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Start Over Author "Kim, Dongin" Publisher elsevier bv
21 results on '"Kim, Dongin"'

6. Grabody B, an IGF1 receptor-based shuttle, mediates efficient delivery of biologics across the blood-brain barrier

Author

Shin, Jung-Won, primary, An, Sungwon, additional, Kim, Dongin, additional, Kim, Hyunjoo, additional, Ahn, Jinhyung, additional, Eom, Jaehyun, additional, You, Weon-Kyoo, additional, Yun, Hyesu, additional, Lee, Bora, additional, Sung, Byungje, additional, Jung, Jinwon, additional, Kim, Sehyun, additional, Son, Yonggyu, additional, Sung, Eunsil, additional, Lee, Hanbyul, additional, Lee, Suyeon, additional, Song, Daehae, additional, Pak, Youngdon, additional, Sandhu, Jagdeep K., additional, Haqqani, Arsalan S., additional, Stanimirovic, Danica B., additional, Yoo, Jiseon, additional, Kim, Donghwan, additional, Maeng, Sungho, additional, Lee, Jeonghun, additional, and Lee, Sang Hoon, additional

Published
2022
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10. Grabody B, a Novel IGF-1 Receptor-Based Shuttle, Mediates Efficient Delivery of Biologics Across the Blood-Brain Barrier

Author

Eom Jaehyun, Ahn Jinhyung, Eun-Sil Sung, An Sungwon, Kim Dongin, Yoo Jiseon, Weon-Kyoo You, Jung Jinwon, Hyesu Yun, Lee Bora, Han-Byul Lee, Sung Byungje, Sehyun Kim, Song Daehae, Jeonghun Lee, Danica Stanimirovic, Jung-Won Shin, Sungho Maeng, SuYeon Lee, Jagdeep K. Sandhu, Donghwan Kim, Arsalan S. Haqqani, Pak Youngdon, Sang-Hoon Lee, and Son Yonggyu

Subjects
Alpha-synuclein, biology, business.industry, Growth factor, medicine.medical_treatment, Transferrin receptor, Pharmacology, Blood–brain barrier, chemistry.chemical_compound, medicine.anatomical_structure, Molecular shuttle, chemistry, biology.protein, Medicine, Antibody, business, Receptor, Insulin-like growth factor 1 receptor
Abstract

Delivering effective therapeutics to the brain is a great challenge. Molecular shuttles use receptors expressed on brain endothelial cells to deliver therapeutics. Currently, antibodies targeting transferrin receptor (TfR) have been widely developed as the molecular shuttle. However, TfR-based approach raised concerns about safety and developmental burden. Here, we report insulin growth factor 1 receptor (IGF1R) as an ideal target for the molecular shuttle. Further, we describe Grabody B, an antibody against the IGF1R as a novel molecular shuttle. Grabody B has broad cross-species reactivity and did not interfere with IGF1R-mediated signaling. Administration of Grabody B-fused therapeutic antibody induced better improvement in neuropathology and behavior than the therapeutic antibody alone in a Parkinson’s disease animal model, owing to its superior serum pharmacokinetics and enhanced brain exposure. Taken together, our study demonstrated IGF1R as an ideal shuttle target and Grabody B as a novel, safe and efficient molecular shuttle.

Published
2020
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11. Grabody B, a Novel IGF-1 Receptor-Based Shuttle, Mediates Efficient Delivery of Biologics Across the Blood-Brain Barrier

Author

Shin, Jung-Won, primary, An, Sungwon, additional, Kim, Dongin, additional, Ahn, Jinhyung, additional, Eom, Jaehyun, additional, You, Weonkyoo, additional, Yun, Hyesu, additional, Lee, Bora, additional, Sung, Byungje, additional, Jung, Jinwon, additional, Kim, Sehyun, additional, Son, Yonggyu, additional, Lee, Hanbyul, additional, Lee, Suyeon, additional, Sung, Eunsil, additional, Song, Daehae, additional, Pak, Youngdon, additional, Sandhu, Jagdeep K., additional, Haqqani, Arsalan S., additional, Stanimirovic, Danica B., additional, Yoo, Jiseon, additional, Kim, Donghwan, additional, Maeng, Sungho, additional, Lee, Jeonghun, additional, and Lee, Sang Hoon, additional

Published
2020
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