1. Effectiveness of seasonal 2008–2009, 2009–2010 and pandemic vaccines, to prevent influenza hospitalizations during the autumn 2009 influenza pandemic wave in Castellón, Spain. A test-negative, hospital-based, case–control study
- Author
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Joan, Puig-Barberà, Alberto, Arnedo-Pena, Francisco, Pardo-Serrano, María Dolores, Tirado-Balaguer, Silvia, Pérez-Vilar, Ester, Silvestre-Silvestre, Consuelo, Calvo-Mas, Lourdes, Safont-Adsuara, Montserrat, Ruiz-García, and Ramón, Jiménez-Marcos
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Orthomyxoviridae ,medicine.disease_cause ,Disease Outbreaks ,Young Adult ,Influenza A Virus, H1N1 Subtype ,Environmental health ,Influenza, Human ,Epidemiology ,Pandemic ,Odds Ratio ,medicine ,Influenza A virus ,Humans ,Child ,Aged ,General Veterinary ,General Immunology and Microbiology ,biology ,business.industry ,Vaccination ,Public Health, Environmental and Occupational Health ,Infant ,virus diseases ,Middle Aged ,biology.organism_classification ,Virology ,Hospitalization ,Treatment Outcome ,Infectious Diseases ,Immunization ,Influenza Vaccines ,Spain ,Case-Control Studies ,Child, Preschool ,Human mortality from H5N1 ,Molecular Medicine ,Female ,Viral disease ,business - Abstract
We estimate the impact of the two previous influenza seasonal vaccines and the pandemic vaccine on risk of A (H1N1) 2009 laboratory confirmed hospitalizations during the autumn 2009 pandemic wave in Castellón, Spain. We conducted a test-negative, hospital-based, case-control study. Influenza A (H1N1) 2009 infection was detected in 147 (44%) of 334 patients hospitalized for a presumptive influenza related illness. No effect was observed for the 2008-2009 and 2009-2010 seasonal influenza vaccines. However, the pandemic vaccine was associated with an adjusted vaccine effectiveness of 90% (95% CI, 48-100%). Pandemic vaccines were effective in preventing pandemic influenza associated hospitalizations.
- Published
- 2010
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