1. Non-tuberculous mycobacterial infections—A neglected and emerging problem
- Author
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Imran Ahmed, Simon Tiberi, Kauser Jabeen, Dorothy Yeboah-Manu, Giovanni Battista Migliori, Rumina Hasan, and Joveria Farooqi
- Subjects
0301 basic medicine ,Microbiology (medical) ,Non tuberculous mycobacterial ,Treatment response ,medicine.medical_specialty ,Tuberculosis ,Isolation (health care) ,030106 microbiology ,Population ,Mycobacterium Infections, Nontuberculous ,Disease ,Communicable Diseases, Emerging ,lcsh:Infectious and parasitic diseases ,03 medical and health sciences ,0302 clinical medicine ,Epidemiology ,Prevalence ,medicine ,Humans ,lcsh:RC109-216 ,030212 general & internal medicine ,Intensive care medicine ,education ,education.field_of_study ,business.industry ,Incidence ,Incidence (epidemiology) ,Nontuberculous Mycobacteria ,General Medicine ,bacterial infections and mycoses ,medicine.disease ,Infectious Diseases ,business ,Biomarkers - Abstract
Non-tuberculous mycobacteria (NTM) are ubiquitous dwellers of environmental niches and are an established cause of natural and nosocomial infections. The incidence of NTM infections is rising owing to a growing population of immunocompromised and vulnerable individuals, complex medical and surgical procedures, as well as increased awareness and diagnostic capabilities. The prevalence of different NTM varies between continents, regions, and countries. The true global burden of pulmonary and extrapulmonary disease is unknown and estimates are subject to under and/or over-estimation. Diagnosis requires confirmation by isolation of NTM along with clinical and radiological criteria, which may be suboptimal at all levels. Susceptibility testing is complex and clinical breakpoints are not available for many of the drugs. Frequently, NTM infections are not considered until late in the course of disease. Improved and rapid detection of tuberculosis cases in high-burden countries has, however, also brought NTM infections into the limelight, and has identified a need for research efforts towards rapid diagnostic tests and the identification of biomarkers to monitor the treatment response in patients with NTM infections. Keywords: Non-tuberculous mycobacteria, Diagnosis, Epidemiology, Tuberculosis endemic regions
- Published
- 2020