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20 results on '"Mangas, Alipio"'

1. Colesterol remanente, riesgo vascular y prevención de la arteriosclerosis

Author

Pintó, Xavier, primary, Fanlo, Marta, additional, Esteve, Virginia, additional, Millán, Jesús, additional, Blanco, Agustín, additional, Blasco, Mariano, additional, Díaz Díaz, José Luís, additional, Díaz Rodríguez, Ángel, additional, Mangas, Alipio, additional, Pascual, Vicente, additional, Pedro Botet, Juan, additional, and Pérez Martínez, Pablo, additional

Published
2023
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5. Peripheral microRNA panels to guide the diagnosis of familial cardiomyopathy

Author

Belmonte, Thalía, primary, Mangas, Alipio, additional, Calderon-Dominguez, Maria, additional, Quezada-Feijoo, Maribel, additional, Ramos, Monica, additional, Campuzano, Oscar, additional, Gomez, Silvia, additional, Peña, Maria Luisa, additional, Cubillos-Arango, Andres M., additional, Dominguez, Fernando, additional, Llorente-Cortés, Vicenta, additional, de Gonzalo-Calvo, David, additional, and Toro, Rocio, additional

Published
2020
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6. Peripheral microRNA panels to guide the diagnosis of familial cardiomyopathy

Author

Belmonte, Thalia, Mangas, Alipio, Calderón‐Domínguez, María, Quezada-Feijoo, Maribel, Ramos-Sánchez, Mónica, Campuzano, Oscar, Gómez, Silvia, Peña-Peña, María Luisa, Cubillos-Arango, Andres M., Domínguez, Fernando, Llorente-Cortés, Vicenta, Gonzalo-Calvo, David de, Toro, Rocío, Belmonte, Thalia, Mangas, Alipio, Calderón‐Domínguez, María, Quezada-Feijoo, Maribel, Ramos-Sánchez, Mónica, Campuzano, Oscar, Gómez, Silvia, Peña-Peña, María Luisa, Cubillos-Arango, Andres M., Domínguez, Fernando, Llorente-Cortés, Vicenta, Gonzalo-Calvo, David de, and Toro, Rocío

Abstract

Etiology-based diagnosis of dilated cardiomyopathy (DCM) is challenging. We evaluated whether peripheral microRNAs (miRNAs) could be used to characterize the DCM etiology. We investigated the miRNA plasma profiles of 254 subjects that comprised 5 groups: Healthy subjects (n = 70), idiopathic DCM patients (n = 55), ischemic DCM patients (n = 60) and 2 groups of patients with pathogenic variants responsible for familial DCM in the LMNA (LMNA, n = 37) and BAG3 (BAG3, n = 32) genes. Diagnostic performance was assessed using receiver operating characteristic curves. In a screening study (n = 30), 179 miRNAs robustly detected in plasma samples were profiled in idiopathic DCM and carriers of pathogenic variants. After filtering, 26 miRNA candidates were selected for subsequent quantification in the whole study population. In the validation study, a 6-miRNA panel identified familial DCM with an AUC (95% confidence interval [CI]) of 87.8 (82.0–93.6). The 6-miRNA panel also distinguished between specific DCM etiologies with AUCs ranging from 85.9 to 89.9. Only 1 to 10 of the subjects in the first and second tertiles of the 6-miRNA panel were patients with familial DCM. Additionally, a 5-miRNA panel showed an AUC (95% CI) of 87.5 (80.4–94.6) for the identification of carriers with pathogenic variants who were phenotypically negative for DCM. The 5-miRNA panel discriminated between carriers and healthy controls with AUCs ranging from 83.2 to 90.8. Again, only 1 to 10 of the subjects in the lowest tertiles of the 5-miRNA panel were carriers of pathogenic variants. In conclusion, miRNA signatures could be used to rule out patients with pathogenic variants responsible for DCM.

Published
2020

7. Emerging role of microRNAs in dilated cardiomyopathy: evidence regarding etiology

Author

Junta de Andalucía, European Commission, Ministerio de Economía y Competitividad (España), Calderón‐Domínguez, María, Belmonte, Thalia, Quezada-Feijoo, Maribel, Ramos-Sánchez, Mónica, Fernandez-Armenta, J., Pérez-Navarro, Amparo, Cesar, Sergi, Peña-Peña, María Luisa, Vea, Ángela, Llorente-Cortés, Vicenta, Mangas, Alipio, Gonzalo-Calvo, David de, Toro, Rocío, Junta de Andalucía, European Commission, Ministerio de Economía y Competitividad (España), Calderón‐Domínguez, María, Belmonte, Thalia, Quezada-Feijoo, Maribel, Ramos-Sánchez, Mónica, Fernandez-Armenta, J., Pérez-Navarro, Amparo, Cesar, Sergi, Peña-Peña, María Luisa, Vea, Ángela, Llorente-Cortés, Vicenta, Mangas, Alipio, Gonzalo-Calvo, David de, and Toro, Rocío

Abstract

Dilated cardiomyopathy (DCM) is a heart muscle disease characterized by ventricular dilation and systolic dysfunction in the absence of abnormal loading conditions or coronary artery disease. This cardiac disorder is a major health problem due to its high prevalence, morbidity, and mortality. DCM is a complex disease with a common phenotype but heterogeneous pathological mechanisms. Early etiological diagnosis and prognosis stratification is crucial for the clinical management of the patient. Advances in imaging technology and genetic tests have provided useful tools for clinical practice. Nevertheless, the assessment of the disease remains challenging. Novel noninvasive indicators are still needed to assist in decision-making. microRNAs (miRNAs), a group of small noncoding RNAs, have been identified as key mediators of cell biology. They are found in a stable form in body fluids and their concentration is altered in response to stress. Previous research has suggested that the miRNA signature constitutes a novel source of noninvasive biomarkers for a wide array of cardiovascular diseases. Specifically, several studies have reported the potential role of miRNAs as clinical indicators among the etiologies of DCM. However, this field has not been reviewed in detail. Here, we summarize the evidence of intracellular and circulating miRNAs in DCM and their usefulness in the development of novel diagnostic, prognostic and therapeutic approaches, with a focus on DCM etiology. Although the findings are still preliminary, due to methodological and technical limitations and the lack of robust population-based studies, miRNAs constitute a promising tool to assist in the clinical management of DCM.

Published
2020

8. Emerging role of microRNAs in dilated cardiomyopathy: evidence regarding etiology

Author

Calderon-Dominguez, Maria, primary, Belmonte, Thalía, additional, Quezada-Feijoo, Maribel, additional, Ramos-Sánchez, Monica, additional, Fernández-Armenta, Juan, additional, Pérez-Navarro, Amparo, additional, Cesar, Sergi, additional, Peña-Peña, Luisa, additional, Vea, Àngela, additional, Llorente-Cortés, Vicenta, additional, Mangas, Alipio, additional, de Gonzalo-Calvo, David, additional, and Toro, Rocio, additional

Published
2020
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9. Molecular basis of the familial chylomicronemia syndrome in patients from the National Dyslipidemia Registry of the Spanish Atherosclerosis Society

Author

Ariza, María José, primary, Rioja, José, additional, Ibarretxe, Daiana, additional, Camacho, Ana, additional, Díaz-Díaz, José Luis, additional, Mangas, Alipio, additional, Carbayo-Herencia, Julio A., additional, Ruiz-Ocaña, Pablo, additional, Lamíquiz-Moneo, Itziar, additional, Mosquera, Daniel, additional, Sáenz, Pedro, additional, Masana, Luis, additional, Muñiz-Grijalvo, Ovidio, additional, Pérez-Calahorra, Sofía, additional, Valdivielso, Pedro, additional, Suárez Tembra, M., additional, Iglesias, Gonzalo Pías, additional, Carbayo Herencia, J.A., additional, Guerrero Buitrago, C., additional, Vila, L., additional, Morales Coca, C., additional, Llargués Rocabruna, E., additional, Perea Castillo, V., additional, Pedro-Botet, J., additional, Climent, E., additional, Mauri Pont, M., additional, Pinto, X., additional, Ortega Martínez de la Victoria, E., additional, Amor, J., additional, Zambón Rados, D., additional, Blanco Vaca, F., additional, Ramiro Lozano, J.M., additional, Fuentes Jiménez, F.J., additional, Soler, I., additional, Ferrer, C., additional, Zamora Cervantes, A., additional, Vila Belmonte, A., additional, Novoa Mogollón, F.J., additional, Sanchez-Hernández, R.M., additional, Expósito Montesdeoca, A.B., additional, Romero Jiménez, M.J., additional, González García, M.P., additional, Bueno Díez, M., additional, Brea Hernando, A., additional, Lahoz, C., additional, Mostaza Prieto, J., additional, Millán Núñez-Cortés, J., additional, Reinares García, L., additional, Blanco Echevarría, A., additional, Ariza Corbo, María José, additional, Rioja Villodres, J., additional, Sánchez-Chaparro, M.A., additional, Jansen Chaparro, S., additional, Sáenz Aranzubía, P., additional, Martorell Mateu, E., additional, Almagro Múgica, F., additional, Muñiz Grijalvo, O., additional, Masana Martín, L., additional, Plana Gil, N., additional, Ibarretxe Gerediaga, D., additional, Rodríguez Borjabad, C., additional, Zabala López, S., additional, Hernández Mijares, A., additional, Ascaso Gimilio, J.F., additional, Pérez García, L., additional, Civeira Murillo, F., additional, Pérez-Calahorra, S., additional, Lamiquiz-Moneo, I., additional, Mateo Gallego, R., additional, Marco Benedí, V., additional, and Ferrando Vela, J., additional

Published
2018
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10. Proteomic identification of putative biomarkers for early detection of sudden cardiac death in a family with a LMNA gene mutation causing dilated cardiomyopathy

Author

Izquierdo, Irene, primary, Rosa, Isaac, additional, Bravo, Susana Belén, additional, Guitián, Esteban, additional, Pérez-Serra, Alexandra, additional, Campuzano, Oscar, additional, Brugada, Ramon, additional, Mangas, Alipio, additional, García, Ángel, additional, and Toro, Rocio, additional

Published
2016
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16. Cocientes lipoproteicos: significado fisiológico y utilidad clínica de los índices aterogénicos en prevención cardiovascular

Author

Millán, Jesús, primary, Pintó, Xavier, additional, Muñoz, Anna, additional, Zúñiga, Manuel, additional, Rubiés-Prat, Joan, additional, Pallardo, Luis Felipe, additional, Masana, Luis, additional, Mangas, Alipio, additional, Mijares, Antonio Hernández, additional, Santos, Pedro González, additional, Ascaso, Juan F., additional, and Pedro-Botet, Juan, additional

Published
2010
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18. Diagnóstico de síndrome metabólico. Adecuación de los criterios diagnósticos en nuestro medio

Author

Ascaso, Juan F., primary, González-Santos, Pedro, additional, Hernández Mijares, Antonio, additional, Mangas, Alipio, additional, Masana, Luis, additional, Millan, Jesús, additional, Pallardo, Luis F., additional, Pedro-Botet, Juan, additional, Pérez-Jiménez, Francisco, additional, Pintó, Xavier, additional, Plaza, Ignacio, additional, Rubiés, Juan, additional, and Zúñiga, Manuel, additional

Published
2006
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