Author: "Jiyu Yu" / Publisher: elsevier bv - Searchworks@Jio Institute Digital Library Search Results

Author: Da Gao, Ge Li, and Jiyu Yu
Subjects: General Energy, Mechanical Engineering, Building and Construction, Electrical and Electronic Engineering, Pollution, Industrial and Manufacturing Engineering, Civil and Structural Engineering
Published: 2022

Author: Yun-Zhou Yu, Zhi-Wei Sun, Jiyu Yu, Shuang Wang, Wei-Yuan Yu, and Na Li
Subjects: Serotype, Botulinum Toxins, Semliki Forest virus, medicine.disease_cause, Bivalent (genetics), DNA vaccination, Microbiology, law.invention, Mice, law, Clostridium botulinum, Vaccines, DNA, medicine, Animals, Replicon, Botulinum Toxins, Type A, Mice, Inbred BALB C, General Veterinary, General Immunology and Microbiology, biology, Public Health, Environmental and Occupational Health, Botulism, biology.organism_classification, Antibodies, Bacterial, Semliki forest virus, Virology, Vaccination, Infectious Diseases, Bacterial Vaccines, Recombinant DNA, Molecular Medicine, Female
Abstract: We evaluated individual and bivalent replicon vaccines against Clostridium botulinum neurotoxin serotypes A (BoNT/A) or B (BoNT/B). The DNA replicon vaccine (pSCARSBHc) encoding the Hc domain of BoNT/B (BHc) induced better responses and protection against BoNT/B mouse challenge than conventional DNA vaccine. The dual-expressing DNA vaccine (pSCARSA/BHc) protected similarly to a DNA replicon vaccine mixture (pSCARSAHc + pSCARSBHc). Additionally, recombinant SFV particles, VRP-AHc or VRP-BHc, protected mice from high-dose BoNT/A or BoNT/B challenge, respectively. Mice given either dual-expressing VRP-A/BHc or mixture of VRP-AHc and VRP-BHc were protected from challenge with serotype A/B mixtures. These data justify further testing in other animals or humans.
Published: 2009

Searchworks