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Your search keyword '"Jiang, Yixiang"' showing total 11 results
Start Over Author "Jiang, Yixiang" Publisher elsevier bv
11 results on '"Jiang, Yixiang"'

2. Emergence of chromosomally located blaCTX-M-14b and qnrS1 in Salmonella enterica serotype Kentucky ST198 in China

Author

She, Yiying, primary, Jiang, Yixiang, additional, Luo, Miaomiao, additional, Duan, Xiangke, additional, Xie, Li, additional, Yang, Chao, additional, Xu, Liangcai, additional, Fu, Yulin, additional, Lv, Ziquan, additional, Cai, Rui, additional, Li, Yinghui, additional, Qiu, Yaqun, additional, Hu, Lulu, additional, Shi, Xiaolu, additional, Wang, Lei, additional, Wu, Shuang, additional, Chen, Qiongcheng, additional, Jiang, Min, additional, and Hu, Qinghua, additional

Published
2023
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3. Targeting tau only extracellularly is likely to be less efficacious than targeting it both intra- and extracellularly

Author

Congdon, Erin E., Jiang, Yixiang, and Sigurdsson, Einar M.

Subjects
Neurons, Tauopathies, Alzheimer Disease, Humans, tau Proteins, Immunotherapy, Cell Biology, Article, Antibodies, Developmental Biology
Abstract

Aggregation of the tau protein is thought to be responsible for the neurodegeneration and subsequent functional impairments in diseases that are collectively named tauopathies. Alzheimer's disease is the most common tauopathy, but the group consists of over 20 different diseases, many of which have tau pathology as their primary feature. The development of tau therapies has mainly focused on preventing the formation of and/or clearing these aggregates. Of these, immunotherapies that aim to either elicit endogenous tau antibodies or deliver exogenous ones are the most common approach in clinical trials. While their mechanism of action can involve several pathways, both extra- and intracellular, pharmaceutical companies have primarily focused on antibody-mediated clearance of extracellular tau. As we have pointed out over the years, this is rather surprising because it is well known that most of pathological tau protein is found intracellularly. It has been repeatedly shown by several groups over the past decades that antibodies can enter neurons and that their cellular uptake can be enhanced by various means, particularly by altering their charge. Here, we will briefly describe the potential extra- and intracellular mechanisms involved in antibody-mediated clearance of tau pathology, discuss these in the context of recent failures of some of the tau antibody trials, and finally provide a brief overview of how the intracellular efficacy of tau antibodies can potentially be further improved by certain modifications that aim to enhance tau clearance via specific intracellular degradation pathways.

Published
2022

7. Excess salt intake promotes M1 microglia polarization via a p38/MAPK/AR-dependent pathway after cerebral ischemia in mice

Author

Zhang, Tongshuai, primary, Wang, Dandan, additional, Li, Xuan, additional, Jiang, Yixiang, additional, Wang, Chao, additional, Zhang, Yao, additional, Kong, Qingfei, additional, Tian, Chao, additional, Dai, Yongfeng, additional, Zhao, Wei, additional, Jiang, Mingyue, additional, Chang, Yanzhong, additional, and Wang, Guangyou, additional

Published
2020
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