1. Cardiovascular alterations in adult GH deficiency
- Author
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Silvia Savastano, Elisabetta Scarano, Carolina Di Somma, Annamaria Colao, Rosario Pivonello, Maria Cristina Savanelli, DI SOMMA, Carolina, Scarano, Elisabetta, Savastano, Silvia, Savanelli, MARIA CRISTINA, Pivonello, Rosario, and Colao, Annamaria
- Subjects
Adult ,Male ,medicine.medical_specialty ,Hormone Replacement Therapy ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,030204 cardiovascular system & hematology ,Carbohydrate metabolism ,Biology ,Growth hormone deficiency ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Insulin resistance ,Risk Factors ,Internal medicine ,GH replacement therapy ,medicine ,Humans ,Insulin-Like Growth Factor I ,Risk factor ,body composition ,medicine.diagnostic_test ,Human Growth Hormone ,medicine.disease ,Somatomedin ,lipid profile ,Cardiovascular Diseases ,Transgender hormone therapy ,growth hormone ,cardiovascular system ,Carbohydrate Metabolism ,Female ,Insulin Resistance ,Lipid profile ,Biomarkers ,GH Deficiency - Abstract
There is a growing body of evidence indicating that patients with adult GH deficiency (GHD) are characterized by a cluster of traditional and emerging cardiovascular risk factors and markers, which can significantly increase their cardiovascular morbidity and mortality possibly linked to aberrations in GH status. Patients with adult GHD present multiple different cardiovascular abnormalities. In addition, cardiovascular risk in adult GHD is increased due to altered body composition, abnormal lipid profile, insulin resistance and impaired glucose metabolism. Cardiovascular risk factors can be reversed, at least partially, after GH replacement. However, evidence on the effects of GH replacement on cardiovascular events and mortality is too limited in adult GHD patients. Aim of this review is to provide an at-a-glance overview of the role of the GH/IGF-I on the cardiovascular system and the state of art of the effects of GH replacement on cardiovascular system.
- Published
- 2017
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