1. MyD88 and TLR4 Expression in Epithelial Ovarian Cancer
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Matthew S. Block, Robert A. Vierkant, Peter F. Rambau, Stacey J. Winham, Philipp Wagner, Nadia Traficante, Aleksandra Tołoczko, Daniel G. Tiezzi, Florin Andrei Taran, Peter Sinn, Weiva Sieh, Raghwa Sharma, Joseph H. Rothstein, Teresa Ramón y Cajal, Luis Paz-Ares, Oleg Oszurek, Sandra Orsulic, Roberta B. Ness, Gregg Nelson, Francesmary Modugno, Janusz Menkiszak, Valerie McGuire, Bryan M. McCauley, Marie Mack, Jan Lubiński, Teri A. Longacre, Zheng Li, Jenny Lester, Catherine J. Kennedy, Kimberly R. Kalli, Audrey Y. Jung, Sharon E. Johnatty, Mercedes Jimenez-Linan, Allan Jensen, Maria P. Intermaggio, Jillian Hung, Esther Herpel, Brenda Y. Hernandez, Andreas D. Hartkopf, Paul R. Harnett, Prafull Ghatage, José M. García-Bueno, Bo Gao, Sian Fereday, Ursula Eilber, Robert P. Edwards, Christiani B. de Sousa, Jurandyr M. de Andrade, Anita Chudecka-Głaz, Georgia Chenevix-Trench, Alicia Cazorla, Sara Y. Brucker, Jennifer Alsop, Alice S. Whittemore, Helen Steed, Annette Staebler, Kirsten B. Moysich, Usha Menon, Jennifer M. Koziak, Stefan Kommoss, Susanne K. Kjaer, Linda E. Kelemen, Beth Y. Karlan, David G. Huntsman, Estrid Høgdall, Jacek Gronwald, Marc T. Goodman, Blake Gilks, María José García, Peter A. Fasching, Anna de Fazio, Suha Deen, Jenny Chang-Claude, Francisco J. Candido dos Reis, Ian G. Campbell, James D. Brenton, David D. Bowtell, Javier Benítez, Paul D.P. Pharoah, Martin Köbel, Susan J. Ramus, Ellen L. Goode, D. Bowtell, G. Chenevix-Trench, A. Green, P. Webb, A. DeFazio, D. Gertig, N. Traficante, S. Fereday, S. Moore, J. Hung, K. Harrap, T. Sadkowsky, N. Pandeya, M. Malt, A. Mellon, R. Robertson, T. Vanden Bergh, M. Jones, P. Mackenzie, J. Maidens, K. Nattress, Y.E. Chiew, A. Stenlake, H. Sullivan, B. Alexander, P. Ashover, S. Brown, T. Corrish, L. Green, L. Jackman, K. Ferguson, K. Martin, A. Martyn, B. Ranieri, J. White, V. Jayde, P. Mamers, L. Bowes, L. Galletta, D. Giles, J. Hendley, K. Alsop, T. Schmidt, H. Shirley, C. Ball, C. Young, S. Viduka, Hoa Tran, Sanela Bilic, Lydia Glavinas, Julia Brooks, R. Stuart-Harris, F. Kirsten, J. Rutovitz, P. Clingan, A. Glasgow, A. Proietto, S. Braye, G. Otton, J. Shannon, T. Bonaventura, J. Stewart, S. Begbie, M. Friedlander, D. Bell, S. Baron-Hay, A. Ferrier, G. Gard, D. Nevell, N. Pavlakis, S. Valmadre, B. Young, C. Camaris, R. Crouch, L. Edwards, N. Hacker, D. Marsden, G. Robertson, P. Beale, J. Beith, J. Carter, C. Dalrymple, R. Houghton, P. Russell, M. Links, J. Grygiel, J. Hill, A. Brand, K. Byth, R. Jaworski, P. Harnett, R. Sharma, G. Wain, B. Ward, D. Papadimos, A. Crandon, M. Cummings, K. Horwood, A. Obermair, L. Perrin, D. Wyld, J. Nicklin, M. Davy, M.K. Oehler, C. Hall, T. Dodd, T. Healy, K. Pittman, D. Henderson, J. Miller, J. Pierdes, P. Blomfield, D. Challis, R. McIntosh, A. Parker, B. Brown, R. Rome, D. Allen, P. Grant, S. Hyde, R. Laurie, M. Robbie, D. Healy, T. Jobling, T. Manolitsas, J. McNealage, P. Rogers, B. Susil, E. Sumithran, I. Simpson, K. Phillips, D. Rischin, S. Fox, D. Johnson, S. Lade, M. Loughrey, N. O'Callaghan, W. Murray, P. Waring, V. Billson, J. Pyman, D. Neesham, M. Quinn, C. Underhill, R. Bell, L.F. Ng, R. Blum, V. Ganju, I. Hammond, Y. Leung, A. McCartney, M. Buck, I. Haviv, D. Purdie, D. Whiteman, and N. Zeps
- Subjects
Carcinoma, Ovarian Epithelial/metabolism ,Adult ,0301 basic medicine ,Oncology ,medicine.medical_specialty ,Myeloid Differentiation Factor 88/metabolism ,Carcinoma, Ovarian Epithelial ,Article ,03 medical and health sciences ,Ovarian tumor ,0302 clinical medicine ,Internal medicine ,Immunohistochemistry/methods ,Biomarkers, Tumor ,medicine ,Carcinoma ,Humans ,Clear-cell ovarian carcinoma ,Tissue Array Analysis/methods ,Survival analysis ,Aged ,Ovarian Neoplasms ,Tissue microarray ,business.industry ,Hazard ratio ,General Medicine ,Middle Aged ,Ovarian Neoplasms/metabolism ,medicine.disease ,ANÁLISE DE SOBREVIVÊNCIA ,Immunohistochemistry ,Survival Analysis ,3. Good health ,Toll-Like Receptor 4 ,Serous fluid ,Toll-Like Receptor 4/metabolism ,030104 developmental biology ,Tissue Array Analysis ,Biomarkers, Tumor/metabolism ,030220 oncology & carcinogenesis ,Myeloid Differentiation Factor 88 ,Female ,business ,Ovarian cancer - Abstract
Objective: To evaluate myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 (TLR4) expression in relation to clinical features of epithelial ovarian cancer, histologic subtypes, and overall survival. Patients and Methods: We conducted centralized immunohistochemical staining, semi-quantitative scoring, and survival analysis in 5263 patients participating in the Ovarian Tumor Tissue Analysis consortium. Patients were diagnosed between January 1, 1978, and December 31, 2014, including 2865 high-grade serous ovarian carcinomas (HGSOCs), with more than 12,000 person-years of follow-up time. Tissue microarrays were stained for MyD88 and TLR4, and staining intensity was classified using a 2-tiered system for each marker (weak vs strong). Results: Expression of MyD88 and TLR4 was similar in all histotypes except clear cell ovarian cancer, which showed reduced expression compared with other histotypes (P
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- 2018