45 results on '"Kakeya, Hideaki"'
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2. FK506-binding protein, FKBP12, promotes serine utilization and negatively regulates threonine deaminase in fission yeast
3. Pharmacologic characterization of TBP1901, a prodrug form of aglycone curcumin, and CRISPR-Cas9 screen for therapeutic targets of aglycone curcumin
4. FK506-binding protein, FKBP12, promotes serine utilization and negatively regulates threonine deaminase in fission yeast
5. Pharmacologic characterization of TBP1901, a prodrug form of aglycone curcumin, and CRISPR-Cas9 screen for therapeutic targets of aglycone curcumin
6. Chemoproteomics profiling of surfactin-producing nonribosomal peptide synthetases in living bacterial cells
7. Design, synthesis, and target identification of new hypoxia-inducible factor 1 (HIF-1) inhibitors containing 1-alkyl-1H-pyrazole-3-carboxamide moiety
8. Retro-aza-Michael reaction of an o-aminophenol adduct in protic solvents inspired by natural products
9. Development of new treatment using CMG for oxaliplatin-resistant colorectal cancer with KRAS mutation
10. Enhancement of saccharothriolide production and discovery of a new metabolite, saccharothriolide C2, by combined-culture of Saccharothrix sp. and Tsukamurella pulmonis
11. Development of an anti-hepatitis B virus (HBV) agent through the structure-activity relationship of the interferon-like small compound CDM-3008
12. Theonellamide A, a marine-sponge-derived bicyclic peptide, binds to cholesterol in aqueous DMSO: Solution NMR-based analysis of peptide-sterol interactions using hydroxylated sterol
13. Curcumin and its demethoxy derivatives possess p300 HAT inhibitory activity and suppress hypertrophic responses in cardiomyocytes
14. Curcumin and its demethoxy derivatives possess p300 HAT inhibitory activity and suppress hypertrophic responses in cardiomyocytes
15. Sterol-dependent membrane association of the marine sponge-derived bicyclic peptide Theonellamide A as examined by 1H NMR
16. Marine sponge cyclic peptide theonellamide A disrupts lipid bilayer integrity without forming distinct membrane pores
17. Design, synthesis, and structure–activity relationships of 1-ethylpyrazole-3-carboxamide compounds as novel hypoxia-inducible factor (HIF)-1 inhibitors
18. Balance between Exocytosis and Endocytosis Determines the Efficacy of Sterol-Targeting Antibiotics
19. A 7-dimethylallyl tryptophan synthase from a fungal Neosartorya sp.: Biochemical characterization and structural insight into the regioselective prenylation
20. Specific enrichment of nonribosomal peptide synthetase module by an affinity probe for adenylation domains
21. RNA-Methylation-Dependent RNA Processing Controls the Speed of the Circadian Clock
22. Chemical tagging of a drug target using 5-sulfonyl tetrazole
23. Stereochemical reassignment of heronamide A, a polyketide macrolactam from Streptomyces sp.
24. Tumescenamide C, an antimicrobial cyclic lipodepsipeptide from Streptomyces sp.
25. HIGHLY ABSORPTIVE CURCUMIN IMPROVES LEFT VENTRICULAR DIASTOLIC FUNCTION REGARDLESS OF BLOOD PRESSURE IN HYPERTENSIVE PATIENTS
26. Total synthesis and determination of the absolute configuration of FD-838, a naturally occurring azaspirobicyclic product
27. Synthesis and structure–activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance protein
28. Synthesis of a biotin-conjugate of phosmidosine O-ethyl ester as a G1 arrest antitumor drug
29. Structure–activity relationship of phosmidosine: importance of the 7,8-dihydro-8-oxoadenosine residue for antitumor activity
30. Structure–activity relationships of epolactaene derivatives: structural requirements for inhibition of Hsp60 chaperone activity
31. RK-805, an endothelial-cell-growth inhibitor produced by Neosartorya sp., and a docking model with methionine aminopeptidase-2
32. Synthesis and cell cycle inhibition of the peptide enamide natural products terpeptin and the aspergillamides
33. Novel non-peptide inhibitors targeting death receptor-Mediated apoptosis
34. Reaction modes of oxidative dimerization of epoxycyclohexenols
35. Epoxycyclohexenone Inhibits Fas-mediated Apoptosis by Blocking Activation of Pro-caspase-8 in the Death-inducing Signaling Complex
36. A practical total synthesis of both enantiomers of epoxyquinols A and B
37. Activation of MST/Krs and c-Jun N-terminal Kinases by Different Signaling Pathways during Cytotrienin A-induced Apoptosis
38. Biosynthesis of 1-aminocyclopropane-1-carboxylic acid moiety on cytotrienin A in Streptomyces sp.
39. Novel triene-ansamycins, cytotrienins A and B, inducing apoptosis on human leukemia HL-60 cells
40. Novel mammalian cell cycle inhibitors, cyclotroprostatins A–D, produced by Aspergillus fumigatus, which inhibit mammalian cell cycle at G2/M phase
41. Novel mammalian cell cycle inhibitors, spirotryprostatins A and B, produced by Aspergillus fumigatus, which inhibit mammalian cell cycle at G2/M phase
42. Screening and biological activity of tyrosine kinase inhibitors.
43. Microbial hydrolysis as a potent method for the preparation of optically active nitriles, amides and carboxylic acids
44. A synthesis of (R)-(-)-mevalonolactone by the combination of enzymatic and chemical methods
45. A synthesis of (−)-deoxypodocarpic acid methyl ester via an enzymatic enantioselective hydrolysis of the key intermidiate enol ester
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