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OBJECTIVE To evaluate the myocutaneous sliding flap for restructuring the eyelid of divided nevus, thus optimizing the aesthetic outcome. DESIGN A retrospective clinical study. PARTICIPANTS Clinical data from patients with a small or medium-sized divided nevus of the eyelids between January 2015 and December 2018 in the Shanghai Ninth People's Hospital were reviewed. METHODS The safety and efficacy of a surgical approach using a myocutaneous sliding flap were evaluated based on postoperative features and complications. RESULTS This study included 53 patients with an average age was 21.6 years (range, 2-68 years). The lesions involved the inner canthus in 5 patients (9.43%) and the lateral canthus in 14 patients (26.42%). Three (5.66%) patients had undergone primary surgery elsewhere. Overall, the eyelid margins were in good shape postoperatively at an average follow-up of 22.7 months, and there were no obvious eyelid deformities, lagophthalmos, or other unacceptable complications postoperatively. The nevi were benign intradermal (60.38%), junctional (16.98%), and compound types (22.64%) without malignant transformation, as confirmed by pathologic examination. No malignant transformation was observed until the end of the follow-up period. CONCLUSION A myocutaneous sliding flap can provide an appropriately size pedicle graft and achieve satisfactory cosmetic results for divided eyelid nevus.

A number of miRNAs and their targets were dragged in the differentiation of bone marrow mesenchymal stem cells (BMSCs). We aimed to elaborate the underlying molecular mechanisms of miRNA-320a in the osteoblast and adipocyte differentiation.Trauma-induced osteonecrosis of the femoral head (TIONFH) and normal control samples (n = 10 for each group) were collected, followed by miRNA chip analysis to identify the differentially expressed miRNAs. HE staining was used to observe the pathological development of TIONFH. Lentiviral vector was used for overexpression and inhibition of miRNA-320a in vitro. Quantitative real-time PCR (qPCR), Western blotting and immunohistochemistry staining were employed to determine the expression of interested genes at mRNA or protein level. Luciferase report assay was employed to determine the binding of miRNA-320a and RUNX2. Alkaline phosphatase (ALP) and Alizarin red staining were performed to observe the osteogenesis and Oil red O staining were conducted to visualize the adipogenesis.Expression of miRNA-320a was up-regulated while RUNX2 expression was down-regulated in TIONFH than Normal control. Luciferase report assay confirmed that miRNA-320a directly targeted to the 3'UTR of RUNX2. miRNA-320a overexpression significantly declined the expressions of osteogenesis-related markers: RUNX2, OSTERIX, Collagen I, Osteocalcin and Osteopontin. ALP and Alizarin red staining confirmed the inhibition function of miRNA-320a in osteogenesis of BMSCs. miRNA-320a inhibition significantly decreased the expression of adipogenesis-related markers: AP2, C/EBPα, FABP4 and PPARγ. Oil Red O staining confirmed the miRNA-320a inhibition reduced adipogenesis of BMSCs.miRNA-320a inhibits osteoblast differentiation via targeting RUNX2 and promotes adipocyte differentiation of BMSCs.

High-hardness TaN compacts with a diameter and height of 6 mm were synthesized through the phase transformation of CoSn-type into WC-type TaN under experimental conditions of high temperature and high pressure. The Vickers hardness of WC-type TaN compacts obtained at the pressure of 5 GPa and the temperature of 1873 K is found to be ~21.5 ± 1.5 GPa with a load of 3 Kg, which is comparable to that of the pure tungsten carbide compact (~20 GPa) and higher than those of ultrahigh temperature ceramics ZrB2 and HfB2 under the same load. The high hardness of WC-type TaN compacts presented in this work is attributed to the deviatoric strain and well-bonded nanograins. The synthesized WC-type TaN compacts also possess a high oxidation temperature (1072 K). These results suggest that the WC-type TaN with high hardness and high thermal stability holds great promise for industrial applications.

Single-atom catalysts (SACs) have demonstrated excellent performances in chemoselective hydrogenation reactions. However, the employment of precious metals and/or organic solvents compromises their sustainability. Herein, we for the first time report the chemoselective hydrogenation of 3-nitrostyrene over noble-metal-free Co-N-C SAC in green solvent — compressed CO2. An interesting inverted V-curve relation is observed between the catalytic activity and CO2 pressure, where the conversion of 3-nitrostyrene reaches the maximum of 100% at 5.0 MPa CO2 (total pressure of 8.1 MPa). Meanwhile, the selectivities to 3-vinylaniline at all pressures remain high (> 99%). Phase behavior studies reveal that, in sharp contrast with the single phase which is formed at total pressure above 10.8 MPa, bi-phase composed of CO2/H2 gas-rich phase and CO2-expanded substrate liquid phase forms at total pressure of 8.1 MPa, which dramatically changes the reaction kinetics of the catalytic system. The reaction order with respect to H2 pressure decreases from ~0.5 to zero at total pressure of 8.1 MPa, suggesting the dissolved CO2 in 3-nitrostyrene greatly promotes the dissolution of H2 in the substrate, which is responsible for the high catalytic activity at the peak of the inverted V-curve.

Fe–Ni nanoparticle–decorated LaSr(Fe,Mo)O4 Ruddlesden–Popper (R–P) perovskite anodes, named R–LSFMNx, were prepared in situ by reducing perovskites La0.5Sr0.5Fe0.9Mo0.1–xNixO3–δ (LSFMNx; x = 0.03–0.07) under SOFC anode operating conditions. Electrolyte–supported single cells with a configuration of R–LSFMNx|La0.9Sr0.1Ga0.8Mg0.2O3–δ (LSGM)|Ba0.5Sr0.5Co0.9Nb0.1O3–δ were used to evaluate the electrochemical performances and redox/long–term stability of the R–LSFMNx anodes fuelled by H2, CO, and simulated syngases (x% H2/CO; x = 50–10). EIS analyses indicated that the increased Ni level in the exsolved Fe–Ni nanocatalysts significantly promotes fuel diffusion/adsorption/dissociation, which plays a rate–limiting role in the anode fuel oxidation. Furthermore, the incremental Ni in Fe–Ni alloy also enhances the anode redox/long–term stability and carbon resistance/tolerance, and the R–LSFMN0.07 anode, i.e., Ni level in Fe–Ni alloy attaining ∼14 mol.%, displays the optimal stability and carbon resistance/tolerance. Finally, the potential of the R–LSFMN0.07 anode for direct utilization of syngas was demonstrated by the characterization of the electrochemical performance and stability based on the R–LSFMN0.07 anode cell.

Hydroxyapatite (HA) coated carbon/carbon composites (CC) is a potential material for orthopedic application because of the combination of good biocompatibility and mechanical properties. In this work, we synthesize a tree-planting interface which is composed of holes formed by micro-oxidized CC substrates and carbon nanotubes (CNTs) to achieve a high bonding strength of HA coating. The holes include annular gaps between carbon fiber and pyrolytic carbon, as well as irregular holes formed by oxidized pyrolytic carbon. The CNTs can grow inside the holes and extend into the HA coating. As a result, the bonding strength of HA coating with tree-planting interface achieves 11.14 ± 0.78 MPa. It increases by 181.3% comparing with the HA coating on CC without interface (3.96 ± 0.30 MPa). The in-vitro bioactivity evaluated by the response of mesenchymal stem cells (MSCs) shows promotions of cell proliferation and cell activity with increasing culture time. After applied with tree-planting interface, the HA coating with strong bonding and good bioactivity may be applied in orthopedic field in the future.

Cobalt–free perovskites Ln0.5Sr0.5Fe0.9Mo0.1O3–δ (Ln = lanthanide; LnSFM) were prepared via a sol–gel process. Pure rhombohedral phases were still not obtained for the samples (Ln = Sm and Gd) even sintered at 1300 °C. Thus, only the LaSFM, PrSFM and NdSFM compositions were assessed as IT–SOFC cathodes in terms of their thermal, electrical and electrochemical properties. Thermal expansion of the LnSFM was well compatible with that of Sm0.2Ce0.8O1.9 (SDC) electrolyte. Both conductivity and electrochemical performances of the LnSFM followed the same sequence of La > Nd > Pr. For the LaSFM, NdSFM and PrSFM cathodes, peak conductivities reached 73, 63 and 59 S·cm–1 at 650 °C; polarization resistances attained 0.211, 0.446 and 0.469 Ω·cm2 at 700 °C; peak power densities of the LnSFM cells with 300–μm–thick SDC electrolyte achieved 269, 261 and 233 mW·cm–2 at 700 °C without cell degradation for operating 100 h. By comprehensive comparison, the LaSFM is assessed as a preferred cobalt–free ceramic cathode for IT–SOFC.

Chemoselective hydrogenation of unsaturated aldehyde to unsaturated alcohol has attracted growing interests in recent years due to its widespread applications in fine chemicals. However, the hydrogenation of the C=O bond was thermodynamically and kinetically unfavorable over the hydrogenation of the C=C bond. Thus, to obtain the unsaturated alcohol from the unsaturated aldehyde is very difficult in most of the catalytic systems. In this work, ZnAl-hydrotalcite-supported cysteine-capped Au25 nanoclusters were used as the precatalysts for chemoselective hydrogenation of cinnamaldehyde to cinnamyl alcohol. The catalyst showed stable high selectivity (~ 95%) at prolonged reaction time and complete conversion of the substrate. According to the results of the control experiments, the in-situ DRIFTS of the substrate under high pressure of hydrogen and the 27Al MAS-NMR spectroscopy, we proposed that the difference of the preferential adsorption of the C=O bond to that of the C=C bond was derived from the nature of the support of the gold catalysts.

Cu@MOF core-shell nanowires are synthesized by introducing oxidizable and CTAB-modified metal nanowires as self-engaged templates and supporting MOFs for a one-dimension nanostructure. The following thermal process is controlled to obtain several one-dimension structures of CuCo-mixed materials, such as nanorods, single-shell and double-shell nanowires. The hollow structure for electrode materials enlarges the surface area, provides buffer space for electrolyte to accelerate the ion/charge transfers and for the structure to reduce injuries of volume expansion during cycling. Together with some other merits, such as adequate oxidation of the MOFs, small crystal grains of the material, and well-mixed Cu/Co oxides, the double-shell Cu@MOF nanowires (CuCo-DS5) applied for pseudocapacitors deliver advanced electrochemical performance with a specific capacitance of 563.8 F g−1 at 1 A g−1 as well as an outstanding cycling stability with a 92 % retention after 3000 cycles at 5 A g−1. Meanwhile, an asymmetric pseudocapacitor constructed with the CuCo-DS5 and active carbon (AC) shows a high specific capacitance and energy density.

Spiral tool path generation methods for the ultra-precision diamond turning of freeform surfaces can significantly affect machining efficiency and surface quality. However, effective methods for freeform surfaces with a high slope, especially nonrotation symmetric surfaces and those determined by the recursive formula, are unavailable. Therefore, a new spiral tool path generation method based on a nonuniform rational B-spline (NURBS) parameter space is proposed for the ultra-precision diamond turning of freeform surfaces. The discrete points are used for NURBS global interpolation by discretizing the surface in a radial Cartesian coordinate system, thereby forming a NURBS surface. A more uniform spiral tool path of freeform surfaces with a higher calculation efficiency can be obtained by directly utilizing the parameters on the NURBS surface than by applying existing methods. In addition, a solution is provided for freeform surfaces determined by the recursive formula. Simulation and experiments are conducted to show the effectiveness and adaptability of our method.

Cobalt − free perovskite oxide La0.5Ba0.5Fe0.95Mo0.05O3−δ (LBFMo) was investigated as the electrode of symmetric solid oxide fuel cell (S − SOFC) based on 300−um − thick La0.9Sr0.1Ga0.8Mg0.2O3−δ (LSGM) electrolyte. The electrochemical performance of the S − SOFC with LBFMo|LSGM|LBFMo configuration was evaluated using ambient air as oxidant and H2 as fuel. The maximum power density (Pmax) of the S − SOFC achieves as high as 0.96 W cm−2 at 800 °C; meanwhile, the total polarization resistance (Rpt) of the S − SOFC (including the contributions of both cathode and anode) is only ∼0.12 Ω cm2. Impedance spectra analysis indicates the polarization associated with anode plays a more rate − limiting role in the whole electrochemical reaction process of the S − SOFC. In addition, using LBFMo as symmetric electrode, the S − SOFC also exhibits good cell stability. All results indicate that the LBFMo is a very potential candidate for S − SOFC electrode.

This article is devoted to establish the explicit analytical expressions for the expected values of the Schultz index, Gutman index, multiplicative degree-Kirchhoff index and additive degree-Kirchhoff index of a random polyphenylene chain. The average values of these four indices with respect to the set of all polyphenylene chains with n hexagons are obtained.

Carbon fiber-Si3N4 nanowires-hydroxyapatite/phenolic resin (CF–Si3N4nws-HA/resin) composites were successfully fabricated by the combined methods of precursor impregnation-pyrolysis (PIP) and pulse electrochemical deposition (PED). The morphology, microstructure and element compositions of Si3N4nws and HA were characterized. The mechanical properties, biological friction performances and in-vitro bioactivity of CF-Si3N4nws-HA/resin composites were investigated. The results showed that the Si3N4nws induced the uniform growth of HA. The tensile strength of the CF-Si3N4nws-HA/resin composites increased by 41.7% compared with CF-HA/resin composites. The wear rate decreased by 85.8% compared with CF-HA/resin composites. CF-Si3N4nws-HA/resin composites showed good in-vitro bioactivity and have potential for applications in bone graft.

In recent years, the damage caused by soil nematodes has become increasingly serious; however, the varieties and structures of the nematicides available on the market are deficient. Fluopyram, a succinate dehydrogenase inhibitor (SDHI) fungicide developed by Bayer AG in Germany, has been widely used in the prevention and control of soil nematodes due to its high efficiency and novel mechanism of action. In this paper, two series of novel target compounds were designed and synthesized with nematicidal and fungicidal fluopyram as the molecular skeleton in order to introduce sulfide and sulfone substructures. The structures were identified and characterized by 1H nuclear magnetic resonance (NMR), 13C NMR, and high-resolution mass spectrometer (HRMS). The bioassays revealed that most of the compounds showed excellent nematicidal activities at 200 µg·mL−1 in comparison with fluopyram, while the nematode mortality rate dropped sharply at 100 µg·mL−1, except for compounds I-11 and II-6. In terms of fungicidal activity, compound I-9 was discovered to have an excellent inhibitory rate, and a molecular docking simulation was performed that can provide important guidance for the design and exploration of efficient fungicidal lead compounds.

Direct assembling 2D zeolitic imidazolate frameworks-derived (ZIFs)-derived Ni-Co oxide on Ni foam (NixCo3−xO4/Ni foam) is a very attractive way to obtain high performance for electrochemical energy storage device. In this work, the highly optimized NixCo3−xO4/Ni foam was prepared via facile co-precipitation, ion-exchange method and subsequently composited with rGO, acting as binder-less electrode for high properties hybrid supercapacitors. As electrode materials, the pure Co3O4/Ni foam shows 94.40 C g−1 (209.78 F g−1) at 1 A g−1, while the highly optimized NixCo3−xO4/Ni foam exhibits a high capacity of 870.3 C g−1 (1934F g−1) at 1 A g−1. Compared with NixCo3−xO4/Ni foam, the reduced graphene oxides (rGO) modified NixCo3−xO4/Ni foam electrodes possess a porous conductive structure, displaying more superior capacity of 1440.99 C g−1 (3202.22F g−1) at 1 A g−1 and a higher cycling stability of 76.10% retention value after 1000 cycles. Subsequently, the NixCo3−xO4/rGO/Ni foam electrodes were assembled as a hybrid supercapacitor, exhibiting a maximum energy density of 36.31 Wh kg−1, a maximum power density of 8000 W kg−1 and a good cycling stability of 76.29% retention value after 3000 cycles. The NixCo3−xO4/rGO/Ni foam also could light the blue LED device. Thereby, it is proved that NixCo3−xO4/rGO/Ni foam is a promising materials for hybrid supercapacitors.

Polyamines (PAs) are key signaling molecules involved in plant growth and stress acclimation processes. This work investigated the effect of spermidine, spermine, and putrescine (alone and in a mixture) in tomato plants using a combined metabolomics and lipidomics approach. The experiments were carried out under non-stress and 100 mM NaCl salinity conditions. Shoot and root biomass, as well as SPAD values, were increased by the application of exogenous PAs but with differences across treatments. Similarly, root length density (F: 34, p 0.001), average root diameter (F: 14, p 0.001), and very fine roots (0.0-0.5 mm) increased in PA-treated plants, compared to control. Metabolomics and lipidomics indicated that, despite being salinity the hierarchically prevalent factor, the different PA treatments imposed distinct remodeling at the molecular level. Plants treated with putrescine showed the broader modulation of metabolite profile, whereas spermidine and spermine induced a comparatively milder effect. The pathway analysis from differential metabolites indicated a broad and multi-level intricate modulation of several signaling molecules together with stress-related compounds like flavonoids and alkaloids. Concerning signaling processes, the complex crosstalk between phytohormones (mainly abscisic acid, cytokinins, the ethylene precursor, and jasmonates), and the membrane lipids signaling cascade (in particular, sphingolipids as well as ceramides and other glycerophospholipids), was involved in such complex response of tomato to PAs. Interestingly, PA-specific processes could be observed, with peculiar responses under either control or salinity conditions.