1. Eosinophils are dispensable for development of MOG35–55-induced experimental autoimmune encephalomyelitis in mice
- Author
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Avery August, Jong-Hyung Lim, Ales Neuwirth, Klara Ruppova, and Georgia Fodelianaki
- Subjects
business.industry ,Multiple sclerosis ,Immunology ,Experimental autoimmune encephalomyelitis ,Neurological disorder ,respiratory system ,Eosinophil ,medicine.disease ,medicine.disease_cause ,Spinal cord ,Autoimmunity ,Immune system ,medicine.anatomical_structure ,immune system diseases ,medicine ,Immunology and Allergy ,business ,Neuroinflammation - Abstract
Experimental autoimmune encephalomyelitis (EAE) represents the mouse model of multiple sclerosis, a devastating neurological disorder. EAE development and progression involves the infiltration of different immune cells into the brain and spinal cord. However, less is known about a potential role of eosinophil granulocytes for EAE disease pathogenesis. In the present study, we found enhanced eosinophil abundance accompanied by increased concentration of the eosinophil chemoattractant eotaxin-1 in the spinal cord in the course of EAE induced in C57BL/6 mice by immunization with MOG35-55 peptide. However, the absence of eosinophils did not affect neuroinflammation, demyelination and clinical development or severity of EAE, as assessed in ∆dblGATA1 eosinophil-deficient mice. Taken together, despite their enhanced abundance in the inflamed spinal cord during disease progression, eosinophils were dispensable for EAE development.
- Published
- 2021