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6,356 results on '"Lei, Wang"'

7. Effect of follicle-stimulating hormone and luteinizing hormone on apoptosis, autophagy and the release and reception of some steroid hormones in yak granulosa cells through miR-23a/ASK1 axis

Author

Xiao-hong, Han, primary, Meng, Wang, additional, Yang-yang, Pan, additional, Jiang-feng, Fan, additional, Jing-lei, Wang, additional, Ling, Zhao, additional, Ya-ying, Wang, additional, Tong-xiang, Zhang, additional, Tian, Zhao, additional, Tian-yi, Ding, additional, Yan, Cui, additional, and Si-jiu, Yu, additional

Published
2023
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29. ·H effectively enhance electrocatalytic nitrogen fixation

Author

Yuyao Sun, Yaodong Yu, Wenxia Xu, Di Wu, Yingying Wei, Jianping Lai, and Lei Wang

Subjects
Biomaterials, Colloid and Surface Chemistry, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials
Published
2023

31. Shield attitude prediction based on Bayesian-LGBM machine learning

Author

Hongyu Chen, Xinyi Li, Zongbao Feng, Lei Wang, Yawei Qin, Miroslaw J. Skibniewski, Zhen-Song Chen, and Yang Liu

Subjects
Information Systems and Management, Artificial Intelligence, Control and Systems Engineering, Software, Computer Science Applications, Theoretical Computer Science
Published
2023

36. Quantitative Assessment of the in vivo Dissolution Rate to Establish a Modified IVIVC for Isosorbide Mononitrate Tablets

Author

Li Zhang, Zeneng Cheng, Lei Wang, Guoqing Zhang, and Yuexiang Tan

Subjects
IVIVC, Chromatography, Pharmacokinetics, In vivo, In vitro dissolution, Chemistry, Isosorbide mononitrate, medicine, Quantitative assessment, Pharmaceutical Science, Dissolution, Dosage form, medicine.drug
Abstract

A modified in vitro-in vivo correlation (IVIVC) of the oral solid dosage forms has been proposed as a linear correlation between in vitro and in vivo dissolution. Nevertheless, the analysis of in vivo dissolution is limited by the lack of available methods. In this proof-of-concept study, a novel pharmacokinetic (PK) model containing the in vivo dissolution process and its quantification was presented to directly estimate the in vivo dissolution rate constant (kd). The new model was validated with a hypothetical oral solution (kd → +∞). The accuracy of the new method was clarified by comparing with the relatively true value of kd from the literature. Isosorbide mononitrate (ISMN) was used as a model drug to explore the practicability of the novel method. The dissolution capacities of ISMN reference and test tablets were discriminated by an improved in vitro dissolution method. Following the human PK studies, the kd values and corresponding in vivo dissolution profiles of two formulations were obtained using the novel method. Finally, a modified level A IVIVC between in vitro and in vivo dissolution of ISMN tablets was established, which is expected to guide the optimization of the tablet formulation containing ISMN.

Published
2023

42. Tislelizumab plus chemotherapy versus placebo plus chemotherapy as first-line treatment for advanced or metastatic oesophageal squamous cell carcinoma (RATIONALE-306): a global, randomised, placebo-controlled, phase 3 study

Author

Jianming Xu, Ken Kato, Eric Raymond, Richard A Hubner, Yongqian Shu, Yueyin Pan, Sook Ryun Park, Lu Ping, Yi Jiang, Jingdong Zhang, Xiaohong Wu, Yuanhu Yao, Lin Shen, Takashi Kojima, Evgeny Gotovkin, Ryu Ishihara, Lucjan Wyrwicz, Eric Van Cutsem, Paula Jimenez-Fonseca, Chen-Yuan Lin, Lei Wang, Jingwen Shi, Liyun Li, and Harry H Yoon

Subjects
Oncology
Published
2023

43. Matrix from urine stem cells boosts tissue-specific stem cell mediated functional cartilage reconstruction

Author

Ming Pei, Yixuan Amy Pei, Sheng Zhou, Elmira Mikaeiliagah, Christopher Erickson, Benjamin Giertych, Halima Akhter, Lei Wang, Amanda Stewart, Joshua Parenti, Bin Wang, Sijin Wen, Sotcheadt Sim, Eric Quenneville, Kirk C. Hansen, Steven Frisch, and Gangqing Hu

Subjects
Biomaterials, Biomedical Engineering, Biotechnology
Abstract

Articular cartilage has a limited capacity to self-heal once damaged. Tissue-specific stem cells are a solution for cartilage regeneration; however

Published
2023

46. High frequency of colorectal neoplasia in patients with sporadic adenomas or adenocarcinomas of the papilla of Vater: The same adenoma-carcinoma sequence?

Author

Fan Zhou, Lu He, Ying Xie, Dehua Tang, Meng Zhang, Ying Lv, Guifang Xu, Xiaoping Zou, Lei Wang, and Chunyan Peng

Subjects
Hepatology, Gastroenterology
Abstract

Data on the frequency of colorectal neoplasia in sporadic ampullary tumors remains scarce.We retrospectively reviewed 135 patients undergoing endoscopic ampullectomy from January 2018 to July 2021, and identified 95 patients with sporadic ampullary adenoma who underwent total colonoscopy. Colonoscopy findings were compared with 380 asymptomatic controls using the chi-squared test. Whole-exome sequencing (WES) was performed on one patient with synchronous adenomas of the ampulla of Vater and ascending colon.Colorectal polyps were present in 60% of Cases vs. 34.7% of Controls (P = 0.001), advanced adenoma in 20% vs. 5.5%, and adenocarcinoma in 4.2% vs. 0.8%. Cases tended to have larger polyps than Controls (P0.001), while there was no difference in polyp location and histology between the two groups. The odds ratio of all the colorectal lesions, advanced colorectal adenoma and adenocarcinoma in Cases was 1.7, 4.2, and 4, respectively. WES in one patient revealed that both of ampullary adenoma and colonic adenoma shared somatic ABCB1 mutation.The frequency of colorectal polyps or neoplasia was significantly higher in Cases than Controls. We proposed that ampullary neoplasia is analogous to colon lesions and warrants total colonoscopy screening in patients diagnosed with ampullary tumors.

Published
2023

49. Frequency-resolved connectome alterations in major depressive disorder: A multisite resting fMRI study

Author

Lei Wang, Qing Ma, Xiaoyi Sun, Zhilei Xu, Jiaying Zhang, Xuhong Liao, Xiaoqin Wang, Dongtao Wei, Yuan Chen, Bangshan Liu, Chu-Chung Huang, Yanting Zheng, Yankun Wu, Taolin Chen, Yuqi Cheng, Xiufeng Xu, Qiyong Gong, Tianmei Si, Shijun Qiu, Ching-Po Lin, Jingliang Cheng, Yanqing Tang, Fei Wang, Jiang Qiu, Peng Xie, Lingjiang Li, Yong He, Mingrui Xia, and Yihe Zhang

Subjects
Psychiatry and Mental health, Clinical Psychology
Published
2023

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