1. The cortical excitability profile of patients with the G209A SNCA mutation versus patients with sporadic Parkinson's disease: A transcranial magnetic stimulation study
- Author
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Kimiskidis, Vasilios K., Papayiannopoulos, Sotirios, Sotirakoglou, Kyriaki, Karakasis, Haralambos, Katsarou, Zoe, Kazis, Dimitrios A., Papaliagkas, Vasileios, Gatzonis, Stylianos, Papadimitriou, Alexandros, Hadjigeorgiou, Georgios, Bostanjopoulou, Sevasti, Hadjigeorgiou, Georgios [0000-0001-5386-4273], Kimiskidis, Vasilios K. [0000-0002-3335-3019], Kazis, Dimitrios A. [0000-0002-7319-2045], Papaliagkas, Vasileios [0000-0003-1064-0290], and Gatzonis, Stylianos [0000-0002-6498-3929]
- Subjects
Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Parkinson's disease ,medicine.medical_treatment ,medicine.disease_cause ,Inhibitory postsynaptic potential ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Physiology (medical) ,Internal medicine ,Humans ,Medicine ,Aged ,Motor threshold ,Alpha-synuclein ,Mutation ,business.industry ,Motor Cortex ,Parkinson Disease ,General Medicine ,Middle Aged ,Evoked Potentials, Motor ,medicine.disease ,Transcranial Magnetic Stimulation ,nervous system diseases ,Transcranial magnetic stimulation ,030104 developmental biology ,Neurology ,chemistry ,Cortical Excitability ,alpha-Synuclein ,Excitatory postsynaptic potential ,Cardiology ,Female ,Silent period ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Mutations in the α-synuclein gene are a rare cause of Parkinson's disease. We investigated, by single-pulse TMS, the cortical excitability profile of nine α-synuclein patients in comparison with 24 idiopathic PD patients, subdivided into “akinetic” (n=17) and “tremor-dominant” (n=7) subgroups. The comparative assessment of rest motor threshold, active MEP and Silent Period Input/Output curves indicated that the cortical excitability of α-Synuclein patients is similar to patients with the “akinetic” form of PD. Both groups of patients exhibited differences in excitatory and inhibitory brain circuits from “tremor-dominant” patients indicating that varying clinical phenotypes are associated with differential profiles of corticospinal excitability. 48 4 203 206
- Published
- 2018
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