1. Daily oral supplementation of Hochu-Ekki-To prevents osteoclastic activation and bone loss in ovariectomized mice
- Author
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Kazuya Tokumura, Eiichi Hinoi, Katsuyuki Kaneda, Sayuki Iwahashi, Kaname Ohta, Tetsuhiro Horie, Takashi Iezaki, Gyujin Park, Shinsuke Ochiai, Hiroki Fusawa, Yasuka Okayama, Kakeru Ozaki, and Takanori Yamada
- Subjects
musculoskeletal diseases ,0301 basic medicine ,medicine.medical_specialty ,Cell type ,Ovariectomy ,medicine.medical_treatment ,Osteoporosis ,Administration, Oral ,Osteoclasts ,Mice, Inbred Strains ,Bone remodeling ,03 medical and health sciences ,0302 clinical medicine ,Osteoclast ,Internal medicine ,medicine ,Animals ,Humans ,Bone Resorption ,Osteoporosis, Postmenopausal ,Reduction (orthopedic surgery) ,Pharmacology ,Hochu ekki to ,Bone Density Conservation Agents ,Traditional herbal medicine ,business.industry ,lcsh:RM1-950 ,medicine.disease ,lcsh:Therapeutics. Pharmacology ,030104 developmental biology ,Endocrinology ,medicine.anatomical_structure ,Ovariectomized rat ,Molecular Medicine ,Female ,business ,Bone volume ,030217 neurology & neurosurgery ,Drugs, Chinese Herbal ,Phytotherapy - Abstract
Bone remodeling is sophisticatedly regulated by two different cell types: bone-resorbing osteoclasts and bone-forming osteoblasts. Hochu-Ekki-To, a Japanese traditional herbal medicine, is commonly used for the treatment of chronic diseases or frailty after an illness; however, its effects on metabolic bone diseases such as osteoporosis are not well known. We herein report that daily oral Hochu-Ekki-To administration significantly inhibits osteoclast activation as well as the reduction in bone volume in ovariectomized mice. Our results suggest that supplementation with Hochu-Ekki-To might be beneficial for the prophylaxis and treatment of metabolic bone diseases associated with abnormal osteoclast activation.
- Published
- 2021
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