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Start Over Author "Jingping Kou" Publisher elsevier bv
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2. A facile synthesis of 2-(N-alkylamino)-pyrimidin-4-one derivatives

Author

Jingping Kou, Jizhen Li, Erkang Fan, and Xuyang Luo

Subjects
chemistry.chemical_compound, Pyrimidinones, Thiourea, Chemistry, Organic Chemistry, Drug Discovery, Intramolecular cyclization, Cleavage (embryo), Protecting group, Biochemistry, Medicinal chemistry
Abstract

Substituted 2-(N-alkylamino)-pyrimidin-4-ones were synthesized from N-alkyl β-amino acid esters starting with guanidinylation using Pbf-activated thiourea. The six-membered pyrimidinones were obtained in good yields via intramolecular cyclization during TFA cleavage of the Pbf protecting group.

Published
2008
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