1. Development of self-healing vanillin/PEI hydrogels for tissue engineering
- Author
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Merve Yasar, Burcu Oktay, Fulya Dal Yontem, Ebru Haciosmanoglu Aldogan, Nilhan Kayaman Apohan, and Yasar M., OKTAY B., Dal Yontem F., Haciosmanoglu Aldogan E., KAYAMAN APOHAN N.
- Subjects
Characterization of Polymers ,Polymers and Plastics ,Uzay bilimi ,Temel Bilimler (SCI) ,Self-healing ,General Physics and Astronomy ,POLYMER SCIENCE ,MATERIALS SCIENCE, MULTIDISCIPLINARY ,Astronomi ve Astrofizik ,Fizik ,Biochemistry ,Physical Chemistry ,MATERIALS SCIENCE ,Organik Kimya ,Kimya ,Polimerler ve Plastikler ,CHEMISTRY ,KİMYA, ORGANİK ,ASTRONOMİ VE ASTROFİZİK ,Biyokimya ,Materials Chemistry ,UV-polymerization ,Biyoinorganik Kimya ,ASTRONOMY & ASTROPHYSICS ,MALZEME BİLİMİ, ÇOKDİSİPLİNLİ ,Engineering, Computing & Technology (ENG) ,SPACE SCIENCE ,Bioinorganic Chemistry ,Malzeme Kimyası ,Temel Bilimler ,Physics ,Polimer Karakterizasyonu ,Organic Chemistry ,Fizikokimya ,Astronomy and Astrophysics ,Mühendislik, Bilişim ve Teknoloji (ENG) ,Hydrogels ,CHEMISTRY, ORGANIC ,Genel Fizik ve Astronomi ,Fizik Bilimleri ,POLİMER BİLİMİ ,Natural Sciences (SCI) ,Physical Sciences ,Vanillin ,Engineering and Technology ,Mühendislik ve Teknoloji ,Natural Sciences ,Malzeme Bilimi - Abstract
Self-healing materials recover mechanical damages to expand the lifetime of the material provided. In this study, self-healing hydrogels have been successfully prepared using a novel and simple technique. Vanillin is a natural monomer, used as a bio-based cross-linker for UV-induced bonding and Schiff-base bonding. Methacrylate-functionalized vanillin (M-VAN) is covalently integrated with the polymer matrix. While M-VAN supports polymer matrix with its vinyl group, its aldehyde functionality helps the formation of dynamic covalent imine bonds via Schiff-base formation. The hydrogel showed excellent self-healing ability overnight under physiological conditions without external addition. In addition, the hydrogel surface was modified by collagen and its cell viability was investigated. The prepared scaffolds showed good cell viability of 124% and 163% compared to the control sample. The developed self-healing material reveals that it has possible uses for future biomedical applications and tissue engineering studies due to the self-healing mechanism taking place under ambient conditions.
- Published
- 2023