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Your search keyword '"Jun Koseki"' showing total 3 results
Start Over Author "Jun Koseki" Publisher elsevier bv
3 results on '"Jun Koseki"'

2. Spatial and single-cell transcriptomics decipher the cellular environment containing HLA-G+ cancer cells and SPP1+ macrophages in colorectal cancer

Author

Yuki Ozato, Yasuhiro Kojima, Yuta Kobayashi, Yuuichi Hisamatsu, Takeo Toshima, Yusuke Yonemura, Takaaki Masuda, Kouichi Kagawa, Yasuhiro Goto, Mitsuaki Utou, Mituko Fukunaga, Ayako Gamachi, Kiyomi Imamura, Yuta Kuze, Junko Zenkoh, Ayako Suzuki, Atsushi Niida, Haruka Hirose, Shuto Hayashi, Jun Koseki, Eiji Oki, Satoshi Fukuchi, Kazunari Murakami, Taro Tobo, Satoshi Nagayama, Mamoru Uemura, Takeharu Sakamoto, Masanobu Oshima, Yuichiro Doki, Hidetoshi Eguchi, Masaki Mori, Takeshi Iwasaki, Yoshinao Oda, Tatsuhiro Shibata, Yutaka Suzuki, Teppei Shimamura, and Koshi Mimori

Subjects
General Biochemistry, Genetics and Molecular Biology
Published
2023
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3. Theoretical study of the reversible photoconversion mechanism in Dronpa

Author

Yukiumi Kita, Masanori Tachikawa, Umpei Nagashima, and Jun Koseki

Subjects
Proton, Computer science, Photoactivatable fluorescent proteins, Chromophore, Ring (chemistry), Photochemistry, Photobleaching, Cis trans isomerization, Proton transfer, Dronpa, Molecular dynamics, chemistry.chemical_compound, cis-trans isomerization, chemistry, General Earth and Planetary Sciences, Imidazole, Density functional theory, Isomerization, General Environmental Science
Abstract

We propose a new scheme of the photoactivation and the photobleaching for Dronpa with molecular dynamics method and density functional theory. These processes can be explained by considering cis-trans isomerization in neutral state of chromophore. The proton transfer from anionic to neutral chromophore makes cis-trans isomerization possible via hula-twist rotation process, since the space for cis-trans isomerization is opened at around the region near chromophore by moving out of the imidazole ring on H193 from the position below the phenol ring on chromophore. Then the cis-trans isomerization can occur through the hula-twist process. The contributions from the protein environment around CRO, especially S142 and H193, are indispensable for photoconversion of Dronpa.

Published
2011
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