periciliary mucins to infect nasal epithelium remains unclear. Using primary nasal epithelial organoid cultures, we found that the virus attaches to motile cilia via the ACE2 receptor. SARS-CoV-2 traverses the mucus layer, using motile cilia as tracks to access the cell body. Depleting cilia blocks infection for SARS-CoV-2 and other respiratory viruses. SARS-CoV-2 progeny attach to airway microvilli 24 h post-infection and trigger formation of apically extended and highly branched microvilli that organize viral egress from the microvilli back into the mucus layer, supporting a model of virus dispersion throughout airway tissue via mucociliary transport. Phosphoproteomics and kinase inhibition reveal that microvillar remodeling is regulated by p21-activated kinases (PAK). Importantly, Omicron variants bind with higher affinity to motile cilia and show accelerated viral entry. Our work suggests that motile cilia, microvilli, and mucociliary-dependent mucus flow are critical for efficient virus replication in nasal epithelia.

Published
2023
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29. Intratumoral plasma cells predict outcomes to PD-L1 blockade in non-small cell lung cancer

Author

Patil, Namrata S., primary, Nabet, Barzin Y., additional, Müller, Sören, additional, Koeppen, Hartmut, additional, Zou, Wei, additional, Giltnane, Jennifer, additional, Au-Yeung, Amelia, additional, Srivats, Shyam, additional, Cheng, Jason H., additional, Takahashi, Chikara, additional, de Almeida, Patricia E., additional, Chitre, Avantika S., additional, Grogan, Jane L., additional, Rangell, Linda, additional, Jayakar, Sangeeta, additional, Peterson, Maureen, additional, Hsia, Allison W., additional, O’Gorman, William E., additional, Ballinger, Marcus, additional, Banchereau, Romain, additional, and Shames, David S., additional

Published
2022
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30. Clinical outcomes, Kadish-INSICA staging and therapeutic targeting of somatostatin receptor 2 in olfactory neuroblastoma

Author

Lechner, Matt, primary, Takahashi, Yoko, additional, Turri-Zanoni, Mario, additional, Liu, Jacklyn, additional, Counsell, Nicholas, additional, Hermsen, Mario, additional, Kaur, Raman Preet, additional, Zhao, Tianna, additional, Ramanathan, Murugappan, additional, Schartinger, Volker H., additional, Emanuel, Oscar, additional, Helman, Sam, additional, Varghese, Jordan, additional, Dudas, Jozsef, additional, Riechelmann, Herbert, additional, Sprung, Susanne, additional, Haybaeck, Johannes, additional, Howard, David, additional, Engel, Nils Wolfgang, additional, Stewart, Sarah, additional, Brooks, Laura, additional, Pickles, Jessica C., additional, Jacques, Thomas S., additional, Fenton, Tim R., additional, Williams, Luke, additional, Vaz, Francis M., additional, O'Flynn, Paul, additional, Stimpson, Paul, additional, Wang, Simon, additional, Hannan, S. Alam, additional, Unadkat, Samit, additional, Hughes, Jonathan, additional, Dwivedi, Raghav, additional, Forde, Cillian T., additional, Randhawa, Premjit, additional, Gane, Simon, additional, Joseph, Jonathan, additional, Andrews, Peter J., additional, Royle, Gary, additional, Franchi, Alessandro, additional, Maragliano, Roberta, additional, Battocchio, Simonetta, additional, Bewicke-Copley, Helen, additional, Pipinikas, Christodoulos, additional, Webster, Amy, additional, Thirlwell, Chrissie, additional, Ho, Debbie, additional, Teschendorff, Andrew, additional, Zhu, Tianyu, additional, Steele, Christopher D., additional, Pillay, Nischalan, additional, Vanhaesebroeck, Bart, additional, Mohyeldin, Ahmed, additional, Fernandez-Miranda, Juan, additional, Park, Ki Wan, additional, Le, Quynh-Thu, additional, West, Robert B., additional, Saade, Rami, additional, Manes, R. Peter, additional, Omay, Sacit Bulent, additional, Vining, Eugenia M., additional, Judson, Benjamin L., additional, Yarbrough, Wendell G., additional, Sansovini, Maddalena, additional, Silvia, Nicolini, additional, Grassi, Ilaria, additional, Bongiovanni, Alberto, additional, Capper, David, additional, Schüller, Ulrich, additional, Thavaraj, Selvam, additional, Sandison, Ann, additional, Surda, Pavol, additional, Hopkins, Claire, additional, Ferrari, Marco, additional, Mattavelli, Davide, additional, Rampinelli, Vittorio, additional, Facchetti, Fabio, additional, Nicolai, Piero, additional, Bossi, Paolo, additional, Henriquez, Oswaldo A., additional, Magliocca, Kelly, additional, Solares, C. Arturo, additional, Wise, Sarah K., additional, Llorente, Jose L., additional, Patel, Zara M., additional, Nayak, Jayakar V., additional, Hwang, Peter H., additional, Lacy, Peter D., additional, Woods, Robbie, additional, O'Neill, James P., additional, Jay, Amrita, additional, Carnell, Dawn, additional, Forster, Martin D., additional, Ishii, Masaru, additional, London, Nyall R., additional, Bell, Diana M., additional, Gallia, Gary L., additional, Castelnuovo, Paolo, additional, Severi, Stefano, additional, Lund, Valerie J., additional, and Hanna, Ehab Y., additional

Published
2022
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32. SARS-CoV-2 Replication in Airway Epithelia Requires Motile Cilia and Microvillar Reprogramming

Author

Wu, Chien-Ting, primary, Lidsky, Peter V., additional, Xiao, Yinghong, additional, Cheng, Ran, additional, Lee, Ivan T., additional, Nakayama, Tsuguhisa, additional, Jiang, Sizun, additional, He, Wei, additional, Demeter, Janos, additional, Knight, Miguel G., additional, Turn, Rachel E., additional, Rojas-Hernandez, Laura S., additional, Nolan, Garry, additional, Milla, Carlos, additional, Nayak, Jayakar V., additional, Andino, Raul, additional, and Jackson, Peter K., additional

Published
2022
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35. A Survey of Neuromonitoring Practices in North American Pediatric Intensive Care Units

Author

Kirschen, Matthew P., primary, LaRovere, Kerri, additional, Balakrishnan, Binod, additional, Erklauer, Jennifer, additional, Francoeur, Conall, additional, Ganesan, Saptharishi Lalgudi, additional, Jayakar, Anuj, additional, Lovett, Marlina, additional, Luchette, Matthew, additional, Press, Craig A., additional, Wolf, Michael, additional, Ferrazzano, Peter, additional, Wainwright, Mark S., additional, and Appavu, Brian, additional

Published
2022
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36. Targeted replacement of full-length CFTR in human airway stem cells by CRISPR-Cas9 for pan-mutation correction in the endogenous locus

Author

Vaidyanathan, Sriram, primary, Baik, Ron, additional, Chen, Lu, additional, Bravo, Dawn T., additional, Suarez, Carlos J., additional, Abazari, Shayda M., additional, Salahudeen, Ameen A., additional, Dudek, Amanda M., additional, Teran, Christopher A., additional, Davis, Timothy H., additional, Lee, Ciaran M., additional, Bao, Gang, additional, Randell, Scott H., additional, Artandi, Steven E., additional, Wine, Jeffrey J., additional, Kuo, Calvin J., additional, Desai, Tushar J., additional, Nayak, Jayakar V., additional, Sellers, Zachary M., additional, and Porteus, Matthew H., additional

Published
2022
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38. Determinants of SARS-CoV-2 entry and replication in airway mucosal tissue and susceptibility in smokers

Author

Nakayama, Tsuguhisa, primary, Lee, Ivan T., additional, Jiang, Sizun, additional, Matter, Matthias S., additional, Yan, Carol H., additional, Overdevest, Jonathan B., additional, Wu, Chien-Ting, additional, Goltsev, Yury, additional, Shih, Liang-Chun, additional, Liao, Chun-Kang, additional, Zhu, Bokai, additional, Bai, Yunhao, additional, Lidsky, Peter, additional, Xiao, Yinghong, additional, Zarabanda, David, additional, Yang, Angela, additional, Easwaran, Meena, additional, Schürch, Christian M., additional, Chu, Pauline, additional, Chen, Han, additional, Stalder, Anna K., additional, McIlwain, David R., additional, Borchard, Nicole A., additional, Gall, Phillip A., additional, Dholakia, Sachi S., additional, Le, Wei, additional, Xu, Le, additional, Tai, Chih-Jaan, additional, Yeh, Te-Huei, additional, Erickson-Direnzo, Elizabeth, additional, Duran, Jason M., additional, Mertz, Kirsten D., additional, Hwang, Peter H., additional, Haslbauer, Jasmin D., additional, Jackson, Peter K., additional, Menter, Thomas, additional, Andino, Raul, additional, Canoll, Peter D., additional, DeConde, Adam S., additional, Patel, Zara M., additional, Tzankov, Alexandar, additional, Nolan, Garry P., additional, and Nayak, Jayakar V., additional

Published
2021
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39. Incorporating Perioperative Point-of-Care Ultrasound as Part of the Anesthesia Residency Curriculum

Author

Jose R Navas-Blanco, Xiaoxia Han, Derrick V. Williams, Nicholas S Yeldo, Jayakar Guruswamy, and Joseph A. Sanders

Subjects
Male, Point-of-Care Systems, education, Psychological intervention, 030204 cardiovascular system & hematology, Cohort Studies, Hospitals, University, 03 medical and health sciences, 0302 clinical medicine, Anesthesiology, 030202 anesthesiology, Humans, Medicine, Anesthesia, Prospective Studies, Curriculum, Ultrasonography, Interventional, business.industry, Point of care ultrasound, Residency curriculum, Internship and Residency, Perioperative, Test (assessment), Anesthesiology and Pain Medicine, Cohort, Female, Observational study, Clinical Competence, Cardiology and Cardiovascular Medicine, business
Abstract

Objective The purposes of this study were to establish whether implementing a curriculum of perioperative point-of-care ultrasound (POCUS) of the heart and lungs for current in-training anesthesia residents during their required month of cardiac anesthesia was feasible and whether an evaluation tool would demonstrate improvement in the residents’ baseline knowledge of POCUS. Design Single-center, prospective, cohort, and observational study. Setting A tertiary-care, university-affiliated hospital. Participants The study comprised 16 anesthesia residents on their third postgraduate training year during their required cardiac anesthesia rotation. Interventions The implementation of a curriculum to educate anesthesia residents in perioperative POCUS of the heart and lungs on patients undergoing elective cardiothoracic procedures that included both theoretical and practical approaches. A 21-question, multiple-choice, electronic-generated test was developed to gauge performance improvement from before (“pretest”) to after (“posttest”) the 4-week period. Measurements and Main Results Of the 16 residents, 13 (81.3%) showed improved scores between the pretest and posttest periods after the 4-week rotation. The difference between pretest and posttest mean score was 5 (p = 0.001). Conclusions This study demonstrates that integrating a curriculum dedicated to perioperative POCUS of the heart and lungs as part of the goals and objectives during the rotation of cardiac anesthesia is feasible and that anesthesia residents who received the training proposed by the authors improved their cognitive and technical skills.

Published
2019
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40. Micro-bunching for generating tunable narrow-band THz radiation at the FAST photoinjector

Author

Jayakar Thangaraj, J. Hyun, Tanaji Sen, and Philippe Piot

Subjects
Accelerator Physics (physics.acc-ph), Physics, Nuclear and High Energy Physics, 010308 nuclear & particles physics, Terahertz radiation, business.industry, Wiggler, FOS: Physical sciences, Physics::Optics, Electron, 01 natural sciences, Optics, Transition radiation, 0103 physical sciences, Quadrupole, Physics::Accelerator Physics, Physics - Accelerator Physics, Fermilab, 010306 general physics, business, Chicane, Instrumentation, Beam (structure)
Abstract

This paper presents expected THz radiation spectra emitted by micro-bunched electron beams produced using a slit-mask placed within a magnetic chicane in the FAST (Fermilab Accelerator Science and Technology) electron injector at Fermilab. Our purpose is to generate tunable narrow-band THz radiation with a simple scheme in a conventional photo-injector. Using the slit-mask in the chicane, we create a longitudinally micro-bunched beam after the chicane by transversely slicing an energy chirped electron bunch at a location with horizontal dispersion. In this paper, we discuss the theory related to the micro-bunched beam structure, the beam optics, the simulation results of the micro-bunched beam and the bunching factors. Energy radiated at THz frequencies from two sources: coherent transition radiation and from a wiggler is calculated and compared. We also discuss the results of a simple method to observe the micro-bunching on a transverse screen monitor using a skew quadrupole placed in the chicane., Comment: 25 pages, 8 figures

Published
2019
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42. Trends in personal protective equipment use by clinicians performing airway procedures for patients with coronavirus disease 2019 in the USA from the intubateCOVID registry

Author

Sabry Ayad, May Hua, Michael F. Aziz, Guy Shochat, Cynthia A. Lien, Timothy G. Gaulton, Frederick G. Mihm, Laura Fonseca, Marian Sherman, Ahmed Salih, Danny J.N. Wong, Jill M. Mhyre, Julie K. Freed, Elizabeth Abramowicz, Richard P. Dutton, Miriam M. Treggiari, Mark Giska, Catherine Chen, Lynnette Harris, Aratara Nutcharoen, Timothy T. Houle, Matthew T. Murrell, James Dattilo, Robert B. Schonberger, Kay B. Leissner, Amy Gunnett, Kathleen N. Johnson, Michael A. Gropper, Karen B. Domino, Jochen D. Muehlschlegel, Jessica L Shanahan, Michael R. Mathis, Steven I. Bott, Laurie K. Davies, Dhanesh K. Gupta, Katherine Nowak, Jacob G. Fowler, P. M. Desai, Yatish S. Ranganath, Anoop Chhina, Yinhui Low, Benjamin H. Cloyd, Alyssa Brzenski, Meir Dashevksy, Ludmil Mitrev, Andrea J. Strathman, Mark D. Neuman, Mark I. Neuman, Aaron M. Joffe, Andrew Volio, Max W. Breidenstein, Donald H. Penning, Kariem El-Boghdadly, Richard Lee Applegate, Imran Ahmad, Timothy Gaulton, Michael B Majewski, Meghan B. Lane-Fall, J. Matthew Fisher, Lyle Gerety, Samuel A. Schechtman, Lakisha J. Gaskins, Ashish Khanna, Peter Panzica, Craig Johnstone, Matthew Wecksell, Kelsey Adair, Alexander Nagrebetsky, Jayakar Guruswamy, Andrea Olmos, Shannon Michel, Daniel Kim, Zita Sibenellar, Shanna S. Hill, Vanessa Cervantes, B. Scott Segal, J. Doug Jaffe, Alexander F. Friend, Nadir Sharawi, Howard B. Gutstein, Alexander Mittnacht, Joy Steadman, Ami R. Stuart, Steven Berstein, Jinlei Li, Michael Y. Lin, David W. Healy, Amie Hoefnagel, Alexis Skolaris, Brenda G. Fahy, and Douglas A. Colquhoun

Subjects
Adult, Male, medicine.medical_specialty, 2019-20 coronavirus outbreak, Infectious Disease Transmission, Patient-to-Professional, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), medicine.medical_treatment, Physicians, Correspondence, medicine, Intubation, Intratracheal, Humans, tracheal intubation, Personal protective equipment, business.industry, Tracheal intubation, respiratory failure, aerosol-generating procedures, COVID-19, Middle Aged, United States, Anesthesiology and Pain Medicine, Respiratory failure, Emergency medicine, personal protective equipment, Female, business, Airway
Published
2021
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44. UBA2 variants underlie a recognizable syndrome with variable aplasia cutis congenita and ectrodactyly

Author

Schnur, Rhonda E., primary, Yousaf, Sairah, additional, Liu, James, additional, Chung, Wendy K., additional, Rhodes, Lindsay, additional, Marble, Michael, additional, Zambrano, Regina M., additional, Sobreira, Nara, additional, Jayakar, Parul, additional, Pierpont, Mary Ella, additional, Schultz, Matthew J., additional, Pichurin, Pavel N., additional, Olson, Rory J., additional, Graham, Gail E., additional, Osmond, Matthew, additional, Contreras-García, Gustavo A., additional, Campo-Neira, Karina A., additional, Peñaloza-Mantilla, Camilo A., additional, Flage, Mark, additional, Kuppa, Srikar, additional, Navarro, Karina, additional, Sacoto, Maria J. Guillen, additional, Wentzensen, Ingrid M., additional, Scarano, Maria I., additional, Juusola, Jane, additional, Prada, Carlos E., additional, and Hufnagel, Robert B., additional

Published
2021
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45. SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment

Author

Wu, Chien-Ting, primary, Lidsky, Peter V., additional, Xiao, Yinghong, additional, Lee, Ivan T., additional, Cheng, Ran, additional, Nakayama, Tsuguhisa, additional, Jiang, Sizun, additional, Demeter, Janos, additional, Bevacqua, Romina J., additional, Chang, Charles A., additional, Whitener, Robert L., additional, Stalder, Anna K., additional, Zhu, Bokai, additional, Chen, Han, additional, Goltsev, Yury, additional, Tzankov, Alexandar, additional, Nayak, Jayakar V., additional, Nolan, Garry P., additional, Matter, Matthias S., additional, Andino, Raul, additional, and Jackson, Peter K., additional

Published
2021
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46. SARS-CoV-2 entry factors are expressed in nasal, ocular, and oral tissues: implications for COVID-19 prophylaxes/therapeutics

Author

Tsuguhisa Nakayama, Yury Goltsev, Pauline Chu, Han Chen, Ivan T. Lee, Bokai Zhu, Matthias S. Matter, David R. McIlwain, Alexandar Tzankov, Sizun Jiang, Garry P. Nolan, Christian M. Schürch, and Jayakar V. Nayak

Subjects
2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Immunology, Medicine, Immunology and Allergy, business, Virology, Article
Published
2021
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47. The diffusion of National Domain Name Dispute Resolution Policies: A Network Approach

Author

Rachel X. Peng, Ryan Y. Wang, Jenna Grzeslo, Yang Bai, and Krishna Jayakar

Subjects
Country code top-level domain, Information retrieval, Similarity (network science), business.industry, Computer science, Exponential random graph models, Cosine similarity, The Internet, Adjacency matrix, business, Dispute resolution, Network analysis
Abstract

This paper investigates the adoption of national domain name dispute resolution policies (NDRPs) by country code Top Level Domains (ccTLD). We examine the textual similarity between different NDRPs (35 documents) using Exponential Random Graph Modeling (ERGM). First, we measure similarity between the texts (i.e., cosine similarity) and use it to construct a 35*35 adjacency matrix for a directed network early to late adopters. Using EGRM, we predict which nodal attributes and dyadic attributes predict the observed network. We conclude by discussing what the findings imply about the emergence of a global policy regime for the Internet.

Published
2021
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50. Trends in personal protective equipment use by clinicians performing airway procedures for patients with coronavirus disease 2019 in the USA from the intubateCOVID registry

Author

Gaulton, Timothy G., primary, Neuman, Mark D., additional, Gaulton, Timothy, additional, Neuman, Mark, additional, Lane-Fall, Meghan, additional, Gaskins, Lakisha, additional, Dattilo, James, additional, El-Boghdadly, Kariem, additional, Wong, Danny J.N., additional, Ahmad, Imran, additional, Johnstone, Craig, additional, Gutstein, Howard B., additional, Muehlschlegel, Jochen D., additional, Hua, May, additional, Fonseca, Laura, additional, Mitrev, Ludmil, additional, Low, Yinhui, additional, Gupta, Dhanesh, additional, Ayad, Sabry, additional, Volio, Andrew, additional, Salih, Ahmed, additional, Kim, Daniel, additional, Nutcharoen, Aratara, additional, Skolaris, Alexis, additional, Sherman, Marian, additional, Giska, Mark, additional, Nowak, Katherine, additional, Chhina, Anoop, additional, Guruswamy, Jayakar, additional, Penning, Donald, additional, Majewski, Michael, additional, Nagrebetsky, Alexander, additional, Houle, Timothy, additional, Aziz, Michael F., additional, Freed, Julie K., additional, Lien, Cynthia A., additional, Mihm, Fred, additional, Desai, Pankaj M., additional, Fahy, Brenda G., additional, Davies, Laurie, additional, Adair, Kelsey, additional, Gunnett, Amy, additional, Mhyre, Jill M., additional, Sharawi, Nadir, additional, Applegate, Richard, additional, Brzenski, Alyssa, additional, Lin, Michael Y., additional, Olmos, Andrea, additional, Chen, Catherine L., additional, Gropper, Michael, additional, Shochat, Guy, additional, Hoefnagel, Amie, additional, Ranganath, Yatish, additional, Sibenellar, Zita, additional, Colquhoun, Douglas A., additional, Cloyd, Benjamin H., additional, Healy, David W., additional, Mathis, Michael R., additional, Schechtman, Samuel A., additional, Steadman, Joy, additional, Stuart, Ami, additional, Bott, Steven, additional, Gerety, Lyle, additional, Fisher, J. Matthew, additional, Friend, Alexander F., additional, Breidenstein, Max W., additional, Domino, Karen B., additional, Cervantes, Vanessa, additional, Joffe, Aaron M., additional, Dutton, Richard, additional, Shanahan, Jessica, additional, Leissner, Kay B., additional, Jaffe, J. Doug, additional, Strathman, Andrea, additional, Khanna, Ashish K., additional, Segal, B. Scott, additional, Harris, Lynnette, additional, Fowler, Jacob, additional, Johnson, Kathleen, additional, Hill, Shanna S., additional, Murrell, Matthew T., additional, Panzica, Peter, additional, Mittnacht, Alexander, additional, Abramowicz, Elizabeth, additional, Wecksell, Matthew, additional, Schonberger, Robert B., additional, Li, Jinlei, additional, Michel, Shannon, additional, Treggiari, Miriam, additional, Berstein, Steven, additional, and Dashevksy, Meir, additional

Published
2021
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