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Your search keyword '"LUCINI, V."' showing total 22 results
Start Over Author "LUCINI, V." Publisher elsevier bv
22 results on '"LUCINI, V."'

21. Plasma tryptophan levels and tryptophan/neutral amino acid ratios in obsessive-compulsive patients with and without depression

Author

Valentina Lucini, Laura Bellodi, Adelio Lucca, Laura Bianchi, Stefano Erzegovesi, Roberta Conca, Bellodi, Laura, Erzegovesi, S, Bianchi, L, Lucini, V, Conca, R, and Lucca, A.

Subjects
Adult, Male, Obsessive-Compulsive Disorder, medicine.medical_specialty, Fluvoxamine, behavioral disciplines and activities, chemistry.chemical_compound, Internal medicine, mental disorders, medicine, Humans, Neurotransmitter, Psychiatry, Biological Psychiatry, Depression (differential diagnoses), Retrospective Studies, chemistry.chemical_classification, Depressive Disorder, Tryptophan, Middle Aged, medicine.disease, humanities, Amino acid, Psychiatry and Mental health, Endocrinology, chemistry, Major depressive disorder, Female, Serotonin, Psychology, Selective Serotonin Reuptake Inhibitors, Anxiety disorder, medicine.drug
Abstract

We have studied fasting plasma tryptophan (TRP) levels and tryptophan/large neutral amino acid (TRP/LNAA) ratios in 12 patients with obsessive-compulsive disorder (OCD) and 12 patients with OCD and a coexisting current diagnosis of major depressive disorder (OCD-MDD). Assessments were made at baseline and after 6 weeks of treatment with fluvoxamine. OCD-MDD patients had significantly lower baseline TRP levels and TRP/LNAA ratios than OCD patients. After 6 weeks of fluvoxamine treatment, OCD-MDD patients had significant increases in plasma TRP and TRP/LNAA ratio, whereas OCD patients had non-significant decreases. Our data suggest that a major depressive syndrome could be a state variable affecting the changes in plasma TRP and TRP/LNAA ratio in OCD patients. (C) 1997 Elsevier Science Ireland Ltd. Z8 0 ZR 0 ZS 0 ZB 8

Published
1997

22. 2-Bromomelatonin: Synthesis and characterization of a potent melatonin agonist

Author

B. M. Stankov, E. Duranti, Gilberto Spadoni, S. Capsoni, Valeria Lucini, Gabriele Biella, Franco Fraschini, Andrea Duranti, Duranti, E, Stankov, B, Spadoni, G, Lucini, V, Capsoni, Simona, Biella, G, and Fraschini, F.

Subjects
Male, Agonist, medicine.medical_specialty, Magnetic Resonance Spectroscopy, medicine.drug_class, Receptors, Melatonin, Socio-culturale, Hamster, In Vitro Techniques, Biology, Mass Spectrometry, General Biochemistry, Genetics and Molecular Biology, gamma-Aminobutyric acid, Melatonin, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Cricetinae, Internal medicine, medicine, Animals, General Pharmacology, Toxicology and Pharmaceutics, Receptor, gamma-Aminobutyric Acid, Bromosuccinimide, Cerebral Cortex, Neurons, Mesocricetus, Biological activity, Organ Size, General Medicine, Receptors, Neurotransmitter, Endocrinology, chemistry, Chromatography, Thin Layer, Rabbits, Acetamide, medicine.drug
Abstract

A practical synthesis of N-[2-(2-bromo-5-methoxy-1H-indol-3-yl)ethyl]- acetamide (2-bromomelatonin) was achieved by direct bromination of melatonin with N-bromosuccinimide (NBS) in anhydrous acetic acid at room temperature under nitrogen, followed by flash-chromatography. 1H-NMR and mass spectra showed the bromine to be incorporated at the C-2 position of the indole moiety. Tests performed in vitro with isolated melatonin receptors from rabbit parietal cortex demonstrated that the relative binding affinity of 2-bromomelatonin was about ten times higher than that of melatonin and close to that of 2-iodomelatonin. 2-Bromomelatonin behaved as a potent agonist in the physiological studies. It showed enhanced activity in inhibiting the spontaneous firing activity of cortical neurons and similarly to melatonin and 2-iodomelatonin potentiated significantly the inhibitory effect of GABA. 2-Bromomelatonin was also an extremely effective agonist in the tests performed in vivo in the Syrian hamster gonadal regression model.

Published
1992

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