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Your search keyword '"Kant, M"' showing total 17 results
Start Over Author "Kant, M" Publisher elsevier bv
17 results on '"Kant, M"'

1. Impaired balance of oxidative DNA damage and base excision repair (BER) in dorsolateral prefrontal cortex in mood disorders

Author

Özerdem, A., primary, Ho, M.C., additional, Ceylan, D., additional, Winham, S., additional, Kant, M., additional, Dizdaroglu, M., additional, Jaruga, P., additional, Coskun, E., additional, Mahajan, G., additional, Sanchez-Ruiz, J., additional, Choi, D.S., additional, Frye, M., additional, Stockmeier, C., additional, Rajkowska, G., additional, and Veldic, M., additional

Published
2022
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5. In vivo 7Tesla imaging of the dentate granule cell layer in schizophrenia

Author

Graham C. Wiggins, Dolores Malaspina, Melina Warren, Ivan I. Kirov, Julie W. Messinger, Ceylan Z. Cankurtaran, Oded Gonen, Kant M. Matsuda, Raymond R. Goetz, James S. Babb, Nissa N. Perry, Caitlin Hardy, and Ajax E. George

Subjects
Adult, Male, Pathology, medicine.medical_specialty, computer.software_genre, Statistics, Nonparametric, Article, Young Adult, Voxel, Image Processing, Computer-Assisted, medicine, Humans, Hippocampus (mythology), Biological Psychiatry, Aged, medicine.diagnostic_test, business.industry, Dentate gyrus, Magnetic resonance imaging, Histology, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Psychiatry and Mental health, Schizophrenia, Case-Control Studies, Dentate Gyrus, Biomarker (medicine), Female, Histopathology, Psychology, Nuclear medicine, business, computer
Abstract

article i nfo Purpose: The hippocampus is central to the pathophysiology of schizophrenia. Histology shows abnormalities in the dentate granule cell layer (DGCL), but its small size (~100 μm thickness) has precluded in vivo human studies. We used ultra high field magnetic resonance imaging (MRI) to compare DGCL morphology of schizo- phrenic patients to matched controls. Method: Bilateral hippocampi of 16 schizophrenia patients (10 male) 40.7 ± 10.6 years old (mean ± standard de- viation) were imaged at 7 Tesla MRI with heavily T2 ⁎-weighted gradient-echo sequence at 232 μm in-plane resolu- tion (0.08 μL image voxels). Fifteen matched controls (8 male, 35.6 ± 9.4 years old) and one ex vivo post mortem hippocampus (that also underwent histopathology) were scanned with same protocol. Three blinded neuroradiol- ogists rated each DGCL on a qualitative scale of 1 to 6 (from "not discernible" to "easily visible, appearing dark gray or black") and mean left and right DGCL scores were compared using a non-parametric Mann-Whitney test. Results: MRI identification of the DGCL was validated with histopathology. Mean right and left DGCL ratings in pa- tients (3.2 ± 1.0 and 3.5 ± 1.2) were not statistically different from those of controls (3.9 ± 1.1 and 3.8 ± 0.8), but patients had a trend fo rl ower right DGCL score (p = 0.07), which was significantly associated with patient diagnosis (p = 0.05). The optimal 48% sensitivity and 80% specificity for schizophrenia were achieved with a DGCL rating of ≤2. Conclusion: Decreased contrast in the right DGCL in schizophreniawas predictive of schizophrenia diagnosis. Better utility of this metric as a schizophrenia biomarker may be achieved in future studies of patients with homogeneous disease subtypes and progression rates.

Published
2013
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