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Your search keyword '"Lynsey Fazal"' showing total 3 results
Start Over Author "Lynsey Fazal" Publisher elsevier bv
3 results on '"Lynsey Fazal"'

1. Combined inhibition of SHP2 and ERK enhances anti-tumour effects in preclinical models

Author

H. Ochiiwa, Nicola E. Wilsher, Joanne M. Munck, M. Jones, N. Kandola, Nicola G. Wallis, Lynsey Fazal, Sandra Muench, Christopher J. Hindley, John C. Lyons, J. Brothwood, Keisha Hearn, Vanessa Martins, S. Wagner, C.N. Johnson, Y. Nakatsuru, Alpesh Shah, Tomoko Smyth, K. Miyadera, and Harpreet K Saini

Subjects
MAPK/ERK pathway, Cancer Research, Anti tumour, Oncology, Chemistry, Cancer research
Published
2020
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3. 287 POSTER Fragment-based discovery of AT9283; a multi-targeted kinase inhibitor with potent Aurora kinase activity

Author

S. Howard, D. Rees, J.E. Curry, A.L. Gill, Lynsey Fazal, M. Reule, C. Richardson, V. Berdini, P. Wyatt, and D. Tisi

Subjects
Cancer Research, biology, Cyclin-dependent kinase 4, Chemistry, Cyclin-dependent kinase 2, Aurora inhibitor, Aurora B kinase, Mitogen-activated protein kinase kinase, Aurora kinase, Oncology, hemic and lymphatic diseases, biology.protein, Cancer research, Cyclin-dependent kinase 9, c-Raf
Abstract

Ala213 Leu83 Glu211 Glu81 Gln85 The optimisation of fragments to low nanomolar inhibitors can be achieved with a limited number of compounds, particularly if good structural data are available.3 In this work X-ray crystallographic structures were generated using a novel soakable form of Aurora A. Aurora kinases play a key role in the regulation of mitosis and in recent years have become attractive targets for the treatment of cancer.4 In addition to Aurora A and Aurora B, AT9283 was also found to inhibit a number of other kinases including JAK2 and imatinib-resistant Abl (T315I). AT9283 demonstrated in vivo efficacy in mouse xenograft models and is currently under evaluation in Phase I/II clinical trials.

Published
2008
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