1. Linaburiosides A−D, acylated iridoid glucosides from Linaria buriatica
- Author
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Mareshige Kojoma, Davaadagva Damdinjav, Kohji Itoh, Naonobu Tanaka, Daisuke Tsuji, Yoshiki Kashiwada, Kanji Niwa, Perleidulam Bunddulam, Kazuyoshi Kawazoe, Shindai Kitaguchi, Sangyong Kim, Ren Yi, and Ariuntuya Tsogtbaatar
- Subjects
Lipopolysaccharides ,0106 biological sciences ,Iridoid ,medicine.drug_class ,Stereochemistry ,Acylation ,Linaria ,Interleukin-1beta ,Phytochemicals ,Anti-Inflammatory Agents ,Molecular Conformation ,Iridoid Glucosides ,Plant Science ,Horticulture ,01 natural sciences ,Biochemistry ,chemistry.chemical_compound ,Glucosides ,Glucoside ,Tumor Cells, Cultured ,medicine ,Humans ,Plantaginaceae ,Moiety ,Iridoids ,Molecular Biology ,biology ,010405 organic chemistry ,Chemistry ,Absolute configuration ,General Medicine ,biology.organism_classification ,0104 chemical sciences ,A549 Cells ,MCF-7 Cells ,Microglia ,010606 plant biology & botany - Abstract
Four previously undescribed acylated iridoid glucosides, linaburiosides A‒D, one undescribed iridoid, 7-deoxyiridolactonic acid, and one known acylated iridoid glucoside, iridolinarin C, were isolated from the aerial parts of a Mongolian traditional herbal medicine, Linaria buriatica. Linaburiosides A‒D had an acyl moiety corresponding to 7-deoxyiridolactonic acid. Detailed spectroscopic analyses of linaburiosides A‒D and 7-deoxyiridolactonic acid led to the assignment of their structures. The absolute configuration of 7-deoxyiridolactonic acid was elucidated by application of the PGME method; those of linaburiosides A‒D were assigned on the basis of chemical conversions, as well as application of the modified Mosher's method. The absolute configuration of iridolinarin C was also elucidated in this study. Anti-inflammatory and antiproliferative activities of isolated compounds and their derivatives were evaluated.
- Published
- 2020
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