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Your search keyword '"Lehrke, Michael"' showing total 28 results
Start Over Author "Lehrke, Michael" Publisher elsevier bv
28 results on '"Lehrke, Michael"'

1. 2,8-Dihydroxyadenine-induced nephropathy causes hexosylceramide accumulation with increased mTOR signaling, reduced levels of protective SirT3 expression and impaired renal mitochondrial function

Author

Moellmann, Julia, primary, Krueger, Katja, additional, Wong, Dickson W.L., additional, Klinkhammer, Barbara M., additional, Buhl, Eva M., additional, Dehairs, Jonas, additional, Swinnen, Johan V., additional, Noels, Heidi, additional, Jankowski, Joachim, additional, Lebherz, Corinna, additional, Boor, Peter, additional, Marx, Nikolaus, additional, and Lehrke, Michael, additional

Published
2024
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3. Pro-oxidative priming but maintained cardiac function in a broad spectrum of murine models of chronic kidney disease

Author

Wollenhaupt, Julia, primary, Frisch, Janina, additional, Harlacher, Eva, additional, Wong, Dickson W.L., additional, Jin, Han, additional, Schulte, Corinna, additional, Vondenhoff, Sonja, additional, Moellmann, Julia, additional, Klinkhammer, Barbara Mara, additional, Zhang, Li, additional, Baleanu-Curaj, Adelina, additional, Liehn, Elisa A., additional, Speer, Thimoteus, additional, Kazakov, Andrey, additional, Werner, Christian, additional, van der Vorst, Emiel P.C., additional, Selejan, Simina-Ramona, additional, Hohl, Mathias, additional, Böhm, Michael, additional, Kramann, Rafael, additional, Biessen, Erik A.L., additional, Lehrke, Michael, additional, Marx, Nikolaus, additional, Jankowski, Joachim, additional, Maack, Christoph, additional, Boor, Peter, additional, Prates Roma, Leticia, additional, and Noels, Heidi, additional

Published
2022
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7. Pro-oxidative priming but maintained cardiac function in a broad spectrum of murine models of chronic kidney disease

Author

Wollenhaupt, Julia, Frisch, Janina, Harlacher, Eva, Wong, Dickson W. L., Jin, Han, Schulte, Corinna, Vondenhoff, Sonja, Moellmann, Julia, Klinkhammer, Barbara Mara, Zhang, Li, Baleanu-Curaj, Adelina, Liehn, Elisa A., Speer, Thimoteus, Kazakov, Andrey, Werner, Christian, Vorst, Emiel P. C. van der, Selejan, Simina-Ramona, Hohl, Mathias, Bohm, Michael, Kramann, Rafael, Biessen, Erik A. L., Lehrke, Michael, Marx, Nikolaus, Jankowski, Joachim, Maack, Christoph, Boor, Peter, Roma, Leticia Prates, Noels, Heidi, Wollenhaupt, Julia, Frisch, Janina, Harlacher, Eva, Wong, Dickson W. L., Jin, Han, Schulte, Corinna, Vondenhoff, Sonja, Moellmann, Julia, Klinkhammer, Barbara Mara, Zhang, Li, Baleanu-Curaj, Adelina, Liehn, Elisa A., Speer, Thimoteus, Kazakov, Andrey, Werner, Christian, Vorst, Emiel P. C. van der, Selejan, Simina-Ramona, Hohl, Mathias, Bohm, Michael, Kramann, Rafael, Biessen, Erik A. L., Lehrke, Michael, Marx, Nikolaus, Jankowski, Joachim, Maack, Christoph, Boor, Peter, Roma, Leticia Prates, and Noels, Heidi

Abstract

Aims: Patients with chronic kidney disease (CKD) have an increased risk of cardiovascular events and exhibit myocardial changes including left ventricular (LV) hypertrophy and fibrosis, overall referred to as 'uremic cardiomyopathy'. Although different CKD animal models have been studied for cardiac effects, lack of consistent reporting on cardiac function and pathology complicates clear comparison of these models. Therefore, this study aimed at a systematic and comprehensive comparison of cardiac function and cardiac pathophysiological characteristics in eight different CKD models and mouse strains, with a main focus on adenine-induced CKD. Methods and results: CKD of different severity and duration was induced by subtotal nephrectomy or adenine-rich diet in various strains (C57BL/6J, C57BL/6 N, hyperlipidemic C57BL/6J ApoE(-/-), 129/Sv), followed by the analysis of kidney function and morphology, blood pressure, cardiac function, cardiac hypertrophy, fibrosis, myocardial calcification and inflammation using functional, histological and molecular techniques, including cardiac gene expression profiling supplemented by oxidative stress analysis. Intriguingly, despite uremia of variable degree, neither cardiac dysfunction, hypertrophy nor interstitial fibrosis were observed. However, already moderate CKD altered cardiac oxidative stress responses and enhanced oxidative stress markers in each mouse strain, with cardiac RNA sequencing revealing activation of oxidative stress signaling as well as anti-inflammatory feedback responses. Conclusion: This study considerably expands the knowledge on strain-and protocol-specific differences in the field of cardiorenal research and reveals that several weeks of at least moderate experimental CKD increase oxidative stress responses in the heart in a broad spectrum of mouse models. However, this was insufficient to induce relevant systolic or diastolic dysfunction, suggesting that additional "hits " are required to induce uremic c, QC 20221108

Published
2022
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8. A systematic review and meta-analysis of murine models of uremic cardiomyopathy

Author

Soppert, Josefin, primary, Frisch, Janina, additional, Wirth, Julia, additional, Hemmers, Christian, additional, Boor, Peter, additional, Kramann, Rafael, additional, Vondenhoff, Sonja, additional, Moellmann, Julia, additional, Lehrke, Michael, additional, Hohl, Mathias, additional, van der Vorst, Emiel P.C., additional, Werner, Christian, additional, Speer, Thimoteus, additional, Maack, Christoph, additional, Marx, Nikolaus, additional, Jankowski, Joachim, additional, Roma, Leticia Prates, additional, and Noels, Heidi, additional

Published
2022
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10. Empagliflozin improves left ventricular diastolic function of db/db mice

Author

Moellmann, Julia, primary, Klinkhammer, Barbara M., additional, Droste, Patrick, additional, Kappel, Ben, additional, Haj-Yehia, Elias, additional, Maxeiner, Sebastian, additional, Artati, Anna, additional, Adamski, Jerzy, additional, Boor, Peter, additional, Schütt, Katharina, additional, Lopaschuk, Gary D., additional, Verma, Subodh, additional, Marx, Nikolaus, additional, and Lehrke, Michael, additional

Published
2020
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14. Empagliflozin Increases Cardiac Energy Production in Diabetes

Author

Verma, Subodh, primary, Rawat, Sonia, additional, Ho, Kim L., additional, Wagg, Cory S., additional, Zhang, Liyan, additional, Teoh, Hwee, additional, Dyck, John E., additional, Uddin, Golam M., additional, Oudit, Gavin Y., additional, Mayoux, Eric, additional, Lehrke, Michael, additional, Marx, Nikolaus, additional, and Lopaschuk, Gary D., additional

Published
2018
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15. The incretin hormone GIP is upregulated in patients with atherosclerosis and stabilizes plaques in ApoE−/− mice by blocking monocyte/macrophage activation

Author

Kahles, Florian, primary, Liberman, Ana, additional, Halim, Constantin, additional, Rau, Matthias, additional, Möllmann, Julia, additional, Mertens, Robert Werner, additional, Rückbeil, Marcia, additional, Diepolder, Irmgard, additional, Walla, Benedikt, additional, Diebold, Sebastian, additional, Burgmaier, Mathias, additional, Lebherz, Corinna, additional, Marx, Nikolaus, additional, and Lehrke, Michael, additional

Published
2018
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19. GLP-1 Levels Predict Mortality in Patients with Critical Illness as Well as End-Stage Renal Disease

Author

Lebherz, Corinna, primary, Schlieper, Georg, additional, Möllmann, Julia, additional, Kahles, Florian, additional, Schwarz, Marvin, additional, Brünsing, Jan, additional, Dimkovic, Nada, additional, Koch, Alexander, additional, Trautwein, Christian, additional, Flöge, Jürgen, additional, Marx, Nikolaus, additional, Tacke, Frank, additional, and Lehrke, Michael, additional

Published
2017
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21. PDE4 inhibition reduces neointima formation and inhibits VCAM-1 expression and histone methylation in an Epac-dependent manner

Author

Lehrke, Michael, primary, Kahles, Florian, additional, Makowska, Anna, additional, Tilstam, Pathricia V., additional, Diebold, Sebastian, additional, Marx, Judith, additional, Stöhr, Robert, additional, Hess, Katharina, additional, Endorf, Elizabeth B., additional, Bruemmer, Dennis, additional, Marx, Nikolaus, additional, and Findeisen, Hannes M., additional

Published
2015
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24. Relation of Plasma Fatty Acid Binding Proteins 4 and 5 With the Metabolic Syndrome, Inflammation and Coronary Calcium in Patients With Type-2 Diabetes Mellitus

Author

Bagheri, Roshanak, primary, Qasim, Atif N., additional, Mehta, Nehal N., additional, Terembula, Karen, additional, Kapoor, Shiv, additional, Braunstein, Seth, additional, Schutta, Mark, additional, Iqbal, Nayyar, additional, Lehrke, Michael, additional, and Reilly, Muredach P., additional

Published
2010
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25. BMI and hyperinsulinemia in children

Author

Vogeser, Michael, primary, Schwandt, Peter, additional, Haas, Gerda-Maria, additional, Broedl, Uli C., additional, Lehrke, Michael, additional, and Parhofer, Klaus G., additional

Published
2009
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